Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol

Biochemical Pharmacology

Volumn 74, Issue 2, 2007, Pages 352-358

  Riches, Zoe ^a   Bloomer, Jackie C ^b   Coughtrie, Michael W H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Detoxification; Drug metabolism; Enzyme kinetics; Human liver; Sulfation; Sulfotransferase

Indexed keywords

2 AMINOPHENOL; 4 NITROPHENOL; ADENOSINE 3' PHOSPHATE 5' PHOSPHOSULFATE; LIVER ENZYME; RECOMBINANT ENZYME; SULFOTRANSFERASE;

ARTICLE; DETOXIFICATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; HUMAN; IMMUNOBLOTTING; LIVER CYTOSOL; LIVER METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; SULFATION;

AMINOPHENOLS; ARYLSULFOTRANSFERASE; CYTOSOL; HUMANS; LIVER;

EID: 34250015798     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.04.006     Document Type: Article

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