ApoA-I induces a preferential efflux of monounsaturated phosphatidylcholine and medium chain sphingomyelin species from a cellular pool distinct from HDL3 mediated phospholipid efflux

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1771, Issue 7, 2007, Pages 853-863

  Schifferer, Rainer ^a   Liebisch, Gerhard ^a   Bandulik, Sascha ^a   Langmann, Thomas ^a   Dada, Ashraf ^a   Schmitz, Gerd ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Electrospray ionization; Lipidomics; Quantitative lipid analysis; Stable isotope labeling; Tandem mass spectrometry

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN E; CHOLESTEROL; CHOLESTEROL ESTER; CHOLINE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MONOUNSATURATED FATTY ACID; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; POLYUNSATURATED FATTY ACID; SPHINGOMYELIN;

ARTICLE; CELL CULTURE; CELL TYPE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; ENDOCYTOSIS; FIBROBLAST; HUMAN; HUMAN CELL; ISOTOPE LABELING; LIPID ANALYSIS; LIPID COMPOSITION; MACROPHAGE; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS;

APOLIPOPROTEIN A-I; BIOLOGICAL TRANSPORT; CARBON ISOTOPES; CELLS, CULTURED; CHOLESTEROL; CULTURE MEDIA; DEUTERIUM; FIBROBLASTS; HUMANS; ISOTOPE LABELING; LIPOPROTEINS, HDL3; MONOCYTES; PHOSPHATIDYLCHOLINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPHINGOMYELINS;

EID: 34250013464     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbalip.2007.04.011     Document Type: Article

References (47)

1. Rothblat G.H., Llera-Moya M., Favari E., Yancey P.G., and Kellner-Weibel G. Cellular cholesterol flux studies: methodological considerations. Atherosclerosis 163 (2002) 1-8
2. Cavelier C., Lorenzi I., Rohrer L., and Von Eckardstein A. Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1. Biochim. Biophys. Acta 1761 (2006) 655-666
3. Bodzioch M., Orso E., Klucken J., Langmann T., Bottcher A., Diederich W., Drobnik W., Barlage S., Buchler C., Porsch-Ozcurumez M., Kaminski W.E., Hahmann H.W., Oette K., Rothe G., Aslanidis C., Lackner K.J., and Schmitz G. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat. Genet. 22 (1999) 347-351
4. Brooks-Wilson A., Marcil M., Clee S.M., Zhang L.H., Roomp K., van Dam M., Yu L., Brewer C., Collins J.A., Molhuizen H.O., Loubser O., Ouelette B.F., Fichter K., Ashbourne-Excoffon K.J., Sensen C.W., Scherer S., Mott S., Denis M., Martindale D., Frohlich J., Morgan K., Koop B., Pimstone S., Kastelein J.J., Genest Jr. J., and Hayden M.R. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat. Genet. 22 (1999) 336-345
5. Rust S., Rosier M., Funke H., Real J., Amoura Z., Piette J.C., Deleuze J.F., Brewer H.B., Duverger N., Denefle P., and Assmann G. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat. Genet. 22 (1999) 352-355
6. Hobbs H.H., and Rader D.J. ABC1: connecting yellow tonsils, neuropathy, and very low HDL. J. Clin. Invest. 104 (1999) 1015-1017
7. Castro G.R., and Fielding C.J. Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein. Biochemistry 27 (1988) 25-29
8. Yokoyama S. Assembly of high density lipoprotein by the ABCA1/apolipoprotein pathway. Curr. Opin. Lipidol. 16 (2005) 269-279
9. Nakamura K., Kennedy M.A., Baldan A., Bojanic D.D., Lyons K., and Edwards P.A. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. J. Biol. Chem. 279 (2004) 45980-45989
10. Wang N., Lan D., Chen W., Matsuura F., and Tall A.R. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 9774-9779
11. Ji Y., Jian B., Wang N., Sun Y., Moya M.L., Phillips M.C., Rothblat G.H., Swaney J.B., and Tall A.R. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J. Biol. Chem. 272 (1997) 20982-20985
12. Acton S., Rigotti A., Landschulz K.T., Xu S., Hobbs H.H., and Krieger M. Identification of scavenger receptor SR-BI as a high density lipoprotein receptor. Science 271 (1996) 518-520
13. Yancey P.G., Llera-Moya M., Swarnakar S., Monzo P., Klein S.M., Connelly M.A., Johnson W.J., Williams D.L., and Rothblat G.H. High density lipoprotein phospholipid composition is a major determinant of the bi-directional flux and net movement of cellular free cholesterol mediated by scavenger receptor BI. J. Biol. Chem. 275 (2000) 36596-36604
14. Xu S., Laccotripe M., Huang X., Rigotti A., Zannis V.I., and Krieger M. Apolipoproteins of HDL can directly mediate binding to the scavenger receptor SR-BI, an HDL receptor that mediates selective lipid uptake. J. Lipid Res. 38 (1997) 1289-1298
15. Fielding P.E., Nagao K., Hakamata H., Chimini G., and Fielding C.J. A two-step mechanism for free cholesterol and phospholipid efflux from human vascular cells to apolipoprotein A-1. Biochemistry 39 (2000) 14113-14120
16. Oram J.F., and Yokoyama S. Apolipoprotein-mediated removal of cellular cholesterol and phospholipids. J. Lipid Res. 37 (1996) 2473-2491
17. Bielicki J.K., Johnson W.J., Glick J.M., and Rothblat G.H. Efflux of phospholipid from fibroblasts with normal and elevated levels of cholesterol. Biochim. Biophys. Acta 1085 (1991) 7-14
18. Bielicki J.K., Johnson W.J., Weinberg R.B., Glick J.M., and Rothblat G.H. Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol. J. Lipid Res. 33 (1992) 1699-1709
19. Gillotte-Taylor K., Nickel M., Johnson W.J., Francone O.L., Holvoet P., Lund-Katz S., Rothblat G.H., and Phillips M.C. Effects of enrichment of fibroblasts with unesterified cholesterol on the efflux of cellular lipids to apolipoprotein A-I. J. Biol. Chem. 277 (2002) 11811-11820
20. Bielicki J.K., McCall M.R., and Forte T.M. Apolipoprotein A-I promotes cholesterol release and apolipoprotein E recruitment from THP-1 macrophage-like foam cells. J. Lipid Res. 40 (1999) 85-92
21. Forte T.M., Bielicki J.K., Goth-Goldstein R., Selmek J., and McCall M.R. Recruitment of cell phospholipids and cholesterol by apolipoproteins A-II and A-I: formation of nascent apolipoprotein-specific HDL that differ in size, phospholipid composition, and reactivity with LCAT. J. Lipid Res. 36 (1995) 148-157
22. Drobnik W., Borsukova H., Bottcher A., Pfeiffer A., Liebisch G., Schutz G.J., Schindler H., and Schmitz G. Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains. Traffic 3 (2002) 268-278
23. Gaus K., Kritharides L., Schmitz G., Boettcher A., Drobnik W., Langmann T., Quinn M., Death A., Dean R.T., and Jessup W. Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. FASEB J. 18 (2004) 574-576
24. Rietveld A., and Simons K. The differential miscibility of lipids as the basis for the formation of functional membrane rafts. Biochim. Biophys. Acta 1376 (1998) 467-479
25. Mendez A.J., and Uint L. Apolipoprotein-mediated cellular cholesterol and phospholipid efflux depend on a functional Golgi apparatus. J. Lipid Res. 37 (1996) 2510-2524
26. Bligh E.G., and Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37 (1959) 911-917
27. Brugger B., Erben G., Sandhoff R., Wieland F.T., and Lehmann W.D. Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 2339-2344
28. Liebisch G., Drobnik W., Lieser B., and Schmitz G. High-throughput quantification of lysophosphatidylcholine by electrospray ionization tandem mass spectrometry. Clin. Chem. 48 (2002) 2217-2224
29. Liebisch G., Lieser B., Rathenberg J., Drobnik W., and Schmitz G. High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm. Biochim. Biophys. Acta 1686 (2004) 108-117
30. Liebisch G., Binder M., Schifferer R., Langmann T., Schulz B., and Schmitz G. High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS). Biochim. Biophys. Acta 1761 (2006) 121-128
31. Binder M., Liebisch G., Langmann T., and Schmitz G. Metabolic profiling of glycerophospholipid synthesis in fibroblasts loaded with free cholesterol and modified low density lipoproteins. J. Biol. Chem. 281 (2006) 21869-21877
32. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., Fujimoto E.K., Goeke N.M., Olson B.J., and Klenk D.C. Measurement of protein using bicinchoninic acid [published erratum appears in Anal Biochem 1987 May 15;163(1):279]. Anal. Biochem. 150 (1985) 76-85
33. Han X., and Gross R.W. Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom. Rev. 24 (2005) 367-412
34. Pulfer M., and Murphy R.C. Electrospray mass spectrometry of phospholipids. Mass Spectrom. Rev. 22 (2003) 332-364
35. Croset M., Brossard N., Polette A., and Lagarde M. Characterization of plasma unsaturated lysophosphatidylcholines in human and rat. Biochem. J. 345 Pt 1 (2000) 61-67
36. Schmitz G., Robenek H., Beuck M., Krause R., Schurek A., and Niemann R. Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. I. Characterization of cellular lipid metabolism. Arteriosclerosis 8 (1988) 46-56
37. Zhang W.Y., Gaynor P.M., and Kruth H.S. Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. J. Biol. Chem. 271 (1996) 28641-28646
38. Kruth H.S., Skarlatos S.I., Gaynor P.M., and Gamble W. Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux. J. Biol. Chem. 269 (1994) 24511-24518
39. Cignarella A., Engel T., Von Eckardstein A., Kratz M., Lorkowski S., Lueken A., Assmann G., and Cullen P. Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors. Atherosclerosis 179 (2005) 229-236
40. Quinn C.M., Kagedal K., Terman A., Stroikin U., Brunk U.T., Jessup W., and Garner B. Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. Biochem. J. 378 (2004) 753-761
41. Do C.S., Seguin D., Milne R., and Rassart E. Modulation of apolipoprotein D and apolipoprotein E mRNA expression by growth arrest and identification of key elements in the promoter. J. Biol. Chem. 277 (2002) 5514-5523
42. Kockx M., Rye K.A., Gaus K., Quinn C.M., Wright J., Sloane T., Sviridov D., Fu Y., Sullivan D., Burnett J.R., Rust S., Assmann G., Anantharamaiah G.M., Palgunachari M.N., Katz S.L., Phillips C., Dean R.T., Jessup W., and Kritharides L. Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux. J. Biol. Chem. 279 (2004) 25966-25977
43. Rigotti A., Trigatti B., Babitt J., Penman M., Xu S., and Krieger M. Scavenger receptor BI - a cell surface receptor for high density lipoprotein. Curr. Opin. Lipidol. 8 (1997) 181-188
44. Schmitz G., Robenek H., Lohmann U., and Assmann G. Interaction of high density lipoproteins with cholesteryl ester-laden macrophages: biochemical and morphological characterization of cell surface receptor binding, endocytosis and resecretion of high density lipoproteins by macrophages. EMBO J. 4 (1985) 613-622
45. Takahashi Y., and Smith J.D. Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 11358-11363
46. Silver D.L., Wang N., Xiao X., and Tall A.R. High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion. J. Biol. Chem. 276 (2001) 25287-25293
47. Schmitz G., Liebisch G., and Langmann T. Lipidomic strategies to study structural and functional defects of ABC-transporters in cellular lipid trafficking. FEBS Lett. 580 (2006) 5597-5610