Association of polymorphisms in vascular endothelial growth factor gene with the age of onset of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis

Volumn 8, Issue 3, 2007, Pages 144-149

  Chen, Dafang ^a   Shen, Li ^b   Wang, Liping ^c   Lu, Aili ^b   Zhang, Huagang ^c   Zhang, Xiaoyan ^b   Zhang, Yingshuang ^c   Shui, Wei ^c   Li, Linsong ^b   Fan, Dongsheng ^c   Zhang, Jun ^c  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

^c PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Age onset; Amyotrophic lateral sclerosis; Polymorphisms; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN;

ADULT; AGED; ALLELE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CHINA; CONTROLLED STUDY; ENZYME ASSAY; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OLIGONUCLEOTIDE PROBE; ONSET AGE; PRIORITY JOURNAL; SYMPTOM;

ADULT; AGE OF ONSET; AGED; AMYOTROPHIC LATERAL SCLEROSIS; DNA; FEMALE; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEX CHARACTERISTICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34249989377     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/17482960601179373     Document Type: Article

References (36)

1. Siddique, T. and Lalani, I. (2002) Genetic aspects of amyotrophic lateral sclerosis. Adv Neurol, 88, pp. 21-32.
2. Andersen, P. M. (2001) Genetics of sporadic ALS. Amyotroph Lateral Scler Other Motor Neuron Disord, 2, pp. 37-41.
3. Hand, C. K. and Rouleau, G. A. (2002) Familial amyotrophic lateral sclerosis. Muscle Nerve, 25, pp. 135-159.
4. Bruijn, L. I., Miller, T. M. and Cleveland, D. W. (2004) Unravelling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci, 27, pp. 723-749.
5. Mulder, D. W. (1982) Clinical limits of amyotrophic lateral sclerosis. Adv Neurol, 36, pp. 15-22.
6. Fernändez-Santiago, R., Sharma, M., Mueller, J. C., Gohlke, H., Illig, T. and Anneser, J. (2006) Possible gender-dependent association of vascular endothelial growth factor gene and ALS. Neurology, 66, pp. 1929-1931.
7. Panas, M., Karadima, G., Kalfakis, N., Psarrou, O., Floroskoufi, P. and Kladi, A. (2000) Genotyping of presenilin-1 polymorphism in amyotrophic lateral sclerosis. J Neurol, 247, pp. 940-942.
8. Veldink, J. H., Berg, L. H. van den, Cobben, J. M., Stulp, R. P., De Jong, J. M. B. V. and Vogels, O. J. (2001) Homozygous deletion of the survival motor neuron 2 gene is a prognostic factor in sporadic ALS. Neurology, 56, pp. 749-752.
9. Siddique, T., Pericak-Vance, M. A. and Caliendo, J. (1998) Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis. Neurogenetics, 1, pp. 213-216.
10. Lacomblez, L., Doppler, V., Beucler, I., Costes, G., Salachas, F. and Raisonnier, A. (2002) APOE: A potential marker of disease progression in ALS. Neurology, 58, pp. 1112-1114.
11. Sondell, M., Lundborg, G. and Kanje, M. (1999) The vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system. J Neurosci, 19, pp. 5731-5740.
12. Schratzberger, P., Schratzberger, G., Silver, M., Curry, C., Kearney, M. and Magner, M. (2000) Favourable effect of the vascular endothelial growth factor gene transfer on ischaemic peripheral neuropathy. Nat Med, 6, pp. 405-413.
13. Jin, K., Zhu, Y. H., Sun, Y. J., Mao, X. O., Xie, L. and Greenberg, D. A. (2002) The vascular endothelial growth factor stimulates neurogenesis in vitro and in vivo. P Natl Acad Sci USA, 99, pp. 11946-11950.
14. Tischer, E., Mitchell, R., Hartman, T., Silva, M., Gospodarowicz, D. and Fiddes, J. C. (1991) The human gene for the vascular endothelial growth factor: Multiple protein forms are encoded through alternative exon splicing. J Biol Chem, 266, pp. 11947-11954.
15. Vincenti, V., Caterina, C., Rocchi, M. and Persico, M. (1996) Assignment of the vascular endothelial growth factor gene to human chromosome 6P21.3. Circulation, 93, pp. 1493-1495.
16. Brogan, I. J., Khan, N., Isaac, K., Hutchinson, J. A., Pravica, V. and Hutchinson, I. V. Novel polymorphisms in the promoter and 5' UTR regions of the human vascular endothelial growth factor gene.
17. Lambrechts, D., Storkebaum, E., Morimoto, M., Del-Favero, J., Desmet, F. and Marklund, S. L. (2003) VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motor neurons against ischaemic death. Nature Genet, 34, pp. 383-394.
18. Zhang, Y., Zhang, H., Fu, Y., Song, H., Wang, L. and Zhang, J. (2006) VEGF C2578A polymorphism does not contribute to amyotrophic lateral sclerosis susceptibility in sporadic Chinese patients. Amyotroph Lateral Scler Other Motor Neuron Disord, 7, pp. 119-122.
19. Brogan, I. J. (1999) Novel polymorphisms in the promoter and 5' UTR regions of the human vascular endothelial growth factor gene. Hum Immunol, 60, pp. 1245-1249.
20. Sondell, M., Lundborg, G. and Kanje, M. (1999) Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system. J Neurosci, 19, pp. 5731-5740.
21. Ilzecka, J. (2004) Cerebrospinal fluid vascular endothelial growth factor in patients with amyotrophic lateral sclerosis. Clin Neurol Neurosurg, 106, pp. 289-293.
22. Carmeliet, P. (2000) Mechanisms of angiogenesis and arteriogenesis. Nat Med, 6, pp. 389-395.
23. Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D. and Brusselmans, K. (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nature Genet, 28, pp. 131-138.
24. Semenza, G. L. (2000) Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol, 59, pp. 47-53.
25. Murakami, T., Ilieva, H., Shiote, M., Nagata, T., Nagano, I. and Shoji, M. (2003) Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene. Brain Res, 989, pp. 231-237.
26. Carmeliet, P. (2003) Blood vessels and nerves: Common signals, pathways and diseases. Nature Rev Genet, 4, pp. 710-720.
27. Schratzberger, P., Schratzberger, G., Silver, M., Curry, C., Kearney, M. and Magner, M. (2000) Favourable effect of VEGF gene transfer on ischaemic peripheral neuropathy. Nature Med, 6, pp. 405-413.
28. Jin, K. L., Mao, X. O. and Greenberg, D. A. (2000) Vascular endothelial growth factor: Direct neuroprotective effect in in vitro ischaemia. Proc Natl Acad Sci USA, 97, pp. 10242-10247.
29. Bosch, L. van den, Storkebaum, E., Vleminckx, V., Moons, L., Vanopdenbosch, L. and Scheveneels, W. (2004) Effects of vascular endothelial growth factor on motor neuron degeneration. Neurobiol Dis, 17, pp. 21-28.
30. Matsuzaki, H., Tamatani, M., Yamaguchi, A., Namikawa, K., Kiyama, H. and Vitek, M. P. (2001) Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades. FASEB J, 15, pp. 1218-1220.
31. Li, B., Xu, W., Luo, C., Gozal, D. and Liu, R. (2003) VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. Brain Res Mol Brain Res, 111, pp. 155-164.
32. Azzouz, M., Ralph, G. S., Storkebaum, E., Walmsley, L. E., Mitrophanous, K. A. and Kingsman, S. M. (2004) VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature, 429, pp. 413-417.
33. Zheng, C., Nennesmo, I., Fadeel, B. and Henter, J. I. (2004) Vascular endothelial growth factor prolongs survival in a transgenic mouse model of ALS. Ann Neurol, 56, pp. 564-567.
34. Moreau, C., Devos, D., Brunaud-Danel, V., Defebvre, L., Perez, T. and Destee, A. (2006) Paradoxical response of VEGF expression to hypoxia in CSF of patients with ALS. J Neurol Neurosurg Psychiatry, 77, pp. 255-257.
35. Devos, D., Moreau, C., Lassalle, P., Perez, T., De Seze, J. and Brunaud-Danel, V. (2004) Low levels of the vascular endothelial growth factor in CSF from early ALS patients. Neurology, 62, pp. 2127-2129.
36. Manly, K. F. (2005) Conventional p-values fail to assure reproducibility for genetic association tests. Trends Genet, 21, pp. 268-269.