Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis

Neurogenetics

Volumn 1, Issue 3, 1998, Pages 213-216

  Siddique, Teepu ^a   Pericak Vance, Margaret A ^b   Caliendo, Janice ^b   Hong, Seong Tshool ^c   Hung, W Y ^a   Kaplan, Jocelyn ^a   McKenna Yasek, Diane ^c   Rimmler, Jackie B ^b   Sapp, Peter ^c,d   Saunders, Ann M ^b   Scott, William K ^b   Siddique, Nailah ^a   Haines, Jonathan L ^c,e   Brown, Robert H ^c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

Amyotrophic lateral sclerosis; Apolipoprotein E; Association studies; Bulbar onset; Limb onset

Indexed keywords

APOLIPOPROTEIN E; APOLIPOPROTEIN E4; DNA;

ADULT; AGED; ALLELE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; FEMALE; GENE FREQUENCY; GENETICS; GENOTYPE; HUMAN; MALE; MIDDLE AGED; ONSET AGE; STATISTICAL MODEL;

ADULT; AGE OF ONSET; AGED; ALLELES; AMYOTROPHIC LATERAL SCLEROSIS; APOLIPOPROTEIN E4; APOLIPOPROTEINS E; DNA; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED;

EID: 0032008650     PISSN: 13646745     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100480050031     Document Type: Article

References (16)

1. Fosgren L, Almay G, Holmgren G, Wall S (1983) Epidemiology of motor neuron disease in northern Sweden. Acta Neurol Scand 68:20-29
2. Mulder DW, Kurland LT, Offord KP, Beard CM (1986). Familial adult motor neuron disease: amyotrophic lateral sclerosis. Neurology 36:511-517
3. Siddique TS, Figlewicz D, Pericak-Vance MA, Haines JL, Roos RP, Rouleu G, Williams D, Watkins PC, Jeffers A, Sapp P, Hung W-Y, Bebout J, Noore FR, Nicholson G, Reed R, McKenna-Yasek D, Deng G, Brooks BR, Festoff B, Antel JP, Tandan R, Munsat TL, Mulder DW, Laing, NG, Halperin J, Norris FH, Van den Bergh R, Swerts L, Tanzi R, Jubelt B, Matthews KD, Bosch EP, Horvitz HR, Gusella JF, Brown RH Jr, Roses AD (1991) Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence for genetic locus heterogeneity. N Engl J Med 324:1381-1384
4. Rosen D, Siddique T, Patterson D, Figlewicz D, Sapp P, Hentati A, Donaldson D, Goto O, O'Regan J, Deng H-X, Rahmani Z, Krizus A, McKenna-Yasek D, Cayabyab A, Gaston S, Berger R, Tanzi RE, Halperin J, Herzfeldt B, Van den Berg R, Hung W-Y, Bird T, Deng G, Mulder D, Smyth C, Laing NG, Soriano E, Pericak-Vance MA, Haines J, Rouleau G, Gusella H, Horvitz HR, Brown RH Jr (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 362:59-62
5. Williams DB, Windebank AJ (1991) Motor neuron disease (amyotrophic lateral sclerosis). Mayo Clin Proc 66:54-82
6. Brownell B, Oppenheimer DR, Hughes JT (1970) The central nervous system in motor neurone disease. J Neurol Neurosurg Psychiatry 33:338-357
7. Saunders AM, Strittmatter WJ, Schmechel D, St. George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Growden J, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD (1993) Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43:1467-1472
8. Pericak-Vance MA, Haines JL (1995) Genetic susceptibility to Alzheimer disease. Trends Genet 11:504-508
9. Mui S, Rebeck GW, McKenna-Yasek D, Hyman BT, Brown RH Jr (1995) Apolipoprotein E ε4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis. Ann Neurol 38:460-463
10. Al-Chalabi A, Enayat ZE, Bakker MC, Sham PC, Ball DM, Shaw CE, Lloyd CM, Powell JF, Leigh PN (1996) Association of apolipoprotein E ε4 allele with bulbar-onset motor neuron disease. Lancet 347:159-160
11. Smith RG, Haverkamp LJ, Case S, Appel V, Appel SH (1996) Apolipoprotein E ε4 in bulbar-onset motor neuron disease. Lancet 348:334-335
12. Moulard B, Sefiani A, Laamri A, Malafosse A, Camu W (1996) Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis. J Neurol Sci 139:34-37
13. Locke P, Conneally PM, Tanzi RE, Gusella JF, Haines JL (1995) APOE and Alzheimer disease: examination of allelic association and effect on age at-onset in both early and late onset cases. Genet Epidemiol 12:83-92
14. Fleiss JL (1981) Statistical methods for rates and proportions, 2nd edn. Wiley, New York
15. Elston RC, Johnson WD (1994) Essentials of biostatistics. Davis, Philadelphia, pp 268-269
16. Gubbay SS, Kahana E, Zilber N, Cooper G, Pintov S, Leibowitz Y (1995) Amyotrophic lateral sclerosis. A study of its presentation and prognosis. J Neurol 232:295-300