Galectins - Potential targets for cancer therapy

Cancer Letters

Volumn 253, Issue 1, 2007, Pages 25-33

  Hasan, Syed Saif ^a   Ashraf, Ghulam Md ^b   Banu, Naheed ^b  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

^b ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

Cancer; Detection; Galectins; Glycoconjugates; Inhibition; Metastasis; Therapy

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; GALECTIN; GLYCOCONJUGATE; PECTIN; STAUROSPORINE;

BREAST CANCER; CANCER THERAPY; CARCINOGENESIS; DRUG TARGETING; GLIOMA; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SHORT SURVEY; THYROID TUMOR;

EID: 34249978481     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2006.11.030     Document Type: Review

References (112)

1. Drickamer K. Two distinct classes of carbohydrate-recognition domains in animal lectins. J. Biol. Chem. 263 (1988) 9557-9560
2. Sharon N., and Lis H. Lectins as cell recognition molecules. Science 246 (1989) 227-234
3. Barondes S.H. Galectins: a personal overview. Trends Glycosci. Glycotechnol. 9 (1997) 1-7
4. Teichberg V.I., Silman I., Beitsch D.D., and Resheff G. A f3-d-galactoside binding protein from electric organ tissue of electrophorus electricus. Proc. Natl. Acad. Sci. USA 72 (1975) 1383-1387
5. Barondes S.H., Castronovo V., Cooper D.N.W., Cummings R.D., Drickamer K., Feizi T., Gitt M.A., Hirabayashi J., Hughes C., Kasai K., Leffler H., Liu F., Lotan R., Mercurio A.M., Monsigni M., Pillai S., Poirer F., Raz A., Rigby P.W.J., Rini J.M., and Wang J.L. Galectins: a family of animal galactoside-binding lectins. Cell 76 (1994) 597-598
6. Barondes S.H., Cooper D.N.W., Gitt M.A., and Leffler H. Galectins: structure and function of a large family of animal lectins. J. Biol. Chem. 269 (1994) 20807-20810
7. Hirabayashi J., and Kasai K. Human placenta β-galactoside-binding lectin. Purification and some properties. Biochem. Biophys. Res. Commun. 122 (1984) 938-944
8. Cooper D.N.W., and Barondes S.H. God must love galectins: he made so many of them. Glycobiology 9 (1999) 979-984
9. Liao D.I., Kapadia G., Ahmed H., Vasta G.R., and Herzberg O. Structure of S-lectin, a developmentally regulated vertebrate beta-galactoside-binding protein. Proc. Natl. Acad. Sci. USA 91 (1994) 1428-1432
10. Hirabayashi J., and Kasai K. The family of metazoan metal-independent β-galactoside binding lectins: structure, function and molecular evolution. Glycobiology 3 (1993) 297-304
11. Stillman B.N., Mischel P.S., and Baum L.G. New roles for galectins in brain tumors-from prognostic markers to therapeutic targets. Brain Pathol. 15 (2005) 124-132
12. Gitt M.A., and Barondes S.H. Genomic sequence and organization of two members of a human lectin gene family. Biochemistry 30 (1991) 82-89
13. Gitt M.A., Massa S.M., Leffler H., and Barondes S.H. Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. J. Biol. Chem. 267 (1992) 10601-10606
14. Gitt M.A., Wisers M.F., Leffler H., Herrmann J., Xia Y.-R., Massa S.M., Cooper D.N.W., Luis A.J., and Barondes S.H. Sequence and mapping of galectin-5, a β-galactoside-binding lectin, found in rat erythrocytes. J. Biol. Chem. 270 (1995) 5032-5038
15. Magnaldo T., Bernerd F., and Darmon M. Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid. Dev. Biol. 168 (1995) 259-271
16. Hirabayashi J., Ubukata T., and Kasai K. Purification and molecular characterization of a novel 16-kDa galectin from the nematode Caenorhabditis elegans. J. Biol. Chem. 271 (1996) 2497-2505
17. Vasta G.R., Ahmed H., Amzel L.M., and Bianchet M.A. Galectins from amphibian species: carbohydrate specificity, molecular structure and evolution. Trends Glycosci. Glycotechnol. 9 (1997) 131-144
18. Paroutaud P., Levi G., Teichberg V.I., and Strosberg A.D. Extensive amino acid homologies between animal lectins. Proc. Natl. Acad. Sci. USA 84 (1987) 6345-6348
19. Ohyama Y., Hirabayashi J., Oda Y., Oono S., Kawasaki H., Suzuki K., and Kasai K. Nucleotide sequence of chick 14 K β-galactoside-binding lectin mRNA. Biochem. Biophys. Res. Commun. 134 (1986) 51-56
20. Sakakura Y., Hirabayashi J., Oda Y., Ohyama Y., and Kasai K. Structure of chicken 16-kDa β-galactoside-binding lectin: complete amino acid sequence, cloning of cDNA and production. J. Biol. Chem. 265 (1990) 21573-21579
21. Ackerman S.J., Corrette S.E., Rosenberg H.F., Bennet J.C., Mastrianni D.M., Nicholson-Weller A., Weller P.F., Chin D.T., and Tenen D.G. Molecular cloning and characterization of human eosinophil Charcot-Leyden crystal protein (lysophospholipase). J. Immunol. 150 (1993) 456-468
22. Rini J.M. Lectin structure. Annu. Rev. Biophys. Biomol. Struct. 24 (1995) 551-577
23. Hughes R.C. Mac-2: a versatile galactose-binding protein of mammalian tissues. Glycobiology 4 (1994) 5-12
24. Oda Y., Herrmann J., Gitt M.A., Turck C.W., Burlingame A.L., Barondes S.H., and Leffler H. Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same chain. J. Biol. Chem. 268 (1993) 5929-5939
25. Gitt M.A., Colnot C., Poirier F., Nani K.J., Barondes S.H., and Leffler H. Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract. J. Biol. Chem. 273 (1998) 2954-2960
26. Hadari Y.R., Paz K., Dekel R., Mestrovic T., Accili D., and Zick Y. Galectin-8: a new rat lectin, related to galectin-4. J. Biol. Chem. 270 (1995) 3447-3453
27. Tureci O., Schmitt H., Fadle N., Pfreundschuh M., and Sahin U. Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease. J. Biol. Chem. 272 (1997) 6416-6422
28. Cooper D.N.W. Galectin-1: secretion and modulation of cell interactions with laminin. Trends Glycosci. Glycotechnol. 9 (1997) 57-67
29. Wells V., and Mallucci L. Identification of an autocrine negative growth factor: mouse β-galactoside-binding protein is a cytostatic factor and cell growth regulator. Cell 64 (1991) 91-97
30. Adams L., Kenneth S.G., and Weinberg C. Biphasic modulation of cell growth by recombinant human galectin-1. Biochem. Biophys. Acta 1312 (1996) 137-144
31. Poirier F., Timmons P.M., Chan C.-T., Guenet J.L., and Rigby P. Expression of the L14 lectin during mouse embryogenesis suggests multiple roles during pre and post-implantation development. Development 115 (1992) 143-155
32. Yamaoka A., Kuwabara I., Frigeri L.G., and Liu F.T. A human lectin, galectin-3 (epsilon-BP/ Mac-2) stimulates superoxide production by neutrophils. J. Immunol. 154 (1995) 3479-3487
33. Raz A., and Lotan R. Endogenous galactoside-binding lectins: a new class of functional tumor cell surface molecules related to metastasis. Cancer Metast. Rev. 6 (1987) 433-452
34. Bresalier R.S., Mazurek N., Sternberg L.R., Byrd J.C., Yunker C.K., Makker P.N., and Raz A. Metastasis of human colon cancer is altered by modifying expression of the β-galactoside binding protein galectin-3. Gastroenterology 115 (1998) 287-296
35. Rabinovich G.A., Iglesias M.M., Modesti N.M., Castagna L.F., Wolfenstein-Todel C., Riera C.M., and Sotomayor C.E. Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: biochemical and functional characterization. J. Immunol. 160 (1998) 4831-4840
36. Perillo N.L., Pace K.E., Seilhamer J.J., and Baum L.G. Apoptosis of T-cells mediated by galectin-1. Nature 378 (1995) 736-739
37. Yang R.Y., Hsu D.K., and Liu F.T. Expression of galectin-3 modulates T cell growth and apoptosis. Proc. Natl. Acad. Sci. USA 93 (1996) 6737-6742
38. Park J.W., Voss P.G., Grabski S., Wang J.L., and Patterson R.J. Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acid Res. 29 (2001) 3595-3602
39. Pellizoni L., Kataoka N., Charroux B., and Dreyfuss G. A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA gene splicing. Cell 95 (1998) 615-624
40. Hsu D.K., Hammes S.R., Kuwabara I., Greene W.C., and Liu F.T. Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside binding lectin, galectin-3. J. Biol. Chem. 148 (1996) 1661
41. Gaudin J.C., Arar C., Monsigny M., and Legrand A. Modulation of the expression of the rabbit galectin-3 gene by p53 and c-Ha-ras proteins and PMA. Glycobiology 7 (1997) 1089-1098
42. Sato S., and Hughes R.C. Regulation of secretion and surface expression of Mac-2, a galactoside-binding protein of macrophages. J. Biol. Chem. 269 (1994) 4424-4430
43. Gillenwater A., Xu X.C., Estrov Y., Sacks P.G., Lotan D., and Lotan R. Modulation of galectin-1 content in human head and neck squamous carcinoma cells by sodium butyrate. Int. J. Cancer 75 (1998) 217-224
44. Kasai K., and Hirabayashi J. Galectins: a family of animal lectins that decipher glycocodes. J. Biochem. 119 (1996) 1-8
45. Cleves A.E., Cooper D.N., Barondes H.S., and Kelly R.B. A new pathway for protein export in Saccharomyces cerevisiae. J. Cell Biol. 133 (1996) 1017-1026
46. Hernandez J.D., and Baum L.G. Ah, sweet mystery of death! Galectins and control of cell fate. Glycobiology 12 (2002) 127-136
47. Iglesias M.M., Rabinovich G.A., Ivanovic V., Sotomayor C.E., and Wolfenstein-Todel C. Galectin-1 from ovine placenta: amino-acid sequence, physicochemical properties and implications in T-cell death. Eur. J. Biochem. 252 (1998) 400-407
48. Rabinovich G.A. Galectins: an evolutionarily conserved family of animal lectins with multifunctional properties; a trip from the gene to clinical therapy. Cell Death Differ. 6 (1999) 711-721
49. Iglesias M.M., Rabinovich G.A., Ambrosio A.L., Sotomayor C.E., and Todel C.W. Lectin-induced immunoregulation in ovine placenta. In: van Driessche E., Beeckmans S., and Bog-Hansen T.C. (Eds). Lectins. Biol. Biochem. Clin. Biochem. vol. 12 (1998), Lextop, Hellerup Denmark
50. Dumic J., Dabelic S., and Flögel M. Galectin-3: an open-ended story. Biochim. Biophys. Acta 1760 (2006) 616-635
51. van den Brule F., Califice S., and Castronovo V. Expression of galectins in cancer: a critical review. Glycoconj. J. 19 (2004) 537-542
52. Paz A., Haklai R., Elad-Sfadai G., Ballan E., and Kloog Y. Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene 20 (2001) 7486-7493
53. Mataresse P., Fusco O., Tinari N., Natoli C., Liu F.T., Semeraro M.L., Malorni W., and Iacobelli S. Galectin-3 overexpression protects from apoptosis by improving cell adhesion properties. Int. J. Cancer 85 (2000) 545-554
54. Warfield P.R., Makker P.N., Raz A., and Ochieng J. Adhesion of human breast carcinoma to extracellular matrix proteins is modulated by galectin-3. Inv. Metastas. 17 (1997) 101-112
55. Lotz M.M., Andrews Jr. C.W., Korzelius C.A., Lee E.C., Steele Jr. G.D., Clarke A., and Mercurio A.M. Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma. Proc. Natl. Acad. Sci. USA 90 (1993) 3466-3470
56. Sanjuan X., Fernandez P.L., Castells A., Castronovo V., van den Brule F., Liu F.-T., Cardesa A., and Campo E. Differential expression of galectin 3 and galectin 1 in colorectal cancer progression. Gastroenterology 113 (1997) 1906-1915
57. Honjo Y., Inohara H., Akahani S., Yoshii T., Takenaka Y., Yoshida J., Hattori K., Tomiyama Y., Raz A., and Kubo T. Expression of cytoplasmic galectin-3 as a prognostic marker in tongue carcinoma. Clin. Cancer Res. 6 (2000) 4635-4640
58. van den Brule F.A., Waltregny D., Liu F.-T., and Castronovo V. Alteration of the cytoplasmic/nuclear expression pattern of galectin-3 correlates with prostate carcinoma progression. Int. J. Cancer 89 (2000) 361-367
59. Puglisi F., Minisini A.M., Barbone F., Intersimone D., Aprile G., Puppin C., Damante G., Paron I., Tell G., Piga A., and Di Loreto C. Galectin-3 expression in non-small cell lung carcinoma. Cancer Lett. 212 (2004) 233-239
60. Califice S., Castronovo V., Bracke M., and van den Brule F. Dual activities of galectin-3 in human prostate cancer: tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3. Oncogene 23 (2004) 7527-7536
61. Rossi D.L., Acebran A., and Santisteban P. Function of the homeo and paired domain proteins TTF-1 and Pax-8 in thyroid cell proliferation. J. Biol. Chem. 270 (1995) 23139-23142
62. Krzeslak A., and Lipinska A. Galectin-3 as a multifunctional protein. Cell. Mol. Biol. Lett. 9 (2004) 305-328
63. Xu X.C., el-Naggar A.K., and Lotan R. Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications. Am. J. Pathol. 147 (1995) 815-822
64. Rorive S., Belot N., Decaestecker C., Lefrane F., Gorodower L., Micik S., Maurage C.A., Kaltner H., Ruchoux M.M., Danguy A., Gabius H.J., Salmon I., Kiss R., and Camby I. galectin-1 is highly expressed in human gliomas with relevance for modulation of invasion of tumor astrocytes into brain parenchyma. Glia 33 (2001) 241-245
65. van Den Brule F.A., Waltregny D., and Castronovo V. Increased expression of galectin-1 in carcinoma-associated stroma predicts poor outcome in prostrate carcinoma patients. J. Pathol. 193 (2001) 80-87
66. Ellehorst J., Nguven T., Cooper D.N.W., Lotan D., and Lotan R. Differential expression of endogenous galectin-1 and galectin-3 in human prostate cancer cell lines and effects of overexpressing galectin-1 on cell phenotype. Int. J. Oncol. 14 (1999) 217-224
67. Rabinovish G.A., Rubinstein N., Matar P., Rozados V., Gervasoni S., and Scharovsky O.G. The anti-metastatic effect of single low-dose cyclophosphamide involves modulation of galectin-1 and Bcl-2 expression. Cancer Immunol. Immunother. 50 (2002) 587-603
68. Yamaoka K., Mishima K., Nagashima Y., Asai A., Sanai Y., and Kirino T. Expression of galectin-1 mRNA correlates with the malignant potential of human gliomas and expression of antisense galectin-1 inhibits the growth of 9 glioma cells. J. Neurosci. Res. 59 (2000) 722-730
69. van Den Brule F.A., Buicu C., Baldet M., Sobel M.E., Cooper D.N.W., Marschal P., and Castronovo V. Galectin-1 modulates human melanoma cell adhesion to laminin. Biochem. Biophys. Res. Commun. 209 (1995) 760-767
70. Bernard F., Sarasin A., and Magnaldo T. Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. Proc. Natl. Acad. Sci. USA 96 (1999) 11329-11334
71. Lahm H., Andre S., Hoeflich A., fischer J.R., Sordat B., Kaltner h., Wolf E., and Gabius H.J. comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J. Cancer Res. Clin. Oncol. 127 (2001) 375-386
72. Gopalkrishnan R.V., Roberts T., Tuli S., Kang D., Christiansen K.A., and Fisher P.B. Molecular characterization of prostate carcinoma tumor antigen-I, a human galectin-8 related gene. Oncogene 19 (2000) 4405-4416
73. Lahm H., Hoeflich A., Andre S., Sordat B., Kaltner H., Wolf E., and Gabius H. Gene expression of galectin-9/ecalectin, a potent eosinophil chemoattractant, and/ or the insertional isoform in human colorectal carcinoma cell lines and detection of frameshift mutations for protein sequence truncations in the second functional lectin domain. Int. J. Oncol. 17 (2000) 519-524
74. Poirier F., and Robertson E.J. Normal development of mice carrying a null mutation in the gene encoding the L-14S-type lectin. Development 119 (1993) 1229-1236
75. Colnot C., Fowlis D., Ripoche M.A., Bouchaert I., and Poirier F. Embryonic implantation in galectin-1/galectin-3 double mutant mice. Dev. Dyn. 211 (1998) 306-313
76. Hakomori S. Glycosylation defining cancer malignancy: new wine in an old bottle. Proc. Natl. Acad. Sci. USA 99 (2002) 10231-10233
77. Kojima N., Hakomori S., and Adhesion C. Spreading, and motility of GM3-expressing cells based on glycolipid-glycolipid interaction. J. Biol. Chem. 266 (1991) 17552-17558
78. Miura Y., Kainuma M., Jiang H., Velasco H., Vogt P.K., and Hakomori S. Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside). Proc. Natl. Acad. Sci. USA 101 (2004) 16204-16209
79. Ono M., Handa K., Sonnino S., Withers D.A., Nagai H., and Hakomori S. GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy. Biochemistry 4 (2001) 6414-6421
80. Satoh M., Ito A., Nojiri H., Handa K., Numahata K., Ohyama C., Saito S., Hoshi S., and Hakomori S.I. Enhanced GM3 expression, associated with decreased invasiveness, is induced by brefeldin A in bladder cancer cells. Int. J. Oncol. 19 (2001) 723-731
81. Ideo H., Seko A., Ishizuka I., and Yamashita K. The N-terminal carbohydrate recognition domain of galectin-8 recognizes specific glycosphingolipids with high affinity. Glycobiology 13 (2003) 713-723
82. Brewer C.F. Cross-linking activities of galectins and other multivalent lectins. Trends Glycosci. Glycotechnol. 9 (1997) 155-165
83. Hirabayashi J., and Kasai K. The family of metazoan metal-independent β-galactoside-binding lectins: structure, function and molecular evolution. Glycobiology 3 (1993) 297-304
84. Nowak T.P., Kobiler D., Roel L.E., and Barondes S.H. Developmentally regulated lectin from embryonic chick pectoral muscle. Purification by affinity chromatography. J. Biol. Chem. 252 (1977) 6026-6030
85. Turner R.H., and Liener I.E. The use of glutaraldehyde-treated erythrocytes for assaying the agglutinating activity of lectins. Anal. Biochem. 68 (1975) 651-653
86. von Wolff M., Wang X., Gabius H.-J., and Strowitzki T. Galectin fingerprinting in human endometrium and decidua during the menstrual cycle and in early gestation. Mol. Hum. Reprod. 11 (2005) 189-194
87. Hittelet A., Legendre H., Nagy N., Bronckart Y., Pector J.-C., Salmon I., Yeaton P., Gabius H.-J., Kiss R., and Camby I. Upregulation of galectins-1 and -3 in human colon cancer and their role in regulating cell migration. Int. J. Cancer 103 (2003) 370-379
88. Perillo N.L., Marcus M.E., and Baum L.G. Galectins: versatile modulators of cell adhesion, cell proliferation and cell death. J. Mol. Med. 76 (1998) 402-412
89. Pieters R.J. Inhibition and detection of galectins. ChemBioChem 7 (2006) 721-728
90. Debray C., Vereecken P., Belot N., Teillard P., Brion J.P., Pandolfo M., and Pocher R. Multifaceted role of galectin-3 on human glioblastoma cell motility. Biochem. Biophys. Res. Commun. 325 (2004) 1393-1398
91. Shen J., Person M.D., Zhu J., Abbruzzese J.L., and Li D. Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res. 64 (2004) 9018-9026
92. Szçke T., Kayser K., BaumhUkel J.-D., Trojan I., Furak J., Tiszlavicz L., Horvath A., Szluha K., Gabius H.-J., and AndrR S. Prognostic significance of endogenous adhesion/growth-regulatory lectins in lung. Cancer Oncol. 69 (2005) 167-174
93. Kamemura K., and Kato S. Detection of lectins using ligand blotting and polyacrylamide-type glycoconjugate probes. Anal. Biochem. 258 (1998) 305-310
94. Human Galectin-3 ELISA, BMS279, Bender MedSystems GmbH, Vienna (Austria).
95. Moiseeva E.V., Rapoport E.M., Bovin N.V., Miroshnikov A.I., Chaadaeva A.V., Krasilshchikova M.S., Bojenko V., Bijleveld C., van Dijk J.E., and den Otter W. Galectins as markers of aggressiveness of mouse mammary carcinoma: towards a lectin target therapy of human breast cancer. Breast Cancer Res. Treat. 91 (2005) 227-241
96. Puche A.C., Poirier F., Hair M., Barlett P.F., and Key B. Role of galectin-1 in the developing mouse olfactory system. Dev. Biol. 179 (1996) 274-287
97. Colnot C., Ripoche M.A., Milon G., Montagutelli X., Crocker P.R., and Poirier F. Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutanat mice. Immunology 94 (1998) 290-296
98. Nangia-Makker P., Hogan V., Honjo Y., Baccarini S., Tait L., Bresalier R., and Raz A. Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J. Natl. Cancer Inst. 94 (2002) 1854
99. Chauhan D., Li G., Podar K., Hideshima T., Neri P., He D., Mitsiades N., Richardson P., Chang Y., Schindler J., Carver B., and Anderson K.C. A novel carbohydrate-based therapeutic GCS-100 overcomes Bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells. Cancer Res. 65 (2005) 8350-8358
100. Monzavi-Karbassi B., Cunto-Amesty G., Luo P., and Kieber-Emmons T. Peptide mimotopes as surrogate antigens of carbohydrates in vaccine discovery. Trends Biotechnol. 20 (2002) 207-214
101. Oldenburg K.R., Loganathan D., Goldstein I.J., Schultz P.G., and Gallop M.A. Peptide ligands for a sugar-binding protein isolated from a random peptide library. Proc. Natl. Acad. Sci. USA 89 (1992) 5393-5397
102. Scott J.K., Loganathan D., Easley R.B., Gong X., and Goldstein I.J. A family of concanavalin A-binding peptides from a hexapeptide epitope library. Proc. Natl. Acad. Sci. USA 89 (1992) 5398-5402
103. Kaur K.J., Khurana S., and Salunke D.M. Topological analysis of the functional mimicry between a peptide and a carbohydrate moiety. J. Biol. Chem. 272 (1997) 5539-5543
104. Ravishankar R., Thomas C.J., Suguna K., Surolia A., and Vijayan M. Structure, function and genetics. Proteins 43 (2001) 260-270
105. Meldal M., Auzanneau F.I., Hindsgaul O., and Palcic M.M. A PEGA resin for use in the solid phase chemical/enzymatic synthesis of glycopeptides. J. Chem Soc. Chem. Commun. (1994) 1849-1850
106. Westerink M.A.J., Giardina P.C., Apicella M.A., and Kieber-Emmons T. Peptide mimicry of the meningococcal group c capsular polysaccharide. Proc. Natl. Acad. Sci. USA 92 (1995) 4021-4025
107. Arnusch C.J., Andre S., Valentini P., Lensch M., Russworm R., Siebert H.-C., Fischer M.J.E., Gabius H.-J., and Pieters R.J. Interference of the galactose-dependant binding of lectins by novel pentapeptide ligands. Bioorg. Med. Chem. Lett. 14 (2004) 1437-1440
108. Zou J., Glinsky V.V., Landon L.A., Matthews L., and Deutscher S.L. Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion. Carcinogenesis 26 (2005) 309-318
109. Yoshii T., Fukumori T., Honjo Y., Inohara H., Kim H.-R.C., and Raz A. Galectin-3 phosphorylation is required for its anti-apoptotic function and cell cycle arrest. J. Biol. Chem. 277 (2002) 6852-6857
110. Mazurek N., Conklin J., Byrd J.C., Raz A., and Bresalier R.S. Phosphorylation of the β-galactoside- binding protein galectin-3 modulates binding to its ligands. J. Biol. Chem. 275 (2000) 36311-36315
111. Gabius H.-J., Andre S., Kaltner H., and Siebert H.-C. The sugar code: functional lectinomics. Biochim. Biophys. Acta 1572 (2002) 165-177
112. Willett W.C., Colditz G.A., and Mueller N.E. Strategies for minimizing cancer risk. Sci. Am. 275 (1996) 58-63