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Pagliaro L, D'Amico G, Pasta L, et al. Portal hypertension in cirrhosis: natural history. In: Bosch J, Groszmann R, editors. Portal hypertension, pathophysiology and treatment. Oxford: Blackwell; 1994. pp. 72-92.
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Identification of risk factors for the presence of esophageal varices in subjects with hepatitis C
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Sanyal A, Fontana R, Everhart J, et al. The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis. Gastrointest Endosc 2006; 64:855-864. Identification of risk factors for the presence of esophageal varices in subjects with hepatitis C.
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Sanyal, A.1
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Platelet count/spleen diameter ratio: Proposal and validation of a noninvasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis
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Giannini E, Botta F, Borro P. Platelet count/spleen diameter ratio: Proposal and validation of a noninvasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis. Gut 2003; 52:1200-1205.
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Giannini E, Zaman A, Kreil A, et al. Platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices: results of a multicenter, prospective, validation study. Am J Gastroenterol 2006; 101:2511-2519. Trial of validation of the platelet count/spleen diameter as a predictive index of presence of esophageal varices in cirrhotic patients.
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Giannini E, Zaman A, Kreil A, et al. Platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices: results of a multicenter, prospective, validation study. Am J Gastroenterol 2006; 101:2511-2519. Trial of validation of the platelet count/spleen diameter as a predictive index of presence of esophageal varices in cirrhotic patients.
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18
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33750523842
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Editorial that comments on invasive methods of diagnosis of esophageal varices and the trial of validation of platelet count/spleen diameter ratio index
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de Franchis R. Noninvasive diagnosis of sophageal varices: is it feasible? Am J Gastroenterol 2006; 101:2520-2522. Editorial that comments on invasive methods of diagnosis of esophageal varices and the trial of validation of platelet count/spleen diameter ratio index.
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Noninvasive diagnosis of sophageal varices: Is it feasible? Am J Gastroenterol
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de Franchis, R.1
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Transient elastography: A new noninvasive method for assessment of hepatic fibrosis
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Sandrin L, Fourquet B, Hasquenoph J, et al. Transient elastography: A new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol 2003; 29:1705-1713.
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Sandrin, L.1
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20
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33745727283
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Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices
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Fibroscan may be used as a non-invasive method to identify patients at risk of having large esophageal varices
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Kazemi F, Kettaneh A, N'kontchou G, et al. Liver stiffness measurement selects patients with cirrhosis at risk of bearing large oesophageal varices. J Hepatol 2006; 45:230-235. Fibroscan may be used as a non-invasive method to identify patients at risk of having large esophageal varices.
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Kazemi, F.1
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21
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27744455132
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Diagnostic value of fibrosis biochemical markers (Fibrotest-Fibrosure) for the prediction of severe portal hypertension in patients with and without cirrhosis
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Thabut D, Imbert-Bismuth F, Cazals-Hatem D, et al. Diagnostic value of fibrosis biochemical markers (Fibrotest-Fibrosure) for the prediction of severe portal hypertension in patients with and without cirrhosis. Hepatology 2004; 40:202A-203A.
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22
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33644812005
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Noninvasive diagnosis of large oesophageal varices with Fibro Test in patients with cirrhosis: A preliminary retrospective study
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Interesting paper on the use of biochemical marker as non-invasive method to identify patients at risk of having large esophageal varices
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Thabut D, Trabut J, Massard J, et al. Noninvasive diagnosis of large oesophageal varices with Fibro Test in patients with cirrhosis: a preliminary retrospective study. Liver Int 2006; 26:271-278. Interesting paper on the use of biochemical marker as non-invasive method to identify patients at risk of having large esophageal varices.
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Liver Int
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Thabut, D.1
Trabut, J.2
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23
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33745810587
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Predictions from a hard liver
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Discusses the usefulness of liver stiffness for the identification of the presence of varices
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Bosch J. Predictions from a hard liver. J Hepatol 2006; 45:174-177. Discusses the usefulness of liver stiffness for the identification of the presence of varices.
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J Hepatol
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Bosch, J.1
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24
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The accuracy of PillCam ESO capsule endoscopy versus conventional upper endoscopy for the diagnosis of esophageal varices: A prospective three-center pilot study
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Pilot study showing that the PillCam ESO might be an alternative to EGDS for screening or surveillance of esophageal varices in cirrhotic patients
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Eisen G, Eliakim R, Zaman A, et al. The accuracy of PillCam ESO capsule endoscopy versus conventional upper endoscopy for the diagnosis of esophageal varices: a prospective three-center pilot study. Endoscopy 2006; 38:31-35. Pilot study showing that the PillCam ESO might be an alternative to EGDS for screening or surveillance of esophageal varices in cirrhotic patients.
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Endoscopy
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Eisen, G.1
Eliakim, R.2
Zaman, A.3
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25
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30744446764
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Esophageal capsule endoscopy versus esophagogastroduodenoscopy for evaluating portal hypertension: A prospective comparative study of performance and tolerance
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Pilot study showing that the PillCam ESO might be an alternative to EGDS for screening or surveillance of esophageal varices in cirrhotic patients
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Lapalus M, Dumortier J, Fumex F, et al. Esophageal capsule endoscopy versus esophagogastroduodenoscopy for evaluating portal hypertension: a prospective comparative study of performance and tolerance. Endoscopy 2006; 38:36-41. Pilot study showing that the PillCam ESO might be an alternative to EGDS for screening or surveillance of esophageal varices in cirrhotic patients.
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Endoscopy
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Lapalus, M.1
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26
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33747032516
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Esophageal capsule endoscopy in patients refusing conventional endoscopy for the study of suspected esophageal pathology
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Sanchez-Yague A, Caunedo-Alvarez A, Garcia-Montes J, et al. Esophageal capsule endoscopy in patients refusing conventional endoscopy for the study of suspected esophageal pathology. Eur J Gastroenterol Hepatol 2006; 18:977-983.
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Eur J Gastroenterol Hepatol
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Sanchez-Yague, A.1
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27
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33750804712
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Bolondi L, Piscaglia F, Gatta A, et al. Effect of potassium canrenoate, an antialdosterone agent, on incidence of ascites and variceal progression in cirrhosis. Clin Gastroenterol Hepatol 2006; 4:1395-1402. Trial on potassium canrenoate showing no effect on the development/progression of esophageal varices.
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Bolondi L, Piscaglia F, Gatta A, et al. Effect of potassium canrenoate, an antialdosterone agent, on incidence of ascites and variceal progression in cirrhosis. Clin Gastroenterol Hepatol 2006; 4:1395-1402. Trial on potassium canrenoate showing no effect on the development/progression of esophageal varices.
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14644399798
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Meta-analysis: Endoscopic variceal ligation for primary prophylaxis of oesophageal variceal bleeding
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Khuroo MS, Khuroo NS, Farahat KLC, et al. Meta-analysis: endoscopic variceal ligation for primary prophylaxis of oesophageal variceal bleeding. Aliment Pharmacol Ther 2005; 21:347-361.
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Khuroo, M.S.1
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29
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Lay C, Tsai Y, Lee F, et al. Endoscopic variceal ligation versus propranolol in prophylaxis of first variceal bleeding in patients with cirrhosis. J Gastroenterol Hepatol 2006; 21:413-419. In primary prophylaxis beta blockers and EBL have similar effects on bleeding and mortality.
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Lay C, Tsai Y, Lee F, et al. Endoscopic variceal ligation versus propranolol in prophylaxis of first variceal bleeding in patients with cirrhosis. J Gastroenterol Hepatol 2006; 21:413-419. In primary prophylaxis beta blockers and EBL have similar effects on bleeding and mortality.
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30
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33748663808
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Primary prophylaxis of variceal bleeding in cirrhotics awaiting liver transplantation
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The association of band ligation with beta blockers in primary prophylaxis of patients awaiting liver transplantation reduces the incidence of bleeding
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Gheorghe C, Gheorghe L, Iacob S, et al. Primary prophylaxis of variceal bleeding in cirrhotics awaiting liver transplantation. Hepatogastroenterology 2006; 53:552-557. The association of band ligation with beta blockers in primary prophylaxis of patients awaiting liver transplantation reduces the incidence of bleeding.
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Gheorghe, C.1
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31
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33644783067
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Turnes J, Garcia-Pagan J, Abraldes J, et al. Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis. Am J Gastroenterol 2006; 101:506-512. Demonstration that haemodynamic response to beta blockers has a long term protective effect from variceal bleeding.
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Turnes J, Garcia-Pagan J, Abraldes J, et al. Pharmacological reduction of portal pressure and long-term risk of first variceal bleeding in patients with cirrhosis. Am J Gastroenterol 2006; 101:506-512. Demonstration that haemodynamic response to beta blockers has a long term protective effect from variceal bleeding.
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32
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30344465734
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Primary prophylaxis with nadolol in cirrhotic patients: Doppler patterns of splanchnic hemodynamics in good and poor responders
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Echo-colour-Doppler patterns may not be used as a non-invasive substitute of HVPG measurement
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Berzigotti A, Rinaldi M, Magalotti D, et al. Primary prophylaxis with nadolol in cirrhotic patients: Doppler patterns of splanchnic hemodynamics in good and poor responders. J Hepatol 2006; 44:310-316. Echo-colour-Doppler patterns may not be used as a non-invasive substitute of HVPG measurement.
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J Hepatol
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Berzigotti, A.1
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de Franchis R. Developing consensus in portal hypertension. J Hepatol 1996; 25:390-394.
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de Franchis, R.1
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33846225492
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Management of digestive bleeding related to portal hypertension in cirrhotic patients: A French multicenter crosssectional practice survey
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In France there is only partial adherence to current guidelines on treatment of portal hypertensive bleeding
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Ingrand P, Gournay J, Bernard P, et al. Management of digestive bleeding related to portal hypertension in cirrhotic patients: A French multicenter crosssectional practice survey. World J Gastroenterol 2006; 12:7810-7814. In France there is only partial adherence to current guidelines on treatment of portal hypertensive bleeding.
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World J Gastroenterol
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Ingrand, P.1
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35
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33749358093
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Cheung J, Wong W, Zandieh I, et al. Acute management and secondary prophylaxis of esophageal variceal bleeding: a western Canadian survey. Can J Gastroenterol 2006; 20:531-534. The application of guidelines on management and secondary prophylaxis of variceal bleeding in Canada is far from satisfactory.
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Cheung J, Wong W, Zandieh I, et al. Acute management and secondary prophylaxis of esophageal variceal bleeding: a western Canadian survey. Can J Gastroenterol 2006; 20:531-534. The application of guidelines on management and secondary prophylaxis of variceal bleeding in Canada is far from satisfactory.
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36
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33750606247
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A comparison of two different dosages of somatostatin combined with sclerotherapy for the treatment of acute esophageal variceal bleeding: A prospective randomized trial
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Higher doses of somatostatin in association with sclerotherapy are associated with lower rates of early rebleeding
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Palazon J, Such J, Sanchez-Paya J, et al. A comparison of two different dosages of somatostatin combined with sclerotherapy for the treatment of acute esophageal variceal bleeding: a prospective randomized trial. Rev Esp Enferm Dig 2006; 98:249-254. Higher doses of somatostatin in association with sclerotherapy are associated with lower rates of early rebleeding.
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Rev Esp Enferm Dig
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Palazon, J.1
Such, J.2
Sanchez-Paya, J.3
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37
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0035743114
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Multicenter randomized controlled trial comparing different schedules of somatostatin in the treatment of acute variceal bleeding
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Moitinho E, Planas R, Banares R, et al. Multicenter randomized controlled trial comparing different schedules of somatostatin in the treatment of acute variceal bleeding. J Hepatol 2001; 35:712-718.
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Moitinho, E.1
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Banares, R.3
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38
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33748100221
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A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding
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EBL is better than EVS as endoscopic treatment for variceal bleeding in conjunction with vasoactive drug treatment
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Villanueva C, Piqueras M, Aracil C, et al. A randomized controlled trial comparing ligation and sclerotherapy as emergency endoscopic treatment added to somatostatin in acute variceal bleeding. J Hepatol 2006; 45:560-567. EBL is better than EVS as endoscopic treatment for variceal bleeding in conjunction with vasoactive drug treatment.
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J Hepatol
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Villanueva, C.1
Piqueras, M.2
Aracil, C.3
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39
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33748937549
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The use of self-expanding metal stents to treat acute esophageal variceal bleeding
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Interesting pilot study showing that self-expanding metal stents are effective as bridge therapy for massive esophageal bleeding
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Hubmann R, Bodlaj G, Czompo M, et al. The use of self-expanding metal stents to treat acute esophageal variceal bleeding. Endoscopy 2006; 38:896-901. Interesting pilot study showing that self-expanding metal stents are effective as bridge therapy for massive esophageal bleeding.
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Hubmann, R.1
Bodlaj, G.2
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D'Amico G, de Franchis R. Upper digestive bleeding in cirrhosis. Posttherapeutic outcome and prognostic indicators. Hepatology 2003; 38:599-612.
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Hepatology
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D'Amico, G.1
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41
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33749823421
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The use of transjugular intrahepatic portosystemic stent shunt in the management of acute oesophageal variceal haemorrhage
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Comprehensive review on the use of TIPS in the treatment of acute esophageal bleeding
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McAvoy N, Hayes P. The use of transjugular intrahepatic portosystemic stent shunt in the management of acute oesophageal variceal haemorrhage. Eur J Gastroenterol Hepatol 2006; 18:1135-1141. Comprehensive review on the use of TIPS in the treatment of acute esophageal bleeding.
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Eur J Gastroenterol Hepatol
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McAvoy, N.1
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Definitions, methodology and therapeutic strategies in portal hypertension
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de Franchis R, Pascal JP, Ancona E, et al. Definitions, methodology and therapeutic strategies in portal hypertension. J Hepatol 1992; 15:256-261.
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de Franchis, R.1
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43
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33746448355
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Comparative study between nadolol and 5-isosorbide mononitrate vs. endoscopic band ligation plus sclerotherapy in the prevention of variceal rebleeding in cirrhotic patients: A randomized controlled trial
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EBL and nadolol are equally effective in preventing rebleeding from esophageal varices
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Romero G, Kravetz D, Argonz J, et al. Comparative study between nadolol and 5-isosorbide mononitrate vs. endoscopic band ligation plus sclerotherapy in the prevention of variceal rebleeding in cirrhotic patients: a randomized controlled trial. Aliment Pharmacol Ther 2006; 24:601-611. EBL and nadolol are equally effective in preventing rebleeding from esophageal varices.
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Aliment Pharmacol Ther
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Romero, G.1
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Ferguson J, Hayes P. Transjugular intrahepatic portosystemic shunt in the prevention of rebleeding in oesophageal varices. Eur J Gastroenterol Hepatol 2006; 18:1167-1171. TIPS cannot be proposed as a first-line alternative to beta-blockers or band ligation for prevention of rebleeding.
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Ferguson J, Hayes P. Transjugular intrahepatic portosystemic shunt in the prevention of rebleeding in oesophageal varices. Eur J Gastroenterol Hepatol 2006; 18:1167-1171. TIPS cannot be proposed as a first-line alternative to beta-blockers or band ligation for prevention of rebleeding.
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45
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42749101393
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Khan S, Tudur Smith C, Williamson P, Sutton R. Portosystemic shunts versus endoscopic therapy for variceal rebleeding in patients with cirrhosis. Cochrane Database Syst Rev 2006; (4):CD000553 Extensive review on portosystemic shunts and endoscopic therapy for variceal rebleeding.
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Khan S, Tudur Smith C, Williamson P, Sutton R. Portosystemic shunts versus endoscopic therapy for variceal rebleeding in patients with cirrhosis. Cochrane Database Syst Rev 2006; (4):CD000553 Extensive review on portosystemic shunts and endoscopic therapy for variceal rebleeding.
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46
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33646370199
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Distal splenorenal shunt versus transjugular intrahepatic portal systemic shunt for variceal bleeding: A randomized trial
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Distal splenorenal shunt and TIPS are equally effective in preventing rebleeding but TIPS is associated with higher reintervention rates
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Henderson J, Boyer T, Kutner M, et al. Distal splenorenal shunt versus transjugular intrahepatic portal systemic shunt for variceal bleeding: a randomized trial. Gastroenterology 2006; 130:1643-1651. Distal splenorenal shunt and TIPS are equally effective in preventing rebleeding but TIPS is associated with higher reintervention rates.
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