Primary prophylaxis with nadolol in cirrhotic patients: Doppler patterns of splanchnic hemodynamics in good and poor responders

Journal of Hepatology

Volumn 44, Issue 2, 2006, Pages 310-316

  Berzigotti, Annalisa ^a   Rinaldi, Maria Francesca ^b   Magalotti, Donatella ^a   Morelli, Maria Cristina ^a   Zappoli, Paola ^a   Andreone, Pietro ^a   Rossi, Cristina ^a   Zoli, Marco ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Beta blockers; Echo color Doppler; HVPG; Portal hypertension; Primary prohylaxis

Indexed keywords

NADOLOL;

ADULT; AGED; ARTICLE; BLOOD FLOW VELOCITY; CLINICAL ARTICLE; COLOR ULTRASOUND FLOWMETRY; CONTROLLED STUDY; DRUG MECHANISM; ESOPHAGUS VARICES; ESOPHAGUS VARICES BLEEDING; FEMALE; HEMODYNAMICS; HEPATIC ARTERY; HUMAN; IMPEDANCE PLETHYSMOGRAPHY; LIVER CIRRHOSIS; MALE; MESENTERIC ARTERY; PRIMARY PREVENTION; PRIORITY JOURNAL; PROPHYLAXIS; SPLANCHNIC BLOOD FLOW; SPLEEN ARTERY; TREATMENT DURATION; TREATMENT OUTCOME; VASODILATATION; VENOUS PRESSURE;

ADRENERGIC BETA-ANTAGONISTS; BLOOD FLOW VELOCITY; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HEPATIC VEINS; HUMANS; HYPERTENSION, PORTAL; LIVER CIRRHOSIS; MALE; MESENTERIC ARTERIES; MIDDLE AGED; NADOLOL; PRIMARY PREVENTION; PROSPECTIVE STUDIES; SPLANCHNIC CIRCULATION; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER, DUPLEX; VASOCONSTRICTION;

EID: 30344465734     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.10.015     Document Type: Article

References (35)

1. R. de Franchis Evolving consensus in portal hypertension report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension J Hepatol 43 2005 167 176
2. J. Bosch, J.G. Abraldes, and R. Groszmann Current management of portal hypertension J Hepatol 38 2003 S54 S68
3. R.J. Groszmann, and S. Wongcharatrawee The hepatic venous pressure gradient: anything worth doing should be done right Hepatology 39 2004 280 282
4. A. Viallet, D. Marleau, M. Huet, F. Martin, A. Farley, J.P. Villeneuve, and P. Lavoie Hemodynamic evaluation of patients with intrahepatic portal hypertension. Relationship between bleeding varices and the portohepatic gradient Gastroenterology 69 1975 1297 1300
5. G. Garcia-Tsao, R.J. Groszmann, R.L. Fisher, H.O. Conn, C.E. Atterbury, and M. Glickman Portal pressure, presence of gastroesophageal varices and variceal bleeding Hepatology 5 1985 419 424
6. R.J. Groszmann, J. Bosch, N.D. Grace, H.O. Conn, G. Garcia-Tsao, and M. Navasa Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage Gastroenterology 99 1990 1401 1407
7. C. Merkel, M. Bolognesi, D. Sacerdoti, G. Bombonato, B. Bellini, and R. Bighin The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis Hepatology 32 2000 930 934
8. F. Feu, J.C. Garcia-Pagan, J. Bosch, A. Luca, J. Teres, and A. Escorsell Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis Lancet 346 1995 1056 1059
9. J.G. Abraldes, I. Tarantino, J. Turnes, J.C. Garcia-Pagan, J. Rodes, and J. Bosch Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis Hepatology 37 2003 902 908
10. C. Bureau, J.M. Peron, J. Morales, J. Sanchez, K. Barange, and J.L. Payen 'A La Carte' treatment of portal hypertension: adapting medical therapy to hemodynamic response for the prevention of bleeding Hepatology 36 2002 1361 1366
11. C. Merkel, D. Sacerdoti, M. Bolognesi, G. Bombonato, and A. Gatta Doppler sonography and hepatic vein catheterization in portal hypertension: assessment of agreement in evaluating severity and response to treatment J Hepatol 28 1998 622 630
12. R.N. Pugh, I.M. Murray-Lyon, J.L. Dawson, M.C. Pietroni, and R. Williams Transection of the esophagus for bleeding esophageal varices Br J Surg 60 1973 646 649
13. P.S. Kamath, R.H. Wiesner, M. Malinchoc, W. Kremers, T.M. Therneau, and C.L. Kosberg A model to predict survival in patients with end-stage liver disease Hepatology 33 2001 464 470
14. F. Moriyasu, N. Ban, O. Nishida, T. Nakamura, T. Miyake, and H. Uchino Clinical application of an ultrasonic duplex system in the quantitative measurement of portal blood flow J Clin Ultrasound 14 1986 579 588
15. C. Sabba, C. Merkel, M. Zoli, G. Ferraioli, S. Gaiani, and D. Sacerdoti Interobserver and interequipment variability of echo-Doppler examination of the portal vein: effect of a cooperative training program Hepatology 21 1995 428 433
16. M. Zoli, C. Merkel, C. Sabba, D. Sacerdoti, S. Gaiani, and G. Ferraioli Interobserver and inter-equipment variability of echo-Doppler sonographic evaluation of the superior mesenteric artery J Ultrasound Med 15 1996 99 106
17. F. Moriyasu, O. Nishida, N. Ban, T. Nakamura, M. Sakai, and T. Miyake 'Congestion index' of the portal vein AJR Am J Roentgenol 146 1986 735 739
18. D. Sacerdoti, S. Gaiani, P. Buonamico, C. Merkel, M. Zoli, and L. Bolondi Interobserver and interequipment variability of hepatic, splenic, and renal arterial Doppler resistance indices in normal subjects and patients with cirrhosis J Hepatol 27 1997 986 992
19. B.J. McNeil, E. Keller, and S.J. Adelstein Primer on certain elements of medical decision making N Engl J Med 293 1975 211 215
20. G. Ideo, G. Bellati, E. Fesce, and D. Grimoldi Nadolol can prevent the first gastrointestinal bleeding in cirrhotics: a prospective, randomized study Hepatology 8 1988 6 9
21. M. Bolognesi, D. Sacerdoti, C. Merkel, G. Bombonato, E. Enzo, and A. Gatta Effects of chronic therapy with nadolol on portal hemodynamics and on splanchnic impedance indices using Doppler sonography: comparison between acute and chronic effects J Hepatol 26 1997 305 311
22. M. Zoli, G. Marchesini, A. Marzocchi, C. Marozzini, C. Dondi, and E. Pisi Portal pressure changes induced by medical treatment: US detection Radiology 155 1985 763 766
23. M. Schepke, P. Raab, A. Hoppe, P. Schiedermaier, K.A. Bresnsing, and T. Sauerbruch Comparison of portal vein velocity and the hepatic venous pressure gradient in assessing the acute portal hemodynamic response to propranolol in patients with cirrhosis Am J Gastroenterol 95 2000 2905 2909
24. T. Iwao, K. Oho, T. Sakai, M. Sato, R. Nakano, and M. Yamayaki Noninvasive hemodynamic measurements of superior mesenteric artery in the prediction of portal pressure response to propranolol J Hepatol 28 1998 847 855
25. G. Castano, P. Viudez, O. Carlevaro, C. Ocampo, H. Zandalazini, and M. Riccitelli Evaluation of propranolol response by catheterization and Doppler ultrasonography in patients with cirrhosis Acta Gastroenterol Latinoam 28 1998 291 297
26. Y.J. Choi, S.K. Baik, D.H. Park, H.Y. Kim, H.S. Kim, and D.K. Lee Comparison of Doppler ultrasonography and the hepatic venous pressure gradient in assessing portal hypertension in liver cirrhosis J Gastroenterol Hepatol 18 2003 424 429
27. C. Merkel, M. Bolognesi, D. Sacerdoti, G. Bombonaro, L. Cavasin, and A. Gatta Disagreement between acute and chronic haemodynamic effects of nadolol in cirrhosis: a pathophysiological interpretation Aliment Pharmacol Ther 22 2005 433 439
28. F. Bendtsen, J.H. Henriksen, and T.I. Sorensen Propranolol and haemodynamic response in cirrhosis J Hepatol 13 1991 144 148
29. J. Gonzalez-Abraldes, J.C. Garcia-Pagan, and J. Bosch Nitric oxide and portal hypertension Metab Brain Dis 17 2002 311 324
30. A. Luca, J.C. Garcia-Pagan, F. Feu, J.C. Lopez-Talavera, M. Fernandez, and C. Bru Noninvasive measurement of femoral blood flow and portal pressure response to propranolol in patients with cirrhosis Hepatology 21 1995 83 88
31. A. Escorsell, L. Ferayorni, J. Bosch, J.C. Garcia-Pagan, G. Garcia-Tsao, and N.D. Grace The portal pressure response to beta-blockade is greater in cirrhotic patients without varices than in those with varices Gastroenterology 112 1997 2012 2016
32. R.J. Kroeger, and R.J. Groszmann Increased portal venous resistance hinders portal pressure reduction during the administration of beta-adrenergic blocking agents in a portal hypertensive model Hepatology 5 1985 97 101
33. H. Boldys, M. Hertleb, K. Rudzki, A. Nowak, and S. Nowak Effect of propranolol on portosystemic collateral circulation estimated by per-rectal portal scintigraphy with technetium-99m pertechnetate J Hepatol 22 1995 173 178
34. A. Albillos, H. Perez-Paramo, G. Cacho, J. Iborra, J.L. Calleja, and I. Hillan Accuracy of portal and forearm blood flow measurements in the assessment of the portal pressure response to propranolol J Hepatol 27 1997 496 504
35. The Italian Multicenter Project for Propranolol in Prevention of Bleeding. Propranolol prevents first gastrointestinal bleeding in non-ascitic cirrhotic patients. Final report of a multicenter randomized trial. J Hepatol 1989;9:75-83.