-
2
-
-
0037374604
-
Age related macular degeneration
-
Chopdar, A., Chakravarthy, U., Verma, D. Age related macular degeneration. BMJ - Br Med J 2003, 326: 485-8.
-
(2003)
BMJ - Br Med J
, vol.326
, pp. 485-488
-
-
Chopdar, A.1
Chakravarthy, U.2
Verma, D.3
-
3
-
-
0036875316
-
The role of apoptosis in age-related macular degeneration
-
Dunaief, J.L., Dentchev, T., Ying, G.S., Milam, A.H. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 2002, 120: 1435-42.
-
(2002)
Arch Ophthalmol
, vol.120
, pp. 1435-1442
-
-
Dunaief, J.L.1
Dentchev, T.2
Ying, G.S.3
Milam, A.H.4
-
4
-
-
0037073279
-
Age-related macular degeneration
-
Gottlieb, J.L. Age-related macular degeneration. JAMA - J Am Med Assoc 2002, 288: 2233-6.
-
(2002)
JAMA - J Am Med Assoc
, vol.288
, pp. 2233-2236
-
-
Gottlieb, J.L.1
-
5
-
-
0036014911
-
Mechanisms of age-related macular degeneration
-
Husain, D., Ambati, B., Adamis, A.P., Miller, J.W. Mechanisms of age-related macular degeneration. Ophthalmol Clin North Am 2002, 15: 87-91.
-
(2002)
Ophthalmol Clin North Am
, vol.15
, pp. 87-91
-
-
Husain, D.1
Ambati, B.2
Adamis, A.P.3
Miller, J.W.4
-
6
-
-
0036097438
-
Risk factors for age-related macular degeneration: An update
-
Hyman, L., Neborsky, R. Risk factors for age-related macular degeneration: An update. Curr Opin Ophthalmol 2002, 13: 171-5.
-
(2002)
Curr Opin Ophthalmol
, vol.13
, pp. 171-175
-
-
Hyman, L.1
Neborsky, R.2
-
7
-
-
0032231956
-
Genetic association of apolipoprotein E with age-related macular degeneration
-
Klaver, C.C., Kliffen, M., van Duijn, C.M., Hofman, A., Cruts, M., Grobbee, D.E., van Broeckhoven, C., de Jong, P.T. Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet 1998, 63: 200-6.
-
(1998)
Am J Hum Genet
, vol.63
, pp. 200-206
-
-
Klaver, C.C.1
Kliffen, M.2
Van Duijn, C.M.3
Hofman, A.4
Cruts, M.5
Grobbee, D.E.6
Van Broeckhoven, C.7
De Jong, P.T.8
-
8
-
-
0035675640
-
Apolipoprotein E polymorphisms in age-related macular degeneration in an Italian population
-
Simonelli, F., Margaglione, M., Testa, F., Cappucci, G., Manitto, M.P., Brancato, R., Rinaldi, E. Apolipoprotein E polymorphisms in age-related macular degeneration in an Italian population. Ophthalmic Res 2001, 33: 325-8.
-
(2001)
Ophthalmic Res
, vol.33
, pp. 325-328
-
-
Simonelli, F.1
Margaglione, M.2
Testa, F.3
Cappucci, G.4
Manitto, M.P.5
Brancato, R.6
Rinaldi, E.7
-
9
-
-
0034054041
-
Genetic susceptibility to age related macular degeneration
-
Yates, J.R., Moore, A.T. Genetic susceptibility to age related macular degeneration. J Med Genet 2000, 37: 83-7.
-
(2000)
J Med Genet
, vol.37
, pp. 83-87
-
-
Yates, J.R.1
Moore, A.T.2
-
10
-
-
0342632445
-
Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. One-year results of 2 randomized clinical trials - TAP report
-
Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group
-
Treatment of age-related macular degeneration with photodynamic therapy Study Group. Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. One-year results of 2 randomized clinical trials -TAP report. Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. Arch Ophthalmol 1999, 117: 1329-45.
-
(1999)
Arch Ophthalmol
, vol.117
, pp. 1329-1345
-
-
-
11
-
-
0032871253
-
Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration. Results of retreatments in a phase 1 and 2 study
-
Schmidt-Erfurth, U., Miller, J.W., Sickenberg, M. et al. Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration. Results of retreatments in a phase 1 and 2 study. Arch Ophthalmol 1999, 117: 1177-87.
-
(1999)
Arch Ophthalmol
, vol.117
, pp. 1177-1187
-
-
Schmidt-Erfurth, U.1
Miller, J.W.2
Sickenberg, M.3
-
12
-
-
0029981701
-
Vascular endothelial growth factor, a specific regulator of angiogenesis
-
Ferrara, N., Bunting, S. Vascular endothelial growth factor, a specific regulator of angiogenesis. Curr Opin Nephrol Hypertens 1996, 5: 35-44.
-
(1996)
Curr Opin Nephrol Hypertens
, vol.5
, pp. 35-44
-
-
Ferrara, N.1
Bunting, S.2
-
13
-
-
0029831672
-
Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor
-
Kvanta, A., Algvere, P.V., Berglin, L., Seregard, S. Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest Ophthalmol Vis Sci 1996, 37: 1929-34.
-
(1996)
Invest Ophthalmol Vis Sci
, vol.37
, pp. 1929-1934
-
-
Kvanta, A.1
Algvere, P.V.2
Berglin, L.3
Seregard, S.4
-
14
-
-
0029879849
-
Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes
-
Lopez, P.F., Sippy, B.D., Lambert, H.M., Thach, A.B., Hinton, D.R. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest Ophthalmol Visual Sci 1996, 37: 855-68.
-
(1996)
Invest Ophthalmol Visual Sci
, vol.37
, pp. 855-868
-
-
Lopez, P.F.1
Sippy, B.D.2
Lambert, H.M.3
Thach, A.B.4
Hinton, D.R.5
-
15
-
-
0027942607
-
Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
-
Aiello, L.P., Avery, R.L., Arrigg, RG. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. New Engl J Med 1994, 331: 1480-7.
-
(1994)
New Engl J Med
, vol.331
, pp. 1480-1487
-
-
Aiello, L.P.1
Avery, R.L.2
Arrigg, R.G.3
-
16
-
-
0030067257
-
Inhibition of vascular endothelial growth factor prevents retinal ischemia associated iris neovascularization in a nonhuman primate
-
Adamis, A.P., Shima, D.T., Tolentino, M.J., Gragoudas, E.S., Ferrara, N., Folkman, J., D'Amore, P.A., Miller, J.W. Inhibition of vascular endothelial growth factor prevents retinal ischemia associated iris neovascularization in a nonhuman primate. Arch Ophthalmol 1996, 114: 66-71.
-
(1996)
Arch Ophthalmol
, vol.114
, pp. 66-71
-
-
Adamis, A.P.1
Shima, D.T.2
Tolentino, M.J.3
Gragoudas, E.S.4
Ferrara, N.5
Folkman, J.6
D'Amore, P.A.7
Miller, J.W.8
-
17
-
-
0141530366
-
RhuFab 2 inhibits VEGF-isoforms-stimulated HUVEC proliferation
-
(May 4-9, Fort Lauderdale), Abst 1828
-
Lowe, J., Araujo, J., Palma, M., Wang, Y., Gaudreault, J., Yang, J., Yu, N., Fei, D. RhuFab 2 inhibits VEGF-isoforms-stimulated HUVEC proliferation. Annu Meet Assoc Res Vision Ophthalmol (May 4-9, Fort Lauderdale) 2003, Abst 1828.
-
(2003)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Lowe, J.1
Araujo, J.2
Palma, M.3
Wang, Y.4
Gaudreault, J.5
Yang, J.6
Yu, N.7
Fei, D.8
-
18
-
-
0141865018
-
Ocular pharmacokinetics and antipermeability effect of rhuFab V2 in animals
-
(May 4-9, Fort Lauderdale), Abst 3942
-
Gaudreault, J., Reich, M., Arata, A., Rusit, J., Pelletier, N., Shiu, V. Ocular pharmacokinetics and antipermeability effect of rhuFab V2 in animals. Annu Meet Assoc Res Vision Ophthalmol (May 4-9, Fort Lauderdale) 2003, Abst 3942.
-
(2003)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Gaudreault, J.1
Reich, M.2
Arata, A.3
Rusit, J.4
Pelletier, N.5
Shiu, V.6
-
19
-
-
0141530365
-
26-Week intravitreal injection toxicity study with rhuFab VEGF in cynomolgus monkeys with an 8-week recovery
-
(May 4-9, Fort Lauderdale), Abst 3929
-
O'Neill, C.A., Miller, P.E., Christian, B.J., Beyer, J.C., Bentley, E., VerHoeve, J.N., Nork, T.M., Leedle, R.A., Dubielzig, R.R., Albert, D.M. 26-Week intravitreal injection toxicity study with rhuFab VEGF in cynomolgus monkeys with an 8-week recovery. Annu Meet Assoc Res Vision Ophthalmol (May 4-9, Fort Lauderdale) 2003, Abst 3929.
-
(2003)
Annu Meet Assoc Res Vision Ophthalmol
-
-
O'Neill, C.A.1
Miller, P.E.2
Christian, B.J.3
Beyer, J.C.4
Bentley, E.5
VerHoeve, J.N.6
Nork, T.M.7
Leedle, R.A.8
Dubielzig, R.R.9
Albert, D.M.10
-
20
-
-
0036129304
-
Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment
-
Krzystolik, M.G., Afshari, M.A., Adamis, A.P., Gaudreault, J., Gragoudas, E.S., Michaud, N.A., Li, W., Connolly, E., O'Neill, C.A., Miller, J.W. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol 2002, 120: 338-46.
-
(2002)
Arch Ophthalmol
, vol.120
, pp. 338-346
-
-
Krzystolik, M.G.1
Afshari, M.A.2
Adamis, A.P.3
Gaudreault, J.4
Gragoudas, E.S.5
Michaud, N.A.6
Li, W.7
Connolly, E.8
O'Neill, C.A.9
Miller, J.W.10
-
21
-
-
0141753474
-
Safety and efficacy of intravitreal injection of rhuFab VEGF in combination with verteporfin PDT on experimental choroidal neovascularization
-
(May 4-9, Fort Lauderdale), Abst 566
-
Gauthier, D., Husain, D., Kim, I.K., Ezra, E., Tsilimbaris, M.K., Connolly, E., Lane, A.M., Gragoudas, E.S., O'Neill, C.A., Miller, J.W. Safety and efficacy of intravitreal injection of rhuFab VEGF in combination with verteporfin PDT on experimental choroidal neovascularization. Annu Meet Assoc Res Vision Ophthalmol (May 4-9, Fort Lauderdale) 2003, Abst 566.
-
(2003)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Gauthier, D.1
Husain, D.2
Kim, I.K.3
Ezra, E.4
Tsilimbaris, M.K.5
Connolly, E.6
Lane, A.M.7
Gragoudas, E.S.8
O'Neill, C.A.9
Miller, J.W.10
-
22
-
-
0141641477
-
Preclinical pharmacokinetic comparison of two rhuMAb VEGF molecules
-
(Nov 14-18, New Orleans), Abst
-
Hsei, V., Siguenza, P., Ralph, P., Baughmann, S., Gaudreault, J. Preclinical pharmacokinetic comparison of two rhuMAb VEGF molecules. Annu Meet Am Assoc Pharm Sci (AAPS) (Nov 14-18, New Orleans) 1999, Abst.
-
(1999)
Annu Meet Am Assoc Pharm Sci (AAPS)
-
-
Hsei, V.1
Siguenza, P.2
Ralph, P.3
Baughmann, S.4
Gaudreault, J.5
-
23
-
-
0141865014
-
Vitreal pharmacokinetics of rhuFab V2 in rabbits using a non-invasive method
-
(May 5-10, Fort Lauderdale), Abst 2801
-
Gaudreault, J., Escandon, E., Maruoka, M., Reich, M., Li, D., Hsei, V. Vitreal pharmacokinetics of rhuFab V2 in rabbits using a non-invasive method. Annu Meet Assoc Res Vision Ophthalmol (May 5-10, Fort Lauderdale) 2002, Abst 2801.
-
(2002)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Gaudreault, J.1
Escandon, E.2
Maruoka, M.3
Reich, M.4
Li, D.5
Hsei, V.6
-
24
-
-
0141753471
-
Pharmacokinetics and retinal distribution of AMD rhuFab V2 after intravitreal administration in rabbits
-
(Nov 14-18, New Orleans), Abst
-
Gaudreault, J., Webb, W., Van Hoy, M. et al. Pharmacokinetics and retinal distribution of AMD rhuFab V2 after intravitreal administration in rabbits. Annu Meet Am Assoc Pharm Sci (AAPS) (Nov 14-18, New Orleans) 1999, Abst.
-
(1999)
Annu Meet Am Assoc Pharm Sci (AAPS)
-
-
Gaudreault, J.1
Webb, W.2
Van Hoy, M.3
-
25
-
-
0141641476
-
Ocular pharmacokinetics (PK) of rhuFab V2 following intravitreal (ITV) administration in cynomolgus monkeys
-
(April 29-May 4, Fort Lauderdale), Abst
-
Gaudreault, J., Fei, D., Suboc, P., Chan, P., Nelson, J., Lappin, P., Hartmangruber, M., Rusit, J., O'Neill, C., Hsei, V. Ocular pharmacokinetics (PK) of rhuFab V2 following intravitreal (ITV) administration in cynomolgus monkeys. Annu Meet Assoc Res Vision Ophthalmol (April 29-May 4, Fort Lauderdale) 2001, Abst.
-
(2001)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Gaudreault, J.1
Fei, D.2
Suboc, P.3
Chan, P.4
Nelson, J.5
Lappin, P.6
Hartmangruber, M.7
Rusit, J.8
O'Neill, C.9
Hsei, V.10
-
26
-
-
0141753472
-
Safety of rhuFab V2, an anti-VEGF antibody fragment, as a single intravitreal injection in subjects with neovascular age-related macular degeneration
-
(April 29-May 4, Fort Lauderdale), Abst
-
Blumenkranz, M., Rosenfeld, P.J., Miller, J.W., Haller, J., Fish, G., Lobes, L., Singerman, L., Greene, W.L., Reimann, J. Safety of rhuFab V2, an anti-VEGF antibody fragment, as a single intravitreal injection in subjects with neovascular age-related macular degeneration. Annu Meet Assoc Res Vision Ophthalmol (April 29-May 4, Fort Lauderdale) 2001, Abst.
-
(2001)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Blumenkranz, M.1
Rosenfeld, P.J.2
Miller, J.W.3
Haller, J.4
Fish, G.5
Lobes, L.6
Singerman, L.7
Greene, W.L.8
Reimann, J.9
-
27
-
-
0141641474
-
RhuFab V2, an antiangiogenic Fab antibody fragment that binds VEGF, is being investigated as an intravitreal injection in subjects with neovascular age-related macular degeneration
-
(Feb 28-March 3, Seville), Addendum
-
McCluskey, E.R. RhuFab V2, an antiangiogenic Fab antibody fragment that binds VEGF, is being investigated as an intravitreal injection in subjects with neovascular age-related macular degeneration. 4th Int Symp Ocular Pharmacol Pharm (Feb 28-March 3, Seville) 2002, Addendum.
-
(2002)
4th Int Symp Ocular Pharmacol Pharm
-
-
McCluskey, E.R.1
-
28
-
-
0037530568
-
RhuFab V2 (anti-VEGF antibody fragment) in neovascular AMD: Safety, tolerability, and efficacy of multiple, escalating dose intravitreal injections
-
(May 4-9, Fort Lauderdale), Abst 970
-
Rosenfeld, P.J., Villate, N., Feuer, W.J., Puliafito, C.A., McCluskey, E.R. RhuFab V2 (anti-VEGF antibody fragment) in neovascular AMD: Safety, tolerability, and efficacy of multiple, escalating dose intravitreal injections. Annu Meet Assoc Res Vision Ophthalmol (May 4-9, Fort Lauderdale) 2003, Abst 970.
-
(2003)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Rosenfeld, P.J.1
Villate, N.2
Feuer, W.J.3
Puliafito, C.A.4
McCluskey, E.R.5
-
29
-
-
0141530363
-
Optical coherence tomographic (OCT) findings following treatment of choroidal neovascularization with rhuFabV2
-
(Sept 28-Oct 2, San Francisco), Abst
-
Puliafito, C.A., McCluskey, E.R. Optical coherence tomographic (OCT) findings following treatment of choroidal neovascularization with rhuFabV2. 35th Annu Meet Retina Soc (Sept 28-Oct 2, San Francisco) 2002, Abst.
-
(2002)
35th Annu Meet Retina Soc
-
-
Puliafito, C.A.1
McCluskey, E.R.2
-
30
-
-
0142025829
-
RhuFab V2 in wet AMD - 6 Month continued improvement following multiple intravitreal injections
-
(May 4-9, Fort Lauderdale), Abst 972
-
Heier, J.S., Sy, J.R., McCluskey, E.R. RhuFab V2 in wet AMD - 6 month continued improvement following multiple intravitreal injections. Annu Meet Assoc Res Vision Ophthalmol (May 4-9, Fort Lauderdale) 2003, Abst 972.
-
(2003)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Heier, J.S.1
Sy, J.R.2
McCluskey, E.R.3
-
31
-
-
0141641473
-
-
Genentech Web Site, April
-
2003 First Quarter Report. Genentech Web Site, April 2003.
-
(2003)
2003 First Quarter Report
-
-
-
35
-
-
0141641475
-
RhuFabV2 (anti-VEGF antibody) for treatment of exudative AMD
-
(Sept 28-Oct 2, San Francisco), Abst
-
Heier, J.S., Sy, J.P., McCluskey, E.R. RhuFabV2 (anti-VEGF antibody) for treatment of exudative AMD. 35th Annu Meet Retina Soc (Sept 28-Oct 2, San Francisco) 2002, Abst.
-
(2002)
35th Annu Meet Retina Soc
-
-
Heier, J.S.1
Sy, J.P.2
McCluskey, E.R.3
-
36
-
-
0141865011
-
Safety and efficacy of intravitreai injection of rhuFab VEGF V2 in combination with verteporfin PDT on experimental choroidal neovascularization
-
(Sept 28-Oct 2, San Francisco), Abst
-
Husain, D., Kim, I., Gauthier, D. et al. Safety and efficacy of intravitreai injection of rhuFab VEGF V2 in combination with verteporfin PDT on experimental choroidal neovascularization. 35th Annu Meet Retina Soc (Sept 28-Oct 2, San Francisco) 2002, Abst.
-
(2002)
35th Annu Meet Retina Soc
-
-
Husain, D.1
Kim, I.2
Gauthier, D.3
-
37
-
-
0141753468
-
RhuFab V2 (an anti-VEGF antibody fragment) in neovascular AMD: Safety and tolerability of multiple intravitreal injections
-
(May 5-10, Fort Lauderdale), Abst 2520
-
Heier, J.S., Greene, W.L. RhuFab V2 (an anti-VEGF antibody fragment) in neovascular AMD: Safety and tolerability of multiple intravitreal injections. Annu Meet Assoc Res Vision Ophthalmol (May 5-10, Fort Lauderdale) 2002, Abst 2520.
-
(2002)
Annu Meet Assoc Res Vision Ophthalmol
-
-
Heier, J.S.1
Greene, W.L.2
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