In vivo transfection of C/EBP-α gene could ameliorate CCL4-induced hepatic fibrosis in mice

Hepatology Research

Volumn 37, Issue 7, 2007, Pages 531-539

  Mei, Shuang ^a   Wang, Xueqing ^a   Zhang, Jinsheng ^a   Qian, Jin ^a   Ji, Juling ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

C EBP ; Hepatic fibrosis; HSCs; Hydrodynamic based in vivo gene transfection

Indexed keywords

CARBON TETRACHLORIDE; CCAAT ENHANCER BINDING PROTEIN ALPHA; COLLAGEN; GREEN FLUORESCENT PROTEIN; HYDROXYPROLINE; PLASMID DNA; RECOMBINANT CCAAT ENHANCER BINDING PROTEIN ALPHA; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EARLY INTERVENTION; EXPRESSION VECTOR; GENE EXPRESSION; HISTOPATHOLOGY; HYDRODYNAMICS BASED TRANSFECTION; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IN VIVO GENE TRANSFER; LIVER CELL; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STELLATE CELL; WESTERN BLOTTING;

EID: 34249892151     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2007.00074.x     Document Type: Article

References (43)

1. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000; 275: 2247-50.
2. Brenner DA, Waterboer T, Choi SK et al. New aspects of hepatic fibrosis. J Hepatol 2000; 32 (1 Suppl.): 32-8.
3. Constandinou C, Henderson N, Iredale JP. Modeling liver fibrosis in rodents. Methods Mol Med 2005; 117: 237-50.
4. Friedman SL. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med 1993; 328 (25): 1828-35.
5. Reeves HL, Friedman SL. Activation of hepatic stellate cells - a key issue in liver fibrosis. Front Biosci 2000; 7: D808-26.
6. Safadi R, Friedman SL. Hepatic fibrosis - Role of hepatic stellate cell activation. Med Genet Med 2002; 4: 27.
7. Bataller R, Brenner DA. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 2001; 21: 437-51.
8. Isono M, Soda M, Inoue A, Akiyoshi H, Sato K. Reverse transformation of hepatic myofibroblast-like cells by TGFb1/LAP. Biochem Biophys Res Commun 2003; 311: 959-65.
9. Sato M, Suzuki S, Senoo H. Hepatic stellate cells: Unique characteristics in cell biology and phenotype. Cell Struct Funct 2003; 28: 105-12.
10. Senoo H. Structure and function of hepatic stellate cells. Med Electron Microsc 2004; 37: 3-15.
11. Vicente CP, Fortuna VA, Margis R, Trugo L, Borojevic R. Retinol uptake and metabolism, and cellular retinol binding protein expression in an in vitro model of hepatic stellate cells. Mol Cell Biochem 1998; 187: 11-21.
12. Ohata M, Lin M, Satre M, Tsukamoto H. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis. Am J Physiol 1997; 272: G589-96.
13. Uchio K, Tuchweber B, Manabe N, Gabbiani G, Rosenbaum J, Desmouliere A. Cellular retinol-binding protein-1 expression and modulation during in vivo and in vitro myofibroblastic differentiation of rat hepatic stellate cells and portal fibroblasts. Lab Invest 2002; 82: 619-28.
14. Davis BH, Rapp UR, Davidson NO. Retinoic acid and transforming growth factor b differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation. Biochem J 1991; 278 (Pt 1): 43-7.
15. Hellemans K, Grinko I, Rombouts K, Schuppan D, Geerts A. All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially. Gut 1999; 45: 134-42.
16. Cardoso CC, Paviani ER, Cruz LA, Guma FC, Borojevic R, Guaragna RM. Effect of pentoxifylline on arachidonic acid metabolism, neutral lipid synthesis and accumulation during induction of the lipocyte phenotype by retinol in murine hepatic stellate cell. Mol Cell Biochem 2003; 254: 37-46.
17. Martucci RB, Ziulkoski AL, Fortuna VA et al. b-Carotene storage, conversion to retinoic acid, and induction of the lipocyte phenotype in hepatic stellate cells. J Cell Biochem 2004; 92: 414-23.
18. Wang L, Tankersley LR, Tang M, Potter JJ, Mezey E. Regulation of a2(I) collagen expression in stellate cells by retinoic acid and retinoid X receptors through interactions with their cofactors. Arch Biochem Biophys 2004; 428: 92-8.
19. Li H, Zhang J, Huang G, Zhang N, Chen Q, Zhang X. Effect of retinoid X receptor alpha (RXRa) transfection on the proliferation and phenotype of rat hepatic stellate cells in vitro. Chin Med J 2002; 115: 928-32.
20. Li H, Zhang JS, Huang GC, Zhang N, Chen Q, Zhang XR. Effect of RARb transfection on the proliferation and phenotype of rat hepatic stellate cells. Chin J Hepatol 2002; 10: 297-300.
21. Koda H, Okuno M, Imai S et al. Retinoic acid-stimulated liver stellate cells suppress the production of albumin from parenchymal cells via TGF-b. Biochem Biophys Res Commun 1996; 221: 565-9.
22. Okuno M, Moriwaki H, Imai S et al. Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-b in liver stellate cells. Hepatology 1997; 26: 913-21.
23. Hellemans K, Verbuyst P, Quartier E et al. Differential modulation of rat hepatic stellate phenotype by natural and synthetic retinoids. Hepatology 2004; 39: 97-108.
24. Zhang JW, Tang QQ, Vinson C, Lane MD. Dominant negative C/EBP disrupts mitotic clonal expansion and differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 2004; 101: 43-7.
25. Tao H, Umek RM. C/EBPa is required to maintain postmitotic growth arrest in adipocytes. DNA Cell Biol 2000; 19: 9-18.
26. Jiang MS, Lane MD. Sequential repression and activation of the CCAAT enhancer-binding protein-a (C/EBPa) gene during adipogenesis. Proc Natl Acad Sci USA 2000; 97: 12519-23.
27. Morrison RF, Farmer SR. Insights into the transcriptional control of adipocyte differentiation. J Cell Biochem 1999; Suppl 32-33: 59-67.
28. Charles A, Tang X, Crouch E, Brody JS, Xiao ZX. Retinoblastoma protein complexes with C/EBP proteins and activates C/EBP-mediated transcription. J Cell Biochem 2001; 83: 414-25.
29. Cram EJ, Ramos RA, Wang EC, Cha HH, Nishio Y, Firestone GL. Role of the CCAAT/enhancer binding protein-a transcription factor in the glucocorticoid stimulation of p21waf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells. J Biol Chem 1998; 273: 2008-14.
30. Timchenko NA, Wilde M, Darlington GJ. C/EBPa regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol 1999; 19: 2936-45.
31. Harris TE, Albrecht JH, Nakanishi M, Darlington GJ. CCAAT/ enhancer-binding protein-a cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding. J Biol Chem 2001; 276: 29200-9.
32. Chen PL, Riley DJ, Chen-Kiang S, Lee WH. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc Natl Acad Sci USA 1996; 93: 465-9.
33. Huang GC, Zhang JS, Tang QQ. Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells. Biochem Biophys Res Commun 2004; 324: 1309-18.
34. Geier A, Kim SK, Gerloff T et al. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. J Hepatol 2002; 37: 198-205.
35. 4-cirrhotic rats is partially normalized by insulin-like growth factor-I. Int J Biochem Cell Biol 2002; 34: 242-52.
36. Chen C, Zhang JS, Li JJ et al. Hydrodynamic-based in vivo transfection of retinoic X receptor-alpha gene can enhance vitamin A-induced attenuation of liver fibrosis in mice. Liver Int 2004; 24: 679-86.
37. Zender L, Hutker S, Mundt B et al. NFkappaB-mediated upregulation of bcl-xl restrains TRAIL-mediated apoptosis in murine viral hepatitis. Hepatology 2005; 41: 280-8.
38. Maruyama H, Higuchi N, Nishikawa Y et al. High-level expression of naked DNA delivered to rat liver via tail vein injection. J Gene Med 2002; 4: 333-41.
39. Zhang B, Wu Q, Ye XF, Liu S, Lin XF, Chen MC. Roles of PLC-gamma2 and PKC alpha in TPA-induced apoptosis of gastric cancer cells. World J Gastroenterol 2003; 9: 2413-18.
40. Sambrook J, Russell DW. Molecular Cloning, a Laboratory Manual, Volume III, 3rd edn. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press, 2001.
41. Kisseleva T, Brenner DA. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol 2006; 21 (Suppl 3): S84-7.
42. Friedman SL. Transcriptional regulation of stellate cell activation. J Gastroenterol Hepatol 2006; 21 (Suppl. 3): S79-83.
43. Corpechot C, Barbu V, Wendum D et al. Hypoxia induced VEGF and collagen I are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 2002; 35: 1010-21.