Dosage form development, in vitro release kinetics, and in vitro-in vivo correlation for leuprolide released from an implantable multi-reservoir array

Pharmaceutical Research

Volumn 24, Issue 7, 2007, Pages 1252-1261

  Prescott, James H ^a   Krieger, Timothy J ^a   Lipka, Sara ^a   Staples, Mark A ^a  

^a MicroCHIPS Inc   (United States)

Author keywords

Drug delivery; Implant; In vitro in vivo correlation; Microchip; Protein and peptide formulation

Indexed keywords

LEUPRORELIN; MACROGOL; MONOMER; PEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; COMPOSITE MATERIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; FREEZE DRYING; GEOMETRY; IMPLANT; IMPLANTABLE PORT SYSTEM; IN VITRO STUDY; IN VIVO STUDY; INTEGRATED CIRCUIT; NONHUMAN; PRIORITY JOURNAL; RESERVOIR; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID; STATISTICAL ANALYSIS; STRUCTURE ANALYSIS; TRANSPORT KINETICS;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG COMPOUNDING; DRUG IMPLANTS; DRUG STABILITY; DRUG STORAGE; KINETICS; LEUPROLIDE; MALE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; REPRODUCIBILITY OF RESULTS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 34249881312     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9243-2     Document Type: Article

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