Hormone-refractory prostate cancer: Where are we going?

Drugs

Volumn 67, Issue 8, 2007, Pages 1109-1124

  Di Lorenzo, Giuseppe ^a   Autorino, Riccardo ^b   Figg, William D ^c   De Placido, Sabino ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; ATRASENTAN; BEVACIZUMAB; CALCITRIOL; CAPECITABINE; CARBOPLATIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DEXAMETHASONE; DN 101; DOCETAXEL; EMD 1219749; ESTRAMUSTINE; GEFITINIB; GEMCITABINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; HORMONE; HYDROCORTISONE; IROFULVEN; IXABEPILONE; MITOXANTRONE; NAVELBINE; OBLIMERSEN; OGX 011; PACLITAXEL; PLACEBO; PREDNISONE; PROSTVAC VF; PROVENGE; SABARUBICIN; SATRAPLATIN; SULINDAC SULFONE; THALIDOMIDE; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZD 4054; ZOLEDRONIC ACID;

BONE MARROW SUPPRESSION; CANCER CHEMOTHERAPY; CARDIOVASCULAR EFFECT; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; DEATH; DIARRHEA; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SUBSTITUTION; FEBRILE NEUTROPENIA; HORMONE REFRACTORY PROSTATE CANCER; HUMAN; META ANALYSIS; METASTASIS; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; NAUSEA; NAUSEA AND VOMITING; NEUROPATHY; NEUTROPENIA; PATIENT COMPLIANCE; PROSTATE CANCER; REVIEW; SIDE EFFECT; SYSTEMATIC REVIEW; UNSPECIFIED SIDE EFFECT; VACCINATION; VOMITING;

ANDROGEN ANTAGONISTS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CANCER VACCINES; DRUG RESISTANCE; HUMANS; IMMUNOTHERAPY; MALE; PROSTATIC NEOPLASMS; TAXOIDS;

EID: 34249868179     PISSN: 00126667     EISSN: 00126667     Source Type: Journal    
DOI: 10.2165/00003495-200767080-00002     Document Type: Review

References (69)

1. Jamal A, Murray T, Ward E, et al. Cancer statistics 2006. CA Cancer J Clin 2006; 56: 106-30
2. Scher HI, Steineck G, Kelly WK. Hormone-refractory (D3) prostate cancer: refining the concept. Urology 1995; 46: 142-8
3. Yagoda A, Petrylak DP. Cytotoxic chemotherapy for advanced hormone-resistant prostate cancer. Cancer 1993; 71: 1098-109
4. Tannock IF, Osaba D, Stockler MR, et al. Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone resistant prostate cancer: a Canadian randomised trial with palliative end-point. J Clin Oncol 1996; 14: 1764-5
5. Kantoff PW, Halabi S, Conaway M, et al. Hydrocortisone with or without mitoxantrone in men with hormone refractory prostate cancer: results of the Cancer and Leukemia Group B 9182 study. J Clin Oncol 1999; 17: 2506-13
6. Tannock IF, de Wit R, Berry W, et al. Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. N Engl J Med 2004; 351: 1502-12
7. Petrylak DP, Tangen CM, Hussain MH, et al. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med 2004; 351: 1513-20
8. Clarke NW, Wylie JP. Chemotherapy in hormone refractory prostate cancer: where do we stand? Eur Urol 2004; 46: 709-11
9. Di Lorenzo G, Autorino R, Perdona S, et al. Docetaxel, vinorelbine and zoledronic acid in patients with hormone refractory prostate cancer. Eur Urol. In press
10. Goodin S, Rao KV, Kane M, et al. A phase II trial of docetaxel and vinorelbine in patients with hormone-refractory prostate cancer. Cancer Chemother Pharmacol 2005; 56: 199-204
11. Oh WK, Halabi S, Kelly WK, et al. A phase II study of estramustine, docetaxel, and carboplatin with granulocyte-colony-stimulating factor support in patients with hormone-refractory prostate carcinoma: Cancer and Leukemia Group B 99813. Cancer 2003; 98 (12): 2592-8
12. Ferrero JM, Chamorey E, Oudard S, et al. Phase II trial evaluating a docetaxel-capecitabine combination as treatment for hormone-refractory prostate cancer. Cancer 2006; 107 (4): 738-45
13. Ryan CW, Stadler WM, Vogelzang NJ, et al. A phase I/II dose escalation study of exisulind and docetaxel in patients with hormone refractory prostate cancer. BJU Int 2005; 95 (7): 963-8
14. Font A, Murias A, Arroyo FR, et al. Sequential mitoxantrone/prednisone followed by docetaxel/estramustine in patients with hormone refractory metastatic prostate cancer: results of a phase II study. Ann Oncol 2005; 16: 419-24
15. Beer TM, Eilers KM, Garzotto M, et al. Weekly high-dose calcitriol and docetaxel in metastatic androgen-independent prostate cancer. J Clin Oncol 2003; 21: 123-8
16. Kreis W, Budman DR, Calabro A. Unique synergism or antagonism of combinations of chemotherapeutic and hormonal agents in human prostate cancer cell lines. Br J Urol 1997; 79: 196-202
17. Miller VA, Krug LM, Ng KK, et al. Phase II trial of docetaxel and vinorelbine in patients with advanced non small cell lung cancer. J Clin Oncol 2000; 18: 1346-50
18. Abratt RD, Brune D, Dimopoulos MA, et al. Randomised phase III study of intravenous vinorelbine plus hormone therapy versus hormone therapy alone in hormone refractory prostate cancer. Ann Oncol 2004; 15 (11): 1613-21
19. Beer TM, Ryan CW, Venner PM, et al. Double-blinded randomized study of high-dose calcitriol plus docetaxel compared with placebo plus docetaxel in androgen-independent prostate cancer: a report from the ASCENT Investigators. J Clin Oncol 2007; 25 (6): 669-74
20. Latif T, Wood L, Connel C, et al. Phase II study of oral bis (aceto) ammine dichloro (cyclohexamine) platinum (IV) given daily x 5 in hormone refractory prostate cancer (HRPC). Invest New Drugs 2005; 23: 79-84
21. Sternberg CN, Whelan P, Hetherington J, et al. Genitourinary Tract Group of the EORTC, 2005. Phase III trial of satraplatin, an oral platinum plus prednisone vs. prednisone alone in patients with hormone-refractory prostate cancer. Oncology 2005; 68: 2-9
22. Calafro F, Sternberg CN. Current indications for chemotherapy in prostate cancer patients. Eur Urol 2007; 51 (1): 17-26
23. Senzer N, Arsenau J, Richard D, et al. Irofulven demonstrates clinical activity against metastatic hormone refractory prostate cancer in a phase single agent trial. Am J Clin Oncol 2005; 28 (1): 36-42
24. Fiedler W, Tchen N, Bloch J, et al. A study from the EORTC New Drug Development Group: open label phase II study of sabarubicin in patients with progressive hormone refractory prostate cancer. Eur J Cancer 2006; 42 (2): 200-4
25. Daliani DD, Assikis V, Tu SM, et al. Phase II trial of cyclophosphamide, vincristine and dexamethasone in the treatment of androgen-independent prostate carcinoma. Cancer 2003; 97: 561-7
26. Glode LM, Barqwi A, Crighton F, et al. Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma. Cancer 2003; 98: 1643-8
27. Di Lorenzo G, Autorino R, Morelli E, et al. Thalidomide in combination with oral daily cyclophosphamide in patients with hormone refractory prostate cancer: a phase I clinical study. Cancer Biol Ther 2007; 6 (3): 5-11
28. Michels J, Montemurro T, Murray N, et al. First and second-line chemotherapy with docetaxel or mitoxantrone in patients with hormone refractory prostate cancer. Cancer 2006; 106: 1041-6
29. Saad F, Ruether D, Ernst S, et al. Canadian Urologic Oncology Group (CUOG) phase II multicenter study using docetaxel/prednisone in the second line setting for metastatic hormone refractory prostate cancer in patients progressing after first line mitoxantrone/prednisone [abstract]. Proc Am Soc Clin Oncol 2005; 23 (16S): 4612
30. Oh WK, Manola J, Babcic V, et al. Response to second line chemotherapy in patients with HRPC receiving two sequences of mitoxantrone and taxanes. Urology 2006; 67 (6): 1235-40
31. Abbruzzese J. Phase I studies with the novel nucleoside analog, gemcitabine. Semin Oncol 1996; 23: 25-31
32. Morant R, Bernhard J, Maibach R, et al. Response and palliation in a phase II trial of gemcitabine in hormone refractory metastatic prostate cancer. Swiss Group for Clinical Cancer Research (SAKK). Ann Oncol 2000; 11 (2): 183-8
33. Di Lorenzo G, Autorino R, Giuliano M, et al. Phase II trial of gemcitabine, prednisone and zoledronic acid in pre-treated patients with hormone refractory prostate cancer. Urology 2007; 69 (2): 347-51
34. Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001; 1: 34-45
35. Ropke A, Erbersdobler A, Hammerer P, et al. Gain of androgen receptor gene copies in primary prostate cancer due to X chromosome polysomy. Prostate 2004; 59 (1): 59-68
36. Gregory CW, Johnson RT Jr, Mohler JL, et al. Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen. Cancer Res 2001; 61 (7): 2892-8
37. Bakin RE, Gioeli D, Sikes RA, et al. Constitutive activation of the RAS/mitogen-activated protein kinase signaling pathway promotes androgen hypersensitivity in LNCaP prostate cancer cells. Cancer Res 2003; 63 (8): 1981-9
38. Nelson WG, De Marzo AM, Isaacs WB. Prostate cancer. N Engl J Med 2003; 349 (4): 366-81
39. Culig Z, Hobisch A, Cronauer MV, et al. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-1, keratinocyte growth factor and epidermal growth factor. Cancer Res 1994; 54 (20): 5474-8
40. Lin HK, Yen S, Kang HY, et al. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A 2001; 98 (13): 7200-5
41. Wilding G, Soulie P, Trump D, et al. Results from a pilot phase I of gefitinib combined with docetaxel and estramustine in patients with hormone refractory prostate cancer. Cancer 2006; 106 (9): 1917-24
42. Kim SJ, Uehara H, Yazici S, et al. Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer. J Natl Cancer Inst 2006; 98 (11): 783-93
43. Mathew P, Thall PF, Johnson MM, et al. Preliminary results of a randomized placebo-controlled double-blind trial of weekly docetaxel combined with imatinib in men with metastatic androgen-independent prostate cancer (AIPC) and bone metastases (BM) [abstract]. ASCO Annual Meeting Proceedings 2006; 24 (18S) (June 20 Suppl.): 4562
44. Chee KG, Longmate J, Lara PN Jr, et al. Trastuzumab plus docetaxel in Her /2. Cancer 2004; 100: 2125-30
45. de Bono JS, Bellmunt J, Attard G, et al. Open-label phase II study evaluating the efficacy and safety of two doses of pertuzumab in castrate chemotherapy-naïve patients with hormone-refractory prostate cancer. J Clin Oncol 2007; 25: 257-62
46. Lara PN Jr, Twardowski P, Quinn DJ. Angiogenesis targeted therapies in prostate cancer. Clin Prostate Cancer 2004; 3 (3): 165-73
47. Dahut WL, Gulley JL, Arlen PM, et al. Randomized phase II trial of docetaxel plus thalidomide in androgen independent prostate cancer. J Clin Oncol 2004; 22: 2532-7
48. Cox MC, Dahut WL, Figg WD. The use of thalidomide in androgen independent prostate cancer. Urologic Oncol 2006; 24: 246-9
49. Picus J, Halabi S, Rini B, et al. The use of bevacizumab with docetaxel and estramustine in hormone refractory prostate cancer: initial results of CALGB 900006 [abstract]. Proc Am Soc Clin Oncol 2003; 22: 393
50. Berry W, Eisenberger M. Achieving treatment goals for hormone-refractory prostate cancer with chemotherapy. Oncologist 2005; 10 Suppl. 3: 30-9
51. Carducci M, Padley RJ, Breul J, et al. Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone refractory prostate cancer: a randomized, phase II, placebo-controlled trial. J Clin Oncol 2003; 4: 679-89
52. Vogelzang NJ, Nelson JB, Schulman CC, et al. Meta-analysis of clinical trials of atrasentan 10mg in metastatic hormone-refractory prostate cancer [abstract no. 4615]. Proc Am Soc Clin Oncol 2005; 23: 406s
53. George DJ, Cockerman JP, Petrow W, et al. A phase I/II study of docetaxel and atrasentan in men with metastatic hormone-refractory prostate cancer (HRPC) [abstract]. J Clin Oncol, 2005 ASCO Annual Meeting Proceedings; 23 Suppl. 16S: 4667
54. Tolcher AW, Chi K, Kuhn J, et al. A phase II, pharmacokinetic, and biological correlative study of oblimersen sodium and docetaxel in patients with hormone-refractory prostate cancer. Clin Cancer Res 2005; 11: 3854-61
55. Sternberg CN. Soup to nuts [online]. Prostate cancer symposium 2007 Feb 22-24; Orlando (FL). Available from URL: http:// www.prostateline.org [Accessed 2007 May 9]
56. Hussain M, Tangen CM, Lara PN Jr, et al. Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: a Southwest Oncology Group trial S0111. J Clin Oncol 2005; 23 (34): 8724-9
57. Galsky MD, Small EJ, Oh WK, et al. Multi-institutional randomized phase II trial of the epothilone B analogue ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer. J Clin Oncol 2005; 23: 1439-46
58. Rosenberg JE, Weinberg VK, Kelly WK, et al. Randomized phase II study of ixabepilone or mitoxantrone and prednisone in patients with taxane resistant hormone refractory prostate cancer [abstract]. Proceedings from the 2006 Prostate Cancer Symposium, 2005 Feb 17-19, Orlando (FL): 253
59. Miyake H, Nelson C, Rennie PS, et al. Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer. Cancer Res 2000; 60: 170-6
60. Chi KN, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2′-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst 2005; 97: 1287-96
61. Chi KN, Eisenhauer E, Siu L, et al. A phase I study of a second generation antisense oligonucleotide to clusterin (OGX-011) in combination with docetaxel: NCIC CTG IND.154 [abstract]. J Clin Oncol, 2005 ASCO Annual Meeting Proceedings; 23 Suppl. 16S: 3085
62. Rowinsky EK, Calvo E. Novel agents that target tubulin and related elements. Semin Oncol 2006; 33 (4): 421-35
63. Jordan MA, Kamath K, Manna T, et al. The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth. Mol Cancer Ther 2005 Jul; 4 (7): 1086-95
64. Beekman KW, Colevas AD, Cooney K, et al. Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design. Clin Genitourin Cancer 2006; 4 (4): 299-302
65. Fu Y, Hsieh TC, Guo J, et al. Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem Biophys Res Commun 2004; 322 (1): 263-70
66. Small EJ, Schellammer PF, Higano CS, et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 2006; 24 (19): 3089-94
67. Brand TC, Tolcher AW. Management of high risk metstatic prostate cancer: the case of novel therapies. J Urol 2006; 176: S76-80
68. Simons J, Higano C, Corman J. A phase I/II trial of high dose allogeneic GM-CSF gene-transduced prostate cancer cell line vaccine in patients with metastatic hormone-refractory prostate cancer [abstract]. Proc Am Soc Clin Oncol 2003; 22: 166
69. Dipaola R, Plante M, Kaufman H, et al. A phase I trial of pox PSA vaccines (PROSTVACR-VF) with B7-1, ICAM-1, and LFA-3 co-stimulatory molecules (TRICOM™) in patients with prostate cancer. J Transl Med 2006; 3: 1-5