Elevated glucose attenuates agonist- and flow-stimulated endothelial nitric oxide synthase activity in microvascular retinal endothelial cells

Endothelium: Journal of Endothelial Cell Research

Volumn 14, Issue 1, 2007, Pages 17-24

  Connell, Paul ^a,b   Walshe, Tony ^a   Ferguson, Gail ^a   Gao, Wei ^a   O'Brien, Colm ^c   Cahill, Paul A ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

^b MATER MISERICORDIAE UNIVERSITY HOSPITAL   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; MANNITOL; NITRATE; NITRIC OXIDE; MANNOSE; VASODILATOR AGENT;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DIABETIC RETINOPATHY; ENDOTHELIUM CELL; HYPERGLYCEMIA; IN VITRO STUDY; LAMINAR FLOW; NONHUMAN; OSMOSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULSATILE FLOW; RETINA BLOOD VESSEL; SHEAR STRESS; ANIMAL; CATTLE; CELL CULTURE; CHEMISTRY; COCULTURE; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; FLUOROMETRY; MECHANICAL STRESS; METABOLISM; OSMOTIC PRESSURE; VASCULAR ENDOTHELIUM;

BOVINAE;

ACETYLCHOLINE; ANIMALS; CATTLE; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLUOROMETRY; GLUCOSE; HYPERGLYCEMIA; MANNOSE; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; OSMOTIC PRESSURE; PULSATILE FLOW; RETINAL VESSELS; STRESS, MECHANICAL; VASODILATOR AGENTS;

EID: 34249846758     PISSN: 10623329     EISSN: 10292373     Source Type: Journal    
DOI: 10.1080/10623320601177213     Document Type: Article

References (39)

1. Arun, C. S., Ngugi, N., Lovelock, L. and Taylor, R. (2003) Effectiveness of screening in preventing blindness due to diabetic retinopathy. Diabetic Medicine, 20, pp. 186-190.
2. Chakravarthy, U., Hayes, R. G. and Stitt, A. W. (1998) Constitutive nitric oxide synthase expression in retinal vascular endothelial cells is suppressed by high glucose and advanced glycation end products. Diabetes, 47, pp. 94-99.
3. Conway, E., Collen, D. and Carmeliet, M. (2001) Molecular mechanisms of blood vessel growth. Cardiovascular Research, 49, pp. 507-521.
4. Cosentino, F. and Hishikawa, K. (2001) High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation, 96, pp. 25-28.
5. Davis, B. J., Xie, Z., Viollet, B. and Zou, M. H. (2006) Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase. Diabetes, 55, pp. 496-505.
6. Du, X. L. and Edelstein, D. (2001) Hypergylcaemia inhibits endothelial nitric oxide synthase activity by post-translational modification at the Akt site. Journal of Clinical Investigation, 108, pp. 1341-1348.
7. Feke, G. T., Tagawa, H., Yoshida, A., Goger, D. G., Weiter, J. J., Buzney, S. M. and McMeel, J. W. (1985) Retinal circulatory changes related to retinopathy progression in insulin dependent diabetes mellitus. Ophthalmology, 92, pp. 1517-1522.
8. Furchgott, R. F. and Zawadzki, J. V. (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, pp. 373-376.
9. Garcia, J. P., Garcia, P. T. and Rosen, R. B. (2002) Retinal blood flow in the normal human eye using the canon laser blood flowmeter. Ophthalmic Research, 34, pp. 295-299.
10. Girach, A. and Vignati, L. (2006) Diabetic microvascular complications-Can the presence of one predict the development of another?. Journal of Diabetes Complications, 20, pp. 228-237.
11. Goldstein, I. and Ostwald, P. (1996) Nitric oxide: A review of its role in retinal function and disease. Vision Research, 36, pp. 2979-2994.
12. Grammas, P. and Riden, M. (2003) Retinal endothelial cells are more susceptible to oxidative stress and increased permeability than brain derived endothelial cells. Microvascular Research, 65, pp. 18-23.
13. Grunwald, J. E., Dupont, J. and Riva, C. (1996) Retinal haemodynamics in patients with early diabetes. British Journal of Ophthalmology, 80, pp. 327-331.
14. Guven, D. and Ozdemir, H. (1996) Haemodynamic alterations in diabetic retinopathy. Ophthalmology, 103, pp. 1245-1249.
15. Haefliger, I. O. and Flammer, J. (2001) Endothelium-dependent vasoactive modulation in the ophthalmic circulation. Progress in Retinal and Eye Research, 20, pp. 209-225.
16. Ishii, H., Jirousek, M. R. and Koya, D. (1996) Amelioration of vascular dysfunction in diabetic rats by an oral PKC B inhibitor. Science, 272, pp. 728-731.
17. Kelly, R. F., Ruane-Ohara, T., Noble, M. I., Drake-Holland, A. J. and Jnow, H. M. (2006) Differnential inhibition by hyperglycaemia of shear stress but not acetylcholine mediated dilation of the iliac artery of the anaesthesised pig. Journal of Physiology, 373, pp. 133-145.
18. Kimata, K., Miyata, N. and Kasuya, Y. (1989) Impairment of endothelium dependent relaxation and changes in the levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. British Journal of Pharmacology, 97, pp. 612-618.
19. King, G. L. and Brownlee, M. (1996) The cellular and molecular mechanisms of diabetic complications. Endocrinol Metam Clin North Am., 25, pp. 255-270.
20. King, H., Aubert, R. E. and Herman, W. H. (1998) Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care, 21, pp. 1414-1431.
21. Klein, R., Klein, B. E., Moss, S. E., Wong, T. Y. and Sharrett, A. R. (2006) Retinal vascular caliber in persons with type 2 diabetes. The Wisconsin Epidemiological Study of Diabetic Retinopathy: XX. Ophthalmology, 113, pp. 1488-1498.
22. Konno, S., Feke, G. T. and Yoshida, A. (1996) Retinal blood flow changes in type 1 diabetes. Investigative Ophthalmology and Visual Science, 37, pp. 1140-1148.
23. Laties, A. M. and Jacobowitx, D. (1966) A comparative study of the autonomic innervation of the eye in monkey, cat and rabbit. Anatomy Research, 156, pp. 383-389.
24. Lefebvre, P. (2005) Diabetes yesterday, today and tomorrow. The action of the International Diabetes Federation. Revue Medicale de Leige, 60, pp. 273-277.
25. Lin, L. Y., Lin, C. Y., Ho, F. M. and Liau, C. S. (2005) Up-regulation of the association between heat shock protein 90 and endothelial nitric oxide synthase prevents high glucose-induced apoptosis in human endothelial cells. Journal of Cellular Biochemistry, 94, pp. 194-201.
26. McCarty, M. F. (1998) Nitric oxide deficiency, leukocyte activation and resultant ischaemia are crucial to the pathogenesis of diabetic retinopathy-preventive potential of antioxidants, essential fatty acids, chromium, ginkgolides, and pentoxifylline. Medical Hypotheses, 50, pp. 435-449.
27. McVeigh, G. E., Brennan, G. M., Johnston, G. D., McDermott, B. J., McGrath, L. T., Henry, W. R., Andrews, J. W. and Hayes, J. R. (1992) Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia, 35, pp. 771-776.
28. Meyer, P., Flammer, J. and Luscher, T. F. (1993) Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: Role of nitric oxide and the endothelins. Investigative Ophthalmology and Visual Science, 34, pp. 3614-3621.
29. Morisaki, N., Watanabe, S., Fukuda, K. and Saito, Y. (1999) Angiogenic interaction between retinal endothelial cells and pericytes from normal and diabetic rabbits, and phenotypic changes of diabetic cells. Cellular and Molecular Biology, 45, pp. 67-77.
30. Noyman, I. and Marikovsky, M. (2002) Hyperglycaemia reduces nitric oxide synthase and glycogen synthase activity in endothelial cells. Nitric Oxide, 7, pp. 187-193.
31. Rhatigan, M. C., Leese, G. P., Ellis, J., Ellingford, A., Morris, A. D., Newton, R. W. and Roxburgh, S. T. (1999) Blindness in patients with diabetes who have been screened for eye disease. Eye, 13, pp. 166-169.
32. Schmetterer, L. P. and Polak, L. (2001) Role of nitric oxide in the control of blood flow. Progress in Retinal and Eye Research, 20, pp. 823-847.
33. Timini, F. K., Ting, H. H. and Haley, E. A. (1998) Vitamin C improves endothelium-dependent vasodilation in patients with insulin dependent diabetes mellitus. Journal of the American College of Cardiology, 31, pp. 552-557.
34. Vallance, P., Collier, J. and Moncada, S. (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet, 2, pp. 997-1000.
35. Walshe, T., Ferguson, G. and Connell, P. (2005) Pulsatile flow increases the expression of eNOS, Et-1 and prostacyclin in a novel in vitro model of the retinal vasculature. Investigative Ophthalmology and Visual Science, 46, pp. 375-382.
36. Wessells, H., Teal, T. H., Engel, K., Sullivan, C. J., Gallis, B., Tran, K. B. and Chitaley, K. (2006) Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: Inhibition by hyperglycaemia. BJU Int, 97:5, pp. 1047-1052.
37. Wild, S., Roglie, G. and Green, A. (2004) Global burden of diabetes 1995-2025: Prevalence, numerical estimates, and projections for 2030. Diabetes Care, 27, pp. 1047-1053.
38. Williams, S. B., Cruso, J. A. and Roddy, M. A. (1996) Impaired nitric-oxide mediated vasodilation in patients with non-insulin dependent diabetes mellitus. Journal of the American College of Cardiology, 27, pp. 567-574.
39. Wong, T. Y., Klein, R. and Klein, B. E. (2003) Retinal vessel diameters and their associations with age and blood pressure. Investigative Ophthalmology and Visual Science, 44, pp. 4644-4650.