Pharmacokinetics of dirlotapide in the dog

Journal of Veterinary Pharmacology and Therapeutics

Volumn 30, Issue SUPPL. 1, 2007, Pages 24-32

  Merritt, D A ^a   Lynch, M P ^a   King, V L ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIRLOTAPIDE; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSE INCREASE; DRUG FORMULATION; DRUG METABOLISM; FEMALE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ANIMALS; ANTI-OBESITY AGENTS; AREA UNDER CURVE; CARBAMATES; CROSS-OVER STUDIES; DOGS; FEMALE; INDOLES; INJECTIONS, INTRAVENOUS; MALE;

CANIS FAMILIARIS;

EID: 34249811757     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2007.00862.x     Document Type: Article

References (16)

1. Amidon, G.L., Lennernäs, H., Shah, V.P. Crison, J.R. (1995) A theoretical basis for a biopharmaceutical classification: the correlation of in vitro drug product dissolution and in vivo permeability. Pharmaceutical Research, 12, 413 420.
2. Chandler, C.E., Wilder, D.E., Pettini, J.L., Savoy, Y.E., Petras, S.F., Chang, G., Vincent, J. Harwood, H.J. Jr. (2003) CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. Journal of Lipid Research, 44, 1887 1901.
3. Charman, W.N., Porter, C.J.H., Mithani, S. Dressman, J.B. (1997) Physicochemical and physiological mechanisms for the effect of food on drug absorption: the role of lipids and pH. Journal of Pharmaceutical Sciences, 86, 269 282.
4. Fleisher, D., Li, C., Zhou, Y., Pao, L.-H. Karim, A. (1999) Drug, meal and formulation interactions influencing drug absorption after oral administration: clinical implications. Clinical Pharmacokinetics, 36, 233 254.
5. Hoffman, D.J., Seifert, T., Borre, A. Nellans, H.N. (1995) Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling. Pharmaceutical Research, 12, 889 894.
6. Kirk, C.A., Boucher, J.F., Sunderland, S.F. Wren, J.A. (2007) Influence of dirlotapide, a microsomal triglyceride transfer protein inhibitor, on the digestibility of a dry expanded diet in adult dogs. Journal of Veterinary Pharmacology and Therapeutics, 30 (Suppl. 1), 66 72.
7. Kwon, Y. Inskeep, P.B. (1996) Theoretical considerations on two equations for estimating the extent of absorption after oral administration of drugs. Pharmaceutical Research, 13, 566 569.
8. Martinez, M., Ausburger, L., Johnston, T. Warren Jones, W. (2002a) Applying the biopharmaceutics classification system to veterinary pharmaceutical products: Part I. Biopharmaceutics and formulation considerations. Advanced Drug Delivery Reviews, 54, 805 824.
9. Martinez, M., Amidon, G., Clarke, L., Warren Jones, W., Mitra, A. Riviere, J. (2002b) Applying the biopharmaceutics classification system to veterinary pharmaceutical products: Part II. Physiologic considerations. Advanced Drug Delivery Reviews, 54, 825 850.
10. Merritt, D.A., Bessire, A.J., Vaz, A.D., Sams, J.P. Lynch, M.P. (2007) Absorption, distribution, metabolism, and excretion of dirlotapide in the dog. Journal of Veterinary Pharmacology and Therapeutics, 30 (Suppl. 1), 17 23.
11. Toutain, P.L. Bousquet-Mélou, A. (2004) Plasma clearance. Journal of Veterinary Pharmacology and Therapeutics, 27, 415 425.
12. Wetterau, J.R., Lin, M.C.M. Jamil, H. (1997) Review: Microsomal triglyceride transfer protein. Biochimica Biophysica Acta, 1345, 136 150.
13. Williams, S. Best, J. (2003) Novel microsomal triglyceride transfer protein inhibitors. Expert Opinion on Therapeutic Patents, 13, 479 488.
14. Wren, J.A., Gossellin, J. Sunderland, S.J. (2007a) Dirlotapide: a review of its properties and role in the management of obesity in dogs. Journal of Veterinary Pharmacology and Therapeutics, 30 (Suppl. 1), 11 16.
15. Wren, J.A., King, V.L., Campbell, S.L. Hickman, M.A. (2007b) Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs. Journal of Veterinary Pharmacology and Therapeutics, 30 (Suppl. 1), 33 42.
16. Wu, C.-Y. Benet, L.Z. (2005) Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharmaceutical Research, 22, 11 23.