Bisphosphonate rescue in distraction osteogenesis: A case series

Journal of Pediatric Orthopaedics

Volumn 27, Issue 4, 2007, Pages 467-471

  Kiely, Patrick ^a   Ward, Kate ^a   Bellemore C , Michael ^a   Briody, Julie ^a   Cowell, Christopher T ^a   Little, David G ^a,b  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b University of Sydney   (Australia)

Author keywords

Bisphosphonate; Bone morphogenetic protein; Bone resorption; Distraction osteogenesis; Osteopenia

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; COLLAGEN TYPE 1; PAMIDRONIC ACID; RECOMBINANT OSTEOGENIC PROTEIN 1; ZOLEDRONIC ACID;

ADOLESCENT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BIOSYNTHESIS; BONE DENSITY; BONE REGENERATION; BONE STRENGTH; CATABOLISM; CLINICAL ARTICLE; CONTINUOUS INFUSION; DEVICE REMOVAL; DISTRACTION OSTEOGENESIS; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMUR; FOLLOW UP; HEALING; HUMAN; INFORMED CONSENT; LEG LENGTHENING; MINIMALLY INVASIVE SURGERY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; SCHOOL CHILD; SURGICAL EQUIPMENT; TIBIA; TIME; TREATMENT DURATION; TREATMENT RESPONSE;

ADOLESCENT; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; BONE LENGTHENING; BONE RESORPTION; CHILD; DENSITOMETRY, X-RAY; DIPHOSPHONATES; FEMALE; FEMUR; FOLLOW-UP STUDIES; HUMANS; LEG LENGTH INEQUALITY; OSTEOGENESIS, DISTRACTION; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; TIBIA; TIME FACTORS; TREATMENT OUTCOME;

EID: 34249796609     PISSN: 02716798     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.bpb.0000271326.41363.d1     Document Type: Article

References (25)

1. Fischgrund J, Paley D, Suter C. Variables affecting time to bone healing during limb lengthening. Clin Orthop Relat Res. 1994;301:31-37.
2. Curran AR, Kuo KN, Lubicky JP. Simultaneous ipsilateral femoral and tibial lengthening with the Ilizarov method. J Pediatr Orthop. 1999;19:386-390.
3. Aldegheri R. Femoral callotasis. J Pediatr Orthop B. 1997;6:42-47.
4. Paley D, Herzenberg JE, Paremain G, et al. Femoral lengthening over an intramedullary nail. A matched-case comparison with Ilizarov femoral lengthening. J Bone Joint Surg Am. 1997;79:1464-1480.
5. Guichet JM, Deromedis B, Donnan LT, et al. Gradual femoral lengthening with the Albizzia intramedullary nail. J Bone Joint Surg Am. 2003;85:838-848.
6. Simpson AH, Cole AS, Kenwright J. Leg lengthening over an intramedullary nail. J Bone Joint Surg Br. 1999;81:1041-1045.
7. Eyres KS, Bell MJ, Kanis JA. New bone formation during leg lengthening. Evaluated by dual energy x-ray absorptiometry. J Bone Joint Surg Br. 1993;75:96-106.
8. Maffulli N, Cheng JC, Sher A, et al. Dual-energy x-ray absorptiometry predicts bone formation in lower limb callotasis lengthening. Ann R Coll Surg Engl. 1997;79:250-256.
9. Danziger MB, Kumar A, DeWeese J. Fractures after femoral lengthening using the Ilizarov method. J Pediatr Orthop. 1995;15:220-223.
10. Simpson AH, Kenwright J. Fracture after distraction osteogenesis. J Bone Joint Surg Br. 2000;82:659-665.
11. Little DG, Cornell MS, Briody J, et al. Intravenous pamidronate reduces osteoporosis and improves formation of the regenerate during distraction osteogenesis. A study in immature rabbits. J Bone Joint Surg Br. 2001;83:1069-1074.
12. Little DG, Smith NC, Williams PR, et al. Zoledronic acid prevents osteopenia and increases bone strength in a rabbit model of distraction osteogenesis. J Bone Miner Res. 2003;18:1300-1307.
13. Smith EJ, McEvoy A, Little DG, et al. Transient retention of endochondral cartilaginous matrix with bisphosphonate treatment in a long-term rabbit model of distraction osteogenesis. J Bone Miner Res. 2004;19:1698-1705.
14. Takahashi M, Yukata K, Matsui Y, et al. Bisphosphonate modulates morphological and mechanical properties in distraction osteogenesis through inhibition of bone resorption. Bone. 2006;39:573-581.
15. Hogler W, Yap F, Little D, et al. Short-term safety assessment in the use of intravenous zoledronic acid in children. J Pediatr. 2004;145:701-704.
16. Rucci N, Rufo A, Alamanou M, et al. Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratio. J Cell Biochem. 2006. Advanced online publication, August 22, 2006.
17. Li G, Dickson GR, Marsh DR, et al. Rapid new bone tissue remodeling during distraction osteogenesis is associated with apoptosis. J Orthop Res. 2003;21:28-35.
18. Hamdy RC, Amako M, Beckman L, et al. Effects of osteogenic protein-1 on distraction osteogenesis in rabbits. Bone. 2003;33:248-255.
19. Paley D. Problems, obstacles, and complications of limb lengthening by the Ilizarov technique. Clin Orthop Relat Res. 1990;250:81-104.
20. O'Carrigan T, Herzenberg J, Paley D. Fractures during and after limb lengthening [Paper No. 212]. Presented at: 2003 Annual Meeting of the American Academy of Orthopaedic Surgeons.
21. Little DG, McDonald M, Bransford R, et al. Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. J Bone Miner Res. 2005;20:2044-2052.
22. Tägil M, W-Dahl A, Åstrand J, et al. Decreasing the catabolic response by a single bisphosphonate infusion shortens the healing time in hemicallotasis operations. Bone. 2006;38:84-85.
23. Marx RE, Sawatari Y, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567-1575.
24. Aspenberg P. Osteonecrosis of the jaw: what do bisphosphonates do? Expert Opin Drug Saf. 2006;5:743-745.
25. Bilezikian JP. Osteonecrosis of the jaw - do bisphosphonates pose a risk? N Engl J Med. 2006;355:2278-2281.