Design, synthesis and molecular docking studies of novel triazole antifungal compounds

Chinese Chemical Letters

Volumn 18, Issue 6, 2007, Pages 663-666

  He, Qiu Qin ^a   Li, Ke ^a   Cao, Yong Bing ^a   Dong, Huan Wen ^a   Zhao, Li Hua ^a   Liu, Chao Mei ^a   Sheng, Chun Quan ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antifungal activity; Fluconazole resistant; Lanosterol 14 demethylase; tert Butyl; Triazole

Indexed keywords

EID: 34249788969     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2007.04.025     Document Type: Article

References (6)

1. Pfaller M.A., Messer S.A., Hollis R.J., and Jones R.N. Antimicrob. Agents Chemother. 45 (2001) 2862
2. Jeu L., Piacenti F.J., Lyakhovetskiy A.G., and Fung H.B. Clin. Ther. 25 (2003) 1321
3. Sheng C.Q., Zhang W.N., Ji H.T., et al. Chin. Chem. Lett. 15 (2004) 404
4. Gollapudy R., Ajmani S., and Kulkarni S.A. Bioorg. Med. Chem. 12 (2004) 2937
5. G. Holmwood, E. Regel, US patent, 1984, 4499281.
6. Compound 11, 113-115 (C. 1H NMR (600 MHz, DMSO-d6, (ppm): 1.01 (s, 9H), 3.01-3.77 (m, 12H), 4.34-4.57(dd, 2H), 4.75 (s, 1H), 6.74-6.86 (m, 4H), 7.54-7.55 (m, 4H), 7.89 (s, 1H), 8.36 (s, 1H). ESI-MS, m/z: 475.2[M + 1]+ (calcd for C27H34N6O2, 474.2). IR (KBr, cm(1): 3416, 2959, 2830, 2226, 1511. 13C NMR (300 MHz, CDCl3, (ppm): 151.9, 146.1, 144.9, 132.2, 129.6, 118.9, 118.2, 115.0, 76.0, 68.5, 62.3, 53.2, 51.7, 50.3, 37.0, 25.7.