Modification of chicken avian β-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity

Immunogenetics

Volumn 59, Issue 7, 2007, Pages 573-580

  Higgs, Rowan ^a   Lynn, David J ^b   Cahalane, Sarah ^a   Alaña, Iñigo ^c   Hewage, Chandralal M ^c   James, Tharappel ^b   Lloyd, Andrew T ^a   O'Farrelly, Cliona ^a,c  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Antimicrobial peptide; Chicken; Defensin; Positive selection

Indexed keywords

AMINO ACID; BETA DEFENSIN; BETA DEFENSIN 8; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; CHICKEN; ESCHERICHIA COLI; FOWL; IMMUNOGENETICS; INNATE IMMUNITY; LISTERIA MONOCYTOGENES; MOLECULAR EVOLUTION; NONHUMAN; PEPTIDE SYNTHESIS; PREDICTION; PRIORITY JOURNAL; PROTEIN MODIFICATION; SALMONELLA TYPHIMURIUM; STATISTICAL SIGNIFICANCE; STREPTOCOCCUS PYOGENES;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; AVIAN PROTEINS; BACTERIA; BETA-DEFENSINS; CHICKENS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; EVOLUTION, MOLECULAR; HUMANS; MOLECULAR SEQUENCE DATA;

AVES; ESCHERICHIA COLI; LISTERIA MONOCYTOGENES; SALMONELLA TYPHIMURIUM; STREPTOCOCCUS PYOGENES;

EID: 34249780856     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-007-0219-5     Document Type: Article

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