Transplantation of 3D scaffolds seeded with human embryonic stem cells: Biological features of surrogate tissue and teratoma-forming potential

Regenerative Medicine

Volumn 2, Issue 3, 2007, Pages 289-300

  Lees, Justin G ^a   Lim, Sue Anne ^b   Croll, Tristan ^b   Williams, Georgia ^a   Lui, Sylvia ^a   Cooper White, Justin ^b   McQuade, Leon R ^a   Mathiyalagan, Bagyalakshmi ^a   Tuch, Bernard E ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

3D cell culturing; Human embryonic stem cells; Scaffolds; Surrogate tissue; Teratomas

Indexed keywords

ALPHA FETOPROTEIN; AMYLIN; BETA ACTIN; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN TYPE 1; COLLAGEN TYPE 4; GLUCAGON LIKE PEPTIDE 1; INSULIN; LAMININ; NESTIN; OCTAMER TRANSCRIPTION FACTOR 4; POLYGLACTIN; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX17;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMEDICAL ENGINEERING; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDODERM; EXTRACELLULAR MATRIX; FETUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; LIVER CIRCULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; SCID MOUSE; STEM CELL; STEM CELL TRANSPLANTATION; TERATOMA; TUMOR GROWTH;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; HUMANS; LIVER; MICE; MICE, SCID; NEURONS; PANCREAS; PROSTHESES AND IMPLANTS; TERATOMA; TISSUE ENGINEERING;

EID: 34249774273     PISSN: 17460751     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460751.2.3.289     Document Type: Article

References (29)

1. D'Amour KA, Bang AG, Eliazer S et al.: Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat. Biotechnol. 24(11), 1392-1401 (2006).
2. McLean AB, D'Amour KA, Jones KL et al.: Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 25(1), 29-38 (2007).
3. Lees JG, Tuch BE: Conversion of embryonic stem cells into pancreatic β-cell surrogates guided by ontogeny. Regenerative Med. 1(3), 327-336 (2006).
4. Konstantinova I, Lammert E: Microvascular development: learning from pancreatic islets. Bioessays 26(10), 1069-1075 (2004).
5. Wang R, Li J, Lyte K, Yashpal NK, Fellows F, Goodyer CG: Role for β1 integrin and its associated α3, α5, and α6 subunits in development of the human fetal pancreas. Diabetes 54(7), 2080-2089 (2005).
6. Hammar E, Parnaud G, Bosco D et al.: Extracellular matrix protects pancreatic β-cells against apoptosis: role of short- and long-term signaling pathways. Diabetes 53(8), 2034-2041 (2004).
7. Wang RN, Rosenberg L: Maintenance of β-cell function and survival following islet isolation requires re-establishment of the islet-matrix relationship. J. Endocrinol. 163(2), 181-190 (1999).
8. Levenberg S, Rouwkema J, Macdonald M et al.: Engineering vascularized skeletal muscle tissue. Nat. Biotechnol. 23(7), 879-884 (2005).
9. Liu H, Lin J, Roy K: Effect of 3D scaffold and dynamic culture condition on the global gene expression profile of mouse embryonic stem cells. Biomaterials 27, 5978-5989 (2006).
10. Levenberg S, Huang NF, Lavik E, Rogers AB, Itskovitz-Eldor J, Langer R: Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc. Natl Acad. Sci. USA 100(22), 12741-12746 (2003).
11. Fujikawa T, Oh SH, Pi L, Hatch HM, Shupe T, Petersen BE: Teratoma formation leads to failure of treatment for Type I diabetes using embryonic stem cell-derived insulin-producing cells. Am. J. Pathol. 166(6), 1781-1791 (2005).
12. Costa M, Dottori M, Ng E et al.: The hESC line Envy expresses high levels of GFP in all differentiated progeny. Nat. Med. 2(4), 259-260 (2005).
13. Cao Y, Croll TI, Cooper-White JJ, O'Connor AJ, Stevens GW: Production and surface modification of polylactide-based polymeric scaffolds for soft tissue engineering. In: Methods in Tissue Engineering. Hatton PV (Ed.). Humana Press, Totowa, NJ, USA 400 (2004).
14. Sidhu KS, Tuch BE: Derivation of three clones from human embryonic stem cell lines by FACS sorting and their characterization. Stem Cells Dev. 15(1), 61-69 (2006).
15. Movassat J, Beattie GM, Lopez AD, Hayek A: Exendin 4 up-regulates expression of PDX 1 and hastens differentiation and maturation of human fetal pancreatic cells. J. Clin. Endocrinol. Metab. 87(10), 4775-4781 (2002).
16. Vallier L, Reynolds D, Pedersen RA: Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway. Dev. Biol. 275(2), 403-421 (2004).
17. Micallef SJ, Janes ME, Knezevic K, Davis RP, Elefanty AG, Stanley EG: Retinoic acid induces Pdx1-positive endoderm in differentiating mouse embryonic stem cells. Diabetes 54(2), 301-305 (2005).
18. Bai L, Meredith G, Tuch BE: Glucagon-like peptide-1 enhances production of insulin in insulin-producing cells derived from mouse embryonic stem cells. J. Endocrinol. 186(2), 343-352 (2005).
19. Jiang FX, Harrison LC: Laminin-1 and epidermal growth factor family members co-stimulate fetal pancreas cell proliferation and colony formation. Differentiation 73(1), 45-49 (2005).
20. Badylak SF: The extracellular matrix as a scaffold for tissue reconstruction. Semin. Cell. Dev. Biol. 13(5), 377-383 (2002).
21. Khoo ML, McQuade LR, Smith MS, Lees JG, Sidhu KS, Tuch BE: Growth and differentiation of embryoid bodies derived from human embryonic stem cells: effect of glucose and basic fibroblast growth factor. Biol. Reprod. 73(6), 1147-1156 (2005).
22. Nelson CM, Tien J: Microstructured extracellular matrices in tissue engineering and development. Curr. Opin. Biotechnol. 17(5), 518-523 (2006).
23. Eventov-Friedman S, Katchman H, Shezen E et al.: Embryonic pig liver, pancreas, and lung as a source for transplantation: optimal organogenesis without teratoma depends on distinct time windows. Proc. Natl Acad. Sci. USA 102(8), 2928-2933 (2005).
24. Hebrok M, Kim SK, Melton DA: Notochord repression of endodermal Sonic hedgehog permits pancreas development. Gen. Dev. 12(11), 1705-1713 (1998).
25. Beattie GM, Lopez AD, Bucay N et al.: Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layers. Stem Cells 23(4), 489-495 (2005).
26. Kubo A, Shinozaki K, Shannon JM et al.: Development of definitive endoderm from embryonic stem cells in culture. Development 131(7), 1651-1662 (2004).
27. Xu C, Rosler E, Jiang J et al.: Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium. Stem Cells 23(3), 315-323 (2005).
28. Xu C, Inokuma MS, Denham J et al.: Feeder-free growth of undifferentiated human embryonic stem cells. Nat. Biotechnol. 19(10), 971-974 (2001).
29. Cooke MJ, Stojkovic M, Przyborski SA: Growth of teratomas derived from human pluripotent stem cells is influenced by the graft site. Stem Cells Dev. 15(2), 254-259 (2006).