3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3504-3507

  Zhao, Shu Hai ^a   Berger, Jacob ^a   Clark, Robin D ^a   Sethofer, Steven G ^a   Krauss, Nancy E ^a   Brothers, Julie M ^a   Martin, Renee S ^a   Misner, Dinah L ^a   Schwab, Dietmar ^a   Alexandrova, Ludmila ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

5 HT6 antagonist; Benzoxazine; Brain penetration; hERG; Lipophilicity

Indexed keywords

3,4 DIHYDRO 2H BENZO[1,4]OXAZINE DERIVATIVE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; POTASSIUM CHANNEL HERG; R 1485; RO 65 7674; SEROTONIN 6 ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BRAIN LEVEL; DRUG DESIGN; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IC 50; INHIBITION KINETICS; LIPOPHILICITY; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SEROTONIN RELEASE; SINGLE DRUG DOSE;

ANIMALS; MODELS, CHEMICAL; OXAZINES; RATS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 34249739164     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.12.093     Document Type: Article

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