MRI of mouse models of neurological disorders

NMR in Biomedicine

Volumn 20, Issue 3, 2007, Pages 200-215

  Anderson, Stasia A ^a   Frank, Joseph A ^b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Brain; Central nervous system diseases; Mouse; MRI; Spinal cord

Indexed keywords

CENTRAL NERVOUS SYSTEM DISEASES; MOUSE; SPINAL CORD;

ANIMALS; BRAIN; DISEASES; MEDICAL IMAGING; NEUROLOGY; TUMORS;

MAGNETIC RESONANCE IMAGING;

AMYLOID BETA PROTEIN; APOLIPOPROTEIN E; GADOLINIUM; GADOLINIUM PENTETATE; GADOLINIUM PUTRESCINE AMYLOID BETA PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; HEAT SHOCK PROTEIN 70; MANGANESE CHLORIDE; MINOCYCLINE; POLYLYSINE; SUPERPARAMAGNETIC IRON OXIDE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TETRAMETHYLAMMONIUM; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD BRAIN BARRIER; BRAIN BLOOD VOLUME; BRAIN ISCHEMIA; BRAIN MALARIA; BRAIN TUMOR; CELL LABELING; CEREBROVASCULAR ACCIDENT; CONTRAST ENHANCEMENT; DEMYELINATION; DIFFUSION TENSOR IMAGING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENE OVEREXPRESSION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUNTINGTON CHOREA; IMAGE QUALITY; INTERMETHOD COMPARISON; MAGNETIC RESONANCE ANGIOGRAPHY; MALIGNANT TRANSFORMATION; NEUROANATOMY; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRION DISEASE; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; SPINAL CORD INJURY; TRANSGENIC MOUSE; TRAUMATIC BRAIN INJURY; VIRUS ENCEPHALITIS; WILD TYPE;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; NERVOUS SYSTEM DISEASES;

EID: 34249738489     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1167     Document Type: Review

References (96)

1. Benveniste H, Blackband SJ. Translational neuroscience and magnetic-resonance microscopy. Lancet Neurol 2006; 5(6): 536-544.
2. Nieman BJ, Bock NA, Bishop J, Chen XJ, Sled JG, Rossant J, Henkelman RM. Magnetic resonance imaging for detection and analysis of mouse phenotypes. NMR Biomed 2005; 18(7): 447-468.
3. Kooy RF, Verboye M, Lemmon V, Van Der Linden A. Brain studies of mouse models for neurogenetic disorders using in vivo magnetic resonance imaging (MRI). Eur J Hum Genet 2001; 9(3): 153-159.
4. Koretsky AP. New developments in magnetic resonance imaging of the brain. NeuroRx 2004; 1(1): 155-164.
5. Mori S, Zhang J, Bulte JW. Magnetic resonance microscopy of mouse brain development. Methods Mol Med 2006; 124: 129-147.
6. Benveniste H, Einstein G, Kim KR, Hulette C, Johnson GA. Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy. Proc Natl Acad Sci USA 1999; 96(24): 14079-14084.
7. Poduslo JF, Wengenack TM, Curran GL, Wisniewski T, Sigurdsson EM, Macura SI, Borowski BJ, Jack CR Jr. Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging. Neurobiol Dis 2002; 11(2): 315-329.
8. Zhang J, Yarowsky P, Gordon MN, Di Carlo G, Munireddy S, van Zijl PC, Mori S. Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imaging. Magn Reson Med 2004; 51(3): 452-457.
9. Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li Y, Scholtzova H, Tang CY, Aguinaldo G, Pappolla M, Duff K, Wisniewski T, Turnbull DH. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magn Reson Med 2003; 50(2): 293-302.
10. Jack CR Jr, Garwood M, Wengenack TM, Borowski B, Curran GL, Lin J, Adriany G, Grohn OH, Grimm R, Podusl, JF. In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent. Magn Reson Med 2004; 52(6): 1263-1271.
11. Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magn Reson Med 2004; 52(3): 538-544.
12. Dhenain M, Privat N, Duyckaerts C, Jacobs RE. Senile plaques do not induce susceptibility effects in T2*-weighted MR microscopic images. NMR Biomed 2002; 15(3): 197-203.
13. Jack CR Jr, Wengenack TM, Reyes DA, Garwood M, Curran GL, Borowski BJ, Lin J, Preboske GM, Holasek SS, Adriany G, Poduslo JF. In vivo magnetic resonance microirnaging of individual amyloid plaques in Alzheimer's transgenic mice. J Neurosci 2005; 25(43): 10041-10048.
14. Vanhoutte G, Dewachter I, Borghgraef P, Van Leuven F, Van der Linden A. Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease. Magn Reson Med 2005; 53(3): 607-613.
15. Dhenain M, Delatour B, Walczak C, Volk A. Passive staining: a novel ex vivo MRI protocol to detect amyloid deposits in mouse models of Alzheimer's disease. Magn Reson Med 2006; 55(3): 687-693.
16. Johnson GA, Cofer GP, Gewalt SL, Hedlund LW, Jacobs RE, Ahrens ET, Dickinson ME, Laidlaw D. Morphologic phenotyping with MR microscopy: the visible mouse Towards a microMRI atlas of mouse development. Radiology 2002; 222(3): 789-793.
17. 1H MRI detection of amyloid beta plaques in vivo. Nat Neurosci 2005; 8(4): 527-533.
18. Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magn Reson Med 2004; 51(4): 794-798.
19. Gonzalez-Lima F, Berndt JD, Valla JE, Games D, Reiman EM. Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease. Neuroreport 2001; 12(11): 2375-2379.
20. Redwine JM, Kosofsky B, Jacobs RE, Games D, Reilly JF, Morrison JH, Young WG, Bloom FE. Dentate gyrus volume is reduced before onset of plaque forrnation in PDAPP mice: a magnetic resonance microscopy and stercologic analysis. Proc Natl Acad Sci USA 2003; 100(3): 1381-1386.
21. Weiss C, Venkatasubramanian PN, Aguado AS, Power JM, Tom BC, Li L, Chen KS, Disterhoft JF, Wyrwicz AM. Impaired eye-blink conditioning and decreased hippocampal volume in PDAPP V717F mice. Neurobiol Dis 2002; 11(3): 425-433.
22. Mueggler T, Meyer-Luehmann M, Rausch M, Staufenbiel M, Jucker M, Rudin M. Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis. Eur J Neurosci 2004; 20(3): 811-817.
23. Sykova E, Vorisek I, Antonova T, Mazel T, Meyer-Luehmann M, Jucker M, Hajek M, Ort M, Bures J. Changes in extracellular space size and geometry in APP23 transgenic mice: a model of Alzheimer's disease. Proc Natl Acad Sci USA 2005; 102(2): 479-484.
24. Sun SW, Song SK, Harms MP, Lin SJ, Holtzman DM, Merchant KM, Kotyk JJ. Detection of age-dependent brain injury in a mouse model of brain amyloidosis associated with Alzheimer's disease using magnetic resonance diffusion tensor imaging. Exp Neurol 2005; 191(1): 77-85.
25. Mueggler T, Sturchler-Pierrat C, Baumann D, Rausch M, Staufenbiel M, Rudin M. Compromised hemodynamic response in amyloid precursor protein transgenic mice. J Neurosci 2002; 22(16): 7218-7224.
26. Lee WT, Chang C. Magnetic resonance imaging and spectroscopy in assessing 3-nitropropionic acid-induced brain lesions: an animal model of Huntington's disease. Prog Neurobiol 2004; 72(2): 87-110.
27. Ferrante RJ, Andreassen OA, Dedeoglu A, Ferrante KL, Jenkins BG, Hersch SM, Beal MF. Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease. J Neurosci 2002; 22(5): 1592-1599.
28. Ferrante RJ, Andreassen OA, Jenkins BG, Dedeoglu A, Kuemmerle S, Kubilus JK, Kaddurah-Daouk R, Hersch SM, Beal MF. Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease. J Neurosci 2000; 20(12): 4389-4397.
29. Angenstein F, Niessen HG, Goldschmidt J, Vielhaber S, Ludolph AC, Scheich H. Age-dependent changes in MRI of motor brain stem nuclei in a mouse model of ALS. Neutoreport 2004; 15(14): 2271-2274.
30. Zang da W, Yang Q, Wang HX, Egan G, Lopes EC, Cheema SS. Magnetic resonance imaging reveals neuronal degeneration in the brainstern of the superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis. Eur J Neurosci 2004; 20(7): 1745-1751.
31. Niessen HG, Angenstein F, Sander K, Kunz WS, Teuchert M, Ludolph AC, Heinze HJ, Scheich H, Vielhaber S. In vivo quantification of spinal and bulbar motor neuron degeneration in the G93A-SOD1 transgenic mouse model of ALS by T2 relaxation time and apparent diffusion coefficient. Exp Neurol 2006; 201(2): 293-300.
32. Wamil AW, Wamil BD, Hellerqvist CG. CM101-mediated recovery of walking ability in adult mice paralyzed by spinal cord injury. Proc Natl Acad Sci USA 1998; 95(22): 13188-13193.
33. Bilgen M. Simple, low-cost multipurpose RF coil for MR microscopy at 9.4 T. Magn Reson Med 2004; 52(4): 937-940.
34. Narayana P, Fenyes D, Zacharopoulos N. In vivo relaxation times of gray matter and white matter in spinal cord. Magn Reson Imaging 1999; 17(4): 623-626.
35. Bilgen M, Al-Hafez B, Berman NE, Festoff BW. Magnetic resonance imaging of mouse spinal cord. Magn Reson Med 2005; 54(5): 1226-1231.
36. Bonny JM, Gaviria M, Donnat JP, Jean B, Privat A, Renou JP. Nuclear magnetic resonance microimaging of mouse spinal cord in vivo. Neurobiol Dis 2004; 15(3): 474-482.
37. Ahrens ET, Laidlaw DH, Readhead C, Brosnan CF, Fraser SE, Jacobs RE. MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis. Magn Reson Med 1998; 40(1): 119-132.
38. Lanens D, Van der Linden A, Gerrits PO, s-Gravenmade EJ. In vitro NMR micro imaging of the spinal cord of chronic relapsing EAE rats. Magn Reson Imaging 1994; 12(3): 469-475.
39. Xu S, Jordan EK, Brocke S, Bulte JW, Quigley L, Tresser N, Ostuni JL, Yang Y, McFarland HF, Frank JA. Study of relapsing remitting experimental allergic encephalomyelitis SJL mouse model using MION-46L enhanced in vivo MRI: early histopathological correlation. J Neurosci Res 1998; 52(5): 549-558.
40. Kim JH, Budde MD, Liang HF, Klein RS, Russell JH, Cross AH, Song SK. Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiol Dis 2006; 21(3): 626-632.
41. Song SK, Sun SW, Ramsbottom MJ, Chang C, Russell J, Cross AH. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002; 17(3): 1429-1436.
42. Anderson SA, Shukaliak-Quandt J, Jordan EK, Arbab AS, Martin R, McFarland H, Frank JA. Magnetic resonance imaging of labeled T-cells in a mouse model of multiple sclerosis. Ann Neurol 2004; 55(5): 654-659.
43. Pirko I, Johnson A, Ciric B, Gamez J, Macura SI, Pease LR, Rodriguez M. In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies. FASEB J 2004; 18(1): 179-182.
44. Weber R, Ramos-Cabrer P, Hoehn M. Present status of magnetic resonance imaging and spectroscopy in animal stroke models. J Cereb Blood Flow Metab 2006; 26(5): 591-604.
45. Xue R, Sawada M, Goto S, Hurn PD, Traystman RJ, van Zijl PC, Mori S. Rapid three-dimensional diffusion MRI facilitates the study of acute stroke in mice. Magn Reson Med 2001; 46(1): 183-188.
46. Hesselbarth D, Franke C, Hata R, Brinker G, Hoehn-Berlage M. High resolution MRI and MRS: a feasibility study for the investigation of focal cerebral ischemia in mice. NMR Biomed 1998; 11(8): 423-429.
47. Hoehn M, Nicolay K, Franke C, van der Sanden B. Application of magnetic resonance to animal models of cerebral ischemia. J Magn Reson Imaging 2001; 14(5): 491-509.
48. Barber PA, Hoyte L, Kirk D, Foniok T, Buchan A, Tuor U. Early T1- and T2-weighted MRI signatures of transient and permanent middle cerebral artery occlusion in a murine stroke model studied at 9.4T. Neurosci Lett 2005; 388(1): 54-59.
49. Beckmann N, Stirnimann R, Bochelen D. High-resolution magnetic resonance angiography of the mouse brain: application to murine focal cerebral ischemia models. J Magn Reson 1999; 140(2): 442-450.
50. Barber PA, Foniok T, Kirk D, Buchan AM, Laurent S, Boutry S, Muller RN, Hoyte L, Tomanek B, Tuor UI. MR molecular imaging of early endothelial activation in focal ischemia. Ann Neurol 2004; 56(1): 116-120.
51. Ten VS, Wu EX, Tang H, Bradley-Moore M, Fedarau MV, Ratner VI, Stark RI, Gingrich JA, Pinsky DJ. Late measures of brain injury after neonatal hypoxia-ischemia in mice. Stroke 2004; 35(9): 2183-2188.
52. Zaharchuk G, Hara H, Huang PL, Fishman MC, Moskowitz MA, Jenkins BG, Rosen BR. Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia. Magn Reson Med 1997; 37(2): 170-175.
53. van der Weerd L, Lythgoe MF, Badin RA, Valentim LM, Akbar MT, de Belleroche JS, Latchman DS, Gadian DG. Neuroprotective effects of HSP70 overexpression after cerebral ischaemia: an MRI study. Exp Neurol 2005; 195(1): 257-266.
54. Koistinaho M, Malm TM, Kettunen MI, Goldsteins G, Starckx: S, Kauppinen RA, Opdenakker G, Koistinaho J. Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice. J Cereb Blood Flow Metab 2005; 25(4): 460-467.
55. Gibson CL, Jones NC, Prior MJ, Bath PM, Murphy SP. G-CSF suppresses edema formation and reduces interleukin-1 beta expression after cerebral ischemia in mice. J Neuropathol Exp Neurol 2005; 64(9): 763-769.
56. Lazovic J, Basu A, Lin HW, Rothstein RP, Krady JK, Smith MB, Levison SW. Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection. Stroke 2005; 36(10): 2226-2231.
57. Holland EC. Brain tumor animal models: importance and progress. Curr Opin Oncol 2001; 13(3): 143-147.
58. Koutcher JA, Hu X, Xu S, Gade TP, Leeds N, Zhou XJ, Zagzag D, Holland EC. MRI of mouse models for gliomas shows similarities to humans and can be used to identify mice for preclinical trials. Neoplasia 2002; 4(6): 480-485.
59. Leenders W, Kusters B, Pikkemaat J, Wesseling P, Ruiter D, Heerschap A, Barentsz J, de Waal RM. Vascular endothelial growth factor-A determines detectability of experimental melanoma brain metastasis in GD-DTPA-enhanced MRI. Int J Cancer 2003; 105(4): 437-443.
60. Adzamli K, Yablonskiy DA, Chicoine MR, Won EK, Galen KP, Zahner MC, Woolsey TA, Ackerman JJ. Albumin-binding MR blood pool agents as MRI contrast agents in an intracranial mouse glioma model. Magn Reson Med 2003; 49(3): 586-590.
61. Cha S, Johnson G, Wadghiri YZ, Jin O, Babb J, Zagzag D, Turnbull DH. Dynamic, contrast-enhanced perfusion MRI in mouse gliomas: correlation with histopathology. Magn Reson Med 2003; 49(5): 848-855.
62. Sun Y, Schmidt NO, Schmidt K, Doshi S, Rubin JB, Mulkern RV, Carroll R, Ziu M, Erkmen K, Poussaint TY, Black P, Albert M, Burstein D, Kieran MW. Perfusion MRI of U87 brain tumors in a mouse model. Magn Reson Med 2004; 51(5): 893-899.
63. Brubaker LM, Bullitt E, Yin C, Van Dyke T, Lin W. Magnetic resonance angiography visualization of abnormal tumor vasculature in genetically engineered mice. Cancer Res 2005; 65(18): 8218-8223.
64. Sun Y, Mulkern RV, Schmidt K, Doshi S, Albert MS, Schmidt NO, Ziu M, Black P, Carrol R, Kieran MW. Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model. NMR Biomed 2004; 17(6): 399-404.
65. Sherburn EW, Wanebo JE, Kim P, Song SK, Chicoine MR, Woolsey TA. Gliomas in rodent whisker barrel cortex: a new tumor model. J Neurosurg 1999; 91(5): 814-821.
66. Nelson JA, Dou H, Ellison B, Uberti M, Xiong H, Anderson E, Mellon M, Gelbard HA, Boska M, Gendelman HE. Coregistration of quantitative proton magnetic resonance spectroscopic imaging with neuropathological and neurophysiological analyses defines the extent of neuronal impairments in murine human immunodeficiency virus type-1 encephalitis. J Neurosci Res 2005; 80(4): 562-575.
67. Persidsky Y, Gendelman HE. Murine models for human immunodeficiency virus type 1-associated dementia: the development of new treatment testing paradigms. J Neurovirol 2002; 8(Suppl 2): 49-52.
68. Vidal C, Meric P, Provost F, Herzog C, Lasmezas C, Gillet B, Beloeil JC, Dormont D. Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy. Neuroreport 2006; 17(1): 89-93.
69. Sadowski M, Tang CY, Aguinaldo JG, Carp R, Meeker HC, Wisniewski T. in vivo micro magnetic resonance imaging signal changes in scrapie infected mice. Neurosci Lett 2003; 345(1): 1-4.
70. Pirko I, Gamez J, Johnson AJ, Macura SI, Rodriguez M. Dynamics of MRI lesion development in an animal model of viral-induced acute progressive CNS demyelination. Neuroimage 2004; 21(2): 576-582.
71. Kennan RP, Machado FS, Lee SC, Desruisseaux MS, Wittner M, Tsuji M, Tanowitz HB. Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria. Parasitol Res 2005; 96(5): 302-307.
72. Penet MF, Viola A, Confort-Gouny S, Le Fur Y, Duhamel G, Kober F, Ibarrola D, Izquierdo M, Coltel N, Gharib B, Gran GE, Cozzone PJ. Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema. J Neurosci 2005; 25(32): 7352-7358.
73. Lynch JR, Pineda JA, Morgan D, Zhang L, Warner DS, Benveniste H, Laskowitz DT. Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. Ann Neurol 2002; 51(1): 113-117.
74. Siren AL, Radyushkin K, Boretius S, Kammer D, Riechers CC, Natt O, Sargin D, Watanabe T, Sperling S, Michaelis T, Price J, Meyer B, Frahm J, Ehrenreich H. Global brain atrophy after unilateral parietal lesion and its prevention by erythropoietin. Brain 2006; 129(Pt 2): 480-489.
75. Zohar O, Schreiber S, Getslev V, Schwartz JP, Mullins PG, Pick CG. Closed-head minimal traumatic brain injury produces long-term cognitive deficits in mice. Neuroscience 2003; 118(4): 949-955.
76. 1H MR spectroscopic findings in traumatic contusion of ICR mouse brain induced by fluid percussion injury. Eur J Radiol 2005; 55(1): 96-101.
77. Kim GM, Xu J, Xu J, Song SK, Yan P, Ku G, Xu XM, Hsu CY. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. J Neurosci 2001; 21(17): 6617-6625.
78. Stieltjes B, Klussmann S, Bock M, Umathum R, Mangalathu J, Letellier E, Rittgen W, Edler L, Krammer PH, Kauczor HU, Martin-Villalba A, Essig M. Manganese-enhanced magnetic resonance imaging for in vivo assessment of damage and functional improvement following spinal cord injury in mice. Magn Reson Med 2006; 55(5): 1124-1131.
79. Anderson SA, Lee KK, Frank JA. Gadolinium-fullerenol as a paramagnetic contrast agent for cellular imaging. Invest Radiol 2006; 41(3): 332-338.
80. Modo M, Cash D, Mellodew K, Williams SC, Fraser SE, Meade TJ, Price J, Hodges H. Tracking transplanted stem cell migration using bifunctional, contrast agent-enhanced, magnetic resonance imaging. Neuroimage 2002; 17(2): 803-811.
81. Modo M, Hoehn M, Bulte JW. Cellular MR imaging. Mol Imaging 2005; 4(3): 143-164.
82. Frank JA, Anderson SA, Kalsih H, Jordan EK, Lewis BK, Yocum GT, Arbab AS. Methods for magnetically labeling stem and other cells for detection by in vivo magnetic resonance imaging. Cytotherapy 2004; 6(6): 621-625.
83. Shapiro EM, Sharer K, Skrtic S, Koretsky AP. In vivo detection of single cells by MRI. Magn Reson Med 2006; 55(2): 242-249.
84. Bulte JW, Arbab AS, Douglas T, Frank JA. Preparation of magnetically labeled cells for cell tracking by magnetic resonance imaging. Methods Enzymol 2004; 386: 275-299.
85. Modo M, Mellodew K, Cash D, Fraser SE, Meade TJ, Price J, Williams SC. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage 2004; 21(1): 311-317.
86. Bulte JW, Ben-Hur T, Miller BR, Mizrachi-Kol R, Einstein O, Reinhartz E, Zywicke HA, Douglas T, Frank JA. MR microscopy of magnetically labeled neurospheres transplanted into the Lewis EAE rat brain. Magn Reson Med 2003; 50(1): 201-205.
87. Bulte JW, Douglas T, Witwer B, Zhang SC, Strable E, Lewis BK, Zywicke H, Miller B, van Gelderen P, Moskowitz BM, Duncan ID, Frank JA. Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 2001; 19(12): 1141-1147.
88. Hoehn M, Kustermann E, Blunk J, Wiedermann D, Trapp T, Wecker S, Focking M, Arnold H, Hescheler J, Fleischmann BK, Schwindt W, Buhrle C. Monitoring of implanted stem cell migration in vivo: a highly resolved in vivo magnetic resonance imaging investigation of experimental stroke in rat. Proc Natl Acad Sci USA 2002; 99(25): 16267-16272.
89. Magnitsky S, Watson DJ, Walton RM, Pickup S, Bulte JW, Wolfe JH, Poptani H. In vivo and ex vivo MRI detection of localized and disseminated neural stem cell grafts in the mouse brain. Neuroimage 2005; 26(3): 744-754.
90. Tunici P, Bulte JW, Bruzzone MG, Poliani PL, Cajola L, Grisoli M, Douglas T, Finocchiaro G. Brain engraftment and therapeutic potential of stem/progenitor cells derived from mouse skin. J Gene Med 2006; 8(4): 506-513.
91. Anderson SA, Glod J, Arbab AS, Noel M, Ashari P, Fine HA, Frank JA. Noninvasive MR imaging of magnetically labeled stem cells to directly identify neovasculature in a glioma model. Blood 2005; 105(1): 420-425.
92. Allport JR, Weissleder R. in vivo imaging of gene and cell therapies. Exp Hematol 2001; 29(11): 1237-1246.
93. Song Y, Morikawa S, Morita M, Inubushi T, Takada T, Torii R, Tooyama I. Magnetic resonance imaging using hemagglutinating virus of Japan-envelope vector successfully detects localization of intra-cardially administered microglia in normal mouse brain. Neurosci Lett 2006; 395(1): 42-45.
94. Ragge NK, Brown AG, Poloschek CM, Lorenz B, Henderson RA, Clarke MP, Russell-Eggitt I, Fielder A, Gerrelli D, Martinez-Barbera JP, Ruddle P, Hurst J, Collin JR, Salt A, Cooper ST, Thompson PJ, Sisodiya SM, Williamson KA, Fitzpatrick DR, van Heyningen V, Hanson IM. Heterozygous mutations of OTX2 cause severe ocular malformations. Am J Hum Genet 2005; 76(6): 1008-1022.
95. Heyn C, Ronald JA, Mackenzie LT, MacDonald IC, Chambers AF, Rutt BK, Foster PJ. in vivo magnetic resonance imaging of single cells in mouse brain with optical validation. Magn Reson Med 2006; 55(1): 23-29.
96. Genove G, DeMarco U, Xu H, Goins WF, Ahrens ET. A new transgene reporter for in vivo magnetic resonance imaging. Nat Med 2005; 11(4): 450-454.