Stability of dexamethasone sodium phosphate in rat plasma

International Journal of Pharmaceutics

Volumn 301, Issue 1-2, 2005, Pages 262-266

  Samtani, Mahesh N ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Corticosteroid; EDTA; HPLC; Pharmacokinetics; Prodrug; Stability in plasma

Indexed keywords

ANTICOAGULANT AGENT; CORTICOSTEROID; DEXAMETHASONE; DEXAMETHASONE SODIUM PHOSPHATE; EDETIC ACID; ORGANOPHOSPHATE; PRODRUG; STABILIZING AGENT; STEROID;

ALLOMETRY; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DEGRADATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; ION PAIR CHROMATOGRAPHY; MEASUREMENT; NONHUMAN; PLASMA; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SAMPLE; SHEEP;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTICOAGULANTS; BODY WEIGHT; DEXAMETHASONE; EDETIC ACID; FREEZING; HALF-LIFE; HUMANS; HYDROLYSIS; PLASMA; PRODRUGS; RATS; SHEEP;

EID: 23944457633     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.06.003     Document Type: Article

References (15)

1. M.J. Cwik, M. Liang, K. Deyo, C. Andrews, and J. Fischer Simultaneous rapid high-performance liquid chromatographic determination of phenytoin and its prodrug, fosphenytoin in human plasma and ultrafiltrate J. Chromatogr. B: Biomed. Sci. Appl. 693 1997 407 414
2. D.Z. D'Argenio, and A. Schumitzky ADAPT II User's Guide: Pharmacokinetic/Pharmacodynamic Systems Analysis Software 1997 Biomedical Simulations Resource Los Angeles
3. H. Derendorf, P. Rohdewald, G. Hochhaus, and H. Mollmann HPLC determination of glucocorticoid alcohols, their phosphates and hydrocortisone in aqueous solutions and biological fluids J. Pharm. Biomed. Anal. 4 1986 197 206
4. V. Garg, Y.Y. Hon, and W.J. Jusko Effects of acute and chronic inflammation on the pharmacokinetics of prednisolone in rats Pharm. Res. 11 1994 541 544
5. L.E. Hare, K.C. Yeh, C.A. Ditzler, F.G. McMahon, and D.E. Duggan Bioavailability of dexamethasone. II. Dexamethasone phosphate Clin. Pharmacol. Ther. 18 1975 330 337
6. D.E. Mager, N.A. Pyszczynski, and W.J. Jusko Integrated QSPR-pharmacodynamic model of genomic effects of several corticosteroids J. Pharm. Sci. 92 2003 881 889
7. H. Mollmann, S. Balbach, G. Hochhaus, J. Barth, and H. Derendorf Pharmacokinetic-pharmacodynamic correlations of corticosteroids H. Derendorf G. Hochhaus Handbook of Pharmacokinetic/Pharmacodynamic Correlation 1995 CRC Press Inc. Boca Raton 323 361
8. S. Mulay, and D.R. Varma Influence of streptozotocin-diabetes on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats Br. J. Pharmacol. 83 1984 139 144
9. M.C. Petersen, J.J. Ashley, W.G. McBride, and R.L. Nation Disposition of betamethasone in parturient women after intramuscular administration Br. J. Clin. Pharmacol. 18 1984 383 392
10. Ramakrishnan, R., 2001. Pharmacodynamics of receptor-mediated complex pharmacological responses. Ph.D. Thesis. State University of New York at Buffalo, USA.
11. S. Reif, D. Kingreen, C. Kloft, J. Grimm, W. Siegert, W. Schunack, and U. Jaehde Bioequivalence investigation of high-dose etoposide and etoposide phosphate in lymphoma patients Cancer Chemother. Pharmacol. 48 2001 134 140
12. M.N. Samtani, M. Schwab, P.W. Nathanielsz, and W.J. Jusko Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats Pharm. Res. 21 2004 2279 2292
13. M.N. Samtani, M. Schwab, P.W. Nathanielsz, and W.J. Jusko Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma J. Pharm. Sci. 93 2004 726 732
14. M.N. Samtani, and W.J. Jusko Comparison of dexamethasone pharmacokinetics in female rats after intravenous and intramuscular administration Biopharm. Drug. Dispos. 26 2005 85 91
15. D.R. Varma, and T.L. Yue Influence of protein-calorie malnutrition on the pharmacokinetics, placental transfer and tissue localization of dexamethasone in rats Br. J. Pharmacol. 83 1984 131 137