BK viral nephropathy: an overview

Transplantation Reviews

Volumn 21, Issue 2, 2007, Pages 77-85

  Randhawa, Parmjeet ^a   Ramos, Emilio ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CAPSID PROTEIN; CIDOFOVIR; CYCLOSPORIN; IMMUNOGLOBULIN; IMMUNOSUPPRESSIVE AGENT; LEFLUNOMIDE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; PROTEIN VP1; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RAPAMYCIN; STEROID; TACROLIMUS; VIRUS ANTIGEN; VIRUS DNA;

ACUTE GRAFT REJECTION; ARTICLE; BK VIRUS; CELL MIGRATION; CLINICAL FEATURE; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DRUG BLOOD LEVEL; GRAFT FAILURE; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; IN SITU HYBRIDIZATION; INCIDENCE; INFECTION RISK; KIDNEY ALLOGRAFT; KIDNEY DISEASE; KIDNEY TRANSPLANTATION; LABORATORY DIAGNOSIS; NEEDLE BIOPSY; NEPHROTOXICITY; NONHUMAN; PATHOGENESIS; POLYMERASE CHAIN REACTION; PREVALENCE; SEROPREVALENCE; VIREMIA; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS INFECTION; VIRUS LOAD; VIRUS REACTIVATION; VIRUS REPLICATION; VIRUS TRANSMISSION;

EID: 34249650296     PISSN: 0955470X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trre.2007.03.001     Document Type: Article

References (100)

1. Randhawa P.S., Vats A., Shapiro R., et al. BK virus: discovery, epidemiology, and biology. Graft 5 Suppl (2002) S19-S27
2. Meneguzzi G., Pignatti P.F., Barbanti-Brodano G., et al. Minichromosome from BK virus as a template for transcription in vitro. Proc Natl Acad Sci U S A 75 (1978) 1126-1130
3. Darbinyan A., Siddiqui K.M., Slonina D., et al. Role of JC virus agnoprotein in DNA repair. J Virol 78 (2004) 8593-8600
4. Gasparovic M.L., Gee G.V., and Atwood W.J. JC virus minor capsid proteins Vp2 and Vp3 are essential for virus propagation. J Virol 80 (2006) 10858-10861
5. Akan I., Sariyer I.K., Biffi R., et al. Human polyomavirus JCV late leader peptide region contains important regulatory elements. Virology 349 (2006) 66-78
6. Shishido-Hara Y., Ichinose S., Higuchi K., et al. Major and minor capsid proteins of human polyomavirus JC cooperatively accumulate to nuclear domain 10 for assembly into virions. J Viol 78 (2004) 9890-9903
7. Hariharan S. BK virus nephritis after renal transplantation. Kidney Int 69 (2006) 655-662
8. Ramos E., Drachenberg C.B., Papadimitriou J.C., et al. Clinical course of polyoma virus nephropathy in 67 renal transplant patients. J Am Soc Nephrol 13 (2002) 2145-2151
9. Randhawa P.S., Finkelstein S., Scantlebury V., et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 67 (1999) 103-109
10. Nickeleit V., Hirsch H.H., Zeiler M., et al. BK-virus nephropathy in renal transplants-tubular necrosis, MHC-class II expression and rejection in a puzzling game. Nephrol Dial Transplant 15 (2000) 324-332
11. Wadei H.M., Rule A.D., Lewin M., et al. Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). Am J Transplant 6 (2006) 1025-1032
12. Boldorini R., Veggiani C.I., Barco D., et al. Kidney and urinary tract polyomavirus infection and distribution-molecular biology investigation of 10 consecutive autopsies. Arch Pathol Lab Med 129 (2005) 69-73
13. Smith J.M., McDonald R.A., Finn L.S., et al. Polyomavirus nephropathy in pediatric kidney transplant recipients. Am J Transplant 4 (2004) 2109-2117
14. Andrews C.A., Shah K.V., Daniel R.W., et al. A serological investigation of BK virus and JC virus infections in recipients of renal allografts. J Infect Dis 158 (1988) 176-181
15. Ginevri F., De Santis R., Comoli P., et al. Polyomavirus BK infection in pediatric kidney-allograft recipients: a single-center analysis of incidence, risk factors, and novel therapeutic approaches. Transplantation 75 (2003) 1266-1270
16. Bohl D.L., Storch G., Ryschkewitsch C., et al. Donor origin of BK virus in renal transplantation and role of HLA C7 in susceptibility to sustained BK viremia. Am J Transplant 5 (2005) 2213-2221
17. Vanchiere J.A., Nicome R.K., Greer J.M., et al. Frequent detection of polyomaviruses in stool samples from hospitalized children. J Infect Dis 192 (2005) 658-664
18. Dugan A.S., Eash S., and Atwood W.J. An N-linked glycoprotein with alpha-(2,3)-linked sialic acid is a receptor for BK virus. J Virol 79 (2005) 14442-14445
19. Gilbert J., Dahl J., Riney C., et al. Ganglioside GD1a restores infectibility to mouse cells lacking functional receptors for polyomavirus. J Virol 79 (2005) 615-618
20. Gee G.V., Dugan A.S., Tsomaia N., et al. The role of sialic acid in human polyomavirus infections. Glycoconj J 23 (2006) 19-26
21. Low J.A., Magnuson B., Tsai B., et al. Identification of gangliosides GD1b and GT1b as receptors for BK virus. J Virol 80 (2006) 1361-1366
22. Eash S., and Atwood W.J. Involvement of cytoskeletal components in BK virus infectious entry. J Virol 79 (2005) 11734-11741
23. Hirsch H.H., Brennan D.C., Drachenberg C.B., et al. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation 79 (2005) 1277-1286
24. Brennan D.C., Agha I., Bohl D.L., et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 5 (2005) 582-594
25. Bressollette-Bodin C., Coste-Burel M., Hourmant M., et al. A prospective longitudinal study of BK virus infection in 104 renal transplant recipients. Am J Transplant 5 (2005) 1926-1933
26. Awadalla Y., Randhawa P., Ruppert K., et al. HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients. Am J Transplant 4 (2004) 1691-1696
27. Drachenberg C.B., Papadimitriou J.C., Mann D., et al. Negative impact of human leukocyte antigen matching in the outcome of polyomavirus nephropathy. Transplantation 80 (2005) 276-278
28. Awadallah Y., Duquesnoy R., Randhawa P., et al. HLA susceptibility to BKV infection. Am J Transplant 6 (2006) 640
29. Boldorini R., Veggiani C., Turello E., et al. Are sequence variations in the BK virus control region essential for the development of polyomavirus nephropathy?. Am J Clin Pathol 124 (2005) 303-312
30. Rubio L., Vera-Sempere F.J., Moreno-Baylach M.J., Garcia A., Zamora I., and Simon J. LT, VP11, and TCR-BKV sequence analysis in a patient with post-transplant BKV nephropathy associated with BKV nephropathy associated with EBV-related PTLD. Pediatr Nephrol 20 (2005) 1506-1509
31. Geetha D., Tong B.C., Racusen L., Markiwitz J.S., and Westra W.H. Bladder carcinoma in a transplant recipient: evidence to implicate the BK human polyomavirus as a causal transforming agent. Transplantation 73 (2002) 1933-1936
32. Haysom L., Rosenberg A.R., Kainer G., et al. BK viral infection in an Australian pediatric renal transplant population. Pediatr Transplant 8 (2004) 480-484
33. Herman J., Van Ranst M., Snoeck R., et al. Polyomavirus infection in pediatric renal transplant recipients: evaluation using a quantitative real-time PCR technique. Pediatr Transplant 8 (2004) 485-492
34. Alexander R.T., Langlois V., Tellier R., et al. The prevalence of BK viremia and urinary viral shedding in a pediatric renal transplant population: a single-center retrospective analysis. Pediatr Transplant 10 (2006) 586-592
35. Gupta G., Shapiro R., Thai N., et al. Low incidence of BK virus nephropathy after simultaneous kidney pancreas transplantation. Transplantation 82 (2006) 382-388
36. Barton T.D., Blumberg E.A., Doyle A., et al. A prospective cross-sectional study of BK virus infection in non-renal solid organ transplant recipients with chronic renal dysfunction. Transpl Infect Dis 8 (2006) 102-107
37. Limaye A.P., Smith K.D., Cook L., et al. Polyomavirus nephropathy in native kidneys of non-renal transplant recipients. Am J Transplant 5 (2005) 614-620
38. Barber C.E.H., Hewlett T.J.C., Geldenhuys L., et al. BK virus nephropathy in a heart transplant recipient: case report and review of the literature. Transplant Infect Dis 8 (2006) 113-121
39. Shapiro S., Robin M., Esperou H., et al. Polyomavirus nephropathy in the native kidneys of an unrelated cord blood transplant recipient followed by a disseminated polyomavirus infection. Transplantation 82 (2006) 292-293
40. Herawi M., Parwani A.V., Chan T., et al. Polyoma virus-associated cellular changes in the urine and bladder biopsy samples-a cytohistologic correlation. Am J Surg Pathol 30 (2006) 345-350
41. Kim G.Y., Peji J., Nuovo G., et al. BK virus colonic ulcerations. Clin Gastroenterol Hepatol 2 (2004) 175-177
42. Humar A., and Michaels M. American society of transplantation recommendations for screening, monitoring and reporting of infectious complications in immunosuppression trials in recipients of organ transplantation. Am J Transplant 6 (2006) 262-274
43. Randhawa P., Ho A., Shapiro R., et al. Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. J Clin Microbiol 42 (2004) 1176-1180
44. Limaye A.P., Jerome K.R., Kuhr C.S., et al. Quantitation of BK virus load in serum for the diagnosis of BK virus-associated nephropathy in renal transplant recipients. J Infect Dis 183 (2001) 1669-1672
45. Biel S.S., Held T.K., Landt O., et al. Rapid quantification and differentiation of human polyomavirus DNA in undiluted urine from patients after bone marrow transplantation. J Clin Microbiol 38 (2000) 3689-3695
46. Leung A.Y., Chan M., Tang S.C., et al. Real-time quantitative analysis of polyoma BK viremia and viruria in renal allograft recipients. J Virol Methods 103 (2002) 51-56
47. Boutolleau D., Agut H., and Gautheret-Dejean A. Human herpesvirus 6 genome integration: a possible cause of misdiagnosis of active viral infection?. J Infect Dis 194 (2006) 1019-1020
48. Drachenberg C.B., Hirsch H.H., Ramos E., et al. Polyomavirus disease in renal transplantation-review of pathological findings and diagnostic methods. Hum Pathol 36 (2005) 1245-1255
49. Singh HK, Bubendorf L, Mihatsch MJ. et al. Urine Cytology Findings of Polyomavirus Infections, in Polyomavirus and Human Diseases, edited by Ahsan N, Jacksonville, Springer Science+Business Media, Landes Bioscience/Eurekah.com 2006. pp 201-12.
50. Nickeleit V., Hirsch H.H., Binet I.F., et al. Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease. J Am Soc Nephrol 10 (1999) 1080-1089
51. Kipp B.R., Sebo T.J., Griffin M.D., et al. Analysis of polyomavirus-infected renal transplant recipients' urine specimens-correlation of routine urine cytology, fluorescence in situ hybridization, and digital image analysis. Am J Clin Pathol 124 (2005) 854-861
52. Semple K., Lovchik J., and Drachenberg C. Identification of polyoma BK virus in kidney transplant recipients by shell vial cell culture assay and urine cytology. Am J Clin Pathol 126 (2006) 444-447
53. Randhawa P., Vats A., and Shapiro R. Monitoring for polyomavirus BK and JC in urine: comparison of quantitative polymerase chain reaction with urine cytology. Transplantation 79 (2005) 984-986
54. Drachenberg C., Hirsch H.H., Papadimitriou J.C., et al. Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. Transplant Proc 36 (2004) 3028-3031
55. Jahnukainen T., Malehorn D., et al., Sun M. Proteomic analysis of urine in kidney transplant patients with BK virus nephropathy. J Am Soc Nephrol 17 (2006) 3248-3256
56. Ramos E., Drachenberg C.B., Portocarrero M., et al. BK virus nephropathy diagnosis and treatment: experience at the University of Maryland Renal Transplant Program. In: Cecka J., and Terasaki P. (Eds). Clinical transplants (2002), UCLA Immunogenetics Center, Los Angeles 143-153
57. Kiberd B.A. Screening to prevent polyoma virus nephropathy: a medical decision analysis. Am J Transplant 5 (2005) 2410-2416
58. Nolte F.S. Case studies in cost effectiveness of molecular diagnostics for infectious diseases: pulmonary tuberculosis, enteroviral meningitis, and BK virus nephropathy. Clin Infect Dis 43 (2006) 1463-1467
59. Celik B., and Randhawa P.S. Glomerular changes in BK virus nephropathy. Hum Pathol 35 (2004) 367-370
60. Randhawa P.S. BK virus nephropathy and vascular endothelium. Hum Pathol 36 (2005) 448
61. Nada R., Joshi K., and Jha V. BK virus nephropathy and vascular endothelium. Hum Pathol 36 (2005) 447-448
62. Drachenberg C.B., and Papadimitiou J.C. Polyomavirus associated virus nephropathy: update in diagnosis. Transpl Infect Dis 8 (2006) 68-75
63. Drachenberg C.B., Papadimitriou J.C., Hirsch H.H., et al. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Am J Transplant 4 (2004) 2082-2092
64. Gaber L.W., Egidi M.F., Stratta R.J., et al. Clinical utility of histological features of polyomavirus allograft nephropathy. Transplantation 82 (2006) 196-204
65. Meehan S.M., Kadambi P.V., Manaligod J.R., et al. Polyoma virus infection of renal allografts: relationships of the distribution of viral infection, tubulointerstitial inflammation, and fibrosis suggesting viral interstitial nephritis in untreated disease. Hum Pathol 36 (2005) 1256-1264
66. Boratynska M., Dubinski B., Rybka K., et al. Immunocytological urinalysis and monocyte chemotactic peptide-1 in renal transplant recipients with polyomavirus replication. Transplant Proc 38 (2006) 151-154
67. Kim S.H., Ahn H.J., Kim Y.S., et al. Urinary HLA-DR and CD54 expression-indicators for inflammatory activity in decoy cell shedding patients. Nephrol Dial Transplant 21 (2006) 2601-2606
68. Grinde B., Gayorfar M., and Rinaldo C.H. Impact of a polyomavirus (BKV) infection on mRNA expression in human endothelial cells. Virus Res 123 (2007) 86
69. Randhawa P., and Shapiro R. Conceptual problems in the diagnosis and therapy of acute rejection in patients with polyomavirus nephropathy. Am J Transplant 4 (2004) 840
70. Flower A.J., Banatvala J.E., and Chrystie I.L. BK antibody and virus-specific IgM responses in renal transplant recipients, patients with malignant disease, and healthy people. Br Med J 2 (1977) 220-223
71. Noss G. Human polyoma virus type BK infection and T antibody response in renal transplant recipients. Zentralbl Bakteriol Mikrobiol Hyg [A] 266 (1987) 567-574
72. Hamilton R.S., Gravell M., and Major E.O. Comparison of antibody titers determined by hemagglutination inhibition and enzyme immunoassay for JC virus and BK virus. J Clin Microbiol 38 (2000) 105-109
73. Stolt A., Sasnauskas K., Koskela P., et al. Seroepidemiology of the human polyomaviruses. J Gen Virol 84 (2003) 1499-1504
74. Corallini A., Barbanti-Brodano G., Portolani M., et al. Antibodies to BK virus structural and tumor antigens in human sera from normal persons and from patients with various diseases, including neoplasia. Infect Immun 13 (1976) 1684-1691
75. Randhawa P.S., Gupta G., Vats A., et al. Immunoglobulin G, A, and M responses to BK virus in renal transplantation. Clin Vaccine Immunol 13 (2006) 1057-1063
76. Hariharan S., Cohen E.P., Vasudev B., et al. BK virus specific antibodies and BKV DNA in renal transplant recipients with BKV nephritis. Am J Transplant 5 (2005) 2719-2724
77. Drummond J.E., Shah K.V., and Donnenberg A.D. Cell-mediated immune responses to BK virus in normal individuals. J Med Virol 17 (1985) 237-247
78. Drummond J.E., Shah K.V., Saral R., et al. BK virus specific humoral and cell mediated immunity in allogeneic bone marrow transplant (BMT) recipients. J Med Virol 23 (1987) 331-344
79. Comoli P., Basso S., Azzi A., et al. Dendritic cells pulsed with polyomavirus BK antigen induce ex vivo polyoma BK virus-specific cytotoxic T-cell lines in seropositive healthy individuals and renal transplant recipients. J Am Soc Nephrol 14 (2003) 3197-3204
80. Chen Y.P., Trofe J., Gordon J., et al. Interplay of cellular and humoral immune responses against BK virus in kidney transplant recipients with polyomavirus nephropathy. J Virol 80 (2006) 3495-3505
81. Sharma M.C., Zhou W., Martinez J., et al. Cross-reactive CTL recognizing two HLA-A*02-restricted epitopes within the BK virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals. Virology 350 (2006) 128-136
82. Randhawa P., Popescu I., Macedo C., et al. Detection of CD8+ T-cells sensitized to BK virus large T-antigen in healthy volunteers and kidney transplant recipients. Hum Immunol 67 (2006) 298-302
83. Li J., Melenhorst J., Hensel N., et al. T-cell responses to peptide fragments of the BK virus T antigen: implications for cross-reactivity of immune response to JC virus. J Gen Virol 87 (2006) 2951-2960
84. Provenzano M., Bracci L., Wyler S., et al. Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+BKV-seropositive donors. J Translation Med 4 (2006) 47-48
85. Comoli P., Binggeli S., Ginevri F., et al. Polyomavirus-associated nephropathy: update on BK virus-specific immunity. Transpl Infect Dis 8 (2006) 86-94
86. Hammer M.H., Brestrich G., Andree H., et al. HLA type-independent method to monitor polyoma BK virus-specific CD4(+) and CD8(+) T-cell immunity. Am J Transplant 6 (2006) 625-631
87. Binggeli S., Egli A., Dickenmann M., et al. BKV replication and cellular immune responses in renal transplant recipients. Am J Transplant 6 (2006) 2218-2219
88. Funk G.A., Steiger J., and Hirsch H.H. Rapid dynamics of polyomavirus type BK in renal transplant recipients. J Infect Dis 193 (2006) 80-87
89. Leung A.Y.H., Chan M.T.L., Yuen K.Y., et al. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Transplantation 40 (2005) 528-537
90. Williams J.W., Javaid B., Kadambi P.V., et al. Leflunomide for polyomavirus type BK nephropathy. N Engl J Med 352 (2005) 1157-1158
91. Sener A., House A.A., Jevnikar A.M., et al. Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients. Transplantation 81 (2006) 117-120
92. Randhawa P.S. Anti-BK virus activity of ciprofloxacin and related antibiotics. Clin Infect Dis 41 (2005) 1366-1367
93. Josephson M.A., Williams J.W., Chandraker A., et al. Polyomavirus-associated nephropathy: update on antiviral strategies. Transpl Infect Dis 8 (2006) 95-101
94. Farasati N.A., Shapiro R., Vats A., et al. Effect of leflunomide and cidofovir on replication of BK-virus in an in vitro culture system. Transplantation 79 (2005) 116-118
95. Josephson M.A., Gillen D., Javaid B., et al. Treatment of renal allograft polyoma BK virus infection with leflunomide. Transplantation 81 (2006) 704-710
96. Randhawa P., Farasati N., Shapiro R., et al. Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro. Antimicrob Agents Chemother 50 (2006) 1564-1566
97. Smee D.F., Wong M.H., Bailey K.W., et al. Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice. Int J Antimicrob Agents 23 (2004) 430-437
98. Ramos E., Vincenti F., Lu W.X., et al. Retransplantation in patients with graft loss caused by polyoma virus nephropathy. Transplantation 77 (2004) 131-133
99. Hirsch H.H., and Ramos E. Retransplantation after polyomavirus-associated nephropathy: just do it?. Am J Transplant 6 (2006) 7-9
100. Womer K.L., Meier-Kriesche H.U., Bucci C.M., et al. Pre-emptive retransplantation for BK virus nephropathy: successful outcome despite active viremia. Am J Transplant 6 (2006) 209-213