Polyomavirus-associated nephropathy: Update in diagnosis

Transplant Infectious Disease

Volumn 8, Issue 2, 2006, Pages 68-75

  Drachenberg, C B ^a   Papadimitriou, J C ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

BK; Decoy cells; JC; PVAN; Transplant; Viremia; Viruria

Indexed keywords

ACUTE GRAFT REJECTION; ALLOGRAFT; BK VIRUS; CELLULAR IMMUNITY; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFECTION RISK; INFLAMMATION; JC VIRUS; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; KIDNEY DISEASE; POLYMERASE CHAIN REACTION; POLYOMAVIRUS ASSOCIATED NEPHROPATHY; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME; URINE CYTOLOGY; VIREMIA; VIRUS LOAD;

BIOPSY; BK VIRUS; HUMANS; JC VIRUS; KIDNEY; KIDNEY TRANSPLANTATION; NEPHRITIS; POLYOMAVIRUS INFECTIONS;

EID: 33744780458     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2006.00154.x     Document Type: Review

References (47)

1. Hirsch HH Brennan DC Drachenberg CB, et al. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation 2005: 79: 1277 1286.
2. Ramos E Drachenberg CB Portocarrero M, et al. BK virus nephropathy diagnosis and treatment: experience at the University of Maryland renal transplant program. Clin Transpl 2003: 143 153.
3. Vasudev B Hariharan S Hussain SA Zhu YR Bresnahan BA Cohen EP. BK virus nephritis: risk factors, timing, and outcome in renal transplant recipients. Kidney Int 2005: 68: 1834 1839.
4. Hirsch HH Knowles W Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002: 347: 488 496.
5. Drachenberg CB Papadimitriou JC Wali R, et al. Improved outcome of polyoma virus allograft nephropathy with early biopsy. Transplant Proc 2004: 36: 758.
6. Buehrig CK Lager DJ Stegall MD, et al. Influence of surveillance renal allograft biopsy on diagnosis and prognosis of polyomavirus-associated nephropathy. Kidney Int 2003: 64: 665 673.
7. Brennan DC Agha I Bohl DL, et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 2005: 5: 582 594.
8. Ginevri F. Impact of standard-pre-emptive immunosuppression reduction on the course of BK virus infection in a pediatric kidney transplantation cohort followed prospectively. Second Polyomavirus-Associated Nephropathy Interdisciplinary Conference, May 18-19, 2005, Baltimore, MD.
9. Dorries K. Latent and persistent polyomavirus infection. In Khalili K Stoner GL eds. Human Polyomaviruses: Molecular and Clinical Perspectives (Chapter 10). New York: Wiley-Liss, 2001: 197 236.
10. Hirsch HH Steiger J. Polyomavirus BK. Lancet Infect Dis 2003: 3: 611 623.
11. Boldorini R Veggiani C Barco D Monga G. Kidney and urinary tract polyomavirus infection and distribution: molecular biology investigated on of 10 consecutive autopsies. Arch Pathol Lab Med 2005: 129: 69 73.
12. Ikegaya H Iwase H Yogo Y. Detection of identical JC virus DNA sequences in both human kidneys. Arch Virol 2004: 149: 1215 1220.
13. Nickeleit V. Latent polyoma-BK-virus loads in the urogenital tract of non-immunocompromised patients. Second Polyomavirus-Associated Nephropathy Interdisciplinary Conference, May 18-19, 2005, Baltimore, MD.
14. Nickeleit V Klimkait T Binet IF, et al. Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy. N Engl J Med 2000: 342: 1309.
15. Drachenberg CB Beskow CO Cangro CB, et al. Human polyoma virus in renal allograft biopsies: morphological findings and correlation with urine cytology. Hum Pathol 1999: 30: 970.
16. Drachenberg RC Drachenberg CB Papadimitriou JC, et al. Morphological spectrum of polyoma virus disease in renal allografts: diagnostic accuracy of urine cytology. Am J Transplant 2001: 1: 373.
17. Drachenberg CB Papadimitriou JC Hirsch HH, et al. Histological patterns of polyomavirus nephropathy: correlation with graft outcome and viral load. Am J Transplant 2004: 4: 2082 2092.
18. Randhawa P Ho A Shapiro R, et al. Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. J Clin Microbiol 2004: 42: 1176 1180.
19. Randhawa P Vats A Shapiro R. Monitoring for polyomavirus BK and JC in urine: comparison of quantitative polymerase chain reaction with urine cytology. Transplantation 2005: 79: 984 986.
20. Randhawa PS Vats A Zygmunt D, et al. Quantitation of viral DNA in renal allograft tissue from patients with BK virus nephropathy. Transplantation 2002: 74: 485 488.
21. Hirsch HH Tuncer M Friman S, et al. Prospective study of polyomavirus BK viruria and viremia in de novo renal transplantation (American Transplant Congress 2005). Am J Transplant 2005: 5 Suppl. 11: 79.
22. Bressollette-Bodin C Coste-Burel M Hourman M, et al. A prospective longitudinal study of BK virus infection in 104 renal transplant recipients. Am J Transplant 2005: 5: 1926 1933.
23. Bruno DA Cheng O Hale A, et al. Limiting immunosuppression post-transplant: the role of BK polyoma virus monitoring. (American Transplant Congress 2005). Am J Transplant 2005: 5 Suppl. 11: 79.
24. Gordon J Brennan D Limaye A, et al. Multicenter validation of polyomavirus BK quantification for screening and monitoring of renal transplant recipients. Second Polyomavirus-Associated Nephropathy Interdisciplinary Conference, May 18-19, 2005, Baltimore, MD. Am J Transpl 2005; 5 (Suppl. 11): 79.
25. Randhawa P Uhrmacher J Pasculle W, et al. A comparative study of BK and JC virus infections in organ transplant recipients. J Med Virol 2005: 77: 238 243.
26. Randhawa PS Finkelstein S Scantlebury V, et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 1999: 67: 103.
27. Drachenberg CB Hirsch HH Ramos E Papadimitriou JC. Polyomavirus disease in renal transplantation: review of pathological findings and diagnostic methods. Hum Pathol 2005: 36: 1245 1255.
28. Randhawa P Shapiro R. Conceptual problems in the diagnosis and therapy of acute rejection in patients with polyomavirus nephropathy. Am J Transplant 2004: 4: 840.
29. Mannon RB Hoffmann SC Kampen RL, et al. Molecular evaluation of BK polyomavirus nephropathy. Am J Transplant 2003: 5: 2883 2893.
30. Nickeleit V Mihatsch MJ. Polyomavirus allograft nephropathy and concurrent acute rejection: a diagnostic and therapeutic challenge. Am J Transplant 2004: 4: 838 839.
31. Meehan SM Kadambi PV Manaligod JR Williams JW Josephson MA Javaid B. Polyomavirus infection of renal allografts: relationships of the distribution of viral infection, tubulointerstitial inflammation, and fibrosis suggesting viral interstitial nephritis in untreated disease. Hum Pathol 2005: 36: 1256 1264.
32. Gardner SD Field AM Coleman DV Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1971: 1: 1253 1257.
33. Drachenberg CB. Polyomavirus associated nephropathy (PVAN): role of JC virus. Second Polyomavirus-Associated Nephropathy Interdisciplinary Conference. May 18-19, 2005, Baltimore MD.
34. Drachenberg C Hirsch HH Papadimitriou JC, et al. Cost efficiency in the prospective diagnosis and follow-up of polyomavirus allograft nephropathy. Transplant Proc 2004: 36: 3028 3031.
35. Kazory A Ducloux D Chalopin JM Angonin R Fontaniere B Moret H. The first case of JC virus allograft nephropathy. Transplantation 2003: 76: 1653.
36. Wen MC Wang CL Wang M, et al. Association of JC virus with tubulointerstitial nephritis in a renal allograft recipient. J Med Virol 2004: 72: 675.
37. Hirsch HH Drachenberg CB Munivenkatappa R, et al. Polyomavirus associated nephropathy (PVAN): role of JC virus. Virch Arch 2005: 447: 164.
38. Ahuja M Cohen EP Dayer AM, et al. Polyoma virus infection after renal transplantation. Transplantation 2001: 71: 896 899.
39. Ginevri F De Santis R Comoli P, et al. Polyomavirus BK infection in pediatric kidney-allograft recipients: a single-center analysis of incidence, risk factors, and novel therapeutic approaches. Transplantation 2003: 75: 1266 1270.
40. Trofe J Gordon J Roy-Chaudhury P Koralnik IJ. Polyomavirus nephropathy in kidney transplantation. Prog Transplant 2004: 14: 130 140.
41. Howell DN Smith SR Butterly DW, et al. Diagnosis and management of BK polyomavirus interstitial nephritis in renal transplant recipients. Transplantation 1999: 68: 1279.
42. Celik B Shapiro R Vats A Randhawa PS. Polyomavirus allograft nephropathy: sequential assessment of histologic viral load, tubulitis, and graft function following changes in immunosuppression. Am J Transplant 2003: 3: 1378.
43. Limaye AP Jerome KR Kuhr CS, et al. Quantitation of BK virus load in serum for the diagnosis of BK virus-associated nephropathy in renal transplant recipients. J Infect Dis 2001: 183: 1669.
44. Boldorini R Brustia M Veggiani C Barco D Andorno S Monga G. Periodic assessment of urine and serum by cytology and molecular biology as a diagnostic tool for BK virus nephropathy in renal transplant patients. Acta Cytol 2005: 49: 235 243.
45. Herman J Van Ranst M Snoeck R Beuselinck K Lerut E Van Damme-Lombaerts R. Polyomavirus infection in pediatric renal transplant recipients: evaluation using a quantitative real-time PCR technique. Pediatr Transplant 2004: 8: 485 492.
46. Ding R Medeiros M Dadhania D, et al. Noninvasive diagnosis of BK virus nephritis by measurement of messenger RNA for BK virus VP1 in urine. Transplantation 2002: 74: 987 994.
47. Si-Mohamed A Goff JL Desire N Maylin S Glotz D Belec L. Detection and quantitation of BK virus DNA by real-time polymerase chain reaction in the LT-ag gene in adult renal transplant recipients. J Virol Methods 2006: 131: 21 27.