Role of some newly sythesized tetrahydronaphthalenthiazol derivatives as anticancer compounds

International Journal of Cancer Research

Volumn 3, Issue 2, 2007, Pages 103-110

  Ali, Mamdouh M ^a   Hassan, Sohair A ^a  

^a NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Antitumor activity; Ehrlich's ascites carcinoma cells; Life span; Tetrahydronaphthalenthiazol; Tumor volume

Indexed keywords

2 AMINO 3 [4 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 1,3 THIAZOL 2 YL] 1,3 THIAZOLIDIN 4 ONE; 4 METHYL N[4 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 1,3 THIOL 2 YL]BENZENSULPHONAMIDE; 7 IMINO 3 (5,6,7,8 TETRAHYDRONAPHTHALEN 2 YL) 7H THIOLO[3,2 A]PYRIMIDIN 5 YLAMINE; ANTINEOPLASTIC AGENT; CISPLATIN; DIMETHYL SULFOXIDE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASCITES TUMOR; CANCER INHIBITION; CANCER SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG STRUCTURE; DRUG SYNTHESIS; EHRLICH ASCITES TUMOR CELL; LIFESPAN; MALE; MOUSE; NONHUMAN; SURVIVAL RATE; SURVIVAL TIME; TUMOR VOLUME;

EID: 34249333860     PISSN: 18119727     EISSN: 18119735     Source Type: Journal    
DOI: 10.3923/ijcr.2007.103.110     Document Type: Article

References (31)

1. Ahluwalia, G.S., H.N. Jayaram, J.P. Plowhan, D.A. Cooney and D.G. Johns, 1984. Studies on the mechanism of activity of 2-b-Dribofuranosyl thiazol-4-carboxamide. Biochem. Pharmacol., 33: 1195-1203.
2. Al-Thebeity, M.S., 2001. Synthesis of some new derivatives of thiazolo-[3,2-a] pyrimidine-3,5,7 (2h)-tri-one of potential biological activity. Boll. Chem. Pharm., 140: 221-223.
3. Ajith, T.A. and K.K. Janardhanan, 2003. Cytotoxic and antitumor activities of a polypore macrofungus, Phellinus rimosus (Berk) Pilat. J. Ethnopharmacol., 84: 157-162.
4. Appelbe, R., M. Casey, A. Dunne and E. Pascarella, 2003. Stereoselective synthesis of tetralins using cationic cyclisations. Tetrahedron Lett., 44: 7641-7644.
5. Buc-Calderon, P., M. Preat, J.M. Ruysschaert and M. Roberfroid, 1989. Increasing therapeutic effect and reducing toxicity of doxorubicin by N-acyldehydroalanines. Eur. J. Cancer Clin. Oncol., 25: 679-687.
6. Elslager, E. F., C. Hess, J. Johnson, D. Ortwine, V. Chu and M.W. Leslie, 1981. Heterocyclic synthesis with activated nitriles: An expeditious synthetic approach to polyfunctionally substituted pyrroles, heterocyclopyrimidines and coumarins. J. Med. Chem., 42: 127-140.
7. Ferrante, A., J. Aughera and K. Lewis, 1995. Cloning of an organic solvent-resistance gene in Escherichia coli: The unexpected role of alkylhydroperoxide reductase. Proc. Natl. Acad. Sci. USA., 92: 7617-7621.
8. Fevieg, T., J.L. loyd, J. Zablock and J. Katzenellenbogen, 1987. Preparation receptor-binding and flourescence properties of hextrol, flurophore conjugates-evaluation of site of attachment, flourophore structure and flourophore ligand spacing. J. Med. Chem., 30: 156-162.
9. Fregona, D., L. Roncon and C. Marzano, 2003. Complessi ditiocarbammici di oro (III) e loro impiego come antitumorali. Patent No. MI2003A 000600.
10. Ghosh, M.N., 1984. Toxicity Studies. In: Ghosh, M.N. (Ed.), Fundamentals of Experimental Pharmacology. Scientific Book Agency. Calcutta, India, pp: 153-158.
11. Giovagnini, L., L. Ronconi, D. Aldinucci, D. Lorenzon, S. Sitran and D. Fregona, 2005. Synthesis, characterization and comparative in vitro cytotoxicity studies of platinum (II). J. Med. Chem., 48: 1588-1591.
12. Hara, H., T. Fujihashi and T. Salta, 1997. Tetrahydronaphthalene lignan compounds as potent anti-HIV type I agents. Aides Res. Hum. Retrov., 13: 695-705.
13. Joy, K.L., N. V. Rajeshkumar, G. Kuttan and R. Kuttan, 2000. Effect of Picrorrhhiza kurroa extract on transplanted tumor and chemical carcinogenesis in mice. J. Ethnopharmacol., 71: 261-266.
14. Ma, Y., T. Mizuno and H. Ito, 1991. Antitumor activity of some polysaccharides isolated from a chmese mushroom, Huangmo, the fruiting body of Hohenbuehelia serotina. Agric. Biol. Chem., 55: 2701-2710.
15. Mary, K.I., G. Kuttan and R. Kuttan, 1994. Partial purification of tumor reducing principle from Helicathus elasticus (from Loranthaceae). Cancer Lett., 81: 53-57.
16. Mounetou, E., J. legault, J. Lacroix and R. Gaudreault, 2001. Antimitotic antitumor agents: Synthesis, structure relationships and biological characterization of N (2-chloroethyl) ureas as new selective alkylating agent. J. Med. Chem., 44: 694-702.
17. Murphy, P.V., R.E. Hubbard, D.T. Manallack, J.G. Mantana and J.K. Taylor, 1998. Synthesis of novel structural analogues of Sialyl Lewis X. Tetrahedron Lett., 39: 3273-3276.
18. Musa, D., N. Delsiz, H. Gumushan, G. Ulakoglu and M. Bitiren, 2004. Antitumor activity of an ethanol extract of Nigilla sativa seeds. Biologia Bratislava, 59: 735-740.
19. Nabih, I., J. Michael, H. Zoroob and M.I. El-Zahar, 1985. Novel tetralin derivatives anchored thiazole moiety. Egyptian J. Pharm. Sci., 26: 311-316.
20. Ohmo, K., S. Nakano, T. Kobayashi, Y. Nagao and T. Yamada, 2002. Evaluation of styrene oligomers eluted from polystyrene for estrogen receptor binding assay, reporter gene assay and uterotrophic assay. Food Chem. Toxicol., 41: 525-555.
21. Prasad, S.B. and A. Giri, 1994. Tumor activity of cisplatin against murine ascites Dalton's lymphoma. Indian J. Exp. Biol., 32: 155-162.
22. Prieur, D.J., D.M. Young, R.D. Davis, D.A. Cooney, E.R. Homan, R.L. Dixon and A.M. Guarino, 1973. Procedures for preclinical toxicologic evaluation of cancer chemotherapeutic agents, protocols of the laboratory of toxicity. Cancer Chemoth. Reports, 4: 1-28.
23. Rajeshwar, Y., M. Gupta and U.K. Mazumder, 2005. Antitumor activity and in vivo antioxidant status of Mucuna pruriens (Fabaceae) seeds against Ehrlich carcinoma in swiss albino mice. Iran. J. Pharmacol. Therapeut., 4: 46-53.
24. Rashad, E.R. and M.A. Ali, 2006. Synthesis and antiviral screening of some thieno[2,3-d] pyrimidine nucleosides. Nucleosides, 25: 17-28.
25. Ronconi, L., L. Giovagnini, C. Marzano, F. Bettio, R. Graziani, G. Piloni and D. Fregona, 2005. Gold dithiocarbamate derivatives as potential antineoplastic agents: Design, spectroscopic properties and in vitro antitumor activity. Inorg. Chem., 44: 1867-1881.
26. Ruter, A.P., M. Padilha, J.A. Figueiredo, M.I. Ismael, J. Justino, H. Ferreira, M.J. Ferreira, C. Ragendran, R. Wilkins, P.D. Vas and M.J. Calhorda, 2005. Biactive pseudo c nucleosides and tetrazol rings. J. Carbohydrate Chem., 24: 275-296.
27. Sayed, H.H., A.H. Shamroukh and A.E. Rashad, 2006. Synthesis and biological evaluation of some pyrimidine pyrimido[2,1-b][1,3] thiazine and thiazlo[3,2-a] pyrimidine derivatives. Acta Pharm., 56: 231-244.
28. Shigeta, S.H., S. Mori, F. Watanabe, T. Takahashi, N. Nagata, T. Koike, T. Wakayama and M. Sanyoshi, 2002. Synthesis and antiherpes virus activities of 5-alkyl-2-thiopyrimidine nucleoside analogues. Antivir. Chem. Chemther., 13: 67-82.
29. Shriram, D., P. Yogeeswari and K. Meena, 2006. Synthesis, anti-HIV, antitubercular activities of isaten derivatives. Pharmazie, 61: 274-277.
30. Sondhi, S.M., N. Singhal, M. Jorhar, B.S.N. Reddy and W. Lown, 2002. Heterocyclic compounds as inflammation inhibitors. Curr. Med. Chem., 9: 1045-1074.
31. Tsuchiya, T., Y. Takagi and H. Yamada, 2000. Preparation of 5-(2,6-Dideoxy-2-fluoro-α-L-talopyranosyloxy)-6-hydroxynaphtho [2,3-flquinoline-7,12-dione (FT-Alz), a new-type, potentially antitumor substance with various biological activities. Bioorg. Med. Chem. Lett., 10: 203-207.