Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophrenia

Schizophrenia Research

Volumn 93, Issue 1-3, 2007, Pages 79-89

  Rüsch, Nicolas ^a,e   Spoletini, Ilaria ^a   Wilke, Marko ^b   Bria, Pietro ^c   Di Paola, Margherita ^a   Di Iulio, Fulvia ^a   Martinotti, Giovanni ^c,d   Caltagirone, Carlo ^a   Spalletta, Gianfranco ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c CATHOLIC UNIVERSITY   (Italy)

^d Casa di Cura Neuropsichiatrica Villa Maria Pia   (Italy)

^e UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Dorsolateral prefrontal cortex; Executive functioning; Schizophrenia; Voxel based morphometry; Wisconsin Card Sorting Test

Indexed keywords

ADULT; APPARATUS; ARTICLE; ATTENTION; BRAIN MAPPING; BRAIN SIZE; CEREBELLUM; COGNITION; CONFOUNDING VARIABLE; CONTROLLED STUDY; FEMALE; GRAY MATTER; HIPPOCAMPUS; HUMAN; IMAGE DISPLAY; IMAGE QUALITY; ITALY; MAJOR CLINICAL STUDY; MALE; MORPHOMETRICS; MOTOR DYSFUNCTION; MOTOR PERFORMANCE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; OUTPATIENT; PARAHIPPOCAMPUS; PONS; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE; THALAMUS; VOLUMETRY; WHITE MATTER; WISCONSIN CARD SORTING TEST;

ADULT; ATTENTION; BRAIN MAPPING; CEREBELLUM; DISCRIMINATION LEARNING; DOMINANCE, CEREBRAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMAGING, THREE-DIMENSIONAL; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE NET; NEUROPSYCHOLOGICAL TESTS; ORGAN SIZE; PREFRONTAL CORTEX; PROBLEM SOLVING; PSYCHOMETRICS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; STATISTICS; THALAMUS;

EID: 34249326183     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2007.01.029     Document Type: Article

References (50)

1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition (DSM-IV) (1994), American Psychiatric Association, Washington DC
2. Andreasen N.C., Paradiso S., and O'Leary D.S. "Cognitive dysmetria" as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?. Schizophrenia Bulletin 24 (1998) 203-218
3. Andreasen N.C., Nopoulos P., O'Leary D.S., Miller D.D., Wassink T., and Flaum M. Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biological Psychiatry 46 (1999) 908-920
4. Andrews J., Wang L., Csernansky J.G., Gado M.H., and Barch D.M. Abnormalities of thalamic activation and cognition in schizophrenia. American Journal of Psychiatry 163 (2006) 463-469
5. Antonova E., Sharma T., Morris R., and Kumari V. The relationship between brain structure and neurocognition in schizophrenia: a selective review. Schizophrenia Research 70 (2004) 117-145
6. Antonova E., Kumari V., Morris R., Halari R., Anilkumar A., Mehrotra R., and Sharma T. The relationship of structural alterations to cognitive deficits in schizophrenia: a voxel-based morphometry study. Biological Psychiatry 58 (2005) 457-467
7. Ashburner J., and Friston K.J. Voxel-based morphometry - the methods. NeuroImage 11 (2000) 805-821
8. Ashburner J., and Friston K.J. Unified segmentation. NeuroImage 26 (2005) 839-851
9. Baddeley A.D. Working Memory (1986), Oxford University Press, Oxford
10. Barch D.M. What can research on schizophrenia tell us about the cognitive neuroscience of working memory?. Neuroscience 139 (2006) 73-84
11. Bersani G., Clemente R., Gherardelli S., and Pancheri P. Deficit of executive functions in schizophrenia: relationship to neurological soft signs and psychopathology. Psychopathology 37 (2004) 118-123
12. Camchong J., Dyckman K.A., Chapman C.E., Yanasak N.E., and McDowell J.E. Basal ganglia-thalamocortical circuitry disruptions in schizophrenia during delayed response tasks. Biological Psychiatry 60 (2006) 235-241
13. Clinton S.M., and Meador-Woodruff J.H. Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities. Schizophrenia Research 69 (2004) 237-253
14. DeLisi L.E. Regional brain volume change over the life-time course of schizophrenia. Journal of Psychiatric Research 33 (1999) 535-541
15. Elvevag B., and Goldberg T.E. Cognitive impairment in schizophrenia is the core of the disorder. Critical Reviews in Neurobiology 14 (2000) 1-21
16. First M.B., Spitzer R.L., Gibbon M., and Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Clinician Version (1997), American Psychiatric Press, Washington DC
17. First M.B., Gibbon M., Spitzer R.L., Williams J.B.W., and Benjamin L.S. Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) (1997), American Psychiatric Press, Washington DC
18. Folstein M.F., Folstein S.E., and McHugh P.R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12 (1975) 189-198
19. Friston K.J., and Frith C.D. Schizophrenia: a disconnection syndrome?. Clinical Neuroscience 3 (1995) 89-97
20. Genovese C.R., Lazar N.A., and Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage 15 (2002) 870-878
21. Glahn D.C., Ragland J.D., Abramoff A., Barrett J., Laird A.R., Bearden C.E., and Velligan D.I. Beyond hypofrontality: a quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Human Brain Mapping 25 (2005) 60-69
22. Heaton R.K., Chelune G.J., Talley J.L., Kay G.G., and Curtiss G. Wisconsin Card Sorting Test Manual, Revised and Expanded (1993), Psychological Assessment Resources, Odessa, Florida
23. Honea R., Crow T.J., Passingham D., and Mackay C.E. Regional deficits in brain volume in schizophrenia: a meta-analysis of voxel-based morphometry studies. American Journal of Psychiatry 162 (2005) 2233-2245
24. Honey G.D., and Fletcher P.C. Investigating principles of human brain function underlying working memory: what insights from schizophrenia?. Neuroscience 139 (2006) 59-71
25. Honey G.D., Pomarol-Clotet E., Corlett P.R., Honey R.A., McKenna P.J., Bullmore E.T., and Fletcher P.C. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 128 (2005) 2597-2611
26. Jansma J.M., Ramsey N.F., van der Wee N.J., and Kahn R.S. Working memory capacity in schizophrenia: a parametric fMRI study. Schizophrenia Research 68 (2004) 159-171
27. Kay S.R., Fiszbein A., and Opler L.A. The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13 (1987) 261-276
28. Kim J.J., Kwon J.S., Park H.J., Youn T., Kang D.H., Kim M.S., Lee D.S., and Lee M.C. Functional disconnection between the prefrontal and parietal cortices during working memory processing in schizophrenia: a[15(O)]H2O PET study. American Journal of Psychiatry 160 (2003) 919-923
29. Kurtz M.M., and Wexler B.E. Differences in performance and learning proficiency on the Wisconsin Card Sorting Test in schizophrenia: do they reflect distinct neurocognitive subtypes with distinct functional profiles?. Schizophrenia Research 81 (2006) 167-171
30. Marner L., Soborg C., and Pakkenberg B. Increased volume of the pigmented neurons in the locus coeruleus of schizophrenic subjects: a stereological study. Journal of Psychiatric Research 39 (2005) 337-345
31. Mendrek A., Kiehl K.A., Smith A.M., Irwin D., Forster B.B., and Liddle P.F. Dysfunction of a distributed neural circuitry in schizophrenia patients during a working-memory performance. Psychological Medicine 35 (2005) 187-196
32. Mitelman S.A., Brickman A.M., Shihabuddin L., Newmark R., Chu K.W., and Buchsbaum M.S. Correlations between MRI-assessed volumes of the thalamus and cortical Brodmann's areas in schizophrenia. Schizophrenia Research 75 (2005) 265-281
33. Okugawa G., Nobuhara K., Minami T., Takase K., Sugimoto T., Saito Y., Yoshimura M., and Kinoshita T. Neural disorganization in the superior cerebellar peduncle and cognitive abnormality in patients with schizophrenia: a diffusion tensor imaging study. Progress in Neuropsychopharmacology & Biological Psychiatry 30 (2006) 1408-1412
34. Orsini A., Grossi D., Capitani E., Laiacona M., Papagno C., and Vallar G. Verbal and spatial immediate memory span: normative data from 1355 adults and 1112 children. Italian Journal of Neurological Sciences 8 (1987) 539-548
35. Portas C.M., Goldstein J.M., Shenton M.E., Hokama H.H., Wible C.G., Fischer I., Kikinis R., Donnino R., Jolesz F.A., and McCarley R.W. Volumetric evaluation of the thalamus in schizophrenic male patients using magnetic resonance imaging. Biological Psychiatry 43 (1998) 649-659
36. Premkumar P., and Sharma T. Neuropsychologic functioning and structural MRI of the brain in patients with schizophrenia. Expert Review of Neurotherapeutics 5 (2005) 85-94
37. Ragland J.D., Gur R.C., Valdez J., Turetsky B.I., Elliott M., Kohler C., Siegel S., Kanes S., and Gur R.E. Event-related fMRI of frontotemporal activity during word encoding and recognition in schizophrenia. American Journal of Psychiatry 161 (2004) 1004-1015
38. Rose S.E., Chalk J.B., Janke A.L., Strudwick M.W., Windus L.C., Hannah D.E., McGrath J.J., Pantelis C., Wood S.J., and Mowry B.J. Evidence of altered prefrontal-thalamic circuitry in schizophrenia: an optimized diffusion MRI study. NeuroImage 32 (2006) 16-22
39. Roth R.M., Flashman L.A., Saykin A.J., McAllister T.W., and Vidaver R. Apathy in schizophrenia: reduced frontal lobe volume and neuropsychological deficits. American Journal of Psychiatry 161 (2004) 157-159
40. Schlösser R.G., Wagner G., and Sauer H. Assessing the working memory network: studies with functional magnetic resonance imaging and structural equation modeling. Neuroscience 139 (2006) 91-103
41. Schmahmann J.D. Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. Journal of Neuropsychiatry and Clinical Neurosciences 16 (2004) 367-378
42. Seidman L.J., Yurgelun-Todd D., Kremen W.S., Woods B.T., Goldstein J.M., Faraone S.V., and Tsuang M.T. Relationship of prefrontal and temporal lobe MRI measures to neuropsychological performance in chronic schizophrenia. Biological Psychiatry 35 (1994) 235-246
43. Smith G.N., Lang D.J., Kopala L.C., Lapointe J.S., Falkai P., and Honer W.G. Developmental abnormalities of the hippocampus in first-episode schizophrenia. Biological Psychiatry 53 (2003) 555-561
44. Spalletta G., Tomaiuolo F., Marino V., Bonaviri G., Trequattrini A., and Caltagirone C. Chronic schizophrenia as a brain misconnection syndrome: a white matter voxel-based morphometry study. Schizophrenia Research 64 (2003) 15-23
45. Stratta P., Arduini L., Daneluzzo E., Rinaldi O., di Genova A., and Rossi A. Relationship of good and poor Wisconsin Card Sorting Test performance to illness duration in schizophrenia: a cross-sectional analysis. Psychiatry Research 121 (2004) 219-227
46. Szeszko P.R., Bilder R.M., Lencz T., Ashtari M., Goldman R.S., Reiter G., Wu H., and Lieberman J.A. Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia. Schizophrenia Research 43 (2000) 97-108
47. Talamini L.M., Meeter M., Elvevag B., Murre J.M., and Goldberg T.E. Reduced parahippocampal connectivity produces schizophrenia-like memory deficits in simulated neural circuits with reduced parahippocampal connectivity. Archives of General Psychiatry 62 (2005) 485-493
48. Wechsler D. Wechsler Memory Scale - Revised (1987), The Psychological Corporation, San Antonio
49. Wilke M., Kaufmann C., Grabner A., Putz B., Wetter T.C., and Auer D.P. Gray matter-changes and correlates of disease severity in schizophrenia: a statistical parametric mapping study. NeuroImage 13 (2001) 814-824
50. Wilke M., Sohn J.H., Byars A.W., and Holland S.K. Bright spots: correlations of gray matter volume with IQ in a normal pediatric population. NeuroImage 20 (2003) 202-215