Biological therapy using propolis as nutritional supplement in cancer treatment

International Journal of Cancer Research

Volumn 3, Issue 1, 2007, Pages 43-53

  Galvao, J ^a   Abreu, J A ^a   Cruz, T ^a   Machado, G A S ^b   Niraldo, Paulino ^c   Daugsch, A ^d   Moraes, C S ^d   Fort, P ^d   Park, Y K ^d  

^a Nectar Pharmaceutica Ltda   (Brazil)

^b Machado Business Development Ltda   (Brazil)

^c Barriga Verde University (UBIBAVE)   (Brazil)

^d UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Biological therapy; Propolis; Suppression of cancer cells

Indexed keywords

ACETYLCHOLINE; ALPHA TOCOPHEROL; ASCORBIC ACID; CAFFEIC ACID DERIVATIVE; CISPLATIN; COMFREY EXTRACT; DEXAMETHASONE; DNA FRAGMENT; FLUOROURACIL; GRISEOFULVIN; HESPERIDIN; HONEY EXTRACT; HYDROCORTISONE ACETATE; INDOMETACIN; LANOLIN; METRONIDAZOLE; MITOMYCIN C; NATURAL PRODUCT; NITRIC OXIDE; NYSTATIN; PACLITAXEL; PENICILLIN G; PETROLATUM; PHENYLBUTAZONE; PROPOLIS; QUERCETIN; SCAVENGER; STREPTOMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; BIOLOGICAL THERAPY; BREAST CANCER; CANCER PREVENTION; CANCER THERAPY; CANDIDIASIS; CELL PROTECTION; COMBINATION CHEMOTHERAPY; CORNEA DISEASE; CYTOTOXICITY; DIET SUPPLEMENTATION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM; DRUG MIXTURE; DRUG POTENTIATION; FIBROSARCOMA; HUMAN; IMMUNOMODULATION; LUNG ADENOCARCINOMA; LUNG TUMOR; MACROPHAGE FUNCTION; MELANOMA; MONOTHERAPY; MOUTH HYGIENE; NONHUMAN; POSTOPERATIVE CARE; REVIEW; TUMOR IMMUNITY; UTERINE CERVIX CARCINOMA; WOUND HEALING;

EID: 34249294880     PISSN: 18119727     EISSN: 18119735     Source Type: Journal    
DOI: 10.3923/ijcr.2007.43.53     Document Type: Review

References (56)

1. Ansorge, S., D. Reinhold and U. Lendeckel, 2003. Propolis and some of its constituents down-regulate DNA synthesis and inflammatory cytokine production but Induce TGF-β1 production of human immune cells. Zeitschrift für Naturforschung, 58c: 580-589.
2. Banskota, A.H., Y. Tezuca, K. Midorikawa, K. Matsushige and S. Kadota, 2000. Two novel cytotoxic benzofuran derivatives from brazilian propolis. J. Nat. Prod., 63: 1277-1279.
3. Banskota, A.H., Y. Tezuka and S. Kadota, 2001. Recent process in pharmacological research of propolis. Phytother. Res., 15: 561-571.
4. Bastos, E.M., V.D.C. Oliveira and A.E.E. Scares, 2000. Microscopic characterization of the green propolis, produced in Minas Gerais state, Brazil. Honeybee Sci., 21: 179-180.
5. Bretz, W.A., D.J.J. Chiego, M.C. Marcucci, I.B.S. Cunha, A.R. Custodio and L.G. Schneider, 1998. Preliminary report on the effects of propolis on wound healing in the dental pulp. Zeitschrift für Naturforschung, 53c: 1045-1048.
6. Castaldo, S. and F. Capasso, 2002. Propolis, an old remedy used in modern medicine. Fitoterapia, 73(suppl. 1): S1-S6.
7. Chen, C.N., C.L. Wu, H.S. Shy and J.K. Lin, 2003. Cytotoxic prenylflavanones from taiwanese propolis. J. Nat. Prod., 66: 503-506.
8. Coleman, R. A., W.L. Smith and S. Narumiya, 1994. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution and structure of the receptors and their subtypes. Pharmacol. Rev., 46: 205-229.
9. Czermak, B.J., H.P. Friedl and P.A. Ward, 1999. Complement, cytokines and adhesion molecule expression in inflammatory reactions. Proc. Assoc. Am. Physicians, 110: 306-312.
10. DeVita, V.T.J., S. Hellman and S.A Rosenberg, 1997. Cancer-Principles and Practice of Oncology. 6th Edn, Lippincott-Raven.
11. Dobrowolski, J.W., S.B. Vohora, K. Sharma, S.A. Shah, S.A.H. Naqvi and P.C. Dandiya, 1991. Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic studies on propolis bee products. J. Ethnopharcol., 35: 77-82.
12. El-Ghazaly, M.A. and M.T. Khayyal, 1995. The use of aqueous propolis extract against radiation-induced damage. Drugs Exp. Clin. Res., 21: 229-236.
13. Emim, J.A., A.B. Oliveira and A.J. Lapa, 1994. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin and the isoflavonoids, duartin and claussequinone, in rats and mice. J. Pharm. Pharmacol., 46: 118-122.
14. Fiala, M., Q.N. Liu, J. Sayre, V. Pop, V. Brahmandam, M.C. Graves and H.V. Vinters, 2002. Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. Eur. J. Clin. Invest., 32: 360-371.
15. Fitzpatrick, L.R., J. Wang and T. Le, 2001. Caffeic acid phenethyl ester, an inhibitor of nuclear factor-B, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J. Pharmacol. Exp. Ther., 299: 915-920.
16. Hata, A.N. and R.M. Breyer, 2004. Pharmacology and signaling of prostaglandin receptors: Multiple roles in inflammation and immune modulation. Pharmacol. Ther., 103: 147-166.
17. Havsteen, B., 1983. Flavonoids, a class of natural products of high pharmacological potency. Biochem. Pharmacol., 32: 1141-1148.
18. Heo, M.Y., S.J. Sohn and W.W. Av, 2001. Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate. Mutat. Res., 448: 135-150.
19. Hepsen, I.F., H. Er and O. Cekic, 1999. Topically applied water extract of propolis to suppress corneal neovascularization in rabbits. Ophthalmic Res., 31: 426-431.
20. Ikegaki, M., S.M. Alencar, F.F. Moura, H.H. Sato and Y.K. Park, 1999. Determinação das características fisico-químicas e algumas propriedades biológicas de própolis coletadas na região Sul do Brasil. Revista da Universidade de Franca, 7: 44-45.
21. Ito, J., F.R. Chang, H.K. Wang, Y.K. Park, M. Ikegaki, N. Kilgore and K.H. Lee, 2001. Anti-AIDS agents. 48. Anti-HIV activity of moronic acid derivatives and the New melliferone-related Triterpenoid Isolated from Brazilian Propolis. J. Natural Products, 64: 1278-1281.
22. Ivanovska, N.D., V.D. Dimov, V. Bankova and S. Popov, 1995. Immunomodulatory action of propolis VI. Influence of a water soluble derivative on complement activity in vivo. J. Ethnopharmacol., 47: 145-147.
23. Kasahara, R., 2003. Physiochemical diversity and plant origins of propolis. M.Sc Thesis, University of Tamagawa, Japan.
24. Khayyal, M.T., M.A. El-Ghazaly and A.S. El-Khatib, 1993. Mechanisms involved in the antiinflammatory effect of propolis extract. Drugs Exp. Clin. Res., 19: 197-203.
25. Kimoto, T., S. Arai, M. Kohguchi, M. Aga, Y. Nomura, M.J. Micallef, M. Kurimoto and K. Mito, 1998. Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis. Cancer Detect. Prev., 22: 506-515.
26. Kimoto, T., S. Koya-Miyata, K. Hino, M.J. Micallef, T. Hanaya, S. Arai, M. Ikeda and M. Kurimoto, 2001. Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C. Virchows Arch, 438: 259-270.
27. Magro-Filho, O., A.C. Perri de Carvalho, A.L. Martins and P.R.P. Câmera, 1987. Reačões do tecido conjuntivo à pomada de confrei, propolis e mel. Estudo histológico em ratos. RBO. v. XLIV, 5: 44-48.
28. Magro-Filho, O. and A.C.D. Carvalho, 1994. Topical effect of propolis in the repair of sulcoplasties by the modified Kazanjian technique. Cytological and clinical evaluation. J. Nihon Univ. Sch. Dent., 36: 102-111.
29. Martins, R.S., E.S.J. Pereira, S.M. Lima, M.I. Senna, R.A. Mesquita and V.R. Santos, 2002. Effect of commercial ethanol propolis extract on the in vitro growth of Candida albicans collected from HIV-seropositive and HIV-seronegative Brazilian patients with oral candidiasis. J. Oral Sci., 44: 41-48.
30. Matsushige, K., P. Basnet, K. Hase, S. Kadota, K. Tanaka and T. Namba, 1996a. Propolis protects pancreatic β-cells against toxicity of streptozotocin (STZ). Phytomedicine, 3: 203-209.
31. Matsushige, K., P. Basnet, S. Kadota and T. Namba, 1996b. Potent free radical scavenging activity of dicaffeoyl quinic acid derivatives from propolis. J. Trad. Med., 13: 217-228.
32. Menezes, H., J.M. Alvarez and E.C. Almeida, 1999. Mouse ear edema modulation by different propolis ethanol extracts. Arzneimittel-Forschung, 49: 705-707.
33. Mirzoeva, O.K. and P.C. Calder, 1996. The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot. Essent. Fatty Acids, 55: 441-449.
34. Nagaoka, T., A.H. Banskota, Y. Tezuka, I. Saiki and S. Kadota, 2002. Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-15 carcinoma cell line. Bioorg. Med. Chem., 10: 3351-3359.
35. Nagoaka, T., A.H. Banskota, Y. Tezuka, Y. Harimaya, K. Koizumi, I. Saiki and S. Kadota, 2003. Inhibitory effects of caffeic acid phenethyl ester analogues on experimental lung metastasis of murine colon 26-15 carcinoma cells. Biol. Pharm. Bull., 26: 1-4.
36. National Cancer Institute, 2004. Cancer Topics-Types of Treatment., http://www.cancer.gov/cancertopics/biologicaltherapy.
37. Ohishi, S., 2000. Evaluation of time course and inter-relationship of inflammatory mediators in experimental inflammatory reaction. Yakugaku Zasshi, 120: 455-462.
38. Oliveira, V.D.C. and E.M. Bastos, 1998. Aspectos morfoanatômicos da folha de Baccharis dracunculifolia DC. (Asteraceae) visando a identificaçtio da origem botânica da propolis. Acta. Bot. Bras., 12: 431-439.
39. Orsi, R.O., S.R.C. Funari, A.M.V.C. Soares, S.A. Calvi, S.L. Oliveira, J.M. Sforcin and V. Bankova, 2000. Immunomodulatory action of propolis on macrophage activation. J. Venom. Anim. Toxins, 6: 205-219.
40. Orsolic, N. and I. Basic, 2005. Antitumor, hematostimulative and radioprotective action of water-soluble derivative of propolis (WSDP). Biomed. Pharmacother., 59: 561-570.
41. Ozturk, F., E. Kurt, U. Ubeyt Inan, L. Emiroglu and S.S. Ilker, 1999. The effects of acetylcholine and propolis extract on corneal epithelial wound healing in rats. Cornea, 18: 466-471.
42. Ozturk, F., E. Kurt U.U. Inan, L. Emiroglu and S.S. Ilker, 2000. The effect of propolis extract in experimental chemical corneal injury. Ophthalmic Res., 32: 13-18.
43. Padmavathi, R., P. Senthilnathan, D. Chodon and D. Sakthisekaran, 2005. Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 dimethyl benz(a)anthracene-induced breast cancer in female Sprague Dawley rats. Live Sci., 78: 2820-2825.
44. Park, J.S. and K.S. Woo, 1996. The usage and composition of propolis added cosmetics in Korea. International Conference on Bee Products: Properties, Applications and Apitherapy, Israel, pp: 75.
45. Park, Y.K., H. Koo, J.A.S. Abreu, M. Ikegaki, J.A. Cury and P.L. Rosalen, 1998. Antimicrobial activity of propolis on oral microoorganisms. Curr. Microbiol., 36: 24-28.
46. Park, E.H. and J.H. Kahng, 1999. Suppressive effects of propolis in rat adjuvant arthritis. Arch. Pharm. Res., 22: 554-558.
47. Park, Y.K., S.M. Alencar and C.L. Aguiar, 2002. Botanical origin and chemical composition of brazilian propolis. J. Agric. Food Chem., 50: 2502-2506.
48. Peruchi, C.M.S., F.B. Silva, S.I. Franco and L.T.O. Ramalho, 2000. Efeito da ação da propolis na lamina própria da mucosa bucal de ratos. Estudo histológico. Robrac - Revista de Odontologia do Brasil Central, 9: 4-8.
49. Rankin, J.A., D.E. Picarella, G.P. Geba, U.A. Temann, B. Prasad, B. DiCosmo, A. Tarallo, B. Stripp, J. Whitsett and R.A. Flavell, 1996, Phenotypic and physiologic characterization of transgenic mice expressing interleukin 4 in the lung: Lymphocytic and eosinophilic inflammation without airway hyperreactivity. Proc. Natl. Acad. Sci. USA, 93: 7821-7825.
50. Rosenthal, D.S., 2000. American Cancer Society's Guide to Complementary and Alternative Cancer Methods. 1st Edn., ISBN 0-944235-24-7.
51. Santos, H.S.D. and W.M.S. Cruz, 2001. A Terapia Nutritional com Vitaminas, Antioxidantes e o Tratamento Quimioterápico e Oncológico. Revista Brasileira de Cancerologia, 47: 303-308.
52. Serhan, C.N. and N. Chiang, 2004. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: Entree for resoleomics. Rheum. Dis. Clin. North Am., 30: 69-95.
53. Su, Z.Z., J.K. Lin, M. Prewett, N. Goldstein and P.B. Fisher, 1995. Apoptosis mediates the selective toxicity of caffeic acid phenethyl ester (CAPE) toward oncogene-transformed rat embryo fibroblast cells. Anticancer Res., 15: 1841-1848.
54. Suzuki, I., I. Hayashi, T. Takaki, D.S. Groveman and Y. Fujimiya, 2002. Antitumor and anticytopenic effects of aqueous extracts of propolis in combination with chemotherapeutic agents. Cancer Biother. Radiopharm., 17: 553-562.
55. Than, M.M., A.H. Banskota, Y. Tezuka, K. Midorikawa, K. Matsushige and S. Kadota, 2003. Inhibitors of nitric oxide (NO) production in murine macrophage-like J774.1 cells from Brazilian propolis. J. Trad. Med., 20: 1-8.
56. Thomas, D.B., 1986. Cancer Epidemiology and Prevention. In: Comprehensive Textbook of Oncology. Moosa, A.R., M.C. Robson and S.C. Schimpff (Eds.), Baltimore, pp: 3-27.