Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics

Neuroscience Research

Volumn 49, Issue 4, 2004, Pages 379-385

  Iwamoto, Kazuya ^a   Bundo, Miki ^a   Yamamoto, Megumi ^b   Ozawa, Hiroki ^b   Saito, Toshikazu ^b   Kato, Tadafumi ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

Alcohol dependence; Alcoholism; Gene expression; Microarray; Postmortem brains; Prefrontal cortex

Indexed keywords

ALCOHOL; CHAPERONE;

ADULT; ALCOHOLISM; APOPTOSIS; ARTICLE; BEHAVIOR; CADAVER; CLINICAL ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE; UPREGULATION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALCOHOLISM; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; FEMALE; GENE EXPRESSION; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROFILAMENT PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREFRONTAL CORTEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEX FACTORS;

EID: 3242738202     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neures.2004.04.002     Document Type: Article

References (23)

1. Boronat M.A., Olmos G., Garcia-Sevilla J.A. Attenuation of tolerance to opioid-induced antinociception and protection against morphine-induced decrease of neurofilament proteins by idazoxan and other I2-imidazoline ligands. Br. J. Pharmacol. 125:1998;175-185
2. Enoch M.A., Goldman D. The genetics of alcoholism and alcohol abuse. Curr. Psychiatr. Rep. 3:2001;144-151
3. Erhardt J.A., Legos J.J., Johanson R.A., Slemmon J.R., Wang X. Expression of PEP-19 inhibits apoptosis in PC12 cells. Neuroreport. 11:2000;3719-3723
4. Ferrer-Alcon M., Garcia-Sevilla J.A., Jaquet P.E., et al. Regulation of non-phosphorylated and phosphorylated forms of neurofilament proteins in the prefrontal cortex of human opioid addicts. J. Neurosci. Res. 61:2000;338-349
5. Figlewicz D.A., Krizus A., Martinoli M.G., et al. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum. Mol. Genet. 3:1994;1757-1761
6. Gsell W., Lange K.W., Pfeuffer R., et al. How to run a brain bank. A report from the Austro-German brain bank. J. Neural. Transm. Suppl. 39:1993;31-70
7. Iwamoto K., Kakiuchi C., Bundo M., Ikeda K., Kato T. Comparative genome-wide gene expression analysis of postmortem brains of bipolar disorder and related mental diseases. Mol. Psychiatr. 9:2004;406-416
8. Johnson E.O., van den Bree M.B., Gupman A.E., Pickens R.W. Extension of a typology of alcohol dependence based on relative genetic and environmental loading. Alcohol Clin. Exp. Res. 22:1998;1421-1429
9. Lee M.K., Cleveland D.W. Neuronal intermediate filaments. Annu. Rev. Neurosci. 19:1996;187-217
10. Lewohl J.M., Wang L., Miles M.F., Zhang L., Dodd P.R., Harris R.A. Gene expression in human alcoholism: microarray analysis of frontal cortex. Alcohol Clin. Exp. Res. 24:2000;1873-1882
11. Mayfield R.D., Lewohl J.M., Dodd P.R., Herlihy A., Liu J., Harris R.A. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J. Neurochem. 81:2002;802-813
12. Miles M.F. Alcohol's effects on gene expression. Alcohol Health Res. World. 19:1995;237-243
13. Moselhy H.F., Georgiou G., Kahn A. Frontal lobe changes in alcoholism: a review of the literature. Alcohol Alcohol. 36:2001;357-368
14. Nestler E.J. Psychogenomics: opportunities for understanding addiction. J. Neurosci. 21:2001;8324-8327
15. Rahman S., Miles M.F. Identification of novel ethanol-sensitive genes by expression profiling. Pharmacol. Ther. 92:2001;123-134
16. Saito M., Smiley J., Toth R., Vadasz C. Microarray analysis of gene expression in rat hippocampus after chronic ethanol treatment. Neurochem. Res. 27:2002;1221-1229
17. Slemmon J.R., Hughes C.M., Campbell G.A., Flood D.G. Increased levels of hemoglobin-derived and other peptides in Alzheimer's disease cerebellum. J. Neurosci. 14:1994;2225-2235
18. Slemmon J.R., Morgan J.I., Fullerton S.M., Danho W., Hilbush B.S., Wengenack T.M. Camstatins are peptide antagonists of calmodulin based upon a conserved structural motif in PEP-19, neurogranin, and neuromodulin. J. Biol. Chem. 271:1996;15911-15917
19. Utal A.K., Stopka A.L., Roy M., Coleman P.D. PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease. Neuroscience. 86:1998;1055-1063
20. Weiss F., Porrino L.J. Behavioral neurobiology of alcohol addiction: recent advances and challenges. J. Neurosci. 22:2002;3332-3337
21. Xu Y., Ehringer M., Yang F., Sikela J.M. Comparison of global brain gene expression profiles between inbred long-sleep and inbred short-sleep mice by high-density gene array hybridization. Alcohol Clin. Exp. Res. 25:2001;810-818
22. Ziai M.R., Sangameswaran L., Hempstead J.L., Danho W., Morgan J.I. An immunochemical analysis of the distribution of a brain-specific polypeptide, PEP-19. J. Neurochem. 51:1988;1771-1776
23. Ziai R., Pan Y.C., Hulmes J.D., Sangameswaran L., Morgan J.I. Isolation, sequence, and developmental profile of a brain-specific polypeptide, PEP-19. Proc. Natl. Acad. Sci. U.S.A. 83:1986;8420-8423