Effect of two novel CGRP-binding compounds in a closed cranial window rat model

European Journal of Pharmacology

Volumn 567, Issue 1-2, 2007, Pages 117-124

  Juhl, Louise ^a   Edvinsson, Lars ^a,b   Olesen, Jes ^a   Jansen Olesen, Inger ^a  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CGRP; CGRP antibody; Electrical stimulation; Middle cerebral artery; Middle meningeal artery; Migraine; RNA Spiegelmer

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; MONOCLONAL ANTIBODY; RNA SPIEGELMER; UNCLASSIFIED DRUG;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; DRUG EFFECT; DRUG INHIBITION; ELECTROSTIMULATION; FEMALE; IN VIVO STUDY; MALE; MEAN ARTERIAL PRESSURE; MIGRAINE; MOLECULE; NERVE FIBER; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; RAT; SENSORY NERVE; SKULL; VASODILATATION;

ANIMALS; ANTIBODIES, MONOCLONAL; APTAMERS, NUCLEOTIDE; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; DISEASE MODELS, ANIMAL; DURA MATER; ELECTRIC STIMULATION; MALE; MENINGEAL ARTERIES; MIDDLE CEREBRAL ARTERY; MIGRAINE DISORDERS; OLIGONUCLEOTIDES; PIA MATER; POLYETHYLENE GLYCOLS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 34249075410     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.04.004     Document Type: Article

References (35)

1. Akerman S., Williamson D.J., Kaube H., and Goadsby P.J. Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels. Br. J. Pharmacol. 137 (2002) 62-68
2. Akerman S., Williamson D.J., and Goadsby P.J. Voltage-dependent calcium channels are involved in neurogenic dural vasodilatation via a presynaptic transmitter release mechanism. Br. J. Pharmacol. 140 (2003) 558-566
3. Andrew D.P., Bidgood T.D., Bose C., Brown D., Galfre G., and Sherwood M. Monoclonal antibodies distinguishing alpha and beta forms of calcitonin gene-related peptide. J. Immunol. Methods 134 (1990) 87-94
4. Buckley T.L., Brain S.D., Jose P.J., and Williams T.J. The partial inhibition of inflammatory responses induced by capsaicin using the Fab fragment of a selective calcitonin gene-related peptide antiserum in rabbit skin. Neuroscience 48 (1992) 963-968
5. Denekas T., Troltzsch M., Vater A., Klussmann S., and Messlinger K. Inhibition of stimulated meningeal blood flow by a calcitonin gene-related peptide binding mirror-image RNA oligonucleotide. Br. J. Pharmacol. 148 (2006) 536-543
6. Edvinsson L., and Uddman R. Neurobiology in primary headaches. Brain Res. Brain Res. Rev. 48 (2005) 438-456
7. Edvinsson L., Ekman R., Jansen I., McCulloch J., and Uddman R. Calcitonin gene-related peptide and cerebral blood vessels: distribution and vasomotor effects. J. Cereb. Blood Flow Metab. 7 (1987) 720-728
8. Edvinsson L., Gulbenkian S., Barroso C.P., Cunha e Sa M., Polak J.M., Mortensen A., Jorgensen L., and Jansen-Olesen I. Innervation of the human middle meningeal artery: immunohistochemistry, ultrastructure, and role of endothelium for vasomotility. Peptides 19 (1998) 1213-1225
9. Edvinsson L., Nilsson E., and Jansen-Olesen I. Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery. Br. J. Pharmacol. 150 (2007) 633-640
10. Eulberg D., Buchner K., Maasch C., and Klussmann S. Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist. Nucleic Acids Res. 33 (2005) e45
11. Faulhammer D., Eschgfaller B., Stark S., Burgstaller P., Englberger W., Erfurth J., Kleinjung F., Rupp J., Dan Vulcu S., Schroder W., Vonhoff S., Nawrath H., Gillen C., and Klussmann S. Biostable aptamers with antagonistic properties to the neuropeptide nociceptin/orphanin FQ. RNA 10 (2004) 516-527
12. Goadsby P.J., Edvinsson L., and Ekman R. Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann. Neurol. 23 (1988) 193-196
13. Goadsby P.J., Edvinsson L., and Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann. Neurol. 28 (1990) 183-187
14. Goadsby P.J., Edvinsson L., and Ekman R. Cutaneous sensory stimulation leading to facial flushing and release of calcitonin gene-related peptide. Cephalalgia 12 (1992) 53-56
15. Helmling S., Maasch C., Eulberg D., Buchner K., Schroder W., Lange C., Vonhoff S., Wlotzka B., Tschop M.H., Rosewicz S., and Klussmann S. Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 13174-13179
16. Jansen-Olesen I., Jorgensen L., Engel U., and Edvinsson L. In-depth characterization of CGRP receptors in human intracranial arteries. Eur. J. Pharmacol. 481 (2003) 207-216
17. Kowacs F., Williamson D.J., and Goadsby P.J. Neurogenic vasodilation of dural blood vessels is not mediated by cholinergic transmission in the anaesthetised rat. Eur. J. Pharmacol. 493 (2004) 133-137
18. Lassen L.H., Haderslev P.A., Jacobsen V.B., Iversen H.K., Sperling B., and Olesen J. CGRP may play a causative role in migraine. Cephalalgia 22 (2002) 54-61
19. Leva S., Lichte A., Burmeister J., Muhn P., Jahnke B., Fesser D., Erfurth J., Burgstaller P., and Klussmann S. GnRH binding RNA and DNA Spiegelmers: a novel approach toward GnRH antagonism. Chem. Biol. 9 (2002) 351-359
20. Louis S.M., Jamieson A., Russell N.J., and Dockray G.J. The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat. Neuroscience 32 (1989) 581-586
21. Olesen J., Diener H.C., Husstedt I.W., Goadsby P.J., Hall D., Meier U., Pollentier S., and Lesko L.M. Calcitonin gene-related peptide receptor antagonist BIBN 4096 BS for the acute treatment of migraine. N. Engl. J. Med. 350 (2004) 1104-1110
22. Peskar B.M., Wong H.C., Walsh J.H., and Holzer P. A monoclonal antibody to calcitonin gene-related peptide abolishes capsaicin-induced gastroprotection. Eur. J. Pharmacol. 250 (1993) 201-203
23. Petersen K.A., Birk S., Doods H., Edvinsson L., and Olesen J. Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat. Br. J. Pharmacol. 143 (2004) 697-704
24. Petersen K.A., Dyrby L., Williamson D., Edvinsson L., and Olesen J. Effect of hypotension and carbon dioxide changes in an improved genuine closed cranial window rat model. Cephalalgia 25 (2005) 23-29
25. Petersen K.A., Lassen L.H., Birk S., Lesko L., and Olesen J. BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation. Clin. Pharmacol. Ther. 77 (2005) 202-213
26. Ray B. Experimental studies on headaches, pain sensitive structures of the head and their significance in headaches. Arch. Surg. 41 (1940) 813-856
27. Tan K.K., Brown M.J., Longmore J., Plumpton C., and Hill R.G. Demonstration of the neurotransmitter role of calcitonin gene-related peptides (CGRP) by immunoblockade with anti-CGRP monoclonal antibodies. Br. J. Pharmacol. 111 (1994) 703-710
28. Tan K.K., Brown M.J., Hargreaves R.J., Shepheard S.L., Cook D.A., and Hill R.G. Calcitonin gene-related peptide as an endogenous vasodilator: immunoblockade studies in vivo with an anti-calcitonin gene-related peptide monoclonal antibody and its Fab' fragment. Clin. Sci. (Lond) 89 (1995) 565-573
29. Tvedskov J.F., Lipka K., Ashina M., Iversen H.K., Schifter S., and Olesen J. No increase of calcitonin gene-related peptide in jugular blood during migraine. Ann. Neurol. 58 (2005) 561-568
30. Uddman R., and Edvinsson L. Neuropeptides in the cerebral circulation. Cerebrovasc. Brain Metab. Rev. 1 (1989) 230-252
31. Vater A., and Klussmann S. Toward third-generation aptamers: Spiegelmers and their therapeutic prospects. Curr. Opin. Drug Discov. Dev. 6 (2003) 253-261
32. Vater A., Jarosch F., Buchner K., and Klussmann S. Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: tailored-SELEX. Nucleic Acids Res. 31 (2003) e130
33. Williamson D.J., Hargreaves R.J., Hill R.G., and Shepheard S.L. Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat. Cephalalgia 17 (1997) 518-524
34. Williamson D.J., Hargreaves R.J., Hill R.G., and Shepheard S.L. Sumatriptan inhibits neurogenic vasodilation of dural blood vessels in the anaesthetized rat--intravital microscope studies. Cephalalgia 17 (1997) 525-531
35. Wong H.C., Tache Y., Lloyd K.C., Yang H., Sternini C., Holzer P., and Walsh J.H. Monoclonal antibody to rat alpha-CGRP: production, characterization, and in vivo immunoneutralization activity. Hybridoma 12 (1993) 93-106