Intravital microscope studies on the effects of neurokinin agonists and calcitonin gene-related peptide on dural vessel diameter in the anaesthetized rat

Cephalalgia

Volumn 17, Issue 4, 1997, Pages 518-524

  Williamson, D J ^a   Hargreaves, R J ^a   Hill, R G ^a   Shepheard, S L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

CGRP; Migraine; Substance P; Vasodilation

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; CALCITONIN GENE RELATED PEPTIDE; NEUROKININ A; SAREDUTANT; SENKTIDE; SUBSTANCE P; TACHYKININ RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL DIAMETER; BRAIN BLOOD FLOW; CONTROLLED STUDY; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICROSCOPY; MIGRAINE; NONHUMAN; RAT; TECHNIQUE; VASODILATATION;

ANESTHETICS; ANIMALS; BENZAMIDES; BLOOD PRESSURE; CALCITONIN GENE-RELATED PEPTIDE; DURA MATER; INDOLES; MALE; MICROSCOPY, VIDEO; NEUROKININ A; PEPTIDE FRAGMENTS; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, TACHYKININ; SUBSTANCE P; VASODILATOR AGENTS;

EID: 0031001211     PISSN: 03331024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-2982.1997.1704518.x     Document Type: Article

References (29)

1. Moskowitz MA. Neurogenic versus vascular mechanisms of sumatriptan and ergot alkaloids in migraine. Trends Pharmacol Sci 1992;13:307-11
2. Uddman R, Edvinsson L. Neuropeptides in the cerebral circulation. Cerebrovasc Brain Metab Rev 1989;1:230-52
3. Goadsby PJ, Edvinsson L, Ekman R. Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system. Ann Neurol 1988;23:193-6
4. Jansen I, Uddman R, Ekman R, Olesen J, Ottosson A, Edvinsson L. Distribution and effects of neuropeptide Y, vasoactive intestinal polypeptide, substance P and calcitonin gene-related peptide in human middle meningeal arteries: comparison with cerebral and temporal arteries. Peptides 1992;13:527-36
5. Beattie DT, Stubbs CM, Connor, HE, Feniuk W. Neurokininduced changes in pial artery diameter in the anaesthetized guinea-pig. Br J Pharmacol 1993;108:146-9
6. Jansen I, Alafaci C, McCulloch J, Uddman R, Edvinsson L. Tachykinins (substance P, neurokinin A, Neuropeptide K and Neurokinin B) in the cerebral circulation, vasomotor responses in vitro and in situ. J Cereb Blood Flow Metab 1991;11:567-75
7. Escott KJ, Connor HE, Brain SD, Beattie DT. The involvement of calcitonin gene-related peptide (CGRP) and substance in feline pial artery diameter responses evoked by capsaicin. Neuropeptides 1995;29:129-35
8. Kurosawa M, Messlinger K, Pawlak M, Schmidt RF. Increase of meningeal blood flow after electrical stimulation of rat dura mater encephali: mediation by calcitonin gene-related peptide. Br J Pharmacol 1995;114:1397-2
9. Lee C, Campbell NJ, Williams BJ, Iversen LL. Multiple tachykinin binding in peripheral tissues and in brain. Eur J Pharmacol 1986;130:209-17
10. Cascieri MA, Huang R-RC, Fong TM, Cheung AH, Sadowski S, Ber E, Strader CD. Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors. Mol Pharmacol 1992;41:1096-99
11. Garret C, Carruette A, Fardin V, Moussaoui S, Peyronel J, Blanchard J, Laduron PM. Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc Natl Acad Soc USA 1991;88:10208-12
12. Longmore J, Swain CJ, Hill RG. Neurokinin receptors. Drug News Perspect 1995;8:5-23
13. 2) receptor revisited with SR 48968, a potent non-peptide antagonist. Biochem Biophys Res Commun 1992;184:1418-24
14. Chiba T, Yamaguchi A, Toshiyuki Y, Nakamura A, Morishita T, Inui T, et al. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am J Physiol 1989; 256:E331-5
15. Williamson DJ, Hargreaves RJ, Hill RG, Shepheard SL. Direct measurement of dural blood vessel diameter in the rat using intravital microscopy. Br J Pharmacol 1996;117:271P
16. Tousignant C, Chan C-C, Guevrement D, Brideau C, Hale JJ, MacCoss M, Rodger IW. NK2 receptors mediate plasma extravasation in guinea pig lower airways. Br J Pharmacol 1993 : 383-86
17. Delay-Goyet P, Satoh H, Lundberg JM. Relative involvement of substance P and CGRP mechanisms in antidromic vasodilation in the rat skin. Acta Physiol Scand 1992;146:537-8
18. Edvinsson L, Olesen IJ, Kingman TA, McCulloch J, Uddman R. Modification of vasoconstrictor responses in cerebral blood vessels by lesioning of the trigeminal nerve: possible involvement of CGRP, Cephalalgia 1995;15:373-83
19. Messlinger K, Hanesch U, Baumgartel M, Trost B, Schmidt RF. Innervation of the dura mater encephali of cat and rat: ultrastructure and calcitonin gene-related peptide-like and substance P-like immunoreactivity. Anat Embryol 1993;188: 219-37
20. Edvinsson L, Hara H, Uddman R. Retrograde tracing of nerve fibres to the rat middle cerebral artery with true blue: colocalization with different peptides. J Cereb Blood Flow Metab 1989;9:212-8
21. Lee Y, Kawai Y, Shiosaka S, Takami K, Kiyama H, Hillyard CJ, et al. Coexistence of calcitonin gene-related peptide and substance P-like peptide in single cells of the trigeminal ganglion of the rat: immunohistochemical analysis. Brain Res 1985;330:194-6
22. Uddman R, Hara H, Edvinsson L. Neuronal pathways to the rat middle meningeal artery revealed by retrograde tracing and immunohistochemistry. J Auton Nerv Syst 1989;26:69-75
23. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol 1990;28:183-7
24. Ray BS, Wolff HG. Experimental studies on headache: pain sensitive structures of the head and their significance in headache. Arch Surg 1940;41:813-56
25. Penfield W, McNaughton F. Dural headache and innervation of the dura mater. Arch Neurol Psychiatry 1940;44:43-75
26. Gallai V, Sarchielli P, Franceschini M, Codini M, Glioti G, Trequattrini A, Palumbo R. Vasoactive peptide levels in the plasma on young migraine patients with and without aura assessed both interictally and ictally. Cephalalgia 1995;15:384-90
27. Diener HC for the RPR100893-201 migraine study group. Substance-P antagonist RPR100893-201 is not effective in human migraine attacks. 6th International Headache Research Seminar, 17-19 November 1995, Copenhagen, Denmark
28. Goldstein D. Clinical trials of tachykinin antagonists. IBC Conference on Tachykinins and their Antagonists, 10-11 October 1996, London, UK
29. Edvinsson L. Innervation and effects of dilatory neuropeptides on cerebral vessels. Blood vessels. 1991;28:35-15