High-dose pantoprazole continuous infusion is superior to somatostatin after endoscopic hemostasis in patients with peptic ulcer bleeding

American Journal of Gastroenterology

Volumn 102, Issue 6, 2007, Pages 1192-1199

  Tsibouris, Panagiotis ^a   Zintzaras, Elias ^b   Lappas, Christos ^c   Moussia, Maria ^c   Tsianos, George ^c   Galeas, Theodoros ^c   Potamianos, Spyros ^a  

^a UNIVERSITY HOSPITAL OF LARISSA   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

^c Trikala General Hospital   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; PANTOPRAZOLE; SOMATOSTATIN; STOMACH SECRETION INHIBITOR;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG INDUCED HEADACHE; DRUG MEGADOSE; DRUG POTENCY; DRUG SAFETY; DUODENAL ULCER BLEEDING; FEMALE; GASTRIC PH MONITORING; GASTRIC ULCER BLEEDING; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL SURGERY; GLUCOSE BLOOD LEVEL; HEMOSTASIS; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTIVARIATE ANALYSIS; PEPTIC ULCER BLEEDING; PH MEASUREMENT; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SIDE EFFECT; TREATMENT OUTCOME;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; AGED; ANTI-ULCER AGENTS; DOUBLE-BLIND METHOD; FEMALE; GASTRIC ACIDITY DETERMINATION; HEMOSTASIS, ENDOSCOPIC; HORMONES; HUMANS; INFUSIONS, INTRAVENOUS; MALE; PEPTIC ULCER HEMORRHAGE; RECURRENCE; SOMATOSTATIN;

EID: 34249066436     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2007.01120.x     Document Type: Article

References (31)

1. Selby NM, Kubba AK, Hawkey CJ. Acid suppression in peptic ulcer haemorrhage: A 'meta-analysis'. Aliment Pharmacol Ther 2000 14 : 1119 26.
2. Cook DJ, Guyatt GH, Salena BJ, et al. Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage. A meta-analysis. Gastroenterology 1992 102 : 139 48.
3. Avgerinos A, Sgouros S, Viazis N, et al. Somatostatin inhibitis gastric acid secretion more effectively than pantoprazole in patients with peptic ulcer bleeding: A prospective, randomised, placebo-controlled trial. Scand J Gastroenterol 2005 40 : 515 22.
4. Chalmhoff C, Creter D, Djaldetti M. The effect of pH on platelet and coagulation factor activities. Am J Surg 1978 136 : 257 9.
5. Khuroo MS, Khuroo MS, Farahat KLC, et al. Treatment with proton pump inhibitors in acute non-variceal upper gastrointestinal bleeding: A meta-analysis. J Gastroenterol Hepatol 2005 20 : 11 25.
6. Hasselgren G, Lind T, Lundell L, et al. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results of a placebo-controlled multicenter study. Scand J Gastroenterol 1997 32 : 328 33.
7. Schaffalitzky de Muckadell OB, Havellund T, Harling H, et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers. Randomised double-blind placebo-controlled multicenter study. Scand J Gastroenterol 1997 32 : 320 7.
8. Lau JY, Sung JJ, Lee KK, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 2000 343 : 310 6.
9. Lin HJ, Lo WC, Lee FY, et al. A prospective randomised comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Arch Intern Med 1998 158 : 54 8.
10. Goletti O, Sodorri F, Lippolis PV, et al. Omeprazole versus ranitidine plus somatostatin in the treatement of severe gastrointestinal bleeding: A prospective, randomised, controlled trial. Ital J Gastroenterol 1994 26 : 72 4.
11. Udd M, Miettinen P, Palmu A, et al. Regular dose versus high dose omeprazole in peptic ulcer bleeding: A prospective randomized double-blind study. Scand J Gastroenterol 2001 36 : 1332 8.
12. Brunner G, Luna P, Hartmann M, et al. Optimizing the intragastric pH as a supportive therapy in upper GI bleeding. Yale J Biol Med 1996 69 : 225 31.
13. Van Rensburg CJ, Hartmann M, Thorpe A, et al. Intragastric pH during continuous infusion with pantoprazole in patients with bleeding peptic ulcer. Am J Gastroenterol 2003 98 : 2635 41.
14. Sung JJW, Chan FKL, Lau JYW, et al. The effect of endoscopic therapy in patients receiving omeprazole for bleeding ulcers with non-bleeding visible vessels or adherent clots. A randomised comparison. Ann Intern Med 2003 139 : 237 43.
15. Imperiale TF, Birgisson S. Somatostatin or octreotide compared with H-2 antagonists and placebo in the management of acute nonvariceal upper gastrointestinal hemorrhage: A meta-analysis. Ann Intern Med 1997 127 : 1062 71.
16. Lin HJ, Wang K, Perng CL, et al. Octeotide and heater probe thermocoagulation for arrest of peptic ulcer hemorrhage. A prospective, randomized controlled trial. J Clin Gastroenterol 1995 21 : 95 8.
17. Kayasseh L, Gyr K, Keller U, et al. Somatostatin and simetidine in peptic-ulcer haemorrhage. A randomised controlled trial. Lancet 1980 1 : 844 6.
18. Tulassay Z, Gupta R, Papp J, et al. Somatostatin versus cimetidine in the treatment of actively bleeding duodenal ulcer: A prospective randomized controlled trial. Am J Gastroenterol 1989 84 : 6 9.
19. Coraggio F, Rotondano G, Marmo R, et al. Somatostatin in the prevention of recurrent bleeding after endoscopic haemostasis of peptic ulcer haemorrhage: A preliminary report. Eur J Gastroenterol Hepatol 1998 10 : 673 6.
20. Nikolopoulou VN, Thomopoulos KC, Katsakoulis EC, et al. The effect of octreotide as an adjunct treatment in active nonvariceal upper gastrointestinal bleeding. J Clin Gastroenterol 2004 38 : 243 7.
21. Barkun A, Bardou M, Marshall JK. for the Nonvariceal Upper GI Bleeding Consensus Conference Group. Consensus recommendations for managing patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med 2003 139 : 843 57.
22. Forrest JAH, Finlayson NDC, Shearman DCJ. Endoscopy of upper gastrointestinal bleeding. Lancet 1974 2 : 394 7.
23. Rockall TA, Logan RFA, Devlin HB, et al. Incidence of and mortality from acute upper gastrointestinal haemorrhage. BMJ 1995 311 : 222 6.
24. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990 1 : 43 6.
25. Hsu P-I, Lo G-H, Lo C-C, et al. Intravenous pantoprazole versus ranitidine for prevention of rebleeding after endoscopic hemostasis of bleeding peptic ulcers. World J Gastroenterol 2004 10 : 3666 9.
26. Chalmhoff C, Creter D, Djaldetti M. The effect of pH on platelet and coagulation factor activities. Am J Surg 1978 136 : 257 9.
27. Lin HJ, Lo WC, Cheng WC, et al. Role of intravenous omeprazole in patients with high-risk peptic ulcer bleeding after successful endoscopic epinephrine injection: A prospective randomized comparative trial. Am J Gastroenterol 2006 101 : 500 5.
28. Schonekas H, Ahrens H, Pannewick U, et al. Comparison of two doses of intravenous pantoprazole in peptic ulcer bleeding. Gastroenterology 1999 116 : A305.
29. Schmassmann A, Reubi JC. Cholecystokinine-B/gastrin receptors enhance wound healing in the rat gastric mucosa. J Clin Invest 2000 106 : 1021 9.
30. Lanzon-Miller SP, Ounder RE, Hamilton MR, et al. Twenty-four hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia. Aliment Pharmacol Ther 1987 1 : 225 37.
31. Mirshahi F, Fowler G, Patel A, et al. Omeprazole may exert both a bacteriostatic and a bacteriocidal effect on the growth of Helicobacter pylori (NCTC 11637) in vitro by inhibiting bacterial urease activity. J Clin Pathol 1998 51 : 220 4.