1,25(OH)2D3 blocks TNF-induced monocytic tissue factor expression by inhibition of transcription factors AP-1 and NF-κB

Laboratory Investigation

Volumn 87, Issue 6, 2007, Pages 540-547

  Chung, Jihwa ^a   Koyama, Takatoshi ^a   Ohsawa, Mai ^a   Shibamiya, Aya ^a   Hoshi, Asuka ^a   Hirosawa, Shinsaku ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

1 ,25 dihydroxyvitamin D3; Activator protein 1; Monocytic cells; Nuclear factor B; Tissue factor; Tumor necrosis factor (TNF)

Indexed keywords

CALCITRIOL; EARLY GROWTH RESPONSE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN C JUN; THROMBOPLASTIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ASSAY; GEL MOBILITY SHIFT ASSAY; GENE VECTOR; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOPHARMACOLOGY; IN VITRO STUDY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CELLS, CULTURED; DIHYDROTACHYSTEROL; GENE EXPRESSION REGULATION; HUMANS; MONOCYTES; NF-KAPPA B; THROMBOPLASTIN; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34249043526     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700550     Document Type: Article

References (27)

1. Mackman N. Regulation of the tissue factor gene. Thromb Haemost 1997;78:747-754.
2. Oeth PA, Parry GC, Kunsch C, et al. Lipopolysaccharide induction of tissue factor gene expression in monocytic cells is mediated by binding of c-Rel/p65 heterodimers to a κB-like site. Mol Cell Biol 1994;14:3772-3781.
3. Conkling PR, Greenberg CS, Weinberg JB. Tumor necrosis factor induces tissue factor-like activity in human leukemia cell line U937 and peripheral blood monocytes. Blood 1988;72:128-133.
4. Lyberg T, Prydz H. Phorbol esters induce synthesis of thromboplastin activity in human monocytes. Biochem J 1981;194:699-706.
5. 2-terminal kinase is essential for the regulation of AP-1 by tumor necrosis factor. Mol Cell Biol 2003;23:2871-2882.
6. Fischer C, Page S, Weber M, et al. Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IκB kinase signalsome activation and IκB proteolysis. J Biol Chem 1999;274:24625-24632.
7. Guha M, O'Connell MA, Pawlinski R, et al. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor α expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 2001;98:1429-1439.
8. Reddy SA, Huang JH, Liao WS. Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFκB and AP-1 activation. J Biol Chem 1997;272:29167-29173.
9. Reddy SA, Huang JH, Liao WS. Phosphatidylinositol 3-kinase as a mediator of TNF-induced NF-κB activation. J Immunol 2000;164:1355-1363.
10. Brown AJ. Regulation of vitamin D action. Nephrol Dial Transplant 1999;14:11-16.
11. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998;78:1193-1231.
12. 3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation. Cancer Res 2004;64:5425-5433.
13. 3 on human myelogenous leukemia cells and monocytes. Blood 1998;92:160-167.
14. 3 and its potent synthetic analogs downregulate tissue factor and upregulate thrombomodulin expression in monocytic cells, counteracting the effects of tumor necrosis factor and oxidized LDL. Circulation 2000;102:2867-2872.
15. Aihara K, Azuma H, Akaike M, et al. Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice. J Biol Chem 2004;279:35798-35802.
16. 3 against LPS-induced DIC but not against tissue-factor-induced DIC in rat models. Thromb Haemost 2001;85:287-290.
17. Koyama T, Hirosawa S, Kawamata N, et al. All-trans retinoic acid upregulates thrombomodulin and downregulates tissue-factor expression in acute promyelocytic leukemia cells: distinct expression of thrombomodulin and tissue factor in human leukemic cells. Blood 1994;84:3001-3009.
18. Mackman N, Brand K, Edgington TS. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor κB binding sites. J Exp Med 1991;174:1517-1526.
19. 3 receptors. Cell 1991;65:1255-1266.
20. Mangelsdorf DJ, Borgmeyer U, Heyman RA, et al. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev 1992;6:329-344.
21. 2-plasmin inhibitor for degradation by the proteasome. J Biol Chem 2000;275:4981-4987.
22. Schüle R, Rangarajan P, Yang N, et al. Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci USA 1991;88:6092-6096.
23. Holschermann H, Schuster D, Parviz B, et al. Statins prevent NF-κB transactivation independently of the IKK-pathway in human endothelial cells. Atherosclerosis 2006;185:240-245.
24. Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002;277:32124-32132.
25. Sandur SK, Ichikawa H, Sethi G, et al. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-κB activation and NF-κB-regulated gene products through modulation of p65 and IκBα kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J Biol Chem 2006;281:17023-17033.
26. 3 decreases DNA binding of nuclear factor-κB in human fibroblasts. FEBS Lett 1998;436:329-334.
27. 3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol 2006;36:361-370.