How relevant were the models used to measure the impact of Panton-Valentine leukocidin in human staphylococcal infections? [2]

Journal of Infectious Diseases

Volumn 195, Issue 11, 2007, Pages 1726-1727

  Schwartzman, William A ^a,b,c   Beenhouwer, D O ^a,b,c   Schaberg, D R ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Section of Infectious Diseases   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PANTON VALENTINE LEUKOCIDIN;

BACTERIAL STRAIN; BACTERIUM CULTURE; LETTER; LEUKOCYTE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PRIORITY JOURNAL; SEPSIS; STAPHYLOCOCCUS INFECTION;

ABSCESS; ANIMALS; BACTERIAL TOXINS; COMMUNITY-ACQUIRED INFECTIONS; DISEASE MODELS, ANIMAL; EXOTOXINS; HUMANS; LEUKOCIDINS; METHICILLIN RESISTANCE; MICE; RABBITS; SEPSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE;

EID: 34249020728     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/517529     Document Type: Letter

References (5)

1. Voyich JM, Otto M, Mathema B, et al. Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistance Staphylococcus aureus disease? J Infect Dis 2006; 194:1761-70.
2. Grojec PL, Jeljaszewicz J. Effect of staphylococcal leukocidin on mouse leukocyte system. Zentralbl Bakteriol Mikrobiol Hyg [A] 1981; 250:446-55.
3. Rittirsch D, Hoesel LM, Ward PA. The disconnect between animal models of sepsis and human sepsis. J Leukoc Biol 2007; 81:137-43.
4. Lowy FD. Staphylococcus aureus infections. N Engl J Med 1998; 339:520-32.
5. Genestier AL, Michallet MC, Prevost G, et al. Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils. J Clin Invest 2005; 115:3117-27.