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1
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34249083324
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Mechanisms of critical illness: Classifying microcirculatory flow abnormalities in distributive shock
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Interesting review discussing the different types of microvascular alterations that can be observed. A classification is proposed, however the clinical relevance of these differences needs to be investigated
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Elbers PW, Ince C. Mechanisms of critical illness: classifying microcirculatory flow abnormalities in distributive shock. Crit Care 2006; 10:221. Interesting review discussing the different types of microvascular alterations that can be observed. A classification is proposed, however the clinical relevance of these differences needs to be investigated.
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Crit Care
, vol.10
, pp. 221
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Elbers, P.W.1
Ince, C.2
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2
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27144483559
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Microvascular dysfunction as a cause of organ dysfunction in severe sepsis
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Microvascular dysfunction as a cause of organ dysfunction in severe sepsis. Crit Care 2005; 9 (Suppl 4):S9-S12.
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Clinical manifestations of disordered microcirculatory perfusion in severe sepsis
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Clinical manifestations of disordered microcirculatory perfusion in severe sepsis. Crit Care 2005; (9 Suppl 4):S20-S26.
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Crit Care
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4
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How monitoring of the microcirculation may help us at the bedside
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Verdant C, De Backer D. How monitoring of the microcirculation may help us at the bedside. Curr Opin Crit Care 2005; 11:240-244.
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Curr Opin Crit Care
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Verdant, C.1
De Backer, D.2
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5
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0025796917
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Acute effects of tumor necrosis factor on the microcirculation in rat cremaster muscle
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Vicaut E, Hou X, Payen D, et al. Acute effects of tumor necrosis factor on the microcirculation in rat cremaster muscle. J Clin Invest 1991; 87:1537-1540.
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Vicaut, E.1
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Pannen BHJ, Bauer M, Zhang JX, et al. A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin. Am J Physiol Heart Circ Physiol 1996; 271:H1953-H1961.
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Pannen BHJ, Bauer M, Zhang JX, et al. A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin. Am J Physiol Heart Circ Physiol 1996; 271:H1953-H1961.
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7
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Keller S, Karaa A, Paxian M, et al. Inhibition of endothelin-1-mediated up-regulation of iNOS by bosentan ameliorates endotoxin-induced liver injury in cirrhosis. Shock 2006; 25:306-313. This study relates the improvement in liver microcirculation in sepsis during endothelin inhibition to nitric oxide.
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Keller S, Karaa A, Paxian M, et al. Inhibition of endothelin-1-mediated up-regulation of iNOS by bosentan ameliorates endotoxin-induced liver injury in cirrhosis. Shock 2006; 25:306-313. This study relates the improvement in liver microcirculation in sepsis during endothelin inhibition to nitric oxide.
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8
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34249090606
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Hepatic platelet and leukocyte adherence during endotoxemia
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Very important study investigating the mechanisms of sepsis-induced microvascular alterations
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Croner RS, Hoerer E, Kulu Y, et al. Hepatic platelet and leukocyte adherence during endotoxemia. Crit Care 2006; 10:R15. Very important study investigating the mechanisms of sepsis-induced microvascular alterations.
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Crit Care
, vol.10
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Croner, R.S.1
Hoerer, E.2
Kulu, Y.3
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9
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1942487804
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Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia
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Eipel C, Bordel R, Nickels RM, et al. Impact of leukocytes and platelets in mediating hepatocyte apoptosis in a rat model of systemic endotoxemia. Am J Physiol Gastrointest Liver Physiol 2004; 286:G769-G776.
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Am J Physiol Gastrointest Liver Physiol
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Eipel, C.1
Bordel, R.2
Nickels, R.M.3
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10
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4444368823
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Importance of platelets and fibrinogen in neutrophil-endothelial cell interactions in septic shock
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Kirschenbaum LA, McKevitt D, Rullan M, et al. Importance of platelets and fibrinogen in neutrophil-endothelial cell interactions in septic shock. Crit Care Med 2004; 32:1904-1909.
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Crit Care Med
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Kirschenbaum, L.A.1
McKevitt, D.2
Rullan, M.3
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11
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0043132448
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Alterations of red blood cell shape and sialic acid membrane content in septic patients
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Piagnerelli M, Boudjeltia KZ, Brohee D, et al. Alterations of red blood cell shape and sialic acid membrane content in septic patients. Crit Care Med 2003; 31:2156-2162.
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Crit Care Med
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Piagnerelli, M.1
Boudjeltia, K.Z.2
Brohee, D.3
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12
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21744447497
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Rapid alterations in transferrin sialylation during sepsis
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Piagnerelli M, Boudjeltia KZ, Nuyens V, et al. Rapid alterations in transferrin sialylation during sepsis. Shock 2005; 24:48-52.
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Shock
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Piagnerelli, M.1
Boudjeltia, K.Z.2
Nuyens, V.3
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13
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33847129228
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Suicidal erythrocyte death in sepsis
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16 December [Epub ahead of print, Demonstration of cell membrane alterations leading to adhesion of red blood cells to the endothelium, contributing to microvascular alterations and anemia
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Kempe DS, Akel A, Lang PA, et al. Suicidal erythrocyte death in sepsis. J Mol Med 2006; 16 December [Epub ahead of print]. Demonstration of cell membrane alterations leading to adhesion of red blood cells to the endothelium, contributing to microvascular alterations and anemia.
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J Mol Med
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Kempe, D.S.1
Akel, A.2
Lang, P.A.3
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14
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0034027838
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Influence of rheologic changes and platelet-neutrophil interactions on cell filtration in sepsis
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Kirschenbaum LA, Aziz M, Astiz ME, et al. Influence of rheologic changes and platelet-neutrophil interactions on cell filtration in sepsis. Am J Respir Crit Care Med 2000; 161:1602-1607.
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Am J Respir Crit Care Med
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Kirschenbaum, L.A.1
Aziz, M.2
Astiz, M.E.3
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15
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33745311155
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Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes
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Interesting study on glycocalyx alterations. Glycocalyx size was assessed by OPS, looking at changes in diameter obtained after passage of white blood cells that are much larger than red blood cells and that totally compress the glycocalyx
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Nieuwdorp M, Mooij HL, Kroon J, et al. Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes. Diabetes 2006; 55:1127-1132. Interesting study on glycocalyx alterations. Glycocalyx size was assessed by OPS, looking at changes in diameter obtained after passage of white blood cells that are much larger than red blood cells and that totally compress the glycocalyx.
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(2006)
Diabetes
, vol.55
, pp. 1127-1132
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Nieuwdorp, M.1
Mooij, H.L.2
Kroon, J.3
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16
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33751094014
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Comparison of buccal microcirculation between septic and hemorrhagic shock
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Alterations in microvascular blood flow are more severe in septic than in hemorrhagic shock, even though mean arterial pressure was similarly affected
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Fang X, Tang W, Sun S, et al. Comparison of buccal microcirculation between septic and hemorrhagic shock. Crit Care Med 2006; 34:S447-S453. Alterations in microvascular blood flow are more severe in septic than in hemorrhagic shock, even though mean arterial pressure was similarly affected.
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Crit Care Med
, vol.34
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Fang, X.1
Tang, W.2
Sun, S.3
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17
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0035888676
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Microcirculation in intestinal villi: A comparison between hemorrhagic and endotoxin shock
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Nakajima Y, Baudry N, Duranteau J, et al. Microcirculation in intestinal villi: a comparison between hemorrhagic and endotoxin shock. Am J Respir Crit Care Med 2001; 164:1526-1530.
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Am J Respir Crit Care Med
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Nakajima, Y.1
Baudry, N.2
Duranteau, J.3
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18
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0032828956
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Orthogonal polarization spectral imaging: A new method for study of the microcirculation
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Groner W, Winkelman JW, Harris AG, et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 1999; 5:1209-1212.
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Nat Med
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Groner, W.1
Winkelman, J.W.2
Harris, A.G.3
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19
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27144553471
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The microcirculation is the motor of sepsis
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The microcirculation is the motor of sepsis. Crit Care 2005; (9 Suppl 4):S13-S19.
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(2005)
Crit Care
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, Issue.SUPPL. 4
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20
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31344454525
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Increases in tissue PCO2 during circulatory shock reflect selective decreases in capillary blood flow
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Similar evolution in gut and sublingual blood flow in this model of endotoxic shock
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Fries M, Weil MH, Sun S, et al. Increases in tissue PCO2 during circulatory shock reflect selective decreases in capillary blood flow. Crit Care Med 2006; 34:446-452. Similar evolution in gut and sublingual blood flow in this model of endotoxic shock.
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Crit Care Med
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, pp. 446-452
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Fries, M.1
Weil, M.H.2
Sun, S.3
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22
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33845872563
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Trzeciak S, Dellinger RP, Parrillo JE, et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007; 49:88-98. Confirmatory study showing that microvascular blood flow alterations occur in patients with severe sepsis and septic shock, but patients were included earlier than in Ref. [21]. Confirms the relationship with outcome. Adds interesting data on the relationship between microvascular perfusion and oxygen extraction.
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Trzeciak S, Dellinger RP, Parrillo JE, et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007; 49:88-98. Confirmatory study showing that microvascular blood flow alterations occur in patients with severe sepsis and septic shock, but patients were included earlier than in Ref. [21]. Confirms the relationship with outcome. Adds interesting data on the relationship between microvascular perfusion and oxygen extraction.
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23
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Persistent microvasculatory alterations are associated with organ failure and death in patients with septic shock
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Sakr Y, Dubois MJ, De Backer D, et al. Persistent microvasculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004; 32:1825-1831.
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Crit Care Med
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Sakr, Y.1
Dubois, M.J.2
De Backer, D.3
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24
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0347416931
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Microvascular alterations in patients with acute severe heart failure and cardiogenic shock
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De Backer D, Creteur J, Dubois MJ, et al. Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J 2004; 147:91-99.
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Am Heart J
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, pp. 91-99
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De Backer, D.1
Creteur, J.2
Dubois, M.J.3
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25
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0036179577
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Orthogonal polarization spectral imaging (OPS): A novel method to measure the microcirculation in term and preterm infants transcutaneously
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Genzel-Boroviczeny O, Strotgen J, Harris AG, et al. Orthogonal polarization spectral imaging (OPS): a novel method to measure the microcirculation in term and preterm infants transcutaneously. Pediatr Res 2002; 51:386-391.
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Pediatr Res
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Genzel-Boroviczeny, O.1
Strotgen, J.2
Harris, A.G.3
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26
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Blood transfusion increases functional capillary density in the skin of anemic preterm infants
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Genzel-Boroviczeny O, Christ F, Glas V. Blood transfusion increases functional capillary density in the skin of anemic preterm infants. Pediatr Res 2004; 56:751-755.
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Pediatr Res
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Christ, F.2
Glas, V.3
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Direct observation of the human cerebral microcirculation during aneurysm surgery reveals increased arteriolar contractility
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Pennings FA, Bouma GJ, Ince C. Direct observation of the human cerebral microcirculation during aneurysm surgery reveals increased arteriolar contractility. Stroke 2004; 35:1284-1288.
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Pennings, F.A.1
Bouma, G.J.2
Ince, C.3
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28
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33745776969
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Continuous real-time visualization of the human cerebral microcirculation during arteriovenous malformation surgery using orthogonal polarization spectral imaging
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Nice illustration of the potential use of OPS in the operating field
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Pennings FA, Ince C, Bouma GJ. Continuous real-time visualization of the human cerebral microcirculation during arteriovenous malformation surgery using orthogonal polarization spectral imaging. Neurosurgery 2006; 59:167-171. Nice illustration of the potential use of OPS in the operating field.
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Neurosurgery
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, pp. 167-171
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Pennings, F.A.1
Ince, C.2
Bouma, G.J.3
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Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis
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Ellis CG, Bateman RM, Sharpe MD, et al. Effect of a maldistribution of microvascular blood flow on capillary O(2) extraction in sepsis. Am J Physiol 2002; 282:H156-H164.
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Am J Physiol
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Ellis, C.G.1
Bateman, R.M.2
Sharpe, M.D.3
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33744941056
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Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: Role of heterogeneous capillary spacing and blood flow
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Heart Circ Physiol, Demonstration of the role of heterogeneity of microvascular blood flow in the alterations in extraction capabilities. Confirmation that oxygen extraction is preserved in perfused capillaries, limiting the role of cytopathic hypoxia in early phases of sepsis
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Goldman D, Bateman RM, Ellis CG. Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow. Am J Physiol Heart Circ Physiol 2006; 290:H2277-H2285. Demonstration of the role of heterogeneity of microvascular blood flow in the alterations in extraction capabilities. Confirmation that oxygen extraction is preserved in perfused capillaries, limiting the role of cytopathic hypoxia in early phases of sepsis.
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Am J Physiol
, vol.290
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Goldman, D.1
Bateman, R.M.2
Ellis, C.G.3
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2. The good relation with gastric tonometry denotes the sublingual mucosa can be representative of other organs, including the gut.
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2. The good relation with gastric tonometry denotes the sublingual mucosa can be representative of other organs, including the gut.
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32
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31344453457
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The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects
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The authors reported an improvement in microvascular blood flow with dobutamine administration, but that this effect is quite variable. Importantly, this improvement had no relation with macrohemodynamics effects of the drug
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De Backer D, Creteur J, Dubois MJ, et al. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006; 34:403-408. The authors reported an improvement in microvascular blood flow with dobutamine administration, but that this effect is quite variable. Importantly, this improvement had no relation with macrohemodynamics effects of the drug.
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Crit Care Med
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, pp. 403-408
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De Backer, D.1
Creteur, J.2
Dubois, M.J.3
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Early goal-directed therapy in the treatment of severe sepsis and septic shock
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Rivers E, Nguyen B, Havstadt S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl JMed 2001; 345:1368-1377.
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Rivers, E.1
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Havstadt, S.3
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Dobutamine maintains intestinal villus blood flow during normotensive endotoxemia: An intravital microscopic study in the rat
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Secchi A, Wellmann R, Martin E, et al. Dobutamine maintains intestinal villus blood flow during normotensive endotoxemia: an intravital microscopic study in the rat. J Crit Care 1997; 12:137-141.
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Secchi, A.1
Wellmann, R.2
Martin, E.3
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35
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Effects of dobutamine and dopexamine on hepatic micro- and macrocirculation during experimental endotoxemia: An intravital microscopic study in the rat
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Secchi A, Ortanderl JM, Schmidt W, et al. Effects of dobutamine and dopexamine on hepatic micro- and macrocirculation during experimental endotoxemia: an intravital microscopic study in the rat. Crit Care Med 2001; 29:597-600.
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Secchi, A.1
Ortanderl, J.M.2
Schmidt, W.3
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36
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34249032621
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Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats
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Very important experimental study showing that dopexamine improves microvascular blood flow and that this effect may be related to a decrease in white blood cell adhesion to the endothelium
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Birnbaum J, Klotz E, Spies CD, et al. Effects of dopexamine on the intestinal microvascular blood flow and leukocyte activation in a sepsis model in rats. Crit Care 2006; 10:R117. Very important experimental study showing that dopexamine improves microvascular blood flow and that this effect may be related to a decrease in white blood cell adhesion to the endothelium.
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(2006)
Crit Care
, vol.10
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Birnbaum, J.1
Klotz, E.2
Spies, C.D.3
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37
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33746825988
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Leukocyte-platelet aggregate adhesion and vascular permeability in intact microvessels: Role of activated endothelial cells
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Heart Circ Physiol, Superb experimental study investigating the effects of isoproterenol on the endothelium after activation of inflammatory pathways
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He P, Zhang H, Zhu L, et al. Leukocyte-platelet aggregate adhesion and vascular permeability in intact microvessels: role of activated endothelial cells. Am J Physiol Heart Circ Physiol 2006; 291:H591-H599. Superb experimental study investigating the effects of isoproterenol on the endothelium after activation of inflammatory pathways.
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Am J Physiol
, vol.291
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He, P.1
Zhang, H.2
Zhu, L.3
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Nakajima Y, Baudry N, Duranteau J, et al. Effects of vasopressin, norepinephrine and L-arginine on intestinal microcirculation in endotoxemia. Crit Care Med 2006; 34:1752-1757. Very important study showing that vasopressor and vasodilatory agents minimally affect the microcirculation in nonresuscitated conditions but that a combination of vasopressor and vasodilatory agents markedly improved the microcirculation. These data also confirm the absence of a link between systemic and microvascular blood flows.
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Nakajima Y, Baudry N, Duranteau J, et al. Effects of vasopressin, norepinephrine and L-arginine on intestinal microcirculation in endotoxemia. Crit Care Med 2006; 34:1752-1757. Very important study showing that vasopressor and vasodilatory agents minimally affect the microcirculation in nonresuscitated conditions but that a combination of vasopressor and vasodilatory agents markedly improved the microcirculation. These data also confirm the absence of a link between systemic and microvascular blood flows.
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39
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1642451829
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Arginine vasopressin compromises gut mucosal microcirculation in septic rats
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Westphal M, Freise H, Kehrel BE, et al. Arginine vasopressin compromises gut mucosal microcirculation in septic rats. Crit Care Med 2004; 32:194-200.
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Crit Care Med
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Westphal, M.1
Freise, H.2
Kehrel, B.E.3
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Effect of vasopressin on sublingual microcirculation in a patient with distributive shock
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Dubois MJ, De Backer D, Creteur J, et al. Effect of vasopressin on sublingual microcirculation in a patient with distributive shock. Intensive Care Med 2003; 29:1020-1023.
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Dubois, M.J.1
De Backer, D.2
Creteur, J.3
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41
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Sublingual microcirculatory flow is impaired by the vasopressin-analogue terlipressin in a patient with catecholamine-resistant septic shock
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Boerma EC, van der Voort PH, Ince C. Sublingual microcirculatory flow is impaired by the vasopressin-analogue terlipressin in a patient with catecholamine-resistant septic shock. Acta Anaesthesiol Scand 2005; 49:1387-1390.
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Acta Anaesthesiol Scand
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Boerma, E.C.1
van der Voort, P.H.2
Ince, C.3
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42
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Nitroglycerin in septic shock after intravascular volume resuscitation
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Spronk PE, Ince C, Gardien MJ, et al. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002; 360:1395-1396.
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Lancet
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Spronk, P.E.1
Ince, C.2
Gardien, M.J.3
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43
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33744551974
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L-arginine and vasopressor agents: When antagonists have unexpected synergistic effects
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Editorial discussing why vasodilatory and vasopressor agents may have synergistic rather than opposed effects on the microcirculation
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De Backer D. L-arginine and vasopressor agents: when antagonists have unexpected synergistic effects. Crit Care Med 2006; 34:1847-1849. Editorial discussing why vasodilatory and vasopressor agents may have synergistic rather than opposed effects on the microcirculation.
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Crit Care Med
, vol.34
, pp. 1847-1849
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De Backer, D.1
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44
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13444303827
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Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model
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Iba T, Kidokoro A, Fukunaga M, et al. Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model. Crit Care Med 2005; 33:368-372.
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Crit Care Med
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Iba, T.1
Kidokoro, A.2
Fukunaga, M.3
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45
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34249083323
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Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat
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Important experimental study relating the microvascular effects of activated protein C to its effects on the interaction between white blood cells and the endothelium
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Lehmann C, Meissner K, Knock A, et al. Activated protein C improves intestinal microcirculation in experimental endotoxaemia in the rat. Crit Care 2006; 10:R157. Important experimental study relating the microvascular effects of activated protein C to its effects on the interaction between white blood cells and the endothelium.
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Crit Care
, vol.10
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Lehmann, C.1
Meissner, K.2
Knock, A.3
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46
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33745603201
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Effects of drotecogin alfa activated on microcirculatory alterations in patients with severe sepsis
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Important study showing that activated proteinC administration rapidly improves the microcirculation in patients with severe sepsis. A deterioration in the microcirculation of variable magnitude was observed after stopping the activated protein C infusion
-
De Backer D, Verdant C, Chierego M, et al. Effects of drotecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 2006; 34:1918-1924. Important study showing that activated proteinC administration rapidly improves the microcirculation in patients with severe sepsis. A deterioration in the microcirculation of variable magnitude was observed after stopping the activated protein C infusion.
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(2006)
Crit Care Med
, vol.34
, pp. 1918-1924
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De Backer, D.1
Verdant, C.2
Chierego, M.3
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47
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33748121400
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Effect of recombinant activated protein C and low-dose heparin on neutrophil-endothelial cell interactions in septic shock
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Experimental study on endothelial cultured cells showing that activated protein C attenuates leukocyte-endothelium interactions in the presence of plasma from patients in severe sepsis
-
Kirschenbaum LA, Lopez WC, Ohrum P, et al. Effect of recombinant activated protein C and low-dose heparin on neutrophil-endothelial cell interactions in septic shock. Crit Care Med 2006; 34:2207-2212. Experimental study on endothelial cultured cells showing that activated protein C attenuates leukocyte-endothelium interactions in the presence of plasma from patients in severe sepsis.
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Crit Care Med
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Kirschenbaum, L.A.1
Lopez, W.C.2
Ohrum, P.3
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48
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