Synthesis of asymmetric halomesylate mustards with aziridineethanol/alkali metal halides: application to an improved synthesis of the hypoxia prodrug PR-104

Tetrahedron

Volumn 63, Issue 25, 2007, Pages 5470-5476

  Yang, Shangjin ^a   Atwell, Graham J ^a   Denny, William A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Aniline mustard; Asymmetric mustard synthesis; Aziridineethanol; PR 104

Indexed keywords

ALKALI METAL; ANTINEOPLASTIC AGENT; AZIRIDINE DERIVATIVE; BROMOMESYLATE MUSTARD; CARBOXYLIC ACID; CHLORIDE; HALIDE; HALOALCOHOL; ORGANOPHOSPHATE; PR 104; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG STRUCTURE; DRUG SYNTHESIS; HYPOXIA; PRIORITY JOURNAL; REACTION ANALYSIS;

BRASSICACEAE;

EID: 34248996204     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.04.044     Document Type: Article

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