New antitumoral acetogenin 'Guanacone type' derivatives: Isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 13, 2007, Pages 4369-4381

  Barrachina, Isabel ^a   Royo, Inmaculada ^b   Baldoni, Héctor A ^c,d   Chahboune, Nadia ^a   Suvire, Fernando ^c   DePedro, Nuria ^b   Zafra Polo, M Carmen ^a   Bermejo, Almudena ^a   El Aouad, Noureddine ^a   Cabedo, Nuria ^a   Saez, Jairo ^e   Tormo, José R ^b   Enriz, Ricardo D ^c   Cortes, Diego ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

^c UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

^d Instituto de Matematica Aplicada San Luis   (Argentina)

^e UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

Annonaceae acetogenins; Mitochondrial complex I; Molecular dynamics simulation; Tumor cell lines

Indexed keywords

15 ACETYLGUANACONE; 15,24 DIACETYLGUANACONE; 24 ACETYLGUANACONE; ACETOGENIN; ANTINEOPLASTIC AGENT; DIACETYLGUANACONE; DOXORUBICIN; PLANT EXTRACT; ROTENONE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; MITOCHONDRIAL RESPIRATION; SUSTAINED RELEASE PREPARATION; TUMOR CELL;

ANNONA; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; COMPUTER SIMULATION; ELECTRON TRANSPORT; FATTY ALCOHOLS; FURANS; HUMANS; HYDROGEN BONDING; INDICATORS AND REAGENTS; LACTONES; LIPID BILAYERS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHATIDYLCHOLINES; SEEDS;

ANNONACEAE;

EID: 34248683917     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.04.039     Document Type: Article

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