Screening, purification, and identification of annexin B1 mutants with high phosphatidylserine-binding activity and reduced immunogenicity

Applied Microbiology and Biotechnology

Volumn 75, Issue 3, 2007, Pages 539-548

  Wang, Fang ^a   Luo, Quan Yong ^b   He, Ying ^a   Sun, Shu Han ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

99mTc; Annexin B1; Apoptosis imaging; Immunogenicity

Indexed keywords

ANNEXIN B1; APOPTOSIS IMAGING; IMMUNOGENICITY; PHYSIOLOGICAL CONCENTRATIONS;

AMINO ACIDS; CALCIUM; MEMBRANES; PHOSPHOLIPIDS; PURIFICATION; SCREENING;

PROTEINS;

ANNEXIN; ANNEXIN B1; FLUORESCEIN ISOTHIOCYANATE; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; IMMUNOGLOBULIN G; MUTANT PROTEIN; OLIGONUCLEOTIDE; PHOSPHATIDYLSERINE; TECHNETIUM 99M; UNCLASSIFIED DRUG;

AMINO ACID; ANTIBODY; APOPTOSIS; CALCIUM; GENE EXPRESSION; IMMUNE SYSTEM; IMMUNITY; IMMUNOCOMPETENCE; MUTATION; PHOSPHOLIPID; PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL DEATH; CONTROLLED STUDY; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MOLECULAR IMAGING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; WILD TYPE;

ANIMALS; ANNEXINS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCEIN-5-ISOTHIOCYANATE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; KIDNEY; LIVER; MICE; MICE, INBRED BALB C; MODELS, GENETIC; MUTATION; PHOSPHATIDYLSERINES; PLASMIDS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

MUS;

EID: 34248675210     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-007-0866-3     Document Type: Article

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