Preparation, in vitro and in vivo evaluation of 99mTc-Annexin B1: A novel radioligand for apoptosis imaging

Biochemical and Biophysical Research Communications

Volumn 335, Issue 4, 2005, Pages 1102-1106

  Luo, Quan Yong ^a   Zhang, Zhi Yong ^b   Wang, Fang ^c   Lu, Han Kui ^a   Guo, Yu Zhi ^b   Zhu, Rui Sen ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Radiopharmaceutical Lab   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

99mTc; Annexin B1; Apoptosis; Radionuclide imaging; Radiopharmaceutical

Indexed keywords

ANNEXIN B1 TC 99M; CALCIUM; DRUG BINDING PROTEIN; FAS ANTIBODY; PHOSPHATIDYLSERINE; RADIOLIGAND; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SYNTHESIS; ISOTOPE LABELING; KIDNEY; LIVER HISTOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOCHEMISTRY; THROMBOCYTE ACTIVATION;

ANIMALS; ANNEXINS; APOPTOSIS; BLOOD PLATELETS; CELLS, CULTURED; DRUG STABILITY; HUMANS; ISOTOPE LABELING; MICE; MICE, INBRED BALB C; ORGAN SPECIFICITY; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; TISSUE DISTRIBUTION;

EID: 24044550004     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.07.188     Document Type: Article

References (23)

1. C.B. Thompson Apoptosis in the pathogenesis and treatment of disease Science 267 1995 1456 1462
2. P. Saikumar, Z. Dong, V. Mikhailov, M. Denton, J.M. Weinberg, and M.A. Venkatachalam Apoptosis: definition, mechanisms, and relevance to disease Am. J. Med. 107 1999 489 506
3. T.L. Yue, E.H. Ohlstein, and R.R. Ruffolo Apoptosis: a potential target for discovering novel therapies for cardiovascular diseases Curr. Opin. Chem. Biol. 3 1999 474 480
4. P.C.A. Kam, and N.I. Ferch Apoptosis: mechanisms and clinical implications Anaesthesia 55 2000 1081 1093
5. S.W. Lowe, and A.W. Lin Apoptosis in cancer Carcinogenesis 21 2000 485 495
6. J.F.R. Kerr, C.M. Winterford, and B.V. Harmon Apoptosis: its significance in cancer and cancer therapy Cancer 73 1994 2013 2026
7. W.L. Van Heerde, P.G. de Groot, and C.P.M. Reutelingsperger The complexity of the phospholipid binding protein Annexin V Thromb. Haemost. 73 1995 172 179
8. G. Zhang, V. Gurtu, S.R. Kain, and G. Yan Early detection of apoptosis using a fluorescent conjugate of Annexin V Biotechniques 23 1997 525 531
9. F.G. Blankenberg, P.D. Katsikis, J.F. Tait, R.E. Davis, L. Naumovski, K. Ohtsuki, S. Kopiwoda, M.J. Abrams, M. Darkes, R.C. Robbins, H.T. Maecker, and H.W. Strauss In vivo detection and imaging of phosphatidylserine expression during programmed cell death Proc. Natl. Acad. Sci. USA 95 1998 6349 6354
10. 99mTc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis Clin. Cancer Res. 8 2002 2766 2774
11. 99mTc-HYNIC-Annexin V, a novel human recombinant Annexin V for human application J. Nucl. Med. 44 2003 947 952
12. 2+-dependent phospholipid binding protein, expressed in Escherichia coli by ion-exchange chromatography Chromatographia 58 2003 713 716
13. F. Wang, Y. Zhang, H.L. Yan, Y.J. Gao, F. Liu, Y. He, and S.H. Sun Binding activity of Annexin B1 to externalized phosphatidylserine (in chinese) Acad. J. Sec. Mil. Med. Univ. 25 2004 44 46
14. Y. Zhang, Y.J. Guo, F. Wang, Y.J. Gao, H.L. Yan, and S.H. Sun Annexin B1 as a novel protein for detecting apoptosis (in chinese) Acad. J. Sec. Mil. Med. Univ. 24 2003 333 334
15. 99mTc-pertechnetate at pH 7.4 Int. J. Appl. Radiat. Isot. 29 1978 251 253
16. G. Leoncini, M. Maresca, E. Buzzi, A. Piana, and U. Armani Platelets of patients affected with essential thrombocythemia are abnormal in plasma membrane and adenine nucleotide content Eur. J. Haematol. 44 1990 116 120
17. J. Ogasawara, R. Watanabe-Fukunaga, and M. Adachi Lethal effects of the anti-fas antibody in mice Nature 364 1993 806 809
18. S. Liu The role of coordination chemistry in the development of target specific radiopharmaceuticals Chem. Soc. Rev. 33 2004 445 461
19. 99mTc-labelled peptides Q. J. Nucl. Med. 46 2002 195 205
20. 99mTc Annexin V J. Nucl. Med. 40 1999 184 191
21. K. Ohtsuki, K. Akashi, Y. Aoka, F.G. Blankenberg, S. Kopiwoda, J.F. Tait, and H.W. Strauss Technetium-99m HYNIC-Annexin V: a potential radiopharmaceutical for the in vivo detection of apoptosis Eur. J. Nucl. Med. 26 1999 1251 1258
22. J.F. Tait, M.D. Cerqueira, T.A. Dewhurst, K. Fujikawa, J.L. Ritchie, and J.R. Stratton Evaluation of Annexin V as a platelet-directed thrombus targeting agent Thromb. Res. 75 1994 491 501
23. N. Sterin-Speziale, V.L. Kahane, C.P. Setton, M.C. Fernandez, and E.H. Speziale Compartmental study of rat renal phospholipids metabolism Lipids 27 1992 10 14