Immunostimulatory effects of the anionic alkali mineral complex BARODON on equine lymphocytes

Clinical and Vaccine Immunology

Volumn 13, Issue 11, 2006, Pages 1255-1266

  Hye, Cheong Koo ^a   Ryu, Seung Ho ^a,b   Hyung, Jin Ahn ^c   Woo, Kyung Jung ^a   Young, Kyung Park ^a   Nam, Hoon Kwon ^a   So, Hyun Kim ^a   Jun, Man Kim ^a   Byung, Woo Yoo ^c   Soo, Il Choi ^d   Davis, William C ^e   Yong, Ho Park ^a  

^a Seoul National University   (South Korea)

^b Equine Hospital   (South Korea)

^c Agribrands Purina Korea Inc   (South Korea)

^d Barodon SF Corp   (South Korea)

^e WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALI; AMIKACIN; AMOXICILLIN; AMPICILLIN; BACITRACIN; BARODON; CEFALOTIN; CEFTIOFUR; COTRIMOXAZOLE; DIFFERENTIATION ANTIGEN; ENROFLOXACIN; ERYTHROMYCIN; GENTAMICIN; ISCOM; KANAMYCIN; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN; MONOCLONAL ANTIBODY; NEOMYCIN; OXACILLIN; PENICILLIN G; PHYTOHEMAGGLUTININ; POLYMYXIN B; STREPTOMYCIN; TETRACYCLINE; TRIMETHOPRIM; UNCLASSIFIED DRUG; ANION; IMMUNOLOGICAL ADJUVANT; MINERAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG MECHANISM; DRUG SENSITIVITY; HORSE; HORSE DISEASE; INFECTION RESISTANCE; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RESPIRATORY TRACT DISEASE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS EQUI; T LYMPHOCYTE SUBPOPULATION; ANIMAL; ANIMAL FOOD; CELL CULTURE; CYTOLOGY; IMMUNOLOGY; LYMPHOCYTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; SOLUTION AND SOLUBILITY;

ADJUVANTS, IMMUNOLOGIC; ALKALIES; ANIMAL FEED; ANIMALS; ANIONS; CELL PROLIFERATION; CELLS, CULTURED; HORSES; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MINERALS; SOLUTIONS;

EID: 34248656721     PISSN: 15566811     EISSN: None     Source Type: Journal    
DOI: 10.1128/CVI.00150-06     Document Type: Article

References (75)

1. Ababou, A., W. C. Davis, and D. Levy. 1993. The DA6-147 monoclonal antibody raised against HLA-DR alpha chain identifies a cryptic epitope on the BoLA-DR alpha chain. Ann. Rech. Vet. 24:402-407.
2. Ababou, A., J. Goyeneche, W. C. Davis, and D. Levy. 1994. Evidence for the expression of three different BoLA-class II molecules on the bovine BL-3 cell line: determination of a non-DR non-DQ gene product. J. Leukoc. Biol. 56:182-186.
3. Antonini, J. M., J. R. Roberts, H. M. Yang, M. W. Barger, D. Ramsey, V. Castranova, and J. Y. Ma. 2000. Effect of silica inhalation on the pulmonary clearance of a bacterial pathogen in Fischer 344 rats. Lung 178:341-350.
4. Antonini, J. M., H. M. Yang, J. Y. Ma, J. R. Roberts, M. W. Barger, L. Butterworth, T. G. Charron, and V. Castranova. 2000. Subchronic silica exposure enhances respiratory defense mechanisms and the pulmonary clearance of Listeria monocytogenes in rats. Inhal. Toxicol. 12:1017-1036.
5. Biddison, W. E., and S. Shaw. 1989. CD4 expression and function in HLA class II-specific T cells. Immunol. Rev. 109:5-15.
6. + T cells and expression of MHC class I and MHC class II antigen in horses with borna disease virus-induced encephalitis. Brain Pathol. 5:223-230.
7. Bolin, S. R., A. W. McClurkin, and M. F. Colia. 1985. Effects of bovine viral diarrhea virus on the percentages and absolute numbers of circulating B and T lymphocytes in cattle. Am. J. Vet. Res. 46:884-886.
8. Borm, P. J., N. Palmen, J. J. Engelen, and W. A. Buurman. 1988. Spontaneous and stimulated release of tumor necrosis factor-alpha (TNF) from blood monocytes of miners with coal workers' pneumoconiosis. Am. Rev. Respir. Dis. 138:1589-1594.
9. Brodersen, R., F. Bijlsma, K. Gori, K. T. Jensen, W. Chen, J. Dominguez, K. Haverson, P. F. Moore, A. Saalmuller, D. Sachs, W. J. Slierendrecht, C. Stokes, O. Vainio, F. Zuckermann, and B. Aasted. 1998. Analysis of the immunological cross reactivities of 213 well characterized monoclonal antibodies with specificities against various leucocyte surface antigens of human and 11 animal species. Vet. Immunol. Immunopathol. 64:1-13.
10. Choi, S. I., H. S. Choi, K. S. Jeon, B. W. Yoo, and Y. H. Park. 10 September 2002. Composition of multipurpose high functional alkaline solution composition, preparation thereof, and for the use of nonspecific immunostimulators. U.S. patent 6,447,810 B1.
11. Choi, S. I., H. S. Choi, K. S. Jeon, B. W. Yoo, and Y. H. Park. 26 March 2002. Composition of multipurpose high functional alkaline solution composition, preparation thereof, and for the use of nonspecific immunostimulators. Patent no. 0331952, Korea (application no. 2000-0070054).
12. Choi, S. I., H. S. Choi, K. S. Jeon, B. W. Yoo, and Y. H. Park. 6 January 2004. Composition of multipurpose high functional alkaline solution composition, preparation thereof, and for the use of nonspecific immunostimulators. U.S. patent 6,673,375 B2.
13. Choi, S. I., H. S. Choi, K. S. Jeon, B. W. Yoo, and Y. H. Park. 28 January 2004. Composition of multipurpose high functional alkaline solution composition, preparation thereof, and for the use of nonspecific immunostimulators. Patent no. 2003/3337, Republic of South Africa.
14. + lymphocyte subsets by dual parameter flow cytometry. J. Immunol. Methods 97:165-171.
15. Davis, W. C., S. Marusic, H. A. Lewin, G. A. Splitter, L. E. Perryman, T. C. McGuire, and J. R. Gorham. 1987. The development and analysis of species specific and cross reactive monoclonal antibodies to leukocyte differentiation antigens and antigens of the major histocompatibility complex for use in the study of the immune system in cattle and other species. Vet. Immunol. Immunopathol. 15:337-376.
16. Emmerich, R., K. Pachmann, and D. Milatovic. 1992. Influence of OM-85 BV on different humoral and cellular immune defense mechanisms of the respiratory tract. Respiration 59:19-23.
17. Erf, G. F., W. G. Bottje, and T. K. Bersi. 1998. CD4, CD8 and TCR defined T-cell subsets in thymus and spleen of 2- and 7-week old commercial broiler chickens. Vet. Immunol. Immunopathol. 62:339-348.
18. Flaminio, M. J., B. R. Rush, and W. Shuman. 1998. Immunologic function in horses after non-specific immunostimulant administration. Vet. Immunol. Immunopathol. 63:303-315.
19. Flaminio, M. J., B. R. Rush, E. G. Davis, K. Hennessy, W. Shuman, and M. J. Wilkerson. 2002. Simultaneous flow cytometric analysis of phagocytosis and oxidative burst activity in equine leukocytes. Vet. Res. Commun. 26:85-92.
20. Freeman, K. P., J. F. Roszel, J. M. McClure, R. Mannsman, P. E. Patton, and S. Naile. 1993. A review of cytological specimens from horses with and without clinical signs of respiratory disease. Equine Vet. J. 25:523-526.
21. Furr, M. O., M. V. Crisman, J. Robertson, O. Barta, and W. S. Swecker, Jr. 1992. Immunodeficiency associated with lymphosarcoma in a horse. J. Am. Vet. Med. Assoc. 201:307-309.
22. Gabrilivich, D., and L. Serebrovskaya. 1991. Assessment of phagocytic activity in whole blood using laser flow cytometry. J. Immunol. Methods 140: 289-290.
23. Garn, H., A. Friedetzky, G. S. Davis, D. R. Hemenway, and D. Gemsa. 1997. T-lymphocyte activation in the enlarged thoracic lymph nodes of rats with silicosis. Am. J. Respir. Cell. Mol. Biol. 16:309-316.
24. Grabstein, K., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, L. Johnson, M. R. Alderson, J. D. Watson, D. M. Anderson, and J. G. Giri. 1994. Cloning of T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965.
25. Greene, W. C., J. M. Depper, M. Kronke, and W. J. Leonard. 1986. The human interleukin-2 receptor: analysis of structure and function. Immunol. Rev. 92:29-48.
26. Hadden, J. W. 1993. Immunostimulants. Immunol. Today 14:275.
27. 2 in horses with chronic obstructive pulmonary disease and the effect of lobelin hydrochloride on these indices. Vet. Res. Commun. 25:401-412.
28. Herrmann, L. M., W. P. Cheevers, W. C. Davis, D. P. Knowles, and K. I. O'Rourke. 2003. CD21-positive follicular dendritic cells: a possible source of PrPSc in lymph node macrophages of scrapie-infected sheep. Am. J. Pathol. 162:1075-1081.
29. Higgins, D. A. 1981. Markers for T and B lymphocytes and their application to animals. Vet. Bull. 51:925-963.
30. Horohov, D. W., A. Dimock, P. Guirnalda, R. W. Folsom, K. H. McKever, and K. Malinowski. 1999. Effect of exercise on the immune response of young and old horses. Am. J. Vet. Res. 60:643-647.
31. Horohov, D. W., J. H. Kydd, and D. Hannant. 2002. The effect of aging on T cell responses in the horse. Dev. Comp. Immunol. 26:121-128.
32. Hviid, L., A. Felsing, and T. G. Theander. 1993. Kinetics of human T-cell expression of LFA-1, IL-2 receptor, and ICAM-1 following antigenic stimulation in vitro. J. Clin. Lab. Immunol. 40:163-171.
33. Kumar, R. K. 1989. Quantitative immunohistologic assessment of lymphocyte populations in the pulmonary inflammatory response to intratracheal silica. Am. J. Pathol. 135:605-614.
34. Kumar, R. K., W. Li, and R. O'Grady. 1990. Activation of lymphocytes in the pulmonary inflammatory response to silica. Immunol. Investig. 19:363-372.
35. Kydd, J., D. F. Antczak, W. R. Allen, D. Barbis, G. Butcher, W. Davis, W. P. Duffus, N. Edington, G. Grünig, M. A. Holmes, D. P. Lunn, J. McCulloch, A. O'Brien, L. E. Perryman, A. Tavernor, S. Williamson, and C. Zhang. 1994. Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, United Kingdom, July 1991. Vet. Immunol. Immunopathol. 42:3-60.
36. Lunney, J. K., K. Walker, T. Goldman, B. Aasted, A. Bianchi, R. Binns, S. Licence, R. Bischof, M. Brandon, F. Blecha, T. L. Kielian, D. S. McVey, R. M. Chu, M. Carr, C. Howard, P. Sopp, W. Davis, P. Dvorak, J. Dominguez, A. Canals, J. M. Sanchez Vizcaino, Y. B. Kim, H. Laude, C. R. Mackay, U. Magnusson, K. McCullough, M. Misfeldt, M. Murtaugh, T. Molitor, C. Choi, R. Pabst, R. M. Parkhouse, S. Denham, H. Yang, M. Pescovitz, R. Pospisil, H. Tlaskalova, A. Saalmueller, E. Weiland, H. Salmon, D. Sachs, S. Arn, M. Shimizu, C. Stokes, K. Stevens, L. Valpotic, F. Zuckermann, and R. Husmann. 1994. Overview of the first international workshop to define swine leukocyte cluster of differentiation (CD) antigens. Vet. Immunol. Immunopathol. 43:193-206.
37. Marlin, D. J., C. A. Roberts, R. C. Schroter, and P. Lekeux. 2000. Respiratory responses of mature horses to intravenous lobeline bolus. Equine Vet. J. 32:200-207.
38. Marr, K. A., M. Koudadoust, M. Black, and S. A. Balajee. 2001. Early events in macrophage killing of Aspergillus fumigatus conidia: new flow cytometric viability assay. Clin. Diagn. Lab. Immunol. 8:1240-1247.
39. Massoco, C., and J. Palermo-Neto. 2003. Effects of midazolam on equine innate immune response: a flow cytometric study. Vet. Immunol. Immunopathol. 95:11-19.
40. Mohr, C., D. Gemsa, C. Graebner, D. R. Hemenway, K. O. Leslie, P. M. Absher, and G. S. Davis. 1991. Systemic macrophage stimulation in rats with silicosis: enhanced release of tumor necrosis factor-alpha from alveolar and peritoneal macrophages. Am. J. Respir. Cell. Mol. Biol. 5:395-402.
41. Moore, B. R. 1996. Lower respiratory tract disease. Vet. Clin. N. Am. Equine Pract. 12:457-472.
42. Moore, B. R., S. Krakowka, J. M. Cummins, and J. T. Robertson. 1996. Changes in airway inflammatory cell populations in standard bred racehorses after interferon-alpha administration. Vet. Immunol. Immunopathol. 49:347-358.
43. Moore, B. R., S. Krakowska, and J. T. Robertson. 1996. Evaluation of an immunostimulant in preventing shipping related respiratory disease. J. Equine Vet. Sci. 16:78.
44. Noguchi, M., Y. Nakamura, S. M. Russell, S. F. Ziegler, M. Tsang, X. Cao, and W. J. Leonard. 1993. Interleukin-2 receptor (gamma) chain: a functional component of the interleukin-7 receptor. Science 262:1877.
45. Park, B. K., Y. H. Park, and K. S. Seo. 1999. Lymphocyte subpopulations of peripheral blood in pigs treated with an ionized alkali mineral complex. Seoul Univ. J. Vet. Sci. 24:67-74.
46. Pighetti, G. M., and L. D. Sordillo. 1996. Specific immune response of dairy cattle after primary inoculation with recombinant bovine interferon-gamma as an adjuvant when vaccinating against mastitis. Am. J. Vet. Res. 57:819-824.
47. Ragle, C., R. A. Jack, and C. Klimczak. 1992. Round-table discussion: EqStim immunostimulant. J. Equine Vet. Sci. 12:209.
48. Rees, R. C., and H. Parry. 1991. Macrophages in tumor immunity, p. 3-423. In C. E. Lewis and J. O. McGee (ed.), Macrophage. IRL Press, New York, N.Y.
49. Robb, R. J., W. C. Greene, and C. M. Rusk. 1984. Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen. J. Exp. Med. 160:1126-1146.
50. Rossdale, P. D., R. Hopes, N. J. Digby, and K. Offord. 1985. Epidemiological study of wastage among racehorses 1982 and 1983. Vet. Rec. 116:66-69.
51. Rush, B. R., and M. J. Flaminio. 2000. Immunomodulation in horses. Vet. Clin. N. Am. Equine Pract. 16:183-197.
52. Russell, S. M., A. D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M. C. Friedmann, A. Miyajima, R. K. Puri, W. E. Paul, and W. J. Leonard. 1993. Interleukin-2 receptor (gamma) chain: a functional component of the interleukin-4 receptor. Science 262:1880.
53. Russell, S. M., J. A. Johnston, M. Noguchi, M. Kawamura, C. M. Bacon, M. C. Friedmann, M. Berg, D. W. McVicar, B. A. Witthuhn, O. Silvennoinen, A. S. Goldman, F. C. Schmalstieg, J. N. Ihle, J. J. O'Shea, and W. J. Leonard. 1994. Interaction of IL-2R (beta) and (gamma)/sub c/ chains with Ja. Science 266:1042.
54. Sager, H., W. C. Davis, D. A. Dobbelaere, and T. W. Jungi. 1997. Macrophage-parasite relationship in theileriosis. Reversible phenotypic and functional dedifferentiation of macrophages infected with Theileria annulata. J. Leukoc. Biol. 61:459-468.
55. Schwab, R., L. M. Pfeffer, P. Szabo, D. Gamble, C. M. Schnurr, and M. E. Weksler. 1990. Defective expression of high affinity IL-2 receptors on activated T cells from aged humans. Int. Immunol. 2:239-246.
56. + suppressor lymphocytes alter immune responsiveness during the postpartum period. Vet. Immunol. Immunopathol. 56:53-64.
57. Smith, K. A. 1998. Interleukin-2: inception, impact, and implications. Science 240:1169-1176.
58. Song, L., Y. H. Kim, R. K. Chopra, J. J. Proust, J. E. Nagel, A. A. Nordin, and W. H. Adler. 1993. Age-related effects in T cell activation and proliferation. Exp. Gerontol. 28:313-321.
59. Speert, D. P. 1991. Macrophages in bacterial infection, p. 3-423. In C. E. Lewis and J. O. McGee (ed.), Macrophage. IRL Press, New York, N.Y.
60. Studer, U., E. Marti, D. Stornetta, S. Lazary, and H. Gerber. 1997. The therapy of equine sarcoid with a non-specific immunostimulator-the epidemiology and spontaneous regression of sarcoids. Schweiz. Arch. Tierheilkd. 139:385-391.
61. Sweeney, C. R., R. H. Whitlock, D. A. Meirs, S. C. Whitehead, and S. O. Barningham. 1987. Complications associated with Streptococcus equi infection on a horse farm. J. Am. Vet. Med. Assoc. 191:1446-1448.
62. Sweeney, C. R., C. E. Benson, R. H. Whitlock, D. A. Meirs, S. O. Barningham, S. C. Whitehead, and D. Cohen. 1989. Description of an epizootic and persistence of Streptococcus equi infections in horses. J. Am. Vet. Med. Assoc. 194:1281-1286.
63. Tizard, I. 1992. Veterinary immunology, 3rd ed., p. 72-84. W. B. Saunders, Philadelphia, Pa.
64. Tizard, I. 1993. Treatment of respiratory disease by means of immunomodulators. Presented at the 12th Annual Meeting of the Veterinary Comparative Respiratory Society, Kennett Square, Pa.
65. Tumas, D. B., A. L. Brassfield, A. S. Travenor, M. T. Hines, W. C. Davis, and T. C. McGuire. 1994. Monoclonal antibodies to the equine CD2 T lymphocyte marker, a pan-granulocyte/monocyte marker and a unique pan-B lymphocyte marker. Immunobiology 192:48-64.
66. Tunon, A. M., H. Rodriguez-Martinez, A. Nummijarvi, and U. Magnusson. 1999. Influence of age and parity on the distribution of cells expressing major histocompatibility complex class II, CD4, or CD8 molecules in the endometrium of mares during estrus. Am. J. Vet. Res. 60:1531-1535.
67. Vail, C. D., A. J. Nestved, and J. B. Martins. 1990. Adjunct treatment of equine respiratory disease complex (ERDC) with the Propionibacterium acnes immunostimulant, EqStim. J. Equine Vet. Sci. 10:399.
68. Weingartl, H. M., M. Sabara, J. Pasick, E. van Moorlehem, and L. Babiuk. 2002. Continuous porcine cell lines developed from alveolar macrophages: partial characterization and virus susceptibility. J. Virol. Methods 104:203-216.
69. Westermann, J., and R. Pabst. 1990. Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system? Immunol. Today 11:406-410.
70. Woldehiwet, Z. 1991. Lymphocyte subpopulations in peripheral blood of sheep experimentally infected with tick-borne fever. Res. Vet. Sci. 51:40-43.
71. Wong, C. W., H. L. Thomson, and Y. H. Thong. 1990. Effect of strenuous exercise on chemiluminescence response of equine alveolar macrophages. Equine Vet. J. 22:33-35.
72. Yelle, M. T. 1987. Clinical aspects of Streptococcus equi infection. Equine Vet. J. 19:158-162.
73. Yoo, B. W., S. I. Choi, S. H. Kim, S. J. Yang, H. C. Koo, N. H. Kown, S. H. Seo, B. K. Park, H. S. Yoo, and Y. H. Park. 2001. Immunostimulatory effects of anionic alkali mineral complex solution Barodon in porcine lymphocytes. J. Vet. Sci. 2:15-24.
74. Yoo, B. W., S. I. Choi, S. H. Kim, S. J. Yang, H. C. Koo, N. H. Kown, S. H. Seo, B. K. Park, H. S. Yoo, and Y. H. Park. 2002. Immunostimulatory effects of anionic alkali mineral complex solution Barodon in porcine lymphocytes. J. Swine Health Prod. 10:265-270.
75. Ziebell, K. L., H. Steinmann, D. Kretzdorn, T. Schlapp, K. Failing, and N. Schmeer. 1997. The use of Baypamun N in crowding associated infectious respiratory disease: efficacy of Baypamun N (freeze dried product) in 4-10 month old horses. Zentbl. Veterinarmed. B 44:529-536.