Cross-reactivity between peptide mimics of the immunodominant myelin proteolipid protein epitope PLP139-151: Comparison of peptide priming in CFA vs. viral delivery

Journal of Neuroimmunology

Volumn 186, Issue 1-2, 2007, Pages 5-18

  Ercolini, Anne M ^a   Ludovic Croxford, J ^a   Degutes, Mathew ^a   Miller, Stephen D ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Autoimmunity; EAE; Molecular mimicry; Multiple sclerosis; T cell

Indexed keywords

EPITOPE; GLUTAMYLGLUTAMINYLLEUCYLVALYLLYSYLTRYPTOPHYLLEUCYLGLYCYLLEUCYL PROLYLALANYLPROLYLISOLEUCINE; GLUTAMYLMETHIONYLLEUCYLSERYLLYSYLTYROSYLVALYLGLYCYLALANYLSERYL GLUTAMYLGLUTAMIC ACID; GLUTAMYLVALYLLEUCYLALANYLARGINYLTRYPTOPHYLTHREONYLGLYCYLISOLEUCYL PROLYLVALYLSERINE; HISTIDYLSERYLLEUCYLGLYCYLLYSYLTRYPTOPHYLLEUCYLGLYCYLHISTIDYLPROLYL ASPARTYLLYSYLPHENYLALANINE; ISOLEUCYLSERYLGLUTAMINYLALANYLVALYLHISTIDYLALANYLALANYL HISTIDYLALANYLGLUTAMYLISOLEUCYLASPARAGINYLGLUTAMYLALANYLGLYCYLARGININE; LYSYLVALYLISOLEUCYLALANYLLYSYLTRYPTOPHYLLEUCYLALANYLVALYL ASPARAGINYLVALYLLEUCINE; PEPTIDE; PROTEOLIPID PROTEIN; TRYPTOPHYLTHREONYLTHREONYLSERYLGLUTAMINYLGLUTAMYLALANYLPHENYL ALANYLSERYLHISTIDYLISOLEUCYLARGINYLISOLEUCYLPROLYLLEUCYLPROLYLHISTIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS REACTION; FEMALE; IN VITRO STUDY; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS RECOMBINANT;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CROSS REACTIONS; DEMYELINATING AUTOIMMUNE DISEASES, CNS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FEMALE; FREUND'S ADJUVANT; IMMUNODOMINANT EPITOPES; MICE; MOLECULAR MIMICRY; MYELIN PROTEOLIPID PROTEIN; PEPTIDE FRAGMENTS; TIME FACTORS; VIRUSES;

EID: 34248655911     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2007.02.002     Document Type: Article

References (31)

1. Allegretta M., Nicklas J.A., Sriram S., and Albertini R.J. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 247 (1990) 718-721
2. Andersen O., Lygner P.E., Bergstrom T., Andersson M., and Vahlne A. Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study. J. Neurol. 240 (1993) 417-422
3. Anderson A.C., Nicholson L.B., Legge K.L., Turchin V., Zaghouani H., and Kuchroo V.K. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med. 191 (2000) 761-770
4. Bernard C.C., and de Rosbo N.K. Immunopathological recognition of autoantigens in multiple sclerosis. Acta Neurol. 13 (1991) 171-178
5. Carrizosa A.M., Nicholson L.B., Farzan M., Southwood S., Sette A., Sobel R.A., and Kuchroo V.K. Expansion by self antigen is necessary for the induction of experimental autoimmune encephalomyelitis by T cells primed with a cross-reactive environmental antigen. J. Immunol. 161 (1998) 3307-3314
6. Challoner P.B., Smith K.T., Parker J.D., MacLeod D.L., Coulter S.N., Rose T.M., Shultz E.R., Bennett J.L., Garber R.L., Chang M., Schad P.A., Stewart P.M., Nowinski R.C., Brown J.P., and Burmer G.C. Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 7440-7444
7. Croxford J.L., Olson J.K., and Miller S.D. Epitope spreading and molecular mimicry as triggers of autoimmunity in the Theiler's virus induced demyelinating disease model of multiple sclerosis. Autoimmun. Rev. 1 (2002) 251-260
8. Croxford J.L., Anger H.A., and Miller S.D. Viral delivery of an epitope from Haemophilus influenzae induces central nervous system autoimmune disease by molecular mimicry. J. Immunol. 174 (2005) 907-917
9. Croxford J.L., Olson J.K., Anger H.A., and Miller S.D. Initiation and exacerbation of autoimmune demyelination of the central nervous system via virus-induced molecular mimicry: implications for the pathogenesis of multiple sclerosis. J. Virol. 79 (2005) 8581-8590
10. Croxford J.L., Ercolini A.M., Degutes M., and Miller S.D. Structural requirements for initiation of cross-reactivity and CNS autoimmunity with a PLP139-151 mimic peptide derived from murine hepatitis virus. Eur. J. Immunol. 36 (2006) 2671-2680
11. Derfuss T., Gurkov R., Then B.F., Goebels N., Hartmann M., Barz C., Wilske B., Autenrieth I., Wick M., Hohlfeld R., and Meinl E. Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain 124 (2001) 1325-1335
12. Edwards S., Zvartau M., Clarke H., Irving W., and Blumhardt L.D. Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 64 (1998) 736-741
13. Ercolini A.M., and Miller S.D. Mechanisms of immunopathology in murine models of central nervous system demyelinating disease. J. Immunol. 176 (2006) 3293-3298
14. Fujinami R.S. Can virus infections trigger autoimmune disease?. J. Autoimmun. 16 (2001) 229-234
15. Hellings N., Gelin G., Medaer R., Bruckers L., Palmers Y., Raus J., and Stinissen P. Longitudinal study of antimyelin T-cell reactivity in relapsing-remitting multiple sclerosis: association with clinical and MRI activity. J. Neuroimmunol. 126 (2002) 143-160
16. Hesse M.D., Karulin A.Y., Boehm B.O., Lehmann P.V., and Tary-Lehmann M. A T cell clone's avidity is a function of its activation state. J. Immunol. 167 (2001) 1353-1361
17. Jameson S.C. T cell receptor antagonism in vivo, at last. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 14001-14002
18. Kennedy M.K., Tan L.J., Dal Canto M.C., Tuohy V.K., Lu Z.J., Trotter J.L., and Miller S.D. Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides. J. Immunol. 144 (1990) 909-915
19. Kurtzke J.F. Epidemiologic evidence for multiple sclerosis as an infection. Clin. Microbiol. Rev. 6 (1993) 382-427
20. Lunemann J.D., Ruckert S., Kern F., Wendling U., van der Zee R., Volk H.D., and Zipp F. Cross-sectional and longitudinal analysis of myelin-reactive T cells in patients with multiple sclerosis. J. Neurol. 251 (2004) 1111-1120
21. Moldovan I.R., Rudick R.A., Cotleur A.C., Born S.E., Lee J.C., Karafa M.T., and Pelfrey C.M. Interferon gamma responses to myelin peptides in multiple sclerosis correlate with a new clinical measure of disease progression. J. Neuroimmunol. 141 (2003) 132-140
22. Olson J.K., Croxford J.L., Calenoff M., Dal Canto M.C., and Miller S.D. A virus-induced molecular mimicry model of multiple sclerosis. J. Clin. Invest. 108 (2001) 311-318
23. Ota K., Matsui M., Milford E.L., Mackin G.A., Weiner H.L., and Hafler D.A. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 346 (1990) 183-187
24. Rose L.M., Richards T., and Alvord Jr. E.C. Experimental allergic encephalomyelitis (EAE) in nonhuman primates: a model of multiple sclerosis. Lab. Anim. Sci. 44 (1994) 508-512
25. Saez-Torres I., Brieva L., Espejo C., Barrau M.A., Montalban X., and Martinez-Caceres E.M. Specific proliferation towards myelin antigens in patients with multiple sclerosis during a relapse. Autoimmunity 35 (2002) 45-50
26. Sriram S., Stratton C.W., Yao S., Tharp A., Ding L., Bannan J.D., and Mitchell W.M. Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann. Neurol. 46 (1999) 6-14
27. Steinman L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell 85 (1996) 299-302
28. Sun J.B., Olsson T., Wang W.Z., Xiao B.G., Kostulas V., Fredrikson S., Ekre H.P., and Link H. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 21 (1991) 1461-1468
29. Wucherpfennig K.W., and Strominger J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell 80 (1995) 695-705
30. Wucherpfennig K.W., Zhang J., Witek C., Matsui M., Modabber Y., Ota K., and Hafler D. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152 (1994) 5581-5592
31. Zhang J., and Raus J. Myelin basic protein-reactive T cells in multiple sclerosis: pathologic relevance and therapeutic targeting. Cytotechnology 16 (1994) 181-187