Association of selective HLA class II susceptibility-conferring and protective haplotypes with type 2 diabetes in patients from Bahrain and Lebanon

Clinical and Vaccine Immunology

Volumn 13, Issue 11, 2006, Pages 1296-1298

  Almawi, Wassim Y ^a   Wakim Ghorayeb, Saria F ^b   Arekat, Mona R ^c   Najm, Pierre ^b   Keleshian, Sose H ^d   Al Sayed, Nasreen ^c   Blanchon, Bruno ^c   Samaha, Hanady R ^b   Irani Hakime, Noha ^b  

^a ARABIAN GULF UNIVERSITY   (Bahrain)

^b St Georges University Hospital   (Lebanon)

^c Joslin Diabetes Center Bahrain   (Bahrain)

^d HAIGAZIAN UNIVERSITY   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA-DRB1 ANTIGEN;

ADULT; AGED; ALLELE; ARTICLE; BAHRAIN; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; LEBANON; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; REGRESSION ANALYSIS; COMPARATIVE STUDY; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MIDDLE AGED;

ALLELES; BAHRAIN; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; LEBANON; MALE; MIDDLE AGED;

EID: 34248652101     PISSN: 15566811     EISSN: None     Source Type: Journal    
DOI: 10.1128/CVI.00206-06     Document Type: Article

References (20)

1. Al-Jenaidi, F. A., S. F. Wakim-Ghorayeb, A. Al-Abbasi, M. R. Arekat, N. Irani-Hakime, P. Najm, K. Al-Ola, A. A. Motala, and W. Y. Almawi. 2005. Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs. J. Clin. Endocrinol. Metab. 90:5104-5109.
2. Al-Mahroos, F., and P. M. McKeigue. 1998. High prevalence of diabetes in Bahrainis. Associations with ethnicity and raised plasma cholesterol. Diabetes Care 21:936-942.
3. Almawi, W. Y., M. Busson, H. Tamim, E. M. Al-Harbi, R. R. Finan, S. F. Wakim-Ghorayeb, and A. A. Motala. 2004. HLA class II profile and distribution of HLA-DRB1 and HLA-DQB1 alleles and haplotypes among Lebanese and Bahraini Arabs. Clin. Diagn. Lab. Immunol. 11:770-774.
4. Bach, J. M., H. Otto, G. T. Nepom, G. Jung, H. Cohen, J. Timsit, C. Boitard, and P. M. van Endert. 1997. High affinity presentation of an autoantigenic peptide in type I diabetes by an HLA class II protein encoded in a haplotype protecting from disease. J. Autoimmun. 10:375-386.
5. Barroso, I. 2005. Genetics of type 2 diabetes. Diabet. Med. 22:517-535.
6. Bottazzo, G. F., E. Bosi, C. A. Cull, E. Bonifacio, M. Locatelli, P. Zimmet, I. R. Mackay, and R. R. Holman. 2005. IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71). Diabetologia 48:703-708.
7. Cerna, M., P. Novota, K. Kolostova, P. Cejkova, E. Zdarsky, D. Novakova, P. Kucera, J. Novak, and M. Andel. 2003. HLA in Czech adult patients with autoimmune diabetes mellitus: comparison with Czech children with type 1 diabetes and patients with type 2 diabetes. Eur. J. Immunogenet. 30:401-407.
8. Dyck, R., C. Bohm, and H. Klomp. 2003. Increased frequency of HLA A2/DR4 and A2/DR8 haplotypes in young Saskatchewan aboriginal people with diabetic end-stage renal disease. Am. J. Nephrol. 23:178-185.
9. Egede, L. E., and S. Dagogo-Jack. 2005. Epidemiology of type 2 diabetes: focus on ethnic minorities. Med. Clin. N. Am. 89:949-975.
10. Fukui, M., K. Nakano, N. Nakamura, E. Maruya, H. Saji, H. Obayashi, K. Ohta, M. Ohta, H. Mori, S. Kajiyama, S. Wada, Y. Kida, K. Kosaka, M. Deguchi, H. Shigeta, Y. Kitagawa, and M. Kondo. 1998. HLA-DRB1 alleles contribute to determining the prognosis of Japanese diabetes mellitus positive for antibodies to glutamate decarboxylase. J. Clin. Immunol. 18:89-92.
11. Groop, L., A. Miettinen, P. H. Groop, S. Meri, S. Koskimies, and G. F. Bottazzo. 1988. Organ-specific autoimmunity and HLA-DR antigens as markers for beta-cell destruction in patients with type II diabetes. Diabetes 37:99-103.
12. Hamaguchi, K., A. Kimura, Y. Kusuda, T. Yamashita, M. Yasunami, M. Takahasi, N. Abe, and H. Yoshimatsu. 2004. Clinical and genetic characteristics of GAD-antibody positive patients initially diagnosed as having type 2 diabetes. Diabetes Res. Clin. Pract. 66:163-171.
13. Horton, V., I. Stratton, G. F. Bottazzo, M. Shattock, I. Mackay, P. Zimmet, S. Manley, R. Holman, R. Turner, et al. 1999. Genetic heterogeneity of autoimmune diabetes: age of presentation in adults is influenced by HLA DRB1 and DQB genotypes (UKPDS 43). Diabetologia 42:608-616.
14. Kawabata, Y., H. Ikegami, Y. Kawaguchi, T. Fujisawa, M. Shintani, M. Ono, M. Nishino, Y. Uchigata, I. Lee, and T. Ogihara. 2002. Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes. Diabetes 51:545-551.
15. Kwon, O. J., C. Brautbar, N. Weintrob, E. Sprecher, C. Saphirman, K. Bloch, O. Pinhas-Hamiel, S. Assah, P. Vardi, and S. Israel. 2001. Immunogenetics of HLA class II in Israeli Ashkenazi Jewish, Israeli non-Ashkenazi Jewish, and in Israeli Arab IDDM patients. Hum. Immunol. 62:85-91.
16. Motala, A. A., M. Busson, E. M. Al-Harbi, M. A. Khuzam, E. M. Al-Omari, M. R. Arekat, and W. Y. Almawi. 2005. Susceptible and protective human leukocyte antigen class II alleles and haplotypes in Bahraini type 2 (non-insulin-dependent) diabetes mellitus patients. Clin. Diagn. Lab. Immunol. 12:213-217.
17. Perez-Luque, E., C. Alaez, J. M. Malacara, M. E. Garay, M. E. Fajardo, L. E. Nava, and C. Gorodezky. 2003. Protective effect of DRB1 locus against type 2 diabetes mellitus in Mexican Mestizos. Hum. Immunol. 64:110-118.
18. Valdes, A. M., S. McWeeney, and G. Thomson. 1997. HLA class II DR-DQ amino acids and insulin-dependent diabetes mellitus: application of the haplotype method. Am. J. Hum. Genet. 60:717-728.
19. Wolford, J. K., and B. Vozarova de Courten. 2004. Genetic basis of type 2 diabetes mellitus: implications for therapy. Treat. Endocrinol. 3:257-267.
20. Zavala, A. V., L. E. Fabiano de Bruno, A. I. Cardoso, A. H. Mota, M. Capucchio, E. Poskus, L. Fainboim, and J. C. Basabe. 1992. Cellular and humoural autoimmunity markers in type 2 (non-insulin-dependent) diabetic patients with secondary drug failure. Diabetologia 35:1159-1164.