No evidence for association of NOD2 R702W and G908R with colorectal cancer

International Journal of Cancer

Volumn 121, Issue 1, 2007, Pages 76-79

  Tuupanen, Sari ^a   Alhopuro, Pia ^a   Mecklin, Jukka Pekka ^b   Järvinen, Heikki ^c   Aaltonen, Lauri A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b JYVÄSKYLÄ CENTRAL HOSPITAL   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

CARD15; Colorectal cancer; NOD2; Polymorphism; Susceptibility

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER SUSCEPTIBILITY; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; FEMALE; FINLAND; G908R GENE; GENE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DOMAIN; R702W GENE;

ARGININE; COLORECTAL NEOPLASMS; FEMALE; FINLAND; GLYCINE; HUMANS; MALE; MIDDLE AGED; MUTATION, MISSENSE; NOD2 SIGNALING ADAPTOR PROTEIN; REPRODUCIBILITY OF RESULTS;

EID: 34248590274     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.22651     Document Type: Article

References (18)

1. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Aimer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
2. Ogura Y, Bonen DK, Inohara N, Nicolae DL, Chen FF, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.
3. Helio T, Halme L, Lappalainen M, Fodstad H, Paavola-Sakki P, Turunen U, Farkkila M, Krusius T, Kontula K. CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn's disease. Gut 2003;52:558-62.
4. Hampe J, Cuthbert A, Croucher PJ, Mirza MM, Mascheretti S, Fisher S, Frenzel H, King K, Hasselmeyer A, MacPherson AJ, Bridger S, van Deventer S, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 2001;357:1925-8.
5. Lesage S, Zouali H, Cezard JP, Colombel JF, Belaiche J, Aimer S, Tysk C, O'Morain C, Gassull M, Binder V, Finkel Y, Modigliani R, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet 2002;70:845-57.
6. Economou M, Trikalinos TA, Loizou KT, Tsianos EV, Ioannidis JP. Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol 2004;99:2393-104.
7. Yamazaki K, Takazoe M, Tanaka T, Kazumori T, Nakamura Y. Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. J Hum Genet 2002;47:469-72.
8. Inoue N, Tamura K, Kinouchi Y, Fukuda Y, Takahashi S, Ogura Y, Inohara N, Nunez G, Kishi Y, Koike Y, Shimosegawa T, Shimoyama T, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 2002;123:86-91.
9. Guo QS, Xia B, Jiang Y, Qu Y, Li J. NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality. World J Gastroenterol 2004;10: 1069-71.
10. Arnott ID, Nimmo ER, Drummond HE, Fennell J, Smith BR, MacKinlay E, Morecroft J, Anderson N, Kelleher D, O'Sullivan M, McManus R, Satsangi J. NOD2/CARD15, TLR4 and CD14 mutations in Scottish and Irish Crohn's disease patients: evidence for genetic heterogeneity within Europe? Genes Immun 2004;5:417-25.
11. Gaya DR, Russell RK, Nimmo ER Satsangi J. New genes in inflammatory bowel disease: lessons for complex diseases? Lancet 2006; 367:1271-84.
12. Kurzawski G, Suchy J, Kladny J, Grabowska E, Mierzejewski M, Jakubowska A, Debniak T, Cybulski C, Kowalska E, Szych Z, Domagala W, et al. The NOD2 3020insC mutation and the risk of colorectal cancer. Cancer Res 2004;64:1604-6.
13. Papaconstantinou I, Theodoropoulos G, Gazouli M, Panoussopoulos D, Mantzaris GJ, Felekouras E, Bramis J. Association between mutations in the CARD15/NOD2 gene and colorectal cancer in a Greek population. Int J Cancer 2005; 114:433-5.
14. Alhopuro P, Ahvenainen T, Mecklin JP, Juliola M, Jarvinen HJ Karhu A, Aaltonen LA. NOD2 3020insC alone is not sufficient for colorectal cancer predisposition. Cancer Res 2004;64:7245-47.
15. Roberts RL, Gearry RB, Allington MD, Morrin HR, Robinson BA, Fnzelle FA. Caspase recruitment domain-containing protein 15 mutations in patients with colorectal cancer. Cancer Res 2006;66: 2532-35
16. Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A Peltomaki P, Chadwick RB, Kaariainen H, Eskelinen M Jarvinen H Mecklin JP, Chapelle de la. A Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998;338:1481-87.
17. Salovaara R, Loukola A, Kristo P, Kaariainen H, Ahtola H, Eskelinen M, Harkonen N, Julkunen R, Kangas E, Ojala S, Tulikoura J, et al Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol 2000; 18:2193-200.
18. Roberts RL, Gearry RB, Barclay ML, Kennedy MA. Rapid detection of common CARD 15 variants in patients with inflammatory bowel disease. Mol Diagn 2004;8:101-5.