Factors Influencing Outcomes in Cultivated Limbal Epithelial Transplantation for Chronic Cicatricial Ocular Surface Disorders

American Journal of Ophthalmology

Volumn 143, Issue 6, 2007, Pages 945-953

  Shimazaki, Jun ^a,b   Higa, Kazunari ^a   Morito, Fumito ^a   Dogru, Murat ^a,b   Kawakita, Tetsuya ^a   Satake, Yoshiyuki ^a   Shimmura, Shigeto ^a,b   Tsubota, Kazuo ^a,b  

^a TOKYO DENTAL COLLEGE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL TEAR; CORTICOSTEROID; CYCLOSPORIN A; DEXAMETHASONE; HYALURONIC ACID; METHYLPREDNISOLONE; MITOMYCIN C;

ADULT; AGED; ALLOGRAFT; AMNION; ARTICLE; CELL TRANSPLANTATION; CLINICAL ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA PERFORATION; CORNEA ULCER; DEMOGRAPHY; DRUG DOSE REDUCTION; EPITHELIZATION; EYE DISEASE; FEMALE; GRAFT FAILURE; HUMAN; IMMUNOHISTOCHEMISTRY; KERATITIS; MALE; PHENOTYPE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROGNOSIS; STEVENS JOHNSON SYNDROME; UNSPECIFIED SIDE EFFECT; VISUAL ACUITY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CELL TRANSPLANTATION; CELLS, CULTURED; CHRONIC DISEASE; CONJUNCTIVAL DISEASES; CORNEAL DISEASES; EPITHELIAL CELLS; FEMALE; HUMANS; LIMBUS CORNEAE; MALE; MIDDLE AGED; PEMPHIGOID, BENIGN MUCOUS MEMBRANE; RETROSPECTIVE STUDIES; STEVENS-JOHNSON SYNDROME; TREATMENT OUTCOME;

EID: 34248581691     PISSN: 00029394     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajo.2007.03.005     Document Type: Article

References (39)

1. Pellegrini G., Traverso C.E., Franzi A.T., Zingirian M., Cancedda R., and De Luca M. Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 349 (1997) 990-993
2. Tsai R.J., Li L.M., and Chen J.K. Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N Engl J Med 343 (2000) 86-93
3. Schwab I.R., Reyes M., and Isseroff R.R. Successful transplantation of bioengineered tissue replacements in patients with ocular surface disease. Cornea 19 (2000) 421-426
4. Rama P., Bonini S., Lambiase A., et al. Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiency. Transplantation 72 (2001) 1478-1485
5. Koizumi N., Inatomi T., Suzuki T., Sotozono C., and Kinoshita S. Cultivated corneal epithelial stem cell transplantation in ocular surface disorders. Ophthalmology 108 (2001) 1569-1574
6. Koizumi N., Inatomi T., Suzuki T., Sotozono C., and Kinoshita S. Cultivated corneal epithelial transplantation for ocular surface reconstruction in acute phase of Stevens-Johnson syndrome. Arch Ophthalmol 119 (2001) 298-300
7. Shimazaki J., Aiba M., Goto E., Kato N., Shimmura S., and Tsubota K. Transplantation of human limbal epithelium cultivated on amniotic membrane for the treatment of severe ocular surface disorders. Ophthalmology 109 (2002) 1285-1290
8. Meller D., Pires R.T., and Tseng S.C. Ex vivo preservation and expansion of human limbal epithelial stem cells on amniotic membrane cultures. Br J Ophthalmol 86 (2002) 463-471
9. Grueterich M., Espana E.M., Touhami A., Ti S.E., and Tseng S.C. Phenotypic study of a case with successful transplantation of ex vivo expanded human limbal epithelium for unilateral total limbal stem cell deficiency. Ophthalmology 109 (2002) 1547-1552
10. Sangwan V.S., Vemuganti G.K., Iftekhar G., Bansal A.K., and Rao G.N. Use of autologous cultured limbal and conjunctival epithelium in a patient with severe bilateral ocular surface disease induced by acid injury: a case report of unique application. Cornea 22 (2003) 478-481
11. Nishida K., Yamato M., Hayashida Y., et al. Functional bioengineered corneal epithelial sheet grafts from corneal stem cells expanded ex vivo on a temperature-responsive cell culture surface. Transplantation 77 (2004) 379-385
12. Sangwan V.S., Murthy S.I., Vemuganti G.K., Bansal A.K., Gangopadhyay N., and Rao G.N. Cultivated corneal epithelial transplantation for severe ocular surface disease in vernal keratoconjunctivitis. Cornea 24 (2005) 426-430
13. Ilari L., and Daya S.M. Long-term outcomes of keratolimbal allograft for the treatment of severe ocular surface disorders. Ophthalmology 109 (2002) 1278-1284
14. Shimazaki J., Shimmura S., Fujishima H., and Tsubota K. Association of preoperative tear function with surgical outcome in severe Stevens-Johnson syndrome. Ophthalmology 107 (2000) 1518-1523
15. Samson C.M., Nduaguba C., Baltatzis S., and Foster C.S. Limbal stem cell transplantation in chronic inflammatory eye disease. Ophthalmology 109 (2002) 862-868
16. Tsubota K., Goto E., Shimmura S., and Shimazaki J. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology 106 (1999) 1984-1989
17. Daya S.M., Watson A., Sharpe J.R., et al. Outcomes and DNA analysis of ex vivo expanded stem cell allograft for ocular surface reconstruction. Ophthalmology 112 (2005) 470-477
18. Du Y., Chen J., Funderburgh J.L., Zhu X., and Li L. Functional reconstruction of rabbit corneal epithelium by human limbal cells cultured on amniotic membrane. Mol Vis 8 (2003) 635-643
19. Espana E.M., Ti S.E., Grueterich M., Touhami A., and Tseng S.C. Corneal stromal changes following reconstruction by ex vivo expanded limbal epithelial cells in rabbits with total limbal stem cell deficiency. Br J Ophthalmol 87 (2003) 1509-1514
20. Grueterich M., Espana E.M., and Tseng S.C. Modulation of keratin and connexin expression in limbal epithelium expanded on denuded amniotic membrane with and without a 3T3 fibroblast feeder layer. Invest Ophthalmol Vis Sci 44 (2003) 4230-4236
21. Kim H.S., Jun Song X., de Paiva C.S., Chen Z., Pflugfelder S.C., and Li D.Q. Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res 79 (2004) 41-49
22. Koizumi N., Inatomi T., Quantock A.J., Fullwood N.J., Dota A., and Kinoshita S. Amniotic membrane as a substrate for cultivating limbal corneal epithelial cells for autologous transplantation in rabbits. Cornea 19 (2000) 65-71
23. Koizumi N., Cooper L.J., Fullwood N.J., et al. An evaluation of cultivated corneal limbal epithelial cells, using cell-suspension culture. Invest Ophthalmol Vis Sci 43 (2002) 2114-2121
24. Han B., Schwab I.R., Madsen T.K., and Isseroff R.R. A fibrin-based bioengineered ocular surface with human corneal epithelial stem cells. Cornea 21 (2002) 505-510
25. Ti S.E., Anderson D., Touhami A., Kim C., and Tseng S.C. Factors affecting outcome following transplantation of ex vivo expanded limbal epithelium on amniotic membrane for total limbal deficiency in rabbits. Invest Ophthalmol Vis Sci 43 (2002) 2584-2592
26. Ti S.E., Grueterich M., Espana E.M., Touhami A., Anderson D.F., and Tseng S.C. Correlation of long- term phenotypic and clinical outcomes following limbal epithelial transplantation cultivated on amniotic membrane in rabbits. Br J Ophthalmol 88 (2004) 422-427
27. Tsubota K., Satake Y., Kaido M., et al. Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation. N Engl J Med 340 (1999) 1697-1703
28. Solomon A., Ellies P., Anderson D.F., et al. Long-term outcome of keratolimbal allograft with or without penetrating keratoplasty for total limbal stem cell deficiency. Ophthalmology 109 (2002) 1159-1166
29. Grueterich M., Espana E., and Tseng S.C. Connexin 43 expression and proliferation of human limbal epithelium on intact and denuded amniotic membrane. Invest Ophthalmol Vis Sci 43 (2002) 63-71
30. Grueterich M., and Tseng S.C. Human limbal progenitor cells expanded on intact amniotic membrane ex vivo. Arch Ophthalmol 120 (2002) 783-790
31. Koizumi N., Fullwood N.J., Bairaktaris G., Inatomi T., Kinoshita S., and Quantock A.J. Cultivation of corneal epithelial cells on intact and denuded human amniotic membrane. Invest Ophthalmol Vis Sci 41 (2000) 2506-2513
32. Schwab I.R. Cultured corneal epithelia for ocular surface disease. Trans Am Ophthalmol Soc 97 (1999) 891-986
33. Rheinwald J.G., and Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6 (1975) 331-343
34. Lindberg K., Brown M.E., Chaves H.V., Kenyon K.R., and Rheinwald J.G. In vitro propagation of human ocular surface epithelial cells for transplantation. Invest Ophthalmol Vis Sci 34 (1993) 2672-2679
35. Sun T.T., and Green H. Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated states. Nature 269 (1977) 489-493
36. Wang D.Y., Hsueh Y.J., Yang V.C., and Chen J.K. Propagation and phenotypic preservation of rabbit limbal epithelial cells on amniotic membrane. Invest Ophthalmol Vis Sci 44 (2003) 4698-4704
37. Wei Z.G., Wu R.L., Lavker R.M., and Sun T.T. In vitro growth and differentiation of rabbit bulbar, fornix, and palpebral conjunctival epithelia. Implications on conjunctival epithelial transdifferentiation and stem cells. Invest Ophthalmol Vis Sci 34 (1993) 1814-1828
38. Ban Y., Cooper L.J., Fullwood N.J., et al. Comparison of ultra-structure, tight junction-related protein expression and barrier function of human corneal epithelial cells cultivated on amniotic membrane with and without air-lifting. Exp Eye Res 76 (2003) 735-743
39. Ang L.P., Tan D.T., Beuerman R.W., and Lavker R.M. Development of a conjunctival epithelial equivalent with improved proliferative properties using a multi-step serum-free culture system. Invest Ophthalmol Vis Sci 45 (2004) 1789-1795