The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: Evidence for subregional and genetic differences and involvement of dopamine neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 321, Issue 3, 2007, Pages 1003-1012

  Rodd, Zachary A ^a   Gryszowka, Victoria E ^a   Toalston, Jamie E ^b   Oster, Scott M ^b   Ji, Dong ^a   Bell, Richard L ^a   McBride, William J ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (M CHLOROPHENYL) BIGUANIDE; QUINPIROLE; SEROTONIN 3 AGONIST; SEROTONIN 3 ANTAGONIST; TROPISETRON; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG ACTIVITY; DRUG EFFECT; FEMALE; GENETIC DIFFERENCE; NONHUMAN; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM; WISTAR RAT;

ALCOHOL DRINKING; ANIMALS; BIGUANIDES; CEREBROSPINAL FLUID; CONDITIONING, CLASSICAL; DOPAMINE; DOPAMINE AGONISTS; FEMALE; INDOLES; INFUSIONS, PARENTERAL; NEURONS; QUINPIROLE; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN, 5-HT3; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; VENTRAL TEGMENTAL AREA;

EID: 34248581669     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.112607     Document Type: Article

References (41)

1. Arnt J and Scheel-Kruger J (1979) GABA in the ventral tegmental area: differential regional effects on locomotion, aggression and food intake after microinjection of GABA agonists and antagonists. Life Sci 25:1351-1360.
2. Bankson MG and Yamamoto BK (2004) Serotonin-GABA interactions modulate MDMA-induced mesolimbic dopamine release. J Neurochem 91:852-859.
3. Boehm SL 2nd, Piercy MM, Bergstrom HC, and Phillips TJ (2002) Ventral tegmental area region governs GABA(B) receptor modulation of ethanol-stimulated activity in mice. Neuroscience 115:185-200.
4. 3 receptors. Neuropharmacology 39:2336-2345.
5. Bozarth MA and Wise RA (1980) Electrolytic microinfusion transducer system: an alternative method of intra-cranial drug application. J Neurosci Methods 2:273-275.
6. Bozarth MA and Wise RA (1981) Intracranial self-administration of morphine into the ventral tegmental area in rats. Life Sci 28:551-555.
7. Brog JS, Deutch AY, Salyapongse A, and Zahm DS (1993) The patterns of afferent innervation of the core and shell in the "accumbens" part of the rat ventral striatum: immunohistochemical detection of retrogradely transported Fluoro-Gold. J Comp Neurol 338:255-278.
8. Cameron DL and William JT (1994) Cocaine inhibits GABA release in the VTA through endogenous 5-HT. J Neurosci 14:6763-6767.
9. Campbell AD, Kohl RR, and McBride WJ (1996) Serotonin-3 receptor and ethanolstimulated somatodendritic dopamine release. Alcohol 13:569-574.
10. Campbell AD and McBride WJ (1995) Serotonin-3 receptor and ethanol-stimulated dopamine release in the nucleus accumbens. Pharmacol Biochem Behav 51:835-842.
11. Campbell AD, Womer DE, and Simon JR (1995) The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide interacts with the dopamine transporter in rat brain synaptosomes. Eur J Pharmacol Mol Pharmacol 290:157-162.
12. Carlezon WA, Haile CN, Coppersmith R, Hayashi Y, Malinow R, Neve RL, and Nestler EJ (2000) Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expression GluR1. J Neurosci 20:RC62.
13. Carboni E, Acquas E, Frau R, and DiChiara G (1989) Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release. Eur J Pharmacol 164:515-519.
14. Devine DP and Wise RA (1994) Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats. J Neurosci 14:1978-1984.
15. Gatto GJ, McBride WJ, Murphy JM, Lumeng L, and Li T-K (1994) Ethanol selfinfusion into the ventral tegmental area by alcohol-preferring rats. Alcohol 11: 557-564.
16. Goeders NE and Smith JE (1987) Intracranial self-administration methodologies. Neurosci Biobehav Rev 11:319-329.
17. Hervé D, Pickel VM, Joh TH, and Beaudet A (1987) Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons. Brain Res 435:71-83.
18. Ikemoto S, Murphy JM, and McBride WJ (1997) Self-infusion of GABA-A receptor antagonists directly into the ventral tegmental area and adjacent regions. Behav Neurosci 110:331-345.
19. Ikemoto S, Murphy JM, and McBride WJ (1998) Regional differences within the rat ventral tegmental area for muscimol self-infusions. Pharmacol Biochem Behav 61:87-92.
20. Ikemoto S and Wise RA (2002) Rewarding effects of the cholinergic agents carbachol and neostigmine in the posterior ventral tegmental area. J Neurosci 22:9895-9904.
21. Kalén P, Skagerberg G, and Lindvall O (1988) Projections from the ventral tegmental area and mesencephalic raphe to the dorsal raphe nucleus in the rat. Exp Brain Res 73:69-71.
22. 3 receptor agonist. Eur J Pharmacol 182: 193-197.
23. Lovinger DM and White G (1991) Ethanol potentiation of 5-hydroxytryptamine-3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol Pharmacol 40:263-270.
24. Mansour A, Fox CA, Akil H, and Watson SJ (1995) Immunohistochemical localization of the cloned mu opioid receptor in the rat CNS. J Chem Neuroanat 8:283-305.
25. McBride WJ, Murphy JM, and Ikemoto S (1999) Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies. Behav Brain Res 101:129-152.
26. Minabe Y, Ashby CR, Schwartz JE, and Wang RY (1991) The 5-HT3 receptor antagonists LY277359 and granisetron potentiate the suppressant actions of apomorphine on the basal firing rate of ventral tegmental dopamine cells. Eur J Pharmacol 209:143-150.
27. Olson VG, Zabetian CP, Bolanos CA, Edwards S, Barrot M, Eisch AJ, Hughes T, Self DW, Neve RL, and Nestler EJ (2005) Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. J Neurosci 25:5553-5562.
28. Paxinos G and Watson C (1998) The Rat Brain in Stereotaxic Coordinates, 4th edition. Academic Press, New York.
29. Rasmussen K, Stockton ME, and Czachura JF (1991) The 5-HT3 receptor antagonist zatosetron decreases the number of spontaneously active A10 dopamine neurons. Eur J Pharmacol 205:113-116.
30. Rodd-Henricks ZA, McKinzie DL, Crile RS, Murphy JM, and McBride WJ (2000) Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats. Psychopharmacology 149:217-224.
31. Rodd-Henricks ZA, McKinzie DL, Melendez RI, Berry N, Murphy JM, and McBride WJ (2003) Effects of serotonin-3 receptor antagonists on the intracranial selfadministration of ethanol within the ventral tegmental area of Wistar rats. Psychopharmacology 165:252-259.
32. Rodd-Henricks ZA, Melendez RI, Zaffaroni A, Goldstein A, McBride WJ, and Li T-K (2002) The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats. Pharmacol Biochem Behav 72:55-64.
33. Rodd ZA, Bell RL, Kuc KA, Zhang Y, Murphy JM, and McBride WJ (2005a) Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: evidence for involvement of serotonin-3 receptors and dopamine neurons. J Pharmacol Exp Ther 313:134-145.
34. Rodd ZA, Bell RL, Melendez RI, Kuc KA, Lumeng L, Li T-K, Murphy JM, and McBride WJ (2004a) Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring (P) and Wistar rats. Alcohol Clin Exp Res 28:1212-1219.
35. Rodd ZA, Bell RL, Zhang Y, Murphy JM, Goldstein A, Zaffaroni A, Li T-K, and McBride WJ (2005b) Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcoholpreferring (P) rats: involvement of dopamine and serotonin. Neuropsychopharmacology 30:330-338.
36. Rodd ZA, Melendez RI, Bell RL, Kuc KA, Zhang Y, Murphy JM, and McBride WJ (2004b) Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: evidence for regional heterogeneity and involvement of dopamine neurons. J Neurosci 24:1050-1057.
37. Tan Y, Brog JS, Williams ES, and Zahm DS (1995) Morphometric analysis of ventral mesencephalic neurons retrogradely labeled with Fluoro-Gold following injections in the shell, core, and rostral pole of the rat nucleus accumbens. Brain Res 689:151-156.
38. Van Bockstaele EJ, Cestari DM, and Pickel VM (1994) Synaptic structure and connectivity of serotonin terminals in the ventral tegmental area: potential sites for modulation of mesolimbic dopamine neurons. Brain Res 647:307-322.
39. 3 receptors. Gen Pharmacol 26:553-561.
40. Wise RA and Hoffman DC (1992) Localization of drug reward mechanisms by intracranial injections. Synapse 10:247-262.
41. Wozniak KM, Pert A, and Linnoila M (1990) Antagonism of 5-HT3 receptors attenuates the effects of ethanol on extracellular dopamine. Eur J Pharmacol 187:287-290.