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Volumn 50, Issue 4, 2006, Pages 309-314

Molecular pathology and targeted therapy of clear cell renal cancer;A világossejtes veserák célzott terápiá ja és molekuláris patológiai alapjai

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

EID: 34248547900     PISSN: 00250244     EISSN: 20600399     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (5)

References (45)
  • 1
    • 33744513575 scopus 로고    scopus 로고
    • Sorafinib (BAY 43-9006, Nexavar (R), a dual-action inhibitor that targets FAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
    • Adnane L, Traill PA, Taylor I, Wilhelm SM. Sorafinib (BAY 43-9006, Nexavar (R), a dual-action inhibitor that targets FAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol 407:597-612, 2005
    • (2005) Methods Enzymol , vol.407 , pp. 597-612
    • Adnane, L.1    Traill, P.A.2    Taylor, I.3    Wilhelm, S.M.4
  • 2
    • 35649028432 scopus 로고    scopus 로고
    • Durable disease stabilization and antiumor activity with OSI-774 in renal cell carcinoma: A phase II, pharmacokinetic (PK) and biological correlative study with FGD-PET imaging
    • Beeram M, Rowinsky EK, Weiss GR, et al. Durable disease stabilization and antiumor activity with OSI-774 in renal cell carcinoma: A phase II, pharmacokinetic (PK) and biological correlative study with FGD-PET imaging. J Clin Oncol 22(Suppl 15):3050, 2004
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 15 , pp. 3050
    • Beeram, M.1    Rowinsky, E.K.2    Weiss, G.R.3
  • 3
    • 0025883294 scopus 로고
    • HLA-class-I and -class-II expression on renal tumor xenografts and the relation to sensitivity for alpha-IFN, gamma-IFN and TNF
    • Beniers AJ, Peelen WP, Debruyne FM, Schalken JA. HLA-class-I and -class-II expression on renal tumor xenografts and the relation to sensitivity for alpha-IFN, gamma-IFN and TNF. Int J Cancer 48: 709-716, 1991
    • (1991) Int J Cancer , vol.48 , pp. 709-716
    • Beniers, A.J.1    Peelen, W.P.2    Debruyne, F.M.3    Schalken, J.A.4
  • 4
    • 6944225501 scopus 로고    scopus 로고
    • The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer
    • Bromwich E, McMillan DC, Lamb GW, et al. The systemic inflammatory response, performance status and survival in patients undergoing alpha-interferon treatment for advanced renal cancer. Br J Cancer 91:1236-1238, 2004
    • (2004) Br J Cancer , vol.91 , pp. 1236-1238
    • Bromwich, E.1    McMillan, D.C.2    Lamb, G.W.3
  • 5
    • 84875185821 scopus 로고    scopus 로고
    • Overexpression of glutathione-s-transferase alpha in clear cell renal cell carcinoma
    • Chuang ST, Chu P, Sugimura J, et al. Overexpression of glutathione-s-transferase alpha in clear cell renal cell carcinoma. Am J Clin Pathol 162:925-932, 2005
    • (2005) Am J Clin Pathol , vol.162 , pp. 925-932
    • Chuang, S.T.1    Chu, P.2    Sugimura, J.3
  • 6
    • 0037099598 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a specific vascular endothelial growth factorreceptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
    • Drevs J, Müller-Driver R, Witting C, et al. PTK787/ZK 222584, a specific vascular endothelial growth factorreceptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. Cancer Res 62:4015-4022, 2002
    • (2002) Cancer Res , vol.62 , pp. 4015-4022
    • Drevs, J.1    Müller-Driver, R.2    Witting, C.3
  • 8
    • 3042591842 scopus 로고    scopus 로고
    • A pilot study of antiangiogenic therapy with bevacizumab and thalidomide in patients with metastatic renal cell carcinoma
    • Elaraj DM, White DE, Steinberg SM, et al. A pilot study of antiangiogenic therapy with bevacizumab and thalidomide in patients with metastatic renal cell carcinoma. J Immunother 27:259-264, 2004
    • (2004) J Immunother , vol.27 , pp. 259-264
    • Elaraj, D.M.1    White, D.E.2    Steinberg, S.M.3
  • 9
    • 30944452354 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib
    • Hainsworth JD, Sosman JA, Spigel DR, et al. Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib. J Clin Oncol 23:7889-7896, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 7889-7896
    • Hainsworth, J.D.1    Sosman, J.A.2    Spigel, D.R.3
  • 10
    • 0038823526 scopus 로고    scopus 로고
    • Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray
    • Hedberg Y, Ljungberg B, Roos G, Landberg G. Expression of cyclin D1, D3, E, and p27 in human renal cell carcinoma analysed by tissue microarray. Br J Cancer 88:1417-1423, 2003
    • (2003) Br J Cancer , vol.88 , pp. 1417-1423
    • Hedberg, Y.1    Ljungberg, B.2    Roos, G.3    Landberg, G.4
  • 11
    • 0344127560 scopus 로고    scopus 로고
    • Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray
    • Higgins JP, Shinghal R, Gill H, et al. Gene expression patterns in renal cell carcinoma assessed by complementary DNA microarray. Am J Pathol 162:925- 932, 2003
    • (2003) Am J Pathol , vol.162 , pp. 925-932
    • Higgins, J.P.1    Shinghal, R.2    Gill, H.3
  • 12
    • 84875154951 scopus 로고    scopus 로고
    • Temsirolinus, interferon-A plus temsirolinus for patients with advanced renal cell carcinoma and poor prognostic features
    • in press)
    • Hudes G, Carducci M, Tomczak P, et al. Temsirolinus, interferon-A plus temsirolinus for patients with advanced renal cell carcinoma and poor prognostic features. N Engl J Med, 2006 (in press)
    • (2006) N Engl J Med
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 13
    • 1342288873 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor protein in human renal cell carcinoma
    • Jacobsen J, Grankvist K, Rasmuson T, et al. Expression of vascular endothelial growth factor protein in human renal cell carcinoma. BJU Int 93:297-302, 2004
    • (2004) BJU Int , vol.93 , pp. 297-302
    • Jacobsen, J.1    Grankvist, K.2    Rasmuson, T.3
  • 14
    • 30644478919 scopus 로고    scopus 로고
    • A phase II, openlabel study of gefitinib (IRESSA) in patients with locally advanced, metastatic, or relapsed renal cell carcinoma
    • Jermann M, Stahel RA, Salzberg M, et al. A phase II, openlabel study of gefitinib (IRESSA) in patients with locally advanced, metastatic, or relapsed renal cell carcinoma. Cancer Chemother Pharmacol 57:533-559, 2006
    • (2006) Cancer Chemother Pharmacol , vol.57 , pp. 533-559
    • Jermann, M.1    Stahel, R.A.2    Salzberg, M.3
  • 15
    • 33645972282 scopus 로고    scopus 로고
    • Genomics of renal cell cancer - Does it provide breakthrough?
    • Kopper l, Tímár J. Genomics of renal cell cancer - Does it provide breakthrough? Pathol Oncol Res 12:5-11, 2006
    • (2006) Pathol Oncol Res , vol.12 , pp. 5-11
    • Kopper, L.1    Tímár, J.2
  • 16
    • 33645116503 scopus 로고    scopus 로고
    • Expression of S-100 protein in renal cell neoplasms
    • Lin F, Yang W, Betten M, et al. Expression of S-100 protein in renal cell neoplasms. Hum Pathol 37:462-470, 2006
    • (2006) Hum Pathol , vol.37 , pp. 462-470
    • Lin, F.1    Yang, W.2    Betten, M.3
  • 17
    • 33746871442 scopus 로고    scopus 로고
    • Different vascular endothelial growth factor (VEGF), VEGF-receptor 1 and -2 mRNA expression profiles between clear cell and papillary renal cell carcinoma
    • Ljungberg BJ, Jacobsen J, Rudolfsson SH, et al. Different vascular endothelial growth factor (VEGF), VEGF-receptor 1 and -2 mRNA expression profiles between clear cell and papillary renal cell carcinoma. BJU Int 98:661-667, 2006
    • (2006) BJU Int , vol.98 , pp. 661-667
    • Ljungberg, B.J.1    Jacobsen, J.2    Rudolfsson, S.H.3
  • 18
    • 7044235075 scopus 로고    scopus 로고
    • Alterations of microvascular density in bone metastases of adenocarcinoms
    • Lorincz T, Tímár J, Szendroi M. Alterations of microvascular density in bone metastases of adenocarcinoms. Pathol Oncol Res 10:149-153, 2004
    • (2004) Pathol Oncol Res , vol.10 , pp. 149-153
    • Lorincz, T.1    Tímár, J.2    Szendroi, M.3
  • 19
    • 18244374789 scopus 로고    scopus 로고
    • New treatment for metastatic kidney cancer
    • Mancuso A, Sterngberg CN. New treatment for metastatic kidney cancer. Can J Urol 12(Suppl 1):66-70, 2005
    • (2005) Can J Urol , vol.12 , Issue.SUPPL. 1 , pp. 66-70
    • Mancuso, A.1    Sterngberg, C.N.2
  • 20
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer R, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 24:16-24, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.1    Michaelson, M.D.2    Redman, B.G.3
  • 21
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295:2516-2524, 2006
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 22
    • 0038507194 scopus 로고    scopus 로고
    • Overproduction of vascular endothelial growth factor related to von Hippel Lindau tumor suppressor gene mutations and hypoxiainducible factor-1 alpha expression in renal cell carcinomas
    • Na X, Wu G, Ryan CK, et al. Overproduction of vascular endothelial growth factor related to von Hippel Lindau tumor suppressor gene mutations and hypoxiainducible factor-1 alpha expression in renal cell carcinomas. J Urol 170:588-592, 2003
    • (2003) J Urol , vol.170 , pp. 588-592
    • Na, X.1    Wu, G.2    Ryan, C.K.3
  • 23
    • 2942756034 scopus 로고    scopus 로고
    • Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: Prognostic value of interleukin- 6 - from the Groupe Francais d'Immunothérapie
    • Negrier S, Perol D, Menetier-Caux C et al. Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: Prognostic value of interleukin- 6 - from the Groupe Francais d'Immunothérapie. J Clin Oncol 22:2371-2378, 2004
    • (2004) J Clin Oncol , vol.22 , pp. 2371-2378
    • Negrier, S.1    Perol, D.2    Menetier-Caux, C.3
  • 24
    • 33644636306 scopus 로고    scopus 로고
    • A hazai és nemzetközi daganatos halálozási és megbetegedési mutatók alakulása. A népegészségügyi programok jellegzetességei és várható eredményei
    • Ottó Sz, Kásler M. A hazai és nemzetközi daganatos halálozási és megbetegedési mutatók alakulása. A népegészségügyi programok jellegzetességei és várható eredményei. Magyar Onkológia 49:99-107, 2005
    • (2005) Magyar Onkológia , vol.49 , pp. 99-107
    • Ottó, S.1    Kásler, M.2
  • 25
    • 0346102836 scopus 로고    scopus 로고
    • Prognostic factors of immunotherapy in metastatic renal cell carcinoma
    • Padrik P. Prognostic factors of immunotherapy in metastatic renal cell carcinoma. Med Oncol 20:325-334, 2003
    • (2003) Med Oncol , vol.20 , pp. 325-334
    • Padrik, P.1
  • 26
    • 0142219359 scopus 로고    scopus 로고
    • Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway
    • Pantuck AJ, Zeng G, Belldegrun AS, Figlin RA. Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway. Clin Cancer Res 9:4641-4652, 2003
    • (2003) Clin Cancer Res , vol.9 , pp. 4641-4652
    • Pantuck, A.J.1    Zeng, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 27
    • 33644840580 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma
    • Patel PH, Chaganti RSK, Morzer RJ. Targeted therapy for metastatic renal cell carcinoma. Br J Cancer 94:614- 619, 2006
    • (2006) Br J Cancer , vol.94 , pp. 614-619
    • Patel, P.H.1    Chaganti, R.S.K.2    Morzer, R.J.3
  • 28
    • 33646883733 scopus 로고    scopus 로고
    • Combination therapy of imatinib mesylate and interferon-alpha demonstrates minimal activity and significant toxicity in metastatic renal cell carcinoma: Results of a single-institution phase II trial
    • Polite BN, Desai AA, Manchen B, Stadler WM. Combination therapy of imatinib mesylate and interferon-alpha demonstrates minimal activity and significant toxicity in metastatic renal cell carcinoma: Results of a single-institution phase II trial. Clin Genitourin Cancer 4:257-280, 2006
    • (2006) Clin Genitourin Cancer , vol.4 , pp. 257-280
    • Polite, B.N.1    Desai, A.A.2    Manchen, B.3    Stadler, W.M.4
  • 29
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebocontrolled randomized discontinuation trial of sorafinib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, Stadler WM, et al. Phase II placebocontrolled randomized discontinuation trial of sorafinib in patients with metastatic renal cell carcinoma. J Clin Oncol 24:4669-4670, 2006
    • (2006) J Clin Oncol , vol.24 , pp. 4669-4670
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 30
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • Rini BI, Small EJ. Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J Clin Oncol 23:1028-1043, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2
  • 31
    • 33748526494 scopus 로고    scopus 로고
    • Clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Impact of patient characteristics and Von Hippel-Lindau gene status
    • Rini BI, Jaeger E, Weinberg V. clinical response to therapy targeted at vascular endothelial growth factor in metastatic renal cell carcinoma: Impact of patient characteristics and Von Hippel-Lindau gene status. BJU Int 98:756-762, 2006
    • (2006) BJU Int , vol.98 , pp. 756-762
    • Rini, B.I.1    Jaeger, E.2    Weinberg, V.3
  • 32
    • 1642285328 scopus 로고    scopus 로고
    • Is treatment with interferon- A effective in all patients with metastatic renal carcinoma? A new approach to the investigation of interactions
    • Royston P, Sauerbrei W, Ritchie A. Is treatment with interferon- A effective in all patients with metastatic renal carcinoma? A new approach to the investigation of interactions. Br J Cancer 90:794-799, 2004
    • (2004) Br J Cancer , vol.90 , pp. 794-799
    • Royston, P.1    Sauerbrei, W.2    Ritchie, A.3
  • 33
    • 24944453855 scopus 로고    scopus 로고
    • Phase I trial of the oral antiangiogenesis agent AG-013736 in patient with advanced solid tumors: Pharmacokinetic and clinical result
    • Rugo HS, Herbst R, Lin G, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patient with advanced solid tumors: Pharmacokinetic and clinical result. J Clin Oncol 23:5474-5483, 2005
    • (2005) J Clin Oncol , vol.23 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.2    Lin, G.3
  • 34
    • 25144482324 scopus 로고    scopus 로고
    • EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients
    • Sakaeda T, Okumura N, Gotoh A, et al. EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients. Pharm Res 22:1757-1761, 2005
    • (2005) Pharm Res , vol.22 , pp. 1757-1761
    • Sakaeda, T.1    Okumura, N.2    Gotoh, A.3
  • 35
    • 20844437574 scopus 로고    scopus 로고
    • Molecular classification of renal tumors by gene expression profiling
    • Schuetz AN, Yin-Goen Q, Amin MB, et al. Molecular classification of renal tumors by gene expression profiling. J Mol Diagn =:206-218, 2005
    • (2005) J Mol Diagn , pp. 206-218
    • Schuetz, A.N.1    Yin-Goen, Q.2    Amin, M.B.3
  • 37
    • 0242521464 scopus 로고    scopus 로고
    • Molecular subclassification of kidney tumors and the discovery of new diagnostic markers
    • Takahashi M, Yang XJ, Sugimura J, et al. Molecular subclassification of kidney tumors and the discovery of new diagnostic markers. Oncogene 22:6810-6818, 2003
    • (2003) Oncogene , vol.22 , pp. 6810-6818
    • Takahashi, M.1    Yang, X.J.2    Sugimura, J.3
  • 38
    • 0035570863 scopus 로고    scopus 로고
    • Quantitative analysis of gene expression of vascular endothelial growth factorrelated factors and their receptors in renal cell carcinoma
    • Tsuchiya N, Sato K, Akao T, et al. Quantitative analysis of gene expression of vascular endothelial growth factorrelated factors and their receptors in renal cell carcinoma. Tohoku J Exp Med 195:101-113, 2001
    • (2001) Tohoku J Exp Med , vol.195 , pp. 101-113
    • Tsuchiya, N.1    Sato, K.2    Akao, T.3
  • 39
    • 0029146750 scopus 로고
    • Epidermal growth factor receptor and transforming growth factor alpha expression in papillary and nonpapillary renal cell carcinoma: Correlation with metastatic behavior and prognosis
    • Uhlman DL, Nguyen P, Manivel JC, et al. Epidermal growth factor receptor and transforming growth factor alpha expression in papillary and nonpapillary renal cell carcinoma: Correlation with metastatic behavior and prognosis. Clin Cancer Res 1:913-920, 1995
    • (1995) Clin Cancer Res , vol.1 , pp. 913-920
    • Uhlman, D.L.1    Nguyen, P.2    Manivel, J.C.3
  • 40
    • 4644256561 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate (formerly known as STI-571) in patients with metastatic renal cell carcinoma (RCC)
    • (abstract)
    • Vuky J, Fotoohi M, Isacson C, et al. Phase II trial of imatinib mesylate (formerly known as STI-571) in patients with metastatic renal cell carcinoma (RCC). Proc Am Soc Clin Oncol 22:1672, 2003 (abstract)
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 1672
    • Vuky, J.1    Fotoohi, M.2    Isacson, C.3
  • 41
    • 32944468321 scopus 로고    scopus 로고
    • The sensitivity of renal cell carcinoma cells to interferon alpha correlates with p53-induction and involves Bax
    • Wittnebel S, Jalil A, Thiery J, et al. The sensitivity of renal cell carcinoma cells to interferon alpha correlates with p53-induction and involves Bax. Eur Cytokine Netw 16:123-127, 2005
    • (2005) Eur Cytokine Netw , vol.16 , pp. 123-127
    • Wittnebel, S.1    Jalil, A.2    Thiery, J.3
  • 42
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 349:427-434, 2003
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 43
    • 4644229716 scopus 로고    scopus 로고
    • Bevacizumab for patients with metastatic renal cancer: An update
    • Yang JC. Bevacizumab for patients with metastatic renal cancer: An update. Clin Cancer Res 10:6367S-6370S, 2004
    • (2004) Clin Cancer Res , vol.10
    • Yang, J.C.1
  • 44
    • 13844254987 scopus 로고    scopus 로고
    • Gene expression analysis of renal carcinoma: Adipose differentiation related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma
    • Yao M, Tabuchi H, Nagashima Y, et al. Gene expression analysis of renal carcinoma: Adipose differentiation related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J Pathol 205:377-387, 2005
    • (2005) J Pathol , vol.205 , pp. 377-387
    • Yao, M.1    Tabuchi, H.2    Nagashima, Y.3
  • 45
    • 0037307953 scopus 로고    scopus 로고
    • Beta defensin-1, parvalbumin and vimentin: A panel from gene expression profiling studies using cDNA microarrays
    • Young AN, de Oliveira Salles PG, Lim SD, et al. Beta defensin-1, parvalbumin and vimentin: A panel from gene expression profiling studies using cDNA microarrays. Am J Surg Pathol 27:199-205, 2003
    • (2003) Am J Surg Pathol , vol.27 , pp. 199-205
    • Young, A.N.1    De Oliveira Salles, P.G.2    Lim, S.D.3


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