Sinomenine inhibits primary CD4+ T-cell proliferation via apoptosis

Cell Biology International

Volumn 31, Issue 8, 2007, Pages 784-789

  Shu, Luan ^a   Yin, Wu ^a   Zhang, Jing ^a   Tang, Bo ^a   Kang, Yuan Xi ^a   Ding, Fan ^a   Hua, Zi Chun ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Bcl 2; Caspase 3; CD4+ T cell; Cell cycle; Sinomenine

Indexed keywords

PROTEIN BCL 2; SINOMENINE;

APOPTOSIS; ARTICLE; BINDING ASSAY; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVATION; FEMALE; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED C57BL; MORPHINANS;

SINOMENIUM ACUTUM;

EID: 34248523197     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2007.01.035     Document Type: Article

References (24)

1. Borrow P., Tishon A., Lee S., Xu J.C., Grewal I.S., Oldstone M.B.A., et al. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8(+) CTL response. J Exp Med 183 (1996) 2129-2142
2. Borrow P., Tough D.F., Eto D., Tishon A., Grewal I.S., Sprent J., et al. CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection. J Virol 72 (1998) 7440-7449
3. Candinas D., Walter M., Kaever V., Miyatake T., Koyamada N., Hechenleitner P., et al. Immunomodulatory effects of the alkaloid sinomenine in the high responders ACI-to-Lewis cardiac allograft model. Transplantation 62 (1996) 1855-1860
4. Chan S.L., and Yu V.C. Proteins of the bcl-2 family in apoptosis signalling: from mechanistic insights to therapeutic opportunities. Clin Exp Pharmacol Physiol 31 (2004) 119-128
5. Chen Y.W., Li J.Y., Zhang J.B., Zhao T.T., Zou L.Y., Tang Y., et al. Sinomenine inhibits B7-H1 and B7-DC expression on human renal tubular epithelial cells. Int Immunopharmacol 5 (2005) 1446-1457
6. 2+ involved mitochondrial pathway. Toxicol Sci 91 1 (2006) 59-69
7. He X.B., Wang J.L., Guo Z.H., Liu Q.Y., Chen T.Y., Wang X.J., et al. Requirement for ERK activation in sinomenine-induced apoptosis of macrophages. Immunol Lett 98 (2005) 91-96
8. Hojo H., Kondo Y., Umeda H., Tahira T., and Hashimoto Y. Effect of sinomenine on antibody responses in mice. J Immunopharmacol 7 1 (1985) 33-42
9. Hua Z.C., Sohn S.J., Kang C., Cado D., and Winoto A. A function of fas-associated death domain protein in cell cycle progression localized to a single amino acid at its c-terminal region. Immunity 18 (2003) 513-521
10. Justewicz D.M., Doherty P.C., and Webster R.G. The B-cell response in lymphoid-tissue of mice immunized with various antigenic forms of the influenzavirus hemagglutinin. J Virol 69 (1995) 5414-5421
11. Kalams S.A., and Walker B.D. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 188 (1998) 2199-2204
12. Kondo Y., Takano F., Yoshida K., and Hojo H. Protection by sinomenine against endotoxin-induced fulminant hepatitis in galactosamine- sensitized mice. Biochem Pharmacol 48 (1994) 1050-1052
13. Liblau R.S., Singer S.M., and McDevitt H.O. Th1 and Th2 CD4 T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16 (1995) 34-38
14. Liu L., Riese J., Resch K., and Kaever V. Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. Arzneimittelforschung 44 (1994) 1223-1226
15. Liu L., Buchner E., Beitze D., Schmidt-Weber C.B., Kaever V., Emmrich F., et al. Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine. Int J Immunopharmacol 18 (1996) 529-543
16. Lyons A.B. Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. J Immunol Methods 243 (2000) 147-154
17. Mark W., Schneeberger S., Seiler R., Stroka D.M., Amberger A., Offner F., et al. Sinomenine blocks tissue remodeling in a rat model of chronic cardiac allograft rejection. Transplantation 75 (2003) 940-945
18. Mosmann T.R., and Sad S. The expanding universe of T-cell subsets: Th 1, Th 2 and more. Immunol Today 17 (1996) 138-146
19. Oxenius A., Bachmann M.F., Zinkernagel R.M., and Hengartner H. Virus-specific MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur J Immunol 28 (1998) 390-400
20. Shu L., Yin W., Zhuang H., and Hua Z. Comparison of gene expression profiles in mouse primary T cells under normal and prolonged activation. Blood Cells Mol Dis 37 1 (2006) 64-75
21. Thomsen A.R., Nansen A., Christensen J.P., Andreasen S.O., and Marker O. CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus. J Immunol 161 (1998) 4583-4590
22. Wang Y., Fang Y.F., Huang W.H., Zhou X., Wang M.H., Zhou B., et al. Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats. J Ethnopharmacol 98 (2005) 37-43
23. Yamasaki H. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med 30 (1976) 1-20
24. Yin W., Jiang G., Takeyasu K., and Zhou X. Stimulation of Na,K-ATPase by low potassium is dependent on transferrin. J Membrane Bio 193 (2003) 177-184