Subchronic neurotoxicity screening studies with six organophosphate insecticides: An assessment of behavior and morphology relative to cholinesterase inhibition

Fundamental and Applied Toxicology

Volumn 35, Issue 1, 1997, Pages 101-119

  Sheets, L P ^a   Hamilton, B F ^a   Sangha, G K ^a   Thyssen, J H ^a  

^a BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZINPHOS METHYL; BIOCHEMICAL MARKER; DISULFOTON; METHAMIDOPHOS; METRIFONATE; ORGANOPHOSPHATE INSECTICIDE; SULPROFOS; TEBUPIRIMPHOS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BODY WEIGHT; BRAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG COMPARISON; DRUG SCREENING; ENZYME INHIBITION; ERYTHROCYTE; FEMALE; FOOD INTAKE; MALE; MOTOR ACTIVITY; MUSCLE TISSUE; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMA; RAT; SEX DIFFERENCE;

ANIMALIA;

EID: 85033517335     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.2269     Document Type: Article

References (45)

1. Abou-Donia, M. B. (1981). Organophosphorus ester-induced delayed neurotoxicity. Annu. Rev. Pharmacol. Toxicol. 21, 511-548.
2. Boyes, W. K., Tandon, P., Barone, S., Jr., and Padilla, S. (1994). Effects of organophosphates on the visual system of rats. J. Appl. Toxicol. 14(2), 135-143.
3. Brownson, C., and Watts, D. C. (1973). The modification of cholinesterase activity by 5,5′-dithiobis-(2-nitrobenzoic acid) included in the coupled spectrophotometric assay. Biochem. J. 131, 369-374.
4. Bruner, R. H., Keller, W. F., Stitzel, K. A., Sauers, L. J., Reer, P. J., Long, P. H., Bruce, R. D., and Alden, A. L. (1992). Spontaneous corneal dystrophy and generalized basement membrane changes in Fischer-344 rats. Toxicol. Pathol. 20, 357-366.
5. Dass, P., Mejia, M., Jones, R., Landes, M., Stuart, B., and Thyssen, J. (1994). Cholinesterase: Review of Methods. Clin. Chem. 34(10), 135-158.
6. Davis, C. S., Johnson, M. K., and Richardson, R. J. (1985). Organophosphorus compounds. In Neurotoxicity of Industrial and Commercial Chemicals (J. L. O'Donoghue, Ed.), Vol. II, pp. 1-23. CRC Press, Boca Raton, FL.
7. Davis, C. S., and Richardson, R. J. (1980). Organophosphorus compounds. In Experimental and Clinical Neurotoxicology (P. S. Spencer and H. H. Schaumburg, Eds.), pp. 527-544. Williams and Wilkins, Baltimore.
8. D'Mello, G. D. (1993). Behavioural toxicity of anticholinesterases in humans and animals - A review. Hum. Exp. Toxicol. 12, 3-7.
9. Dyer, K. R., Jortner, B. S., Shell, L. G., and Ehrich, M. (1992). Comparative dose-response studies of organophosphorus ester-induced delayed neuropathy in rats and hens administered mipafox. NeuroToxicology 13, 745-756.
10. Ecobichon, D. J. (1996). Toxic effects of pesticides. In Casarett and Doull's Toxicology: The Basic Science of Poisons (C. D. Klaassen, Ed.), 5th ed., pp. 643-689. McGraw-Hill, New York.
11. Edwards, P. M., and Parker, V. H. (1977). A simple, sensitive, and objective method for early assessment of acrylamide neuropathy in rats. Toxicol. Appl. Pharmacol. 40, 589-591.
12. Ehrich, M., Jortner, B. S., and Padilla, S. (1995). Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors. Fundam. Appl. Toxicol. 24, 94-101.
13. Eisenbrandt, D. L., Mattsson, J. L., Albee, R. R., Spencer, P. J., and Johnson, K. A. (1990). Spontaneous lesions in subchronic neurotoxicity testing of rats. Toxicol. Pathol. 18, 154-164.
14. Ellman, G. L., Courtney, K. D., Andres, V., Jr., and Featherstone, R. M. (1961). A new rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharm. 7, 88-95.
15. Gerber, G. J., and O'Shaughnessy, D. (1986). Comparison of the behavioral effects of neurotoxic and systemically toxic agents: How discriminatory are behavioral tests of neurotoxicity? Neurobehav. Toxicol. Teratol. 8, 703-710.
16. Grassetti, D. R., Murray, J. F., Jr., and Ruan, H. T. (1969). The interaction of 6,6′-dithiodinicotinic acid with thiols and with Ehrlich ascites tumor cells. Biochem. Pharm. 18, 603-611.
17. Hackathorn, D. R., Brinkman, W. J., Hathaway, T. R., Talbott, T. D., and Thompson, L. R. (1983). Validation of a whole-blood method for cholinesterase monitoring. Am. Ind. Hyg. Assoc. J. 44, 547-551.
18. INSTEM Computer Systems, Stone, Staffordshire, England.
19. Inui, K., Mitsumori, K., Harada, T., and Malta, K. (1993). Quantitative analysis of neuronal damage induced by tri-ortho-cresyl phosphate in Wistar rats. Fundam. Appl. Toxicol. 20, 111-119.
20. Johnson, M. K. (1990). Organophosphates and delayed neuropathy - Is NTE alive and well? Toxicol. Appl. Pharmacol. 102, 385-399.
21. Kulwich, B. A. (1994). Epidermoid cysts in the central nervous system of rats and mice: An incidental finding in toxicity-oncogenicity studies. Vet. Pathol. 31, 475-478.
22. Lee, E. W., Render, J. A., Garner, C. D., Brady, A. N., and Li, L. C. (1990). Unilateral degeneration of retina and optic nerve in Fischer-344 rats. Vet. Pathol. 27, 439-444.
23. Levine, S. (1966). Epidermoid cysts of the spinal cord: A spontaneous disease of rats. J. Neuropath. Exp. Neurol. 25, 498-504.
24. Llorens, J., Crofton, K. M., Tilson, H. A., Ali, S. F., and Mundy, W. R. (1993). Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposures. Fundam. Appl. Toxicol. 20, 163-169.
25. Losco, P. E., and Troup, C. M. (1988). Corneal dystrophy in Fischer 344 rats. Lab. Anim. Sci. 38, 702-710.
26. Lotti, M. (1992). The pathogenesis of organophosphate polyneuropathy. Crit. Rev. Toxicol. 21, 465-487.
27. Lynch, M. R., Rice, A., and Robinson, S. E. (1986). Dissociation of locomotor depression and ChE activity after DFP, soman and sarin. Pharmacol. Biochem. Behav. 24, 941-947.
28. Marrs, T. C. (1993). Organophosphate poisoning. Pharmacol. Ther. 58, 51-66.
29. Meyer, D. A., Tilson, H.A., Byrd, W. C., and Riley, M. T. (1979). A method for the routine assessment of fore-and hindlimb grip strength of rats and mice. Neurobehav. Toxicol. 1, 233-236.
30. Moser, V. C. (1988). Comparison of chlordimeform and carbaryl using a functional observational battery. Fundam. Appl. Toxicol. 11, 189-206.
31. Moser, V. C. (1989). Screening approaches to neurotoxicity: A functional observational battery. J. Am. Coll. Toxicol. 8, 85-93.
32. Padilla, S., Moser, V. C., Pope, C. N., and Brimijoin, W. S. (1992). Paraoxon toxicity is not potentiated by prior reduction in blood acetylcholines-terase. Toxicol. Appl. Pharmacol. 117, 110-115.
33. Padilla, S., and Veronesi, B. (1988). Biochemical and morphological valida-tion of a rodent model of organophosphorus-induced delayed neuropathy. Toxicol. Ind. Health 4, 361-371.
34. Padilla, S., Wilson, V. Z., and Bushnell, P. J. (1994). Studies on the correlation between blood cholinesterase inhibition and 'target tissue' inhibition in pesticide-treated rats. Toxicology 92, 11-25.
35. Purina Mills, Inc. (1987). "Certified Lab Chows," Animal Diet Reference Guide, 62.
36. Reiter, L. W. (1983). Chemical exposure and animal activity: Utility of the figure 8 maze, In Developments in the Science and Practice of Toxicology (A. W. Hayes, R. C. Schnell, and T. S. Miyou, Eds.), pp. 73-84. Elsevier, New York.
37. Reiter, L. W., Andersen, G. E., Laskey, J. W., and Cahill, D. F. (1975). Developmental and behavioral changes in the rat during chronic exposure to lead. Environ. Health Perspect. 12, 119-123.
38. SAS Institute, Inc. (1990). SAS/STAT User's Guide, Version 6, 4th ed., Vol. 1. SAS Institute, Cary, NC.
39. Shell, L., Rozum, M., Jortner, B. S., and Ehrich, M. (1992). Neurotoxicity of acrylamide and 2,5-hexanedione in rats evaluated using a functional observational battery and pathological examination. Neurotoxicol Teratol 14, 273-283.
40. Spencer, P. S., and Schaumburg, H. H. (1980). Classification of neurotoxic disease: A morphological approach. In Experimental and Clinical Neurotoxicology (P. S. Spencer and H. H. Schaumburg, Eds.), pp. 92-99. Williams and Wilkins, Baltimore.
41. Traina, M. E., and Serpietri, L. A. (1984). Changes in the levels and forms of rat plasma cholinesterases during chronic diisopropyl-phosphorofluoridate intoxication. Biochem. Pharmacol. 33, 645-654.
42. US-EPA (1991). Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation: Human and Domestic Animals, Guideline Addendum 10, Neurotoxicity: NTIS, EPA 540/09-91-123, PB 91-154617.
43. US-EPA (1990). Report of the SAB/SAP joint Study Group on Cholinester-ase: Review of Cholinesterase Inhibition and Its Effects, EPA-SAB-EC-90-014.
44. US-EPA (1992). Review of the following report: A combined chronic toxicity/oncogenicity study of technical grade trichlorfon (Dylox) with rats. FIFRA Guideline 83-5, 1990.
45. Veronesi, B. (1984). A rodent model of organophosphorus-induced delayed neuropathy: Distribution of central and peripheral neuropathy. Neuropath. Appl. Neurobiol. 10, 357-368.