Effects of the extracts from Mitragyna speciosa Korth. leaves on analgesic and behavioral activities in experimental animals

Songklanakarin Journal of Science and Technology

Volumn 29, Issue SUPPL. 1, 2007, Pages 39-48

  Reanmongkol, Wantana ^a   Keawpradub, Niwat ^a   Sawangjaroen, Kitja ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

Author keywords

Alkaloid; Analgesic; Behavioral; Extract; Mitragyna speciosa leaves

Indexed keywords

EID: 34248366603     PISSN: 01253395     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Anon. 2006. Mitragyna speciosa - Kratom. Available from http://www.entheology.org/edoto/anmviewer.asp?a=63&z=5.
2. Bruce, R.D. 1985. An up- and down procedure for acute toxicity testing. Fundam. Appl. Toxicol., 5: 151-157.
3. Capasso, A., Di Giannuario, A., Loizzo, A., Pieretti, S. and Sorrentino, L. 1996. Dexamethasone reduced clonidine-induced hypoactivity in mice. J. Pharm. Pharmacol., 48: 615-618.
4. D'Amour, F.E. and Smith, D.L. 1941. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther., 72: 74-79.
5. Ferrini, R., Miragoli, G. and Taccardi, B. 1974. Neuropharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class. Arzneim-Forsch., 24: 2029-2032.
6. th ed., Hardman, J.G. and Limbird, L.E. (eds), McGraw-Hill, New York, pp. 602-604.
7. Horie, S., Koyama, F., Takayama, H., Ishikawa, H., Aimi, N., Ponglux, D., Matsumoto, K. and Murayama, T. 2005. Indole alkaloids of a Thai medicinal herb, Mitragyna speciosa, that has opioid agonistic effect in guinea-pig ileum. Planta Med., 71: 231-6.
8. Matsumoto, K., Horie, S., Ishikawa, H., Takayama, H., Aimi, N., Ponglux, D. and Watanabe, K. 2004. Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa. Life Sci., 74: 2143-55.
9. Matsumoto, K., Yamamoto, L.T., Watanabe, K., Yano, S., Shan, J., Pang, P.K., Ponglux, D., Takayama, H. and Horie, S. 2005a. Inhibitory effect of mitragynine, an analgesic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens. Life Sci., 78: 187-94.
10. Matsumoto, K., Horie, S., Takayama, H., Ishikawa, H., Aimi, N, Ponglux, D., Murayama, T. and Watanabe, K. 2005b. Antinociceptive, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa. Life Sci., 78: 2-7.
11. Matsumoto, K., Takayama, H., Ishikawa, H., Aimi, N, Ponglux, D., Watanabe, K. and Horie, S. 2005c. Partial agonistic effect of 9-hydroxycoryn-antheidine on mu-opioid receptor in the guineapig ileum. Life Sci. (in press).
12. Matsumoto, K., Mizowaki, M., Suchitra, T., Takayama, H., Sakai, S., Aimi, N. and Watanabe, H. 1996a. Antinociceptive action of mitragynine in mice: evidence for the involvement of supraspinal opioid receptors. Life Sci., 59: 1149-55.
13. Matsumoto, K., Mizowaki, M., Suchitra, T., Murakami, Y., Takayama, H., Sakai, S., Aimi, N. and Watanabe, H. 1996b. Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems. Eur. J. Pharmacol. 317: 75-81.
14. Matsumoto, K., Mizowaki, M., Takayama, H., Sakai, S., Aimi, N. and Watanabe, H. 1997. Suppressive effect of mitragynine on the 5-methoxy-N, N-dimethyltryptamine-induced head-twitch response in mice. Pharmacol. Biochem. Behav. 57:319-23.
15. Mayer, D.J. and Liebeskind, J.C. 1974. Pain reduction by focal electrical stimulation of the brain and anatomical and behavioral analysis. Brain Res., 68: 73-93.
16. Takayama, H. 2004. Chemistry and pharmacology of analgesic indole alkaloids from the Rubiaceous plant, Mitragyna speciosa. Chem. Pharm. Bull. (Tokyo), 52: 916-28.
17. Takayama, H., Aimi, N, Sakai, S. 2000. Chemical studies on the analgesic indole alkaloids from the traditional medicine (Mitragyna speciosa) used for opium substitute. Yakugaku Zasshi, 120: 959-67. [Abtract]
18. Takayama, H., Ishikawa, H., Kurihara, M., Kitajima, M., Aimi, N., Ponglux, D., Koyama, F., Matsumoto, K., Moriyama, T., Yamamoto, L.T., Watanabe, K., Murayama, T. and Horie, S. 2002. Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands. J. Med. Chem. 45: 1949-56.
19. Thongpradichote, S., Matsumoto, K., Tohda, M., Takayama, H., Aimi, N., Sakai, S. and Watanabe, H. 1998. Identification of opioid receptor subtypes in antinociceptive actions of supraspinally-administered mitragynine in mice. Life Sci., 62: 1371-8.
20. Tohda, M., Thongpraditchote, S., Matsumoto, K., Murakami, Y., Sakai, S., Aimi, N., Takayama, H., Tongroach, P. and Watanabe, H. 1997. Biol. Pharm. Bull. 20: 338-40.
21. Tsuchiya, S., Miyashita, S., Yamamoto, M., Horie, S., Sakai, S., Aimi, N., Takayama, H. and Watanabe, K. 2002. 443: 185-8.
22. Watanabe, K., Yano, S., Horie, S. and Yamamoto, L.T. 1997. Inhibitory effect of mitragynine, an alkaloid with analgesic effect from Thai medicinal plant Mitragyna speciosa, on electrically stimulated contraction of isolated guinea-pig ileum through the opioid receptor. Life Sci., 60: 933-42.
23. Woolfe, G. and MacDonald, A.D. 1944. The evaluation of the analgesic action of pethidine hydrochloride (Demerol). J. Pharmacol. Exp. Ther., 80: 300-307.
24. Yaksh, T.L. and Rubi, T.A. 1976. Analgesia mediated by a direct spinal action of narcotics. Sciences, 192: 1357-1358.
25. Yamamoto, L.T., Horie, S., Takayama, H., Aimi, N., Sakai, S., Yano, S., Shan, J., Pang, P.K., Ponglux, D. and Watanabe, K. 1999. Opioid receptor agonistic characteristics of mitragynine pseudoindoxyl in comparison with mitragynine derived from Thai medicinal plant Mitragyna speciosa. Gen. Pharmacol. 33: 73-81.