GATA3 up-regulation associated with surface expression of CD294/CRTH2: A unique feature of human Th cells

Blood

Volumn 109, Issue 10, 2007, Pages 4343-4350

  De Fanis, Umberto ^a   Mori, Francesca ^a   Kurnat, Rebecca J ^a   Won, Kyung Lee ^a   Bova, Maria ^a   Adkinson, N Franklin ^a   Casolaro, Vincenzo ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS ASTHMA AND ALLERGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; GAMMA INTERFERON; INTERLEUKIN 4; MONOCLONAL ANTIBODY; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET;

ADULT; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL ISOLATION; CELL SELECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE CONTROL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; UPREGULATION;

EID: 34248349587     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-05-025940     Document Type: Article

References (52)

1. Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol. 2001;1:69-75.
2. Eisenbarth SC, Piggott DA, Bottomly K. The master regulators of allergic inflammation: dendritic cells in Th2 sensitization. Curr Opin Immunol. 2003;15:620-626.
3. Murphy KM. Fate vs choice: the immune system reloaded. Immunol Res. 2005;32:193-200.
4. Szabo SJ, Sullivan BM, Peng SL, Glimcher LH. Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol. 2003;21:713-758.
5. Mowen KA, Glimcher LH. Signaling pathways in Th2 development. Immunol Rev. 2004;202:203-222.
6. Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000;100:655-669.
7. Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem. 1997;272:21597-21603.
8. Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell. 1997;89:587-596.
9. Zhang DH, Yang L, Cohn L, et al. Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity. 1999;11:473-482.
10. Nakamura Y, Ghaffar O, Olivenstein R, et al. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J Allergy Clin Immunol. 1999;103:215-222.
11. Finotto S, Neurath MF, Glickman JN, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002;295:336-338.
12. Mestas J, Hughes CC. Of mice and not men: differences between mouse and human immunology. J Immunol. 2004;172:2731-2738.
13. Sallusto F, Lanzavecchia A. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol Rev. 2000;177:134-140.
14. Kaplan AP. Chemokines, chemokine receptors and allergy. Int Arch Allergy Immunol. 2001;124:423-431.
15. Huang JL, Gao PS, Mathias RA, et al. Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. Hum Mol Genet. 2004;13:2691-2697.
16. 2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. J Invest Dermatol. 2002;119:609-616.
17. Cosmi L, Annunziato F, Galli MIG, et al. CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur J Immunol. 2000;30:2972-2979.
18. Nagata K, Tanaka K, Ogawa K, et al. Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol. 1999;162:1278-1286.
19. 2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells. J Immunol. 2005;175:6531-6536.
20. Chevalier E, Stock J, Fisher T, et al. Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment. J Immunol. 2005;175:2056-2060.
21. Abe H, Takeshita T, Nagata K, et al. Molecular cloning, chromosome mapping and characterization of the mouse CRTH2 gene, a putative member of the leukocyte chemoattractant receptor family. Gene. 1999;227:71-77.
22. 2 receptor DP2/CRTH2 increases allergic inflammation in mouse. J Immunol. 2005;174:3703-3708.
23. Noble A, Truman JP, Vyas B, et al. The balance of protein kinase C and calcium signaling directs T cell subset development. J Immunol. 2000;164:1807-1813.
24. + T cells based on cytokine secretion. Eur J Immunol. 1999;29:4053-4059.
25. H cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol. 2002;3:643-651.
26. Corn RA, Hunter C, Liou HC, Siebenlist U, Boothby MR. Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiation. J Immunol. 2005;175:2102-2110.
27. Rozen S, Skaletsky HJ. Primer3 on the WWW for general users and for biologist programmers. In: Krawetz S, Misener S, eds. Bioinformatics Methods and Protocols: Methods in Molecular Biology. Totowa, NJ: Humana Press; 2000:365-386.
28. Whitehead Institute for Biomedical Research, Cambridge, MA. Available at: frodo.wi.mit.edu. Accessed February 4, 2004.
29. National Center for Biotechnology Information. Available at: www.ncbi.nlm.nih.gov. Accessed January 28, 2004.
30. Feroze-Merzoug F, Berquin IM, Dey J, Chen YQ. Peptidylprolyl isomerase A (PPIA) as a preferred internal control over GAPDH and β-actin in quantitative RNA analyses. Biotechniques. 2002;32:776-778, 780, 782.
31. Sundrud MS, Grill SM, Ni D, et al. Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation. J Immunol. 2003;171:3542-3549.
32. H2 responses. Nat Immunol. 2004;5:1157-1165.
33. H2 lymphocytes. Nat Immunol. 2003;4:78-86.
34. Yamashita M, Shinnakasu R, Asou H, et al. Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway. J Biol Chem. 2005;280:29409-29419.
35. H2 cells by IL-12 or the PS-DSP30 oligodeoxynucleotide. J Allergy Clin Immunol. 2001;108:815-821.
36. Guo L, Hu-Li J, Paul WE. Probabilistic regulation of IL-4 production in Th2 cells: accessibility at the Il4 locus. Immunity. 2004;20:193-203.
37. Das J, Chen CH, Yang L, et al. A critical role for NF-κB in GATA3 expression and TH2 differentiation in allergic airway inflammation. Nat Immunol. 2001;2:45-50.
38. Farrar JD, Asnagli H, Murphy KM. T helper subset development: roles of instruction, selection, and transcription. J Clin Invest. 2002;109:431-435.
39. Smits HH, van Rietschoten JG, Hilkens CM, et al. IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression. Eur J Immunol. 2001;31:1055-1065.
40. Cousins DJ, Lee TH, Staynov DZ. Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines. J Immunol. 2002;169:2498-2506.
41. Kitamura N, Kaminuma O, Mori A, et al. Correlation between mRNA expression of Th1/Th2 cytokines and their specific transcription factors in human helper T-cell clones. Immunol Cell Biol. 2005;83:536-541.
42. Georas SN, Guo J, De Fanis U, Casolaro V. T-helper cell type-2 regulation in allergic disease. Eur Respir J. 2005;26:1119-1137.
43. Ho IC, Hodge MR, Rooney JW, Glimcher LH. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell. 1996;85:973-983.
44. Li-Weber M, Salgame P, Hu C, et al. Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter. J Immunol. 1998;161:1380-1389.
45. +-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood. 2005;105:750-758.
46. Casolaro V, Georas SN, Song Z, et al. Inhibition of NF-AT-dependent transcription by NF-κB: implications for differential gene expression in T helper cell subsets. Proc Natl Acad Sci U S A. 1995;92:11623-11627.
47. Caramori G, Lim S, Ito K, et al. Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies. Eur Respir J. 2001;18:466-473.
48. Farrar JD, Ouyang W, Lohning M, et al. An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3. J Exp Med. 2001;193:643-650.
49. Jee YK, Gilmour J, Kelly A, et al. Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment. J Biol Chem. 2005;280:23243-23250.
50. Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430-433.
51. Usui T, Preiss JC, Kanno Y, et al. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J Exp Med. 2006;203:755-766.
52. Hohler T, Reuss E, Adams P, et al. A genetic basis for IFN-γ production and T-bet expression in humans. J Immunol. 2005;175:5457-5462.