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Volumn 29, Issue SUPPL. 1, 2007, Pages 83-93

A phase I trial of Gynostemma pentaphyllum Makino in healthy volunteers

Author keywords

Clinical trials; Gynostemma pentaphyllum; Jiaogulan; Safety

Indexed keywords


EID: 34248345990     PISSN: 01253395     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (32)
  • 3
    • 0033250013 scopus 로고    scopus 로고
    • Gypenoside induces apoptosis in human Hep 3B and HA22T tumour cells
    • Chen, J.C., Chung, J.G. and Chen, L.D. 1999. Gypenoside induces apoptosis in human Hep 3B and HA22T tumour cells. Cytobios. 100: 37-48.
    • (1999) Cytobios , vol.100 , pp. 37-48
    • Chen, J.C.1    Chung, J.G.2    Chen, L.D.3
  • 4
    • 0029693267 scopus 로고    scopus 로고
    • Protective effects of Gynostemma pentaphyllum in y-irradiated mice
    • Chen, W.C., Hau, D.M., Chen, K.T., Wang, M.I. and Lin, I.H. 1996. Protective effects of Gynostemma pentaphyllum in y-irradiated mice. Am. J. Chin. Med. 24: 83-92.
    • (1996) Am. J. Chin. Med , vol.24 , pp. 83-92
    • Chen, W.C.1    Hau, D.M.2    Chen, K.T.3    Wang, M.I.4    Lin, I.H.5
  • 5
    • 16644367875 scopus 로고    scopus 로고
    • Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism
    • in Chinese
    • Chen, Z.L., Guan, Y.Q., Chen, X.,Chen, X.L. and Chen, J.C. 2004. Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism. Zhong Xi Yi Jie He Xue Bao. 2: 281-284. (in Chinese).
    • (2004) Zhong Xi Yi Jie He Xue Bao , vol.2 , pp. 281-284
    • Chen, Z.L.1    Guan, Y.Q.2    Chen, X.3    Chen, X.L.4    Chen, J.C.5
  • 6
    • 0042122450 scopus 로고    scopus 로고
    • N-acetyl-transferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski)
    • Chiu, T.H., Chen, J.C. and Chung, J.G. 2003. N-acetyl-transferase is involved in gypenosides-induced N-acetylation of 2-aminofluorene and DNA adduct formation in human cervix epidermoid carcinoma cells (Ca Ski). In Vivo. 17: 281-288.
    • (2003) In Vivo , vol.17 , pp. 281-288
    • Chiu, T.H.1    Chen, J.C.2    Chung, J.G.3
  • 7
    • 22844437873 scopus 로고    scopus 로고
    • Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino
    • Circosta, C., De Pasquale, R. and Occhiuto, F. 2005. Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino. Phytomedicine. 12: 638-643.
    • (2005) Phytomedicine , vol.12 , pp. 638-643
    • Circosta, C.1    De Pasquale, R.2    Occhiuto, F.3
  • 9
    • 0026132945 scopus 로고
    • Effects of Gynostemma pentaphyllum makino on the immunological function of cancer patients
    • Hou, J., Liu, S., Ma, Z., Lang, X., Wang, J., Wang, J. and Liang, Z. 1991. Effects of Gynostemma pentaphyllum makino on the immunological function of cancer patients. J Tradit Chin Med. 1991. 11: 47-52.
    • (1991) J Tradit Chin Med. 1991 , vol.11 , pp. 47-52
    • Hou, J.1    Liu, S.2    Ma, Z.3    Lang, X.4    Wang, J.5    Wang, J.6    Liang, Z.7
  • 10
    • 0030444924 scopus 로고    scopus 로고
    • New triterpenoid saponins from Gynostemma pentaphyllum
    • Hu, L., Chen, Z. and Xie, Y. 1996. New triterpenoid saponins from Gynostemma pentaphyllum. J. Nat. Prod. 59: 1143-1145.
    • (1996) J. Nat. Prod , vol.59 , pp. 1143-1145
    • Hu, L.1    Chen, Z.2    Xie, Y.3
  • 12
    • 34248385232 scopus 로고    scopus 로고
    • Jiang-Xu New Medical College. Jiao-Gu-Lan. Zhong-Yao-Da-Zhi-Dian. 1979. Sci.&Tech., Shanghai. P.16-17 (in Chinese)
    • Jiang-Xu New Medical College. Jiao-Gu-Lan. Zhong-Yao-Da-Zhi-Dian. 1979. Sci.&Tech., Shanghai. P.16-17 (in Chinese)
  • 13
    • 0007200127 scopus 로고
    • Effects of crude saponins of Gynostemma pentaphyllum on lipid metabolism
    • Kimura, Y., Okuda, H., Arichi, S. and Takemoto, T. 1983. Effects of crude saponins of Gynostemma pentaphyllum on lipid metabolism. Shoyakugaku Zasshi 37: 272-275.
    • (1983) Shoyakugaku Zasshi , vol.37 , pp. 272-275
    • Kimura, Y.1    Okuda, H.2    Arichi, S.3    Takemoto, T.4
  • 15
    • 0029005276 scopus 로고
    • Traditional Chinese medicine in treatment of hyperlipidaemia
    • la Cour, B., Molgaard, P. and Yi, Z. 1995. Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol. 46: 125-129.
    • (1995) J Ethnopharmacol , vol.46 , pp. 125-129
    • la Cour, B.1    Molgaard, P.2    Yi, Z.3
  • 16
    • 34248383590 scopus 로고
    • The influence of Gynostemma pentaphyllum extract on platelet aggregation and arachidonate metabolism in rabbits
    • Li, L. and Jin, YY. 1989. The influence of Gynostemma pentaphyllum extract on platelet aggregation and arachidonate metabolism in rabbits. Clin. Pharmacol. Bull. 5: 213-217.
    • (1989) Clin. Pharmacol. Bull , vol.5 , pp. 213-217
    • Li, L.1    Jin, Y.Y.2
  • 17
    • 34248371208 scopus 로고
    • Effects of gypenosides on lymphocyte proliferation and interleukin-2 production in the spleen of mice
    • Li, L. and Xing, S.T. 1992. Effects of gypenosides on lymphocyte proliferation and interleukin-2 production in the spleen of mice. Pharmacol. Clin. Chin. Nat. Med. 8: 26-29.
    • (1992) Pharmacol. Clin. Chin. Nat. Med , vol.8 , pp. 26-29
    • Li, L.1    Xing, S.T.2
  • 18
    • 0033650715 scopus 로고    scopus 로고
    • Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum
    • Lin, C.C., Huang, P.C. and Lin, J.M. 2000. Antioxidant and hepatoprotective effects of Anoectochilus formosanus and Gynostemma pentaphyllum. Am J Chin Med. 28: 87-96.
    • (2000) Am J Chin Med , vol.28 , pp. 87-96
    • Lin, C.C.1    Huang, P.C.2    Lin, J.M.3
  • 19
    • 0027351284 scopus 로고
    • Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilis formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats
    • Lin, J.M., Lin, C.C., Chiu, H.F., Yang, J.J. and Lee, S.G. 1993. Evaluation of the anti-inflammatory and liver-protective effects of Anoectochilis formosanus, Ganoderma lucidum and Gynostemma pentaphyllum in rats. Am. J. Chin. Med. 21: 59-69.
    • (1993) Am. J. Chin. Med , vol.21 , pp. 59-69
    • Lin, J.M.1    Lin, C.C.2    Chiu, H.F.3    Yang, J.J.4    Lee, S.G.5
  • 20
    • 27144541167 scopus 로고    scopus 로고
    • Three dammarane-type saponins from Gynostemma pentaphyllum
    • Liu, X., Ye, W., Mo, Z.,Yu, B., Wu, H., Zhao, S., Che, C. and Hsiao, W.L. 2005. Three dammarane-type saponins from Gynostemma pentaphyllum. Planta Med. 71: 880-884.
    • (2005) Planta Med , vol.71 , pp. 880-884
    • Liu, X.1    Ye, W.2    Mo, Z.3    Yu, B.4    Wu, H.5    Zhao, S.6    Che, C.7    Hsiao, W.L.8
  • 22
    • 0028998348 scopus 로고
    • New dammarane-type glycosides from Gynostemma pentaphyllum
    • Piacente, S., Pizza, C., De Tommasi, N. and De Simone, F. 1995. New dammarane-type glycosides from Gynostemma pentaphyllum. J. Nat. Prod. 58: 512-519.
    • (1995) J. Nat. Prod , vol.58 , pp. 512-519
    • Piacente, S.1    Pizza, C.2    De Tommasi, N.3    De Simone, F.4
  • 23
    • 3242753426 scopus 로고    scopus 로고
    • The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino
    • Rujjanawate, C., Kanjanapothi, D. and Amornlerdpison, D. 2004. The anti-gastric ulcer effect of Gynostemma pentaphyllum Makino. Phytomedicine. 11: 431-435.
    • (2004) Phytomedicine , vol.11 , pp. 431-435
    • Rujjanawate, C.1    Kanjanapothi, D.2    Amornlerdpison, D.3
  • 24
    • 0034991251 scopus 로고    scopus 로고
    • In vitro effect of Derris scandens on normal lymphocyte proliferation and its activities on natural killer cells in normals and HIV-1 infected patients
    • Sriwanthana, B. and Chavalittumrong, P. 2001. In vitro effect of Derris scandens on normal lymphocyte proliferation and its activities on natural killer cells in normals and HIV-1 infected patients. J. Ethnopharmacol 76: 125-129.
    • (2001) J. Ethnopharmacol , vol.76 , pp. 125-129
    • Sriwanthana, B.1    Chavalittumrong, P.2
  • 26
    • 27944495709 scopus 로고    scopus 로고
    • Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice
    • Sun, H. and Zheng, Q. 2005. Haemolytic activities and adjuvant effect of Gynostemma pentaphyllum saponins on the immune responses to ovalbumin in mice. Phytother Res. 19: 895-900.
    • (2005) Phytother Res , vol.19 , pp. 895-900
    • Sun, H.1    Zheng, Q.2
  • 27
    • 0027601259 scopus 로고
    • Antithrombotic effect of Gynostemma pentaphyllum
    • 278-80, in Chinese
    • Tan, H., Liu, Z.L, and Liu, M.J. 1993. Antithrombotic effect of Gynostemma pentaphyllum. Zhongguo Zhong Xi Yi lie He Za Zhi. 13: 278-80, 261. (in Chinese).
    • (1993) Zhongguo Zhong Xi Yi lie He Za Zhi , vol.13 , pp. 261
    • Tan, H.1    Liu, Z.L.2    Liu, M.J.3
  • 29
    • 0037179551 scopus 로고    scopus 로고
    • Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells
    • Wang, Q.F., Chen, J.C., Hsieh, S.J., Cheng, C.C. and Hsu, S.L. 2002. Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Lett. 26: 169-178.
    • (2002) Cancer Lett , vol.26 , pp. 169-178
    • Wang, Q.F.1    Chen, J.C.2    Hsieh, S.J.3    Cheng, C.C.4    Hsu, S.L.5
  • 30
    • 0345549180 scopus 로고
    • Immunomodulatory action of the total saponin of Gynostemma pentaphylla
    • Zhang, C., Yang, X. and Xu, L. 1990. Immunomodulatory action of the total saponin of Gynostemma pentaphylla. J Mod Dev Tradit Med 10: 69-70.
    • (1990) J Mod Dev Tradit Med , vol.10 , pp. 69-70
    • Zhang, C.1    Yang, X.2    Xu, L.3
  • 31
    • 0034160587 scopus 로고    scopus 로고
    • Experimental study on the influence of Gynostemma pentaphyllam Mak upon point mutation of Haras oncogene in blocking leukoplakia from canceration
    • in Chinese
    • Zhou, Z., Tang, G. and Zhong, W. 2000. Experimental study on the influence of Gynostemma pentaphyllam Mak upon point mutation of Haras oncogene in blocking leukoplakia from canceration. Zhonghua Kou Qiang Yi Xue Za Zhi. 35: 91-94. (in Chinese).
    • (2000) Zhonghua Kou Qiang Yi Xue Za Zhi , vol.35 , pp. 91-94
    • Zhou, Z.1    Tang, G.2    Zhong, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.