Anticonvulsant effect of Origanum majorana L.

Pharmacologyonline

Volumn 1, Issue , 2007, Pages 64-78

  Deshmane, Dipti N ^a   Gadgoli, Chhaya H ^a   Halade, Ganesh V ^b  

^a Saraswathi Vidya Bhavan's College of Pharmacy   (India)

^b Preclinical Testing Department   (India)

Author keywords

Anticonvulsant; Labiatae; Maximal electroshock; Origanum majorana; Pentylenetetrazole; Sedative; Sodium pentobarbitone

Indexed keywords

ACETONE; CHLOROFORM; DIAZEPAM; ESSENTIAL OIL; ETHER; FLAVONOID; METHANOL; ORIGANUM MAJORANA EXTRACT; PENTETRAZOLE; PHENYTOIN; STEROID; TRITERPENOID; URSOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DISEASE MODEL; ELECTRIC SHOCK; FEMALE; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; LATENT PERIOD; MALE; MOUSE; NONHUMAN; OREGANO; PLANT GROWTH; PLANT LEAF; PLANT STEM; SEDATION; SEIZURE; SLEEP TIME; SOUTHERN EUROPE; TREATMENT OUTCOME;

EID: 34248330464     PISSN: None     EISSN: 18278620     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Vagi E, Simandi S, Daood H, Deak A, Sawinsky J. Recovery of pigment from Origanum majorana L. by extraction with supercritical carbon dioxide. J Agri Food Chem; 2002 50:2297-2301.
2. Vagi E, Rapvi E, Hadolin M, Vasarhelyine Perdei K, Balazs A, Blazovics A, Slmandi B. Phenolic and triterpenoid antioxidants from Origanum majorana L. herb and extracts obtained with different solvents. J Agri Food Chem 2005; 53:17-21.
3. Leung Y, Foster S, Encyclopedia of common natural ingredients used in food, drugs and cosmetics: John Wiley & Sons Inc., Press: Netherlands, 1996;364-366.
4. Shirley Price, The aromatherapy workbook; Hammersmith, London: Thorsons, 1993;54-5.
5. Heo HJ, Cho HY, Hong B, Kim H K, Heo TR, Kim EK, Kim SK, Kim CJ, Shin DH. Ursolic acid of Origanum majorana reduces Abeta-induced oxidative injury. Mol Cell2002; 13:5-11.
6. Deans SG, Svoboda KP. The antimicrobial properties of Marjoram ( Origanum majorana L.) volatile oil. Flavour Fragrance J 1990; 5:187-190.
7. Ezzeddine NB, Abedekefi MM, Ben Aissa R, Chaabouni MM. Antibacterial screening of Origanum majorana L. oil from Tunisia. J Essent Oil Res2001; 13:295-297.
8. Nadkarni AK, Copra RN, Indian Materia Medica Indian Popular Prakashan Private Limited, Mumbai, India, 1999;875.
9. Chevallier A, The Encyclopedia of Medicinal Plants, Andrew Chevallier and Dorling Kindersley Limited Publishers, London, 1996;9-78.
10. Piotr C, Barbara B, Stanislaw JC. Mechanisms of Action of Antiepileptic Drugs, Curr Topics Medicinal Chem, 2005;3-14.
11. Committee for the Purpose of Control and Supervision of Experiments on Animals. CPCSEA Guidelines for laboratory animal facility. Indian J Phamacol 2003; 35:257-274.
12. Vogel HG, and Vogel WH, Drug Discovery and Evaluation, Pharmacological Assay Springer, Berlin, 1997;260-261.
13. Toman JEP, Animal techniques for evaluating anticonvulsants In: Animals and Clinical Pharmacologic Techniques in Drug Evaluation, Nodine, J.H. and Siegler, P.E. (eds.) Year Book Medical Publishers. Inc., 35 East Wacker Drive, Chicago, 1964.
14. Swinyard EA, Brown WC, Goodman LS. Comparative assay of antiepileptic drugs in mice and rats. J Pharm Exp Ther1952; 106:319-330.
15. Hosseinzadeh H, Naassiri AM. Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice. BMC Pharmacol2003; 3:3-13.
16. Loscher W, Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposed based on experimental and clinical considerations. Epilepsy Res1998; 2:145-181.
17. Kulkarni SK, Verma A. Protective effect of mentat (BR-16A) a herbal preparation, on alcohol abstinence-induced anxiety and convulsions. Indian J Expt Bio1993; 31:435-440.
18. Rogawski MA, Porter RJ. Antiepileptic drugs and pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds. Pharmacol Rev1995; 42:223-286.
19. Macdonald RL, Kelly KM. Antiepileptic drug mechanisms of action. Epilepsia1995; 36:S2-S12.
20. Librowski T, Czaenecki R, Mendyk A, Jastrzebska M. Influence of new monoterpene homologue of GABA on the central nervous system activity in mice. Pol J Pahrmacol2000; 52:317-321.
21. Silva Brum LF, Emanuelli T, Souza DO, Elisabetsky E. Effects of linalool on glutamate release and uptake in mouse cortical synaptosomes. Neurochem Res2001; 3:191-4.
22. Consroe P, Martin A, Singh V. Antiepileptic potential of cannabinoid analogues. J Clinical Pharmacol1981; 21:428S-436S.
23. Dallmeier K, Carlini EA. Anesthetic hypothermic myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacol 1981; 22:113-127.
24. Wie MB, Won MH, Lee KH, Shin JH, Lee JS, Suh HW, Song DK, Kim YH. Eugenol protects neuronal cells from ecitotoxic and oxidative injury in primary cortical cultures. Neurosci Lett 1981; 225:93-96.
25. Yo-Kyung Chung, Ho-Jin Heo, Eun-Ki Kim, Hye-Kyung Kim, Tae-Lin Huh, Yoohgho Lim, Sung-Koo Kim and Dong-Hoon Shin. Inhibitory effect of ursolic acid purified from Origanum majorana L. on the Acetylcholinesterase. Mol cells2001; 11:137-143.