Cirrhosis in Werner's syndrome: An unusual presentation of premature aging

Medical Science Monitor

Volumn 13, Issue 5, 2007, Pages

  Hakeem, Abdul ^a   Reza, Shahzad ^b   Moinuddin, Salman ^c   Bhatti, Sabha ^a   Khalid, Imran ^c   Noor, Rahat ^c   Mahmood, Khalid ^b  

^a University of Wisconsin Health   (United States)

^b CIVIL HOSPITAL   (Pakistan)

^c AGA KHAN UNIVERSITY HOSPITAL   (Pakistan)

Author keywords

Cirrhosis; Premature ageing; Werner's syndrome

Indexed keywords

ABDOMINAL DISCOMFORT; ADULT; ARTICLE; CASE REPORT; DISEASE DURATION; HEMATEMESIS; HUMAN; LIVER CIRRHOSIS; MALE; PHYSICAL EXAMINATION; PORTAL HYPERTENSION; PREMATURE AGING; SENILITY; WEIGHT REDUCTION; WERNER SYNDROME;

ADOLESCENT; ADULT; AGING, PREMATURE; FATAL OUTCOME; HUMANS; LIVER CIRRHOSIS; MALE; PAKISTAN; WERNER SYNDROME;

EID: 34248227264     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Yamamoto K, Imakiire A, Miyagawa N, Kasahara T: A report of two cases of Werner's syndrome and review of the literature. J Orthop Surg (Hong Kong), 2003; 11(2): 224-33
2. Goto M: Werner's syndrome: from clinics to genetics. Clin Exp Rheumatol, 2000; 18(6): 760-66
3. Werner O: Kiel University. Schmidt and Klauning; Kiel: 1904. On Cataract Associated in Conjunction with Scleroderma [doctoral dissertation]
4. Irwin GW, Ward PB: Werner's syndrome: with a report of two cases. Am J Med, 1953; 15(2): 266-71
5. Tollefsbol TO, Cohen HJ: Werner's syndrome: an underdiagnosed disorder resembling premature aging. Age, 1984; 7: 75-88
6. Epstein CJ, Martin GM, Schultz AL, Motulsky AG: Werner's syndromea review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process. Medicine(Baltimore), 1966; 45(3): 177-221
7. Goto M: Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing. Mech Ageing Dev, 1997; 98(3): 239-54
8. Chen L, Oshima J: Werner Syndrome.J Biomed Biotechnol, 2002; 2(2): 46-54
9. Gray MD, Shen JC, Kamath-Loeb AS et al: The Werner syndrome protein is a DNA helicase. Nat Genet, 1997; 17(1): 100-3
10. Oshima J: The Werner syndrome protein: an update. Bioessays, 2000; 22(10): 894-901
11. Goto M, Miller RW, Ishikawa Y, Sugano H: Excess of rare cancers in Werner Syndrome (adult progeria). Cancer Epidemiol. Biomarkers Prev, 1996, 5: 239-46
12. Byungchan A, Jeanine AH, Fred EI et al: Regulation of WRN Helicase Activity in Human Base Excision Repair. J. Biol. Chem, 2004; 279(51): 53465-74
13. Barak Y, Sirota P, Kimhi R, Slor H: Werner's syndrome (adult progeria): an affected mother and son presenting with resistant psychosis. Compr Psychiatry, 2001; 42(6): 508-10
14. Yamada H, Miyamato Y, Murata K, Horiuchi Y: Two cases of Werner's Syndrome associated with hyperhyaluronuria [in Japanese]. Taisya, 1979; 16: 1215-23
15. Hatamochi A, Arakawa M, Takeda K, Ueki H: Activation of fibroblast proliferation by Werner;s syndrome fibroblast-conditioned medium. J Dermatol Sci, 1994; 7(3): 210-16
16. Arakawa M, Hatamochi A, Takeda K, Ueki H: Increased collagen synthesis accompanying elevated m-RNA levels in cultured Werner's syndrome fibroblasts. J Invest Dermatol, 1990; 94(2): 187-90
17. Yamada K, Ikegami H, Yoneda H et al: All patients with Werner's syndrome are insulin resistant, but only those who also have impaired insulin secretion develop overt diabetes. Diabetes Care, 1999; 22(12): 2094-95
18. Liou I, Kowdley KV: Natural history of nonalcoholic steatohepatitis. J Clin Gastroenterol, 2006; 40(3 Suppl.1): S11-16
19. Goto M, Horiuchi Y, Okumura K et al: Immunological abnormalities of aging: an analysis of T lymphocyte subpopulations of Werner's syndrome. J Clin Invest, 1979; 64(3): 695-99
20. Ishikawa Y, Miller RW, Machinami R et al: Atypical osteosarcomas in Werner Syndrome (adult progeria). Jpn J Cancer Res. 2000; 91(12): 1345-49
21. Hrabko RP, Milgrom H, Schwartz RA: Werner's syndrome with associated malignant neoplasms. Arch Dermatol, 1982; 118(2): 106-8
22. Fossel M: Human aging and progeria. J Pediatr Endocrinol Metab, 2000; 13(Suppl.6): 1477-81
23. Nehlin JO, Skovgaard GL, Bohr VA: The Werner syndrome. A model for the study of human aging. Ann NY Acad Sci, 2000; 908: 167-79
24. Murata K, Nakashima H: Clinical and metabolic studies on Werner's syndrome: with special reference to disorders of lipid and liver function. Adv Exp Med Biol, 1985; 190: 285-304
25. Mori S, Morisaki N, Murano S et al: Fatty liver as a complication of patients with Werner's syndrome. Nippon Ronen Igakkai Zasshi. 1988; 25(6): 626-31
26. Sogawa, M, Kasuya S, Yamamoto K et al: Aortic Valve Replacement for Aortic Stenosis with a Small Aortic Annulus in a Patient having Werner's Syndrome and Liver Cirrhosis. Ann Thorac Cardiovasc Surg, 2001; 7: 378-80